scholarly journals Relationship between lipid profiles with carotid intima--media thickness in children with type I diabetes mellitus

2016 ◽  
Vol 48 (3) ◽  
pp. 147
Author(s):  
Rubiana Sukardi ◽  
Bambang Madiyono ◽  
Sudigdo Sastroasmoro ◽  
Jose RL Batubara
Keyword(s):  
Diabetes Mellitus ◽  
Type I Diabetes ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Lipid Profiles ◽  
Type I Diabetes Mellitus ◽  
Type I ◽  
Duration Of Diabetes ◽  
Media Thickness ◽  
Chronic Hyperglycemia

Background The major cause of morbidity and mortality inpatients with type I diabetes mellitus is premature and extensiveartherosclerosis. Carotid intima-media thickness (IMT) isassociated with cardivascular risk factors and has been used as amarker of early artherosclerosis process.Objective To determine IMT of carotid artery and its relationshipwith duration of diabetes, lipid profiles, and mean HbA 1 level.Methods A cross-sectional study was conducted on patientswith type 1 DM at the Department of Child Health CiptoMangunkusumo Hospital. Ultrasound B-mode imaging wasperformed to measure the IMT. Age-matched non-diabteticsubjects served as controls. Statistical significant was assumedat P<O.S.Results The mean IMT values of type I DM patients aged < 12years, 12-18 years, 18+ years were 0.44 (SD 0.03) mm; 0.46(SD 0.01) mm; 0.51 (SD 0.01) mm, respectively, which weresignificantly greater than those of age-matched non-diabeticsubjects which were 0.39 (SD 0.01), 0.41 (SD 0.01) mm, 0.46(SD 0.01) mm, respectively. Patients with type I DM had ahigher apolipoprotein-Band HDL cholesterol levels than in non-diabetic subjects. Multiple regression analysis showed that therewas no relationship between total cholesterol, cholesterol LDL,chronic hyperglycemia (HbA 1) and IMT. However, IMT in typeI diabetes was linearly related with duration of diabetes .Conclusion Type I DM patients have greater IMT and highermean apolipoprotein B. There is a strong correlation betweenIMT and duration of diabetes.

scholarly journals Diabetic retinopathy and its’ association with carotid intima media thickness.

2019 ◽  
Vol 26 (09) ◽  
pp. 1445-1450
Author(s):  
Farhat Bashir ◽  
Beenish Khan ◽  
Shehla Tanveer
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Glycemic Control ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Categorical Variables ◽  
P Value ◽  
Duration Of Diabetes ◽  
Media Thickness ◽  
Control Serum

Objectives: To evaluate the association of diabetic retinopathy (DR) and CIMT (carotid intima-media thickness) in diabetic subjects and to identify the factors contributing to retinopathy. Study Design: Comparative cross-sectional study. Setting: Creek General Hospital, United Medical and Dental College. Period: August 2017 to July 2018. Material and Methods: After identification of 62 subjects with type 2 diabetes mellitus for the study, their complete history, physical examination and relevant laboratory investigations were recorded. The diabetic retinopathy was assessed by ophthalmoscopy. All subjects underwent Doppler ultrasound scanning of the carotid arteries for measurement of CIMT (carotid intima-media thickness). The data was analyzed through SPSS version 20.0. Student’s t-test was used to assess the association between retinopathy and CIMT and other continuous variables. The association of categorical variables was assessed by Chi-square. P-value of <0.05 was considered significant. Results: The target population constituted 29% males and 71% females. Among the participating subjects 50.2% had retinopathy while 49.8% subjects without retinopathy were included in the study. There was a strong association of retinopathy with carotid intima-media thickness. Retinopathy was also associated with duration of diabetes mellitus, measures of glycemic control, serum creatinine levels, total cholesterol, LDL cholesterol, and serum triglycerides. Conclusion: Retinopathy is strongly associated with CIMT. Poor glycemic control, nephropathy, dyslipidemia and duration of diabetes also show association with retinopathy.

