Comparative Evaluation of Treatment Outcome of Gingival Depigmentation by Surgical Scalpel, Laser and Cryosurgery Techniques for the Management of Gingival Hyperpigmentation – A Randomized Clinical Trial Conducted in