scholarly journals Correlation between serum albumin and creatinine levels in children with nephrotic syndrome

2016 ◽  
Vol 48 (6) ◽  
pp. 354
Author(s):  
Gartika Sapartini ◽  
Dedi Rachmadi ◽  
Herry Garna
Keyword(s):  
Nephrotic Syndrome ◽  
Serum Creatinine ◽  
Serum Albumin ◽  
Serum Creatinine Level ◽  
Creatinine Level ◽  
Pearson Correlation ◽  
Renal Perfusion ◽  
Cross Sectional Study ◽  
Albumin Level ◽  
Cross Sectional

Background Nephrotic syndrome is a glomerular disordercharacterized by massive proteinuria, hypoalbuminemia, edema,and hyperlipidemia. Hypoalbuminemia in nephrotic syndromeleads to hypovolemia, a decrease in renal perfusion and glomerularfiltration rate. Serum creatinine level reflects the glomerularfiltration rate.Objective The aim of this study was to determine the correlationbetween serum albumin and creatinine levels in children withnephrotic syndrome.Methods A cross-sectional study was carried out on children withidiopathic nephrotic syndrome, aged between 1 to 14 years old,admitted to Pediatric Department in Hasan Sadikin Hospitalfrom January 2001 to September 2007. We used data frompatients' medical records to obtain serum albumin and creatininelevels during nephrotic stage. Statistical analysis using Pearsoncorrelation test was performed to establish the correlation betweenserum albumin and creatinine levels. The type of correlation wasdetermined by regression analysis.Results Subjects were 113 children, consisted of 81 boys (72%)with mean of age 6.8 (SD 3.3) years. Mean of serum albumin andcreatinine levels were 1.4 (SD 0.4) g/dL and 0.7 (SD 0.4) mg/dL, respectively. Analysis using Pearson correlation test showeda moderate (r=-0.478) significant correlation (P<O.Ol) betweenserum albumin and creatinine levels in children with nephroticsyndrome. Regression analysis suggested a negative linearrelationship between serum albumin level as the independentvariable (X) and serum creatinine level as the dependent variable(Y) by using equation Y = 1.328-0.460X.Conclusion In patients with nephrotic syndrome there is amoderate negative correlation between serum albumin andcreatinine levels.

Association Between Serum Creatinine Level and Colorectal Adenomas: A Cross-Sectional Study

2014 ◽  
Vol 109 ◽  
pp. S209
Author(s):  
Huafeng Shen ◽  
Seth Lipka ◽  
Jeffrey Silpe ◽  
Andy White ◽  
Samuel Satler ◽  
...  
Keyword(s):  
Serum Creatinine ◽  
Serum Creatinine Level ◽  
Creatinine Level ◽  
Cross Sectional Study ◽  
Colorectal Adenomas ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Subclinical hypothyroidism in pediatric nephrotic syndrome: the correlations with albumin, globulin, and proteinuria

2020 ◽  
Vol 60 (2) ◽  
pp. 90-4
Author(s):  
Erni Nuraeni ◽  
Faiisal Faisal ◽  
Ahmedz Widiasta ◽  
Novina Novina
Keyword(s):  
Nephrotic Syndrome ◽  
Serum Albumin ◽  
Subclinical Hypothyroidism ◽  
Serum Albumin Level ◽  
Cross Sectional Study ◽  
Albumin Level ◽  
Thyroid Stimulating Hormone ◽  
Hormone Deficiency ◽  
Cross Sectional ◽  
Univariate Logistic Regression Analysis

