scholarly journals Creatinine clearance after cimetidine administration in a new short procedure: comparison with plasma and renal clearances of iohexol

2019 ◽  
Vol 13 (4) ◽  
pp. 587-596 ◽  
Author(s):  
Thomas Stehlé ◽  
Khalil El Karoui ◽  
Mehdi Sakka ◽  
Ahmad Ismail ◽  
Marie Matignon ◽  
...  
Keyword(s):  
Creatinine Clearance ◽  
Good Precision ◽  
Limits Of Agreement ◽  
Reference Limits ◽  
Before And After ◽  
Renal Clearances ◽  
The Mean ◽  
High Level ◽  
Level Of Agreement ◽  
Oral Cimetidine

Abstract Background Creatinine clearance after cimetidine administration (Cim-CreatClr) was once proposed as a method of glomerular filtration rate (GFR) measurement, but has been largely abandoned. We investigated whether a new short procedure for Cim-CreatClr determination could be considered an appropriate method for GFR measurement. Methods A 150-min protocol involving oral cimetidine administration was developed to determine Cim-CreatClr. In total, 168 patients underwent simultaneous assessments of creatinine clearance before and after cimetidine administration [basal creatinine clearance (Basal-CreatClr) and Cim-CreatClr, respectively], renal iohexol clearance and plasma iohexol clearance (R-iohexClr and P-iohexClr, respectively). We compared the agreement between the various methods of GFR measurement, using Bland–Altman plots to determine biases, precisions (standard deviation of the biases) and accuracy (proportions of GFR values falling within 10, 15 and 30% of the mean: P10, P15 and P30, respectively). Results After cimetidine administration, Basal-CreatClr decreased by 19.8% [95% reference limits of agreement (95% LoA): −2.2 to 41.7%]. The bias between Cim-CreatClr and P-iohexClr was −0.6% (95% LoA −26.8 to 28%); the precision was 14.0%; P10, P15 and P30 were 57.1% [95% confidence interval (95% CI) 49.3 to 64.7%], 73.2% (95% CI 65.8 to 79.7%) and 97.0% (95% CI 93.2 to 99.0%), respectively. Due to the positive bias (16.7%; 95% LoA −3.6 to 36.9%) of Cim-CreatClr relative to R-iohexClr, accuracy of Cim-CreatClr relative to R-iohexClr was poor despite a good precision (10.3%). Conclusions Our study shows a high level of agreement between Cim-CreatClr and P-iohexClr. These results suggest that this short Cim-CreatClr procedure is a valid method for GFR measurement, which might be useful, in particular, in situations in which P-iohexClr is not suitable or not available.

scholarly journals The influence of oral cimetidine administration on creatinine clearance in chilren with chronic renal failure: A preliminary study

2016 ◽  
Vol 45 (1) ◽  
pp. 14
Author(s):  
Rosalina D Roeslani ◽  
Partini P Trihono ◽  
Sri Rezeki Harun
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Creatinine Clearance ◽  
Reference Value ◽  
Oral Ingestion ◽  
Serum Cystatin ◽  
Before And After ◽  
The Mean ◽  
Preliminary Study ◽  
Oral Cimetidine

Background Serum creatinine and creatinine clearance are usedto assess glomerular filtration rate but have a major disadvantagesince a variable amount of creatinine is secreted in the proximaltubule. This may cause an unpredictable overestimation of GFR.Tubular creatinine secretion can be blocked by cimetidine throughcompetitive inhibition of cation transport in the proximal tubularluminal membrane.Objective Cimetidine administration might improve the reliabilityof creatinine as a marker of glomerular filtration.Methods A preliminary study with a one-group pretest-posttestdesign in 11 children with chronic renal failure. Serum cystatin Clevel as reference value was compared with creatinine clearancemeasured before and after oral ingestion of cimetidine. The doseof cimetidine was adjusted with the GFR using Schwartz formula.Statistical evaluation was done with the Wilcoxon signed rankstest.Result The mean creatinine clearance before cimetidine adminis-tration was 27.4 (SD 14.6) ml/minute/1.73 m 2 BSA, and decreasedafter cimetidine to 21.1 (SD 13,1) ml/minute/1.73 m 2 BSA (p=0.015).Conclusion Oral cimetidine was effective in inhibiting creatininetubular secretion. This study could not prove that cimetidine im-proves the accuracy of creatinine clearance

scholarly journals Agreement analysis between critical power and intensity corresponding to 50% in cycling exercise