Effects of long-term optimization and short-term deterioration of glycemic control on glucose counterregulation in type I diabetes mellitus

Diabetes ◽  
1984 ◽  
Vol 33 (4) ◽  
pp. 394-400 ◽  
Author(s):  
G. Bolli ◽  
P. De Feo ◽  
S. De Cosmo ◽  
G. Perriello ◽  
G. Angeletti ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Type I ◽  
Short Term

Competitive insulin autoantibody assay. Prospective evaluation of subjects at high risk for development of type I diabetes mellitus

Diabetes ◽  
1987 ◽  
Vol 36 (11) ◽  
pp. 1286-1291 ◽  
Author(s):  
P. Vardi ◽  
S. A. Dib ◽  
M. Tuttleman ◽  
J. E. Connelly ◽  
M. Grinbergs ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
High Risk ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Type I ◽  
Prospective Evaluation ◽  
Insulin Autoantibody

Pilot study on omega-3 fatty acids in type I diabetes mellitus

Diabetes ◽  
1990 ◽  
Vol 39 (3) ◽  
pp. 369-375 ◽  
Author(s):  
M. M. Landgraf-Leurs ◽  
C. Drummer ◽  
H. Froschl ◽  
R. Steinhuber ◽  
C. Von Schacky ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Fatty Acids ◽  
Pilot Study ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Type I ◽  
Omega 3 Fatty Acids ◽  
Omega 3

Differential sensitivity to beta-cell secretagogues in "early," type I diabetes mellitus

Diabetes ◽  
1984 ◽  
Vol 33 (6) ◽  
pp. 516-521 ◽  
Author(s):  
O. P. Ganda ◽  
S. Srikanta ◽  
S. J. Brink ◽  
M. A. Morris ◽  
R. E. Gleason ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cell ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Differential Sensitivity ◽  
Type I ◽  
Early Type

Correlation of Waist to Calf Circumference Ratio and Carotid Intima Media Thickness in Diabetes Mellitus

2020 ◽  
Vol 16 ◽  
Author(s):  
Harish A Rao ◽  
Prakash Harischandra ◽  
Srikanth Yadav
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Carotid Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Calf Circumference ◽  
Media Thickness

Introduction: Diabetes mellitus is a well-known risk factor for cardiovascular disease, because of the accelerated process of atherosclerosis. Obesity is an established risk factor and has gained immense importance in recent studies as an important risk factor for clinical cardiovascular disease, yet the fundamental component stays unclear. Calf circumference is another form for lean mass and peripheral subcutaneous fat and is inversely associated with occurrence of carotid plaques (CP). Multiplicative and opposite effects of both Calf Circumference (CC) and Waist Circumference (WC) in event of CP suggest that the two measures should be taken into account commonly while assessing vascular risk profile. Aim & Objective: To ascertain if waist to calf circumference ratio (WCR) is a marker of Carotid atherosclerosis in patients with type 2 diabetes mellitus. To asses s the correlation between waist to calf circumference ratio and carotid intima media thickness (CIMT ) in patients with Type 2 diabetes. Materials and methods: A cross sectional study at Hospital affiliated to Kasturba Medical college Mangalore from Sept 2016 to Sept 2018 . Method of study: Patients with type 2 DM as per ADA criteria, age >18years are recruited for the study. Results and discussion: In our study with 150 population 25 patients had carotid atherosclerosis and 20 patients had CIMT>1.1. The waist circumference in patients with CA is in the range of 93.07 and 99.85 & the CC in patients with CA is in the range of 29.49 to 31.25. The WCR in patients with CA is in the range of 3.12 to 3.26. The difference was statistically significant with a p value of <0.05. In our study it was found that WC and WCR correlated well with carotid atherosclerosis, and surprisingly calf circumference also correlated with carotid atherosclerosis but not as significant as both WC and WCR. Conclusion: To conclude, in our population based study of 150 subjects we found that carotid atherosclerosis is significantly more in people with increased waist calf circumference ratio. WCR may be a new, useful and practical anthropometric index that facilitates the early identification of diabetic subjects with high risk for cardiovascular disease. Validation of this finding in individual populations is required. Future studies should test the association of calf circumference with carotid intima media thickness and carotid plaques using better measures than ultrasound such as magnetic resonance imaging. Further research focusing on underlying mechanisms in the role of lean mass and peripheral fat mass is required.

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