Background Nephrotic syndrome causes loss of medium-sized plasma proteins and binding proteins, resulting in thyroid hormone deficiency. Objective To assess for potential correlations between subclinical hypothyroidism in pediatric nephrotic syndrome with albumin, globulin, and proteinuria. Methods This cross-sectional study was conducted in the Department of Pediatrics, Hasan Sadikin General Hospital, Bandung, West Java. All types of nephrotic syndrome patients aged 1 month to < 18 years were included. Blood and urine specimens were collected from the patients for albumin, globulin, thyroid function (T3, fT4 and TSH), and proteinuria tests and analyzed with standard techniques. Results There were 26 subjects, 20 males and 6 females. Ten subjects developed subclinical hypothyroidism, with mean albumin and thyroid-stimulating hormone (TSH) levels of 0.92 g/dL and 6.9 mIU/L, respectively. There was a negative correlation between albumin level and subclinical hypothyroidism (rpb=-0.702; P<0.001) and a positive correlation between proteinuria and subclinical hypothyroidism (r=0.573; P=0.003). Univariate logistic regression analysis revealed that globulin had no impact on the presence of subclinical hypothyroidism, but albumin and proteinuria did have such an impact. The odds ratios of albumin and proteinuria with subclinical hypothyroidism were 27.00 (95%CI 1.69 to 17.7) and 19.80 (95%CI 1.94 to 201.63), respectively. Conclusion Subclinical hypothyroidism correlates with serum albumin level and proteinuria in nephrotic syndrome patients. Tha low serum albumin level has a high likelihood of subclinical hypothyroidism.  

scholarly journals Relationship between ionized calcium and serum albumin level in children with idiopathic nephrotic syndrome

2016 ◽  
Vol 50 (6) ◽  
pp. 361
Author(s):  
Viiola Irene Winata ◽  
Dida Akhmad Gurnida ◽  
Nanan Sekarwana
Keyword(s):  
Nephrotic Syndrome ◽  
Serum Albumin ◽  
Calcium Level ◽  
Serum Albumin Level ◽  
Pearson Correlation ◽  
Health Department ◽  
Albumin Level ◽  
Ionized Calcium ◽  
Healthy Children ◽  
Cross Sectional

Background Nephrotic syndrome (NS) patients frequently have abnormalities in calcium metabolism that manifest as hypocalcemia and reduced intestinal absorption of calcium. Hypocalcemia is initially attributed to hypoalbuminemia but it may also relate to a low level of ionized calcium. The ionized calcium level depends on the severity and duration of proteinuria.Objective To assess the rel ationship between ionized calcium and serum albumin level in idiopathic NS children.Methods An analytical study with cross-sectional design was applied to NS and healthy children between 1-14 years old in the Child Health Department of Hasan Sadikin Hospital, Bandung from December 2009 to April 2010. Ionized calcium was examined by Ca2 + analyzer AVL 980 with ion-selective electrodes (ISE) methods.Results A total of34 subjects were recruited, consist of 17 NS and 17 healthy children. The mean ionized calcium and serum albumin level in NS children was 4.56 (SD 0.23) mg/dLand 1.45 (SD 0.24) g/dL, respectively. Statistical difference between ionized calcium level in NS and in healthy children was significant (P<0.05). Pearson correlation test between ionized calcium and serum albumin was significant (P<0.05) with correlation coefficient (r) 0.53. We found the following equation to estimate ionized calcium (y) based on the serum albumin level (x): y=3.84+0.49x.Conclusion There is a moderately positive linear relationship between ionized calcium and serum albumin level in NS children.

scholarly journals Subclinical hypothyroidism in pediatric nephrotic syndrome: the correlations with albumin, globulin, and proteinuria

2020 ◽  
Vol 60 (2) ◽  
pp. 91-5
Author(s):  
Erni Nuraeni ◽  
Faiisal Faisal ◽  
Ahmedz Widiasta ◽  
Novina Novina
Keyword(s):  
Nephrotic Syndrome ◽  
Serum Albumin ◽  
Subclinical Hypothyroidism ◽  
Serum Albumin Level ◽  
Cross Sectional Study ◽  
Albumin Level ◽  
Thyroid Stimulating Hormone ◽  
Hormone Deficiency ◽  
Cross Sectional ◽  
Univariate Logistic Regression Analysis