2016 ◽  
Vol 18 (2) ◽  
pp. 197 ◽  
Author(s):  
Kristopher Mendes de Souza ◽  
Ricardo Dantas de Lucas ◽  
Paulo Cesar do Nascimento Salvador ◽  
Lucas Crescenti Abdalla Saad Helal ◽  
Luiz Guilherme Antonacci Guglielmo ◽  
...  
Keyword(s):  
Oxygen Uptake ◽  
Lactate Threshold ◽  
Critical Power ◽  
Limits Of Agreement ◽  
Cycling Exercise ◽  
Significant Difference ◽  
The Mean ◽  
The Difference ◽  
Male Subjects ◽  
Level Of Agreement

DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n2p197 The purpose of this study was to determine the level of agreement between critical power (CP) and intensity corresponding to 50% of the difference (50% Δ) between oxygen uptake (VO2) at lactate threshold (LT) and maximal oxygen uptake (VO2max) in untrained subjects during cycling exercise. Fifteen healthy male subjects (age: 26.0 ± 3.5 years; body weight: 76.6 ± 10.4 kg; height: 178.2 ± 7.6 cm) volunteered to participate in the study. Each subject performed a series of tests to determine LT, VO2LT, CP, VO2CP, 50% Δ, VO250% Δ, and VO2max. The values of LT, VO2LT, CP, VO2CP, 50% Δ, VO250% Δ and VO2max were 109 ± 15 W, 1.84 ± 0.23 L.min-1, 207 ± 17 W, 2.78 ± 0.27 L.min-1, 206 ± 19 W, 2.77 ± 0.29 L.min-1, and 3.71 ± 0.49 L.min-1, respectively. No significant difference was found between CP and 50% Δ (t = 0.16; p = 0.87) or between VO2CP and VO250% Δ (t = 0.12; p = 0.90). However, the bias ± 95% limits of agreement for comparison between CP and 50% Δ and between VO2CP and VO250% Δ were 1 ± 27 W (0.3 ± 14.1%) and 0.01 ± 0.24 L.min-1 (0.2 ± 8.9%), respectively. In summary, the mean CP and 50% Δ values were not significantly different. However, considering the limits of agreement between the two intensities, CP estimated based on 50% Δ might result in a remarkable error when the absolute variability of individual differences is taken into account

scholarly journals Comparison of phoropter and trial frame-based von Graefe heterophoria measures in non-presbyopic participants

2021 ◽  
Vol 80 (1) ◽  
Author(s):  
Annah L. Tsotetsi ◽  
Solani D. Mathebula
Keyword(s):  
South Africa ◽  
University Students ◽  
Limits Of Agreement ◽  
Near Vision ◽  
Subjective Measurement ◽  
Normal University ◽  
Standard Deviations ◽  
High Level ◽  
Level Of Agreement

Background: There are several clinical techniques for the subjective measurement of heterophoria. In South Africa, von Graefe (VG) is a commonly used technique to quantify heterophoria using the phoropter.Purpose: The purpose of the study was to investigate the agreement of VG heterophoria measurement using the phoropter and a trial frame.Setting: The study was conducted at an Optometry Clinic, University of Limpopo, South Africa.Methods: Both distance and near horizontal and vertical heterophoria VG measurements were performed on 88 visually-normal university students using the phoropter and trial frame. The handheld rotary prism was used on the trial frame. The 95% limits of agreement in prism diopters were compared using the Bland-Altman statistical test.Results: For distance horizontal heterophoria, the VG means were 0.39 exophoria ± 2.0Δ and 0.38 exophoria ± 1.8Δ with the phoropter and trial frame respectively. The means for near horizontal heterophoria were 3.69 exophoria ± 3.3Δ and 4.13 exophoria ± 3.27Δ with the phoropter and trial frame. For the vertical heterophoria at distance, the means and standard deviations were 0.18 hyperphoria ± 0.74 and 0.13 hyperphoria ± 0.07Δ, while at near vision they were 0.03 hyperphoria ± 0.71 and 0.07 hyperphoria ± 0.71Δ, respectively.Conclusion: Measurement of VG heterophoria testing using the phoropter and trial frame showed a high level of agreement for both distance and near vision performed through the phoropter and a trial frame. For clinical and research purposes, the phoropter and trial frame can be used interchangeably for measuring heterophoria.

scholarly journals Learning Achievement Improvement of 1st Grade Students by Using Problem-Based Learning (PBL) on TPACK MODEL

