scholarly journals Prevalence of Metallo-Beta-Lactamase among Carbapenem Resistant Pseudomonas aeruginosa Strains Isolated from Patients Attending a Teaching Tertiary Care Hospital in Tamilnadu

2020 ◽  
Vol 9 (52) ◽  
pp. 3968-3972
Author(s):  
Nithyalakshmi Jayakumar ◽  
Mohanakrishnan Kandasamy ◽  
Ravinder Thygarajan ◽  
Sumathi Gnanadesikan ◽  
Anitha S.
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Beta Lactamase ◽  
Carbapenem Resistant

scholarly journals Metallo-β-Lactamase Gene blaIMP-15 in a Class 1 Integron, In95, from Pseudomonas aeruginosa Clinical Isolates from a Hospital in Mexico

2008 ◽  
Vol 52 (8) ◽  
pp. 2943-2946 ◽  
Author(s):  
U. Garza-Ramos ◽  
R. Morfin-Otero ◽  
H. S. Sader ◽  
R. N. Jones ◽  
E. Hernández ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Gene Cassette ◽  
Clinical Isolates ◽  
Care Hospital ◽  
Class 1 Integron ◽  
Carbapenem Resistant ◽  
Class 1 ◽  
Lactamase Gene

ABSTRACT During 2003, 40 carbapenem-resistant Pseudomonas aeruginosa clinical isolates collected in a Mexican tertiary-care hospital were screened for metallo-β-lactamase production. Thirteen isolates produced IMP-15, and 12 had a single pulsed-field gel electrophoresis pattern. The bla IMP-15 gene cassette was inserted in a plasmid-borne integron with a unique array of gene cassettes and was named In95.

scholarly journals Epidemiology of carbapenem-resistant Enterobacteriaceae colonization in ICU: a pilot study from a tertiary care hospital in Western Rajasthan, India

2018 ◽  
Vol 6 (10) ◽  
pp. 3340 ◽  
Author(s):  
Ekadashi Rajni ◽  
Vikas Rajpurohit ◽  
Praveen Rathore ◽  
P. K. Khatri
Keyword(s):  
Pilot Study ◽  
Large Scale ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Control Measures ◽  
Care Hospital ◽  
Beta Lactamase ◽  
Global Public Health ◽  
Carbapenem Resistant ◽  
Carbapenem Resistant Enterobacteriaceae

Background: Carbapenem-resistant Enterobacteriaceae (CRE) is a serious global public health threat. Antibiotic overuse, improper sanitation and unhygienic practices lead to large scale carriage and rapid spread.Methods: This is a prospective hospital based study planned for a period of 3 months including all patients admitted to 14 bedded Trauma ICU of a tertiary care hospital in Rajasthan. Rectal swabs were collected from admitted patients and carriage of carbapenem resistant Enterobacteriaceae looked for as per CDC guidelines. Screening of the Enterobacteriaceae colonies for carbapenemase production was done by Modified Hodge test. Carbapenem-resistant isolates were also tested for Metallo beta lactamase production by phenotypic disc confirmatory test.Results: A total of 73 patients were screened and 27 CRE isolates were obtained, carriage rate being 37%. A high level of resistance was seen to aminoglycosides, fluoroquinolones and cephalosporins. 100% sensitivity was however seen to Colistin, Tigecycline and Fosfomycin. 5 out of 27 strains showed a positive MHT test. Metallo beta lactamase (MBL) production was seen in 21/25 strains as tested by meropenem and Meropenem-EDTA discs.Conclusions: The current pilot study finds out the prevalence of CRE carriage among critically ill patients and stresses upon strong need for stringent infection control measures.

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