scholarly journals Study of Various Gastrointestinal Tract Lesions by Endoscopic Biopsies in a Tertiary Care Centre of Rural District of Maharashtra

2021 ◽  
Vol 10 (16) ◽  
pp. 1135-1139
Author(s):  
Preeti Rajendra Sahu ◽  
Kishor Madhukar Hiwale ◽  
Sunita Jayant Vagha
Keyword(s):  
Gastrointestinal Tract ◽  
Tertiary Care ◽  
Malignant Lesion ◽  
Endoscopic Biopsy ◽  
Gi Tract ◽  
Upper Gi ◽  
Endoscopic Biopsies ◽  
Significant Difference ◽  
Neoplastic Lesions ◽  
Well Differentiated

BACKGROUND In a developing country like India, vast difference exists in people’s religion, culture, and socio-economic condition and along with it, there exists a significant difference in their dietary habits. This has led to an incidence of a large spectrum of gastrointestinal (GI) diseases which is different in different geographical locations. The study was undertaken for studying the spectrum of various histopathological lesions of gastrointestinal tract with the help of endoscopic biopsy. METHODS This cross-sectional study was carried out in a span of 2 years in the histopathology division. The study included 105 patients who had GI complains and underwent endoscopic biopsies for the same. RESULTS The present study included a total of 105 cases out of which there were 64 cases (61 %) of upper GI tract biopsies and remaining 41 cases (39 %) were of lower GI tract biopsies. Among 64 (100 %) cases of upper GI biopsies, reflux oesophagitis (4.67 %) was the most common in non-neoplastic lesions while well differentiated squamous cell carcinoma (20.31 %) was the most common neoplastic pathology. In gastric biopsies, chronic atrophic gastritis (3.12 %) was the most common condition in a non-neoplastic category, while gastric adenocarcinoma (15.61 %) was the malignant lesion which was found. Among duodenal biopsies, the most common lesion was eosinophilic enteritis / duodenitis (14.06 %). Among 41 (100 %) colonoscopic biopsies, the most common lesion was chronic non-specific inflammation (12.19 %) under non-neoplastic category, while well differentiated adenocarcinoma (46.34 %) was most common entity under malignant category in our study. Non-neoplastic lesions were more common in upper GI endoscopic biopsies whereas, neoplastic lesions were more frequently seen with lower GI endoscopic biopsies. CONCLUSIONS Performing endoscopy alone is an incomplete investigative modality for the diagnosis. While performing endoscopy and simultaneously taking biopsy for histopathological evaluation helps in giving an accurate diagnosis. KEY WORDS GIT, Endoscopy, Endoscopic Biopsy

scholarly journals Histopathological Spectrum of Upper Gastrointestinal Endoscopic Biopsies in a Tertiary care centre

2021 ◽  
Vol 8 (6) ◽  
pp. A158-163
Author(s):  
Anjana M.L ◽  
Kavitha Yevoor
Keyword(s):  
Tertiary Care ◽  
Common Symptom ◽  
Female Ratio ◽  
Gi Endoscopy ◽  
Upper Gi ◽  
Wide Range ◽  
Neoplastic Lesions ◽  
Upper Gi Endoscopy ◽  
H Pylori ◽  
Duodenal Biopsies

Background: Upper GI endoscopy is an established procedure for investigating a wide range of upper GI conditions especially inflammatory and malignant diseases of stomach and esophagus. A good correlation in diagnosis can be achieved by complementing endoscopic findings with histopathology of biopsy specimens. Methods: Both retrospective and prospective study of upper GI endoscopic biopsy was carried out at department of pathology, KIMS, Hubli during January 2016 to December 2018. Samples were received in 10% formalin; routine processing was followed with H & E staining. Special stain like Giemsa was done for detection of H. Pylori. 396 endoscopic mucosal biopsies were analyzed and evaluated. Result: Out of 396 cases, 250 cases were esophageal biopsies, 104 cases were gastric biopsies & 42 cases were duodenal biopsies. The male: female ratio was 1:9:1. The highest number of cases was seen between 61 to 70 years. Dyspepsia was the common symptom seen in 61.3%. The most common lesions encountered in the esophagus were carcinomas (67%) followed by esophagitis (16%). The commonly encountered gastric lesion was chronic gastritis in 54.8% with H. pylori gastritis being positive in 38.18%. Among the duodenal biopsies, non-neoplastic lesions were most common (59.5%) followed by neoplastic lesions (26%). Conclusion: Upper GI endoscopy is an effective and appropriate preliminary investigation to assess patients with dysphagia, dyspepsia, vomiting. Endoscopy without biopsy is incomplete and that the combination of methods offers a strong diagnostic tool for better patient care.