2022 ◽  
Vol 11 (2) ◽  
pp. 43
Author(s):  
Orathai Chaidam ◽  
Apantee Poonputta
Keyword(s):  
Problem Based Learning ◽  
Achievement Test ◽  
Lesson Plans ◽  
Learning Achievement ◽  
Average Efficiency ◽  
Class 1 ◽  
Before And After ◽  
The Mean ◽  
High Level ◽  
Academic Year

The objectives of the research were: 1) to develop the lesson plans for “Weight and Measurement” of Mathematics by using Problem-Based Learning on TPACK MODEL based on the efficiency of the process and the overall result (E1/E2) at the established criteria of 75/75; 2) to compare the students’ learning achievement in “Weight and Measurement” of the 1st grade students before and after by using Problem-Based Learning on TPACK MODEL; 3) to study the students’ satisfaction with Problem-Based Learning on TPACK MODEL. The research samples were thirty-five 1st grade students of class 1 in the 1st semester of the academic year 2020 at Sanambin School in Khon Kaen Province. They were selected by purposive sampling. The instruments used in this study were lesson plans, an achievement test, and a questionnaire on students’ satisfaction. The statistics used for analyzing the collected data were mean, standard deviation, percentage, and gain score. The research results showed that 1) the average efficiency of the lesson plans for “Weight and Measurement” by using Problem-Based Learning on TPACK MODEL with exercises was 85.54/78.71, which was higher than theestablished criteria. 2) The mean score of the 1st grade students for “Weight and Measurement” of Mathematics after using Problem-Based Learning on TPACK MODEL was significantly higher than that of before using the Problem-Based Learning Model. 3) The overall satisfaction of the students with the Problem-Based Learning on TPACK MODEL for “Weight and Measurement was at a high level.

Comparison of different autoanalyzers for the determination of lymphocyte and neutrophil counts in mouse blood

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Saurabh Kumar Gupta ◽  
Dievya Gohil ◽  
Girish Ch. Panigrahi ◽  
Swati Vaykar ◽  
Pallavi Rane ◽  
...  
Keyword(s):  
Neutrophil Count ◽  
Gold Standard ◽  
Limits Of Agreement ◽  
Mouse Blood ◽  
Blood Samples ◽  
Manual Counting ◽  
Bland Altman Method ◽  
High Level ◽  
Level Of Agreement

Abstract Objectives Autoanalyzers are used in clinical haematology for analysis of blood samples in clinical as well as in nonclinical studies. The results from these analyzers vary from machine to machine. In this study, we compared the lymphocyte and neutrophil count of mouse blood between ADVIA 2120i, Horiba Yumizen H2500 and CellaVision analyzers against manual counting as gold standard. Methods Blood samples from 28 female BALB/c mice were collected and analyzed. Agreement between different autoanalyzers and manual counting were determined by Bland–Altman method. Results A high level of agreement was found between CellaVision and manual technique for lymphocyte (Bias=4.75, 95% limits of agreement −14 to 24) and neutrophil count (Bias=0.68 (−17 to 19)). Agreement in lymphocyte count was also observed between ADVIA and manual counting, but to a lesser extent compared to CellaVision (Bias=13.9 (−10.45 to 38.27)). However, no agreement was observed for ADVIA (Neutrophils), Horiba (lymphocytes and neutrophils) with manual counting. Conclusions Our data suggests that CellaVision could be used for the differential counting of neutrophil and lymphocytes in mouse blood sample.

scholarly journals Comparison of central corneal thickness measurements with three different optical devices

2021 ◽  
Vol 13 ◽  
pp. 251584142199563
Author(s):  
Mehmet Barış Üçer ◽  
Erdinç Bozkurt
Keyword(s):  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Correlation Coefficients ◽  
Limits Of Agreement ◽  
The Mean ◽  
Mean Differences ◽  
High Level ◽  
Thickness Measurements