Background Nephrotic syndrome causes loss of medium-sized plasma proteins and binding proteins, resulting in thyroid hormone deficiency. Objective To assess for potential correlations between subclinical hypothyroidism in pediatric nephrotic syndrome with albumin, globulin, and proteinuria. Methods This cross-sectional study was conducted in the Department of Pediatrics, Hasan Sadikin General Hospital, Bandung, West Java. All types of nephrotic syndrome patients aged 1 month to < 18 years were included. Blood and urine specimens were collected from the patients for albumin, globulin, thyroid function (T3, fT4 and TSH), and proteinuria tests and analyzed with standard techniques. Results There were 26 subjects, 20 males and 6 females. Ten subjects developed subclinical hypothyroidism, with mean albumin and thyroid-stimulating hormone (TSH) levels of 0.92 g/dL and 6.9 mIU/L, respectively. There was a negative correlation between albumin level and subclinical hypothyroidism (rpb=-0.702; P<0.001) and a positive correlation between proteinuria and subclinical hypothyroidism (r=0.573; P=0.003). Univariate logistic regression analysis revealed that globulin had no impact on the presence of subclinical hypothyroidism, but albumin and proteinuria did have such an impact. The odds ratios of albumin and proteinuria with subclinical hypothyroidism were 27.00 (95%CI 1.69 to 17.7) and 19.80 (95%CI 1.94 to 201.63), respectively. Conclusion Subclinical hypothyroidism correlates with serum albumin level and proteinuria in nephrotic syndrome patients. Tha low serum albumin level has a high likelihood of subclinical hypothyroidism.  

scholarly journals Gambaran Kadar Kreatinin Serum dan Estimasi Laju Filtrasi Glomerulus (eLFG) pada Wanita Hamil Normal

2017 ◽  
Vol 5 (2) ◽  
Author(s):  
. Sumardiani ◽  
Glady I. Rambert ◽  
Arthur E. Mongan
Keyword(s):  
Serum Creatinine ◽  
Serum Creatinine Level ◽  
Pregnant Women ◽  
Creatinine Level ◽  
Creatine Phosphate ◽  
Cross Sectional ◽  
Probability Sampling ◽  
Purposive Sampling ◽  
Laboratory Examinations ◽  
Cross Sectional Design

Abstract: Creatinine is the end result of the metabolism of muscle creatine phosphate which was synthesized in the kidney. Serum creatinine level can normally decrease during pregnancy due to hyperfiltation of the renal glomeruli. Estimation of glomerular filtration rate (GFR) with CKD-EPI formula is beneficially used in populations with GFR >60 ml/min/1.73m2 especially in pregnant women. The creatinine levels of normal pregnant women are lower than of non-pregnant women and pregnant women with pre-eclampsia. This study was aimed to obtain the serum creatinine level and estimated GFR (eGFR) in normal pregnant women. This was a descriptive observational study with a cross sectional design. Samples were obtained by using non-probability sampling of purposive sampling method. Blood samples of 30 normal pregnant women were obtained at three Public Health Centers (Minanga, Sario, and Bahu Manado) from October to November 2017. The laboratory examinations revealed that all samples (100%) showed decreased serum creatinine levels with a mean of 0.53 mg/dL and increased eGRF >90 ml/min/1.73m2. Conclusion: During pregnancy, there was an increase in eGFR and a decrease in serum creatinine level in all trimesters.Keywords: normal pregnant women, serum creatinine, eGFR Abstrak: Kreatinin merupakan hasil akhir metabolisme dari kreatin fosfat otot, yang awalnya disintesis di ginjal. Pemeriksaan kreatinin sering digunakan untuk mengetahui fungsi ginjal. Kadar kreatinin serum normalnya dapat menurun selama kehamilan karena terjadi hiperfiltasi glomerulus ginjal. Estimasi Laju Filtrasi Glomerulus (eLFG) dengan formula CKD-EPI lebih baik digunakan pada populasi dengan laju filtrasi glomerulus >60 ml/min/1,73m2 khususnya wanita hamil. Kadar kreatinin wanita hamil normal lebih rendah daripada wanita tidak hamil dan wanita hamil dengan pre-eklampsi. Penelitian ini bertujuan untuk mengetahui gamabaran kreatinin serum dan eLFG pada wanita hamil normal. Jenis penelitian ialah deskriptif observasional dengan desain potong lintang. Sampel diambil dengan cara non-probability sampling jenis purposive sampling. Sampel penelitian ialah sampel darah dari 30 wanita hamil normal yang memeriksakan diri di Puskesmas Minanga, Sario, dan Bahu selama bulan Oktober-November 2017. Berdasarkan hasil pemeriksaan laboratorium didapatkan 30 orang (100%) wanita hamil normal mengalami penurunan kreatinin dengan rerata 0,53 mg/dL dan peningkatan laju filtrasi glomerulus dengan nilai eLFG >90 ml/min/1,73m2. Simpulan: Selama kehamilan terjadi peningkatan eLFG dan penurunan kreatinin serum pada semua trimester.Kata kunci: wanita hamil normal, kreatinin serum, eLFG