scholarly journals Histopathological Study of Upper Gastrointestinal Tract Endoscopic Biopsies

2019 ◽  
Vol 6 (1) ◽  
pp. 42-46
Author(s):  
Mosammat Suchana Nazrin ◽  
Nur E Jannatul Ferdous ◽  
Madhusudan Saha ◽  
Fahmi Iqbal Rabbi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Gastrointestinal Tract ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Upper Gastrointestinal Tract ◽  
North East ◽  
Endoscopic Biopsies ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions ◽  
Upper Gastrointestinal

Background: Diseases of gastrointestinal tract are a major cause of morbidity and mortality. Objective: This study was carried out to determine the spectrum of histopathological lesions of upper gastrointestinal tract. Methodology: This retrospective study was conducted in the Department of Pathology at North East Medical College, Sylhet, Bangladesh during a 36 months period from January 2013 to December 2015. Endoscopies were performed using Olympus 150, forward viewing upper GI endoscope. The biopsy specimens received were fixed in 10.0% formalin and routinely processed in Haematoxyline & Eosin stain. Results: The present study included 135 endoscopic biopsies. The mean age with SD of the study population was 53.20±16.09 years. Among 53 cases of esophageal biopsies 8(15.08%) cases showed non-neoplastic lesions and 45(84.92%) cases were neoplastic of which 39(73.6%) cases and 6(11.32%) cases were squamous cell carcinoma and adenocarcinoma respectively. Among 6 cases of gastro esophageal junction biopsies 3(50%) cases showed non-neoplastic lesions and 3(50%) were neoplastic, of which 2(33.33%) were adenocarcinoma and 1(16.67%) were squamous cell carcinoma. Among 61 cases of stomach biopsies 34(55.74%) showed non-neoplastic lesions and 27(44.26%) were neoplastic, of which 1(1.64%) case was adenoma and 25(40.98%) were adenocarcinoma. Among 15 cases of duodenal biopsies 13(86.67%) cases showed non-neoplastic lesions and 2(13.33%) were neoplastic one of which was adenocarcinoma (6.67%). Among 135 cases endoscopist reported 82(60.74%) cases as neoplastic and 53(39.26%) as non-neoplastic, whereas histopathology revealed 77(57.03%) cases neoplastic and 58(42.97%) cases non-neoplastic. Conclusion: Common site of upper GIT endoscopic biopsy is stomach which are mostly neoplastic lesion; however, most common malignancy is squamous cell carcinoma of the oesophagus. Journal of Current and Advance Medical Research 2019;6(1):42-46

scholarly journals The Utility of Endoscopic Biopsies in Patients with Normal Upper Endoscopy

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Anouar Teriaky ◽  
Abdullah AlNasser ◽  
Carolyn McLean ◽  
James Gregor ◽  
Brian Yan
Keyword(s):  
Care Center ◽  
Tertiary Care ◽  
Intraepithelial Lymphocytes ◽  
Upper Endoscopy ◽  
Gi Tract ◽  
Upper Gi ◽  
H Pylori ◽  
Pathology Reports ◽  
Duodenal Biopsies ◽  
Upper Gi Tract

Background and Aims. Upper endoscopy is a valuable tool in the workup of gastrointestinal (GI) complaints. The purpose of this study is to determine cost and yield of taking biopsies in a normal upper GI tract.Methods. This is a retrospective study where all upper GI biopsies were identified between May 2012 and April 2013, at a tertiary care center. Clinical, procedural, and pathology reports were reviewed to identify patient demographics, procedure information, and pathology diagnosis.Results. Biopsies of the upper GI tract were taken in 1297 patients with normal upper endoscopies. In patients with normal upper endoscopy, 22% of esophageal, 44% of gastric, and 12% of duodenal biopsies were abnormal. The most frequent abnormality was reflux esophagitis in 16% of esophageal biopsies, chronic gastritis in 23% of gastric biopsies, and increased intraepithelial lymphocytes in 6% of duodenal biopsies. The additional cost for taking biopsies in a normal upper GI tract for a diagnosis of eosinophilic esophagitis was $2963 Canadian (CAD),H. pyloriassociated gastritis was $1404 CAD, and celiac disease was $3024 CAD.Conclusions. The yield of biopsy in normal upper endoscopy varied with location, but the additional expense can be costly and should be tailored to appropriate clinical situations.

A Study on Cytomorphological and Histopathological Correlation of Head and Neck Lesions in a Tertiary Care Centre, Bhubaneswar, Odisha

2021 ◽  
Vol 8 (33) ◽  
pp. 3104-3109
Author(s):  
Anima Hota ◽  
Pranita Mohanty ◽  
Mitu Mohanty
Keyword(s):  
Head And Neck ◽  
Care Center ◽  
Tertiary Care ◽  
Malignant Lesion ◽  
Tertiary Care Centre ◽  
Anatomic Site ◽  
Histopathological Findings ◽  
Statistical Measures ◽  
Neoplastic Lesions ◽  
Thyroid Lesions

BACKGROUND The head and neck region is an anatomic site having lymph nodes, nerves, veins, arteries, muscles, mucosal epithelium to salivary glands, thyroid, and a host of developmental tissues. Any of these tissues can become pathological, resulting in a mass. Fine needle aspiration cytology (FNAC) is regarded as a reliable method of investigation in diagnosis of head and neck lesions. However, histopathology is the gold standard of diagnosis. The purpose of this study was to assess the frequency of head and neck tumours according to the sites of their occurrence and to find out the correlation of cytopathological findings by FNAC and histopathological findings by biopsy. METHODS This prospective study undertaken from June 2012 to June 2014 in the Department of Pathology, IMS and SUM Hospital, Bhubaneswar, a tertiary care center. All the patients attending different outdoor of IMS & SUM Hospital, Bhubaneswar with head & neck lesions referred for FNAC were included in the study. The results of FNAC were compared with that of histopathological findings by tissue biopsy. Data collected was entered in MS Excel and analysed using the same software. Descriptive statistical measures like frequency and percentage. Data was presented in tabular form. RESULTS The commonest site of lesion was in the lymph node followed by thyroid gland. There was preponderance of female sex in thyroid lesions whereas males were commonest in other sites. The accuracy in cyto-histopathology correlation between benign and malignant lesion was 96.36 % and 88.89 % respectively and was most corroborated in the thyroid lesions (50.6 %). CONCLUSIONS Cyto-histo correlation of head and neck lesions provides an important, quick, excellent, and sensitive diagnostic tool to exclude non-neoplastic lesions from neoplastic lesions. KEYWORDS Head and Neck Lesions, FNAC, Histopathology

scholarly journals P0932CLINICAL EVALUATION OF DISTURBANCES GASTROINTESTINAL TRACT IN PATIENT WITH CHRONIC KIDNEY DISEASE

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Marufjon Salokhiddinov ◽  
Faxriddin Umarov
Keyword(s):  
Chronic Kidney Disease ◽  
Duodenal Ulcer ◽  
Renal Failure ◽  
Gastrointestinal Tract ◽  
Comparison Group ◽  
Gi Tract ◽  
Erosive Gastritis ◽  
Upper Gi ◽  
Ulcerative Lesions ◽  
Upper Gastrointestinal

Abstract Background and Aims Chronic kidney disease (CKD) affects gastrointestinal function and results in numerous adaptive and maladaptive responses. Disruption of the colonic microbiome and its attendant consequences - the loss of gut barrier integrity and increased generation of uremic toxins - has become well-recognized. However, less attention has been paid to characterizing the mechanisms behind the dysfunction of the upper gastrointestinal (GI) tract, largely owing to the difficulty of studying small bowel function in vivo Method The study included 72 people, of whom 52 made up the main group (CKD group) and 20 people - the comparison group (healthy volunteers without a kidney and cardiovascular disease). The main group consisted of patients with CKD stage 3 (RCGF creatinine 30-59ml / min / m2). The criterion for the inclusion of patients in the study, in addition to reducing the eGFR (estimated glomerular filtration rate), was the presence of arterial hypertension. The renal filtration function was the preserved comparison group and was reduced in the CKD group (p <0.001), which served as a criterion for the inclusion of patients in the study. To assess the state of the gastrointestinal tract, all patients underwent an endoscopic study with an assessment of the acidity and evacuation function of the stomach Results The study showed that 75% of patients had complaints of a dry and unpleasant taste in the mouth, poor appetite, aversion to meat food, nausea. These symptoms were directly related to the level of eGFR. There was also a difference in the frequency and nature of the erosive, erosive-ulcerative, ulcerative lesions of the esophagus and formation of erosions and ulcers in patients with CKD occurred significantly more often against the background of chronic gastritis and with the severity of the inflammatory process with severe dyspeptic disorders. The frequency of erosive, erosive-ulcerative and ulcerative lesions of the mucous membrane of the upper GI tract among CKD patients was 72%, which were manifested by nausea, decreased appetite, heaviness in the stomach after eating, belching, heartburn, epigastric pain (in 50% of patients), meteorism, pain in the epigastric region during palpation. Endoscopic examination of patients with CKD noted the presence of erosive esophagitis, erosive gastritis, erosive bulb it, erosive duodenitis, mixed erosive lesions, erosive-ulcerative gastritis, gastric ulcer, ulcer of duodenal ulcer. Among them, the leading place is occupied by erosive gastritis and mixed erosive lesions, which account for 22% and 27%, respectively. Hemorrhagic erosions were more common in the stomach (41%) and 12: duodenal ulcer (47%) in patients with CKD Conclusion Erosive, erosive-ulcerative, ulcerative lesions of the upper gastrointestinal tract occur in 76% of patients with CKD. The frequency, nature, prevalence of these lesions are associated with the treatment of CKD - active (hemodialysis) and conservative, the stage of chronic renal failure. In patients with chronic renal failure, the endoscopic picture of erosive, erosive-ulcerative, ulcerative lesions of the upper GI tract is diverse.

scholarly journals Fecal Microbiota Transplantation Using Upper Gastrointestinal Tract for the Treatment of Refractory or Severe ComplicatedClostridium difficileInfection in Elderly Patients in Poor Medical Condition: The First Study in an Asian Country

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Tae-Geun Gweon ◽  
Jinsu Kim ◽  
Chul-Hyun Lim ◽  
Jae Myung Park ◽  
Dong-Gun Lee ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Fecal Microbiota Transplantation ◽  
Medical Condition ◽  
Performance Status ◽  
Fecal Microbiota ◽  
Gi Tract ◽  
Upper Gi ◽  
Low Performance ◽  
Upper Gastrointestinal ◽  
Upper Gi Tract

Background and Aims. Fecal microbiota transplantation (FMT) is a highly effective treatment option for refractoryClostridium difficileinfection (CDI). FMT may be challenging in patients with a low performance status, because of their poor medical condition. The aims of this study were to describe our experience treating patients in poor medical condition with refractory or severe complicated CDI using FMT via the upper GI tract route.Methods. This study was a retrospective review of seven elderly patients with refractory or severe complicated CDI and a poor medical condition who were treated with FMT through the upper GI tract route from May 2012 through August 2013. The outcomes studied included the cure rate of CDI and adverse events.Results. Of these seven patients who received FMT via the upper GI tract route, all patients were cured. During the 11-month follow-up period, CDI recurrence was observed in two patients; rescue FMT was performed in these patients, which led to a full cure. Vomiting was observed in two patients.Conclusions. FMT via the upper gastrointestinal tract route may be effective for the treatment of refractory or severe complicated CDI in patients with a low performance status. Physicians should be aware of adverse events, especially vomiting.

scholarly journals Prospective Study on Histopathological Spectrum of Upper Gastrointestinal Tract Lesions in a Teaching Hospital of Southern India

2020 ◽  
Author(s):  
Eslavath Aruna ◽  
V Kalyan Chakravarthy
Keyword(s):  
Gastrointestinal Tract ◽  
Histopathological Examination ◽  
Tissue Sample ◽  
Age Groups ◽  
Upper Gastrointestinal Tract ◽  
Female Ratio ◽  
Inflammatory Conditions ◽  
Endoscopic Biopsies ◽  
Neoplastic Lesions ◽  
Upper Gastrointestinal

Introduction: The Upper Gastrointestinal Tract (UGIT) disorders are quite common in routine clinical practice and have high degree of morbidity and mortality. They can be studied by collecting tissue sample by way of fiberoptic endoscope and by subjecting the tissue to histopathological examination. Aim: To study the spectrum of histopathological lesions of UGIT lesions by endoscopy. Materials and Methods: This was a prospective observational study done in the Department of Pathology at PSIMS, Chinna Avutapalli, Andhra Pradesh, India, over a period of one year from March 2019 to February 2020 on 160 endoscopic biopsies. All UGIT endoscopic biopsies received were examined histopathologically. The data was entered into excel sheets and percentages and ratios were calculated. Results: Lesions of UGIT were more common in the age groups of 31 to 50 years and the male to female ratio was 1.9:1. The patient age ranged from 20 years to 78 years. Stomach was the common site for UGIT endoscopic biopsies i.e., 80 (50%) followed by oesophagus 50 (31.2%) and then duodenum 30 (18.7%). At all three sites, non-neoplastic lesions predominated over neoplastic lesions. The gastric malignancies were more common in antral and pyloric regions. Conclusion: Males in the fourth and fifth decades are more prone for UGIT lesions with predominance of chronic non-specific inflammatory conditions as compared to neoplastic conditions. Malignancy within the stomach, more commonly affects the antrum and pylorus. Malignant lesions are very rare in duodenum.

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