Purpose: The purpose of this study was to compare and evaluate the agreement of central corneal thickness (CCT) values obtained with three different devices working according to optical principle in healthy eyes. Methods: 60 eyes of 60 individuals (30 men and 30 women) were enrolled in this study. CCT measurements performed with Scheimpflug–Placido topographer (Sirius), spectral-domain optical coherence tomography (RTVue) with an anterior segment module, and optical biometer (AL-Scan) were compared. Bland–Altman analysis was used to demonstrate agreement between methods. Results: The mean age was 30.07 ± 7.313 years (range, 18–47 years). The mean CCT values obtained by RTVue, Sirius, and AL-Scan were 518.25 ± 36.38 µm, 526.08 ± 36.33 µm, and 513.50 ± 39.09 µm, respectively. The mean differences in CCT were 7.83 ± 14.15 µm between Sirius and RTVue, 12.58 ± 11.87 µm between Sirius and AL-Scan, and 4.75 ± 4.50 µm between RTVue and AL-Scan. The mean CCT was statistically different among the three groups ( p < 0.05). All three modalities of CCT measurements correlated closely with each other, with Pearson’s correlation coefficients ranging from 0.924 to 0.961. The 95% limits of agreement were −19.90 to 35.56 µm between Sirius and RTVue, −10.69 to 35.85 µm between Sirius and AL-Scan, and −4.07 to 13.58 µm between RTVue and AL-Scan. Conclusion: Different results could be obtained through different noncontact devices in CCT measurements. Although the measurement values obtained by these devices show a high level of correlation, it would be a more correct approach to not use them directly interchangeably in clinical practice. Evaluation and follow-up of CCT should be performed using the same device.

scholarly journals Prediction of fertility by centrifugal countercurrent distribution (CCCD) analysis: correlation between viability and heterogeneity of ram semen and field fertility

Reproduction ◽  
2002 ◽  
pp. 869-875 ◽  
Author(s):  
R Perez-Pe ◽  
JI Marti ◽  
E Sevilla ◽  
M Fernandez-Sanchez ◽  
E Fantova ◽  
...  
Keyword(s):  
Artificial Insemination ◽  
Mean Value ◽  
Countercurrent Distribution ◽  
Semen Parameters ◽  
Distribution Analysis ◽  
Predictive Capacity ◽  
Before And After ◽  
The Mean ◽  
High Level

The prediction of the fertilizing ability of a sire or a given insemination dose is a primary aim in the field of artificial insemination. Centrifugal countercurrent distribution analysis (CCCD) was used to determine the relationship between some sperm parameters and the in vivo fertility rate obtained with the same sample after cervical artificial insemination. A total of 522 ewes from 26 different farms was inseminated with 53 ejaculates obtained from 25 mature Rasa aragonesa rams. Semen was diluted to 1.6 x 10(9) cells ml-1 and doses of 0.25 ml were prepared and kept at 15 degrees C until used for insemination. The same ejaculates were used for analysis of standard semen parameters and CCCD analysis. Sperm motility, concentration and viability were determined before and after CCCD. Post-CCCD parameters were derived from the analysis of the profile obtained after CCCD. The recovered viability showed the highest correlation with fertility, especially in the central chambers (V2), r = 0.415, P < 0.005). The ejaculate heterogeneity also showed a positive correlation with field fertility (r = 0.23), with a tendency towards significance (P < 0.1). The mean fertility value of all ejaculates used in this study was 46.75%, ranging from 12.5% to 75.0%. Ejaculates were classified into two categories according to their fertility: higher and lower than the mean value. Only the viability recovered in the central chambers (V2) was a parameter with a predictive capacity to discriminate between the two groups (P < 0.05). A predictive equation for field fertility with a correlation coefficient r = 0.488 and a very high level of significance (P < 0.005) was deduced by multiple analysis: PF = 6.02 + 0.069V2 + 0.315H (where PF is predictive fertility, V2 is the recovered viability in the CCCD profile central chambers and H is heterogeneity).

scholarly journals Feasibility and accuracy of teleconcussion for acute evaluation of suspected concussion

Neurology ◽  
2017 ◽  
Vol 88 (16) ◽  
pp. 1580-1583 ◽  
Author(s):  
Bert B. Vargas ◽  
Morgan Shepard ◽  
Joseph G. Hentz ◽  
Cherisse Kutyreff ◽  
L. George Hershey ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Real Time ◽  
Football Players ◽  
Face To Face ◽  
The Face ◽  
The Mean ◽  
High Level ◽  
Collegiate Football ◽  
Balance Error ◽  
Level Of Agreement

Objective:To assess the feasibility and accuracy of telemedical concussion evaluations (teleconcussion) for real-time athletic sideline assessment of concussion, as such assessment may address the gap in access some populations of athletes have to providers with expertise in concussion evaluation.Methods:A cohort of 11 consecutive male collegiate football players with suspected concussion was assessed using Standardized Assessment of Concussion (SAC), King-Devick test (K-D), and modified Balance Error Scoring System (mBESS). A remote neurologist assessed each athlete using a telemedicine robot with real-time, 2-way audiovisual capabilities, while a sideline provider performed a simultaneous face-to-face assessment. After the assessment, a remove-from-play (RFP) determination was made. The remote and the face-to-face providers were blinded to each other’s examination findings and RFP decision until the end of the assessment.Results:The teleconcussion and face-to-face SAC were in agreement 100% of the time (6/6; 95% confidence interval [CI] 54%–100%). The mean (SD) difference between remote and sideline K-D times was 0.7 (1.4) seconds. Remote and sideline K-D times were within a 3-second difference 100% of the time (11/11; 95% CI 72%–100%). Remote and sideline mBESS scores were within 3 points 100% of the time (6/6; 95% CI 54%–100%). RFP decisions were in agreement 100% of the time (11/11; 95% CI 72%–100%).Conclusions:The aim of this study was to investigate the feasibility of teleconcussion for sideline concussion assessments. These data suggest a high level of agreement between remote and face-to-face providers with regard to examination findings and RFP determinations.

scholarly journals About the using of Matiegka’s formulas to evaluate the fat component of body mass. Technical recommendations (short communication)

2021 ◽  
pp. 27-32
Author(s):  
Anna V. Anisimova ◽  
Keyword(s):  
Body Fat ◽  
Short Communication ◽  
Average Thickness ◽  
Mean Values ◽  
Final Estimate ◽  
The Mean ◽  
Highly Correlated ◽  
High Level ◽  
Level Of Agreement ◽  
Technical Recommendations

For this work were taken measurements of the skinfolds of Russian children and adolescents of both sexes 7-17 years old, with a total number of 1103 pupils. Was made a comparison of the mean values of the average skinfolds. Results and discussion. In the investigated group significant differences in the average thickness of the skinfolds were revealed between the initial set of Matiegka and the modification of Lutovinova et al. The revealed differences significantly influenced the final estimates of the mass of body fat. However, the estimates obtained turned out to be highly correlated and with a high level of agreement, on the basis of which conversion formulas between them were proposed. Conclusion. When using Matiegka's formulas, it is necessary to give a detailed description of the method for measuring skinfolds, taking into account the influence of the choice of skinfolds on the final estimate of the fat mass.

Blood Fibrinolysis and the Response to Desmopressin in Glomerulonephritis

1994 ◽  
Vol 71 (01) ◽  
pp. 019-025 ◽  
Author(s):  
E J P Brommer ◽  
A W L Van den Wall Bake ◽  
G Dooijewaard ◽  
B J Potter van Loon ◽  
J J Emeis ◽  
...  
Keyword(s):  
Renal Function ◽  
Creatinine Clearance ◽  
Impaired Renal Function ◽  
Acute Stage ◽  
Severe Renal Failure ◽  
Adult Type ◽  
Before And After ◽  
The Mean ◽  
Baseline Levels ◽  
Fibrinolytic Parameters

SummaryFibrinolytic parameters and von Willebrand factor (VWF) antigen were measured in 22 patients with glomerulonephritis (GN) who underwent renal biopsy after desmopressin (DDAVP) infusion. Blood was collected immediately before and after DDAVP infusion, after one week, and 3–6 months later. The main abnormalities on admission were the following: the mean baseline levels of t-PA antigen and VWF were significantly higher in GN patients than in 22 healthy controls; the median t-PA activity and the mean scu-PA level were significantly lower than normal . The t-PA response to DDAVP was impaired in 7 patients (32%), the response of VWF in 9 patients (41%), and the u-PA: Ag response in 11 patients (50%). When the patients were stratified according to creatinine clearance rate, significant differences between the subgroups with severely and moderately impaired renal function were noted: the baseline levels of PAI activity and VWF were higher in patients with severe renal failure and the VWF response to DDAVP was significantly lower. The response of u-PA (not of t-PA or VWF) to DDAVP appeared to correlate with urine flow during the first 24 h, suggesting the dependence of u-PA release on intact nephrons. A series of 18 patients with adult-type polycystic kidney disease (APKD) with creatinine clearance rates in the same abnormal range as the GN patients, had lower mean PAI and a significantly higher mean scu-PA level. Normalization of scu-PA and t-PA:Ag levels during follow-up despite impaired renal function in GN, and the absence of depressed scu-PA levels in APKD suggest that the fibrinolytic abnormalities are independent of the impaired renal function per se, but associated with the acute stage of nephritis.

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