Serum Albumin Level as a Prognostic Marker for Covid-19 Positive Patients in Western Uttar Pradesh - A Cross Sectional Study

2021 ◽  
Vol 8 (04) ◽  
pp. 204-207
Author(s):  
Shreyansh Talera ◽  
Saurabh Singhal ◽  
Nishant Wadhera ◽  
Mayank Arora ◽  
Ravi Pratap
Keyword(s):  
Serum Albumin ◽  
Prognostic Marker ◽  
Serum Albumin Level ◽  
Uttar Pradesh ◽  
Cross Sectional Study ◽  
Albumin Level ◽  
The Body ◽  
Cross Sectional ◽  
Significant Difference

BACKGROUND WHO has declared Coronavirus disease 2019 (Covid-19) as a pandemic. Covid-19 leads to sickness and death. Human serum albumin (HSA) is the most common circulating protein in the body having oncotic as well as non-oncotic properties. The role of albumin in death among Covid-19 subjects, especially in this part of the country has not been frequently reported. The aim of the study was to analyse the role of serum albumin level as prognostic marker for Covid-19 positive patients. METHODS The present study was conducted in the department of Medicine at Chhatrapati Shivaji Subharti Hospital, Subharti Medical College, Meerut, UP. The study comprised of 100 subjects who were Covid positive from May 2020 to July 2020. A detailed explanation was given to all the participating respondents regarding the study and their contribution to it. Covid-19 was diagnosed on the basis of the WHO interim guidelines. A questionnaire was prepared to collect the patients’ demographic profile. Patients date of admission and discharge was recorded along with the outcome i.e., whether patient expired or survived. Patients’ diagnosis was identified along with the comorbidity (if present). Laboratory investigations comprised of CBC and serum albumin detection. Data so collected was tabulated in an excel sheet, under the guidance of statistician. Collected data was analysed using Statistical Package for the Social Sciences (SPSS) software version 24 and the tests used were t test and Fisher’s exact test and the level of significance was set at p < 0.05. RESULTS The study comprised of 100 subjects, out of which 45 were males and 55 were females. The overall mean age of the study subjects was 37.52 years. In our study, mortality was 35.29 %, 9.33 % and 85.7 % of the subjects having Covid-19+ type 2 diabetes (T2DM), only Covid-19 and Covid-19+ hypertension respectively with statistically significant difference as p < 0.05. Albumin level was significantly lower in expired patients (2.99) as compared to survivors (3.85) as p < 0.05. Hospital stay was also higher in expired patients. CONCLUSIONS Covid-19 patients had low serum albumin levels and that might play a role in the survival of patient. KEYWORDS Covid-19, Mortality, Albumin

scholarly journals Fibrinogen status in relapse and remission of childhood nephrotic syndrome

2016 ◽  
Vol 46 (4) ◽  
pp. 149
Author(s):  
Veronica Lily Limantara ◽  
Ida Bagus Mudita ◽  
I Ketut Suarta
Keyword(s):  
Nephrotic Syndrome ◽  
Serum Albumin ◽  
Cross Sectional Study ◽  
Fibrinogen Concentration ◽  
Strongly Correlated ◽  
Sectional Study ◽  
Laboratory Findings ◽  
Cross Sectional ◽  
Remission Status ◽  
The Mean

Objective To evaluate fibrinogen concentration of relapsing neph-rotic syndrome (NS) in children, and to investigate relationshipbetween fibrinogen with albumin and cholesterol.Methods A cross-sectional study among NS patients admitted topediatric outpatient clinic and pediatric ward at Sanglah Hospital,Denpasar, from November 1, 2003 to January 31, 2004. All pa-tients were evaluated for clinical and laboratory findings of relapseand remission, including edema, proteinuria, serum albumin, totalcholesterol, as well as total platelet count and fibrinogen concen-tration to evaluate coagulation parameters in nephrotic patients.Results There were 36 patients with the mean age of 7.4 (SD 2.3)years included in this study. Mean fibrinogen concentration in re-lapse state was 671.8 (SD 102.7) mg/dl, while in remission statewas 255.2 (SD 50.5 mg/dl); the mean difference was 416.6 mg/dl(95% CI 362.9;470.4; P<0.001). Fibrinogen was inversely andstrongly correlated with serum albumin concentrations (r=-0.91;P<0.001). Fibrinogen was positively and strongly correlated to to-tal cholesterol (r=0.80; P<0.001). Using multiple regression analy-sis, it was shown that only relapse/remission status was signifi-cantly associated with fibrinogen concentration (P<0.001).Conclusion Fibrinogen status is significantly correlated with re-lapse and remission status of NS in childhood patients.

scholarly journals Association between diabetes mellitus and anemia among Korean adults according to sex: a cross-sectional analysis of data from the Korea National Health and Nutrition Examination Survey (2010–2016)

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mihye Kim ◽  
Sook-Hyun Lee ◽  
Kyoung Sun Park ◽  
Eun-Jung Kim ◽  
Sujung Yeo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Serum Creatinine ◽  
Serum Creatinine Level ◽  
Creatinine Level ◽  
National Health ◽  
Nutrition Examination Survey ◽  
Cross Sectional ◽  
Korean Adults ◽  
Health And Nutrition ◽  
Prevalence Of Anemia

Abstract Background There are many conflicting opinions regarding the association between anemia and diabetes mellitus (DM), and the mechanism by which DM influences anemia remains uncertain. Therefore, we aimed to investigate the association between anemia and DM in Korean adults and to analyze the risk factors for anemia among these patients according to sex. Methods This retrospective cross-sectional survey was conducted using data from the Korea National Health and Nutrition Examination Survey V, VI, and VII between January 2010 and December 2016. In total, 25,597 Korean adults aged ≥19 years (10,117 men, 15,480 women) were included. Patients with a fasting blood sugar level of ≥126 mg/dL or who have been diagnosed with DM were classified as the DM group. Anemia was defined as hemoglobin levels of < 13 g/dL in men and < 12 g/dL in women. Logistic regression analysis was used to adjust for demographic characteristics and lifestyle-, disease-, and health-related factors. Results Approximately 11.3% of patients had DM. The prevalence of anemia was significantly higher in the DM group than in the non-DM group. After adjusting for confounding factors, the odds of the prevalence of anemia in men were higher in the DM group than in the non-DM group (odds ratio [OR] 1.87, 95% confidence interval [CI] 1.42–2.50, p < 0.0001). When investigated according to the serum creatinine level, the association was significantly stronger among women (OR 42.63, 95% CI 17.25–105.36, p < 0.0001) than among men (OR 6.30, 95% CI 3.08–12.90, p < 0.0001). Conclusions We found a strong association between DM and anemia that was more prominent among men than among women. We also determined that the serum creatinine level had a greater influence on DM and anemia in women than in men.

scholarly journals ANALISIS KADAR ALBUMIN SERUM DENGAN RASIO DE RITIS PADA PENDERITA HEPATITIS B

2018 ◽  
Vol 13 (2) ◽  
pp. 60
Author(s):  
AT. Lopa ◽  
B. Rusli ◽  
M. Arif ◽  
Hardjoeno Hardjoeno
Keyword(s):  
Hepatitis B ◽  
Serum Albumin ◽  
Serum Albumin Level ◽  
Chronic Phase ◽  
Cross Sectional Study ◽  
Albumin Level ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Significant Difference

Hepatitis is a inflammation process which may present in an acute or chronic phase. A decrease of serum albumin level may befound in liver disease. Ratio de Ritis in mild hepatitis is < 1 while in alcoholic hepatitis is >1. To analyze serum albumin level withratio de Ritis in hepatitis B patients. A cross sectional study was carried out comprising 46 subjects from October 2005 to August 2006measuring albumin level SGOT and SGPT levels using Lyasis autoanalyzer. Thirty eight males and eight females, the level of serumalbumin decreased with an average of albumin level 2.98 gr/dL (p<0.05). Twenty two subjects showed a ratio de Ritis ≤ 1 with theaverage albumin level 3.00 gr/dL and 24 subjects were included in group ratio de Ritis > 1 with average albumin level 2.96 gr/dL(p value = 0.658). There was a decrease of serum albumin level in hepatitis B patient but no significant difference between decrease ofserum albumin level with ratio of de Ritis ≤ 1 and ratio of de Ritis >1.

scholarly journals Relationship between serum zinc and homocysteine in children with nephrotic syndrome

2019 ◽  
Vol 59 (2) ◽  
pp. 98-103
Author(s):  
Welli Hamik ◽  
Dany Hilmanto ◽  
Sri Endah Rahayuningsih
Keyword(s):  
Nephrotic Syndrome ◽  
Serum Zinc ◽  
Cross Sectional Study ◽  
Albumin Level ◽  
Glomerular Sclerosis ◽  
Cross Sectional ◽  
Pearson’S Correlation ◽  
Serum Homocysteine ◽  
Pearson's Correlation ◽  
Zinc Levels

Background In children, most idiopathic nephrotic syndrome (NS) is a minimal lesion, which responds well to steroids. Hyperhomocysteinemia is pathologic and worsens NS by causing chronic inflammation, leading to glomerular sclerosis. Zinc metalloenzymes are involved in homocysteine metabolism. Objective To assess for a possible relationship between serum zinc and homocysteine in children with NS. Methods A cross-sectional study was conducted in children with NS aged 1-18 years, who were admitted to Hasan Sadikin Hospital from November 2017 - January 2018. Subjects were selected consecutively. Serum zinc and homocysteine were measured in all subjects. Statistical analysis was done with Pearson’s correlation test. If the distribution was not linear, the analysis was continued with non-linear regression. Results There were 23 children who met the inclusion criteria. Mean serum homocysteine and zinc levels were 10.37 (SD 4.11) µmol/L and 51.13 (SD 29.69) µg/dL, respectively. Pearson’s correlation analysis showed no linear correlation between them (r coefficient -0.173; P=0.430). However, after adjusting for age and serum albumin level, multiple regression analysis suggested a cubical relationship between serum homocysteine and zinc, using the equation: homocysteine = -4.572 + 0.735 x zinc - 0.0012 x zinc2 + 0.00005 x zinc3 x age (months) (R2 multiple=53.2%; P=0.012). This equation indicates that 53.2% of homocysteine variation was influenced by serum zinc concentration. Conclusion In childhood NS, homocysteine is not correlated linearly with zinc, but related with cubical model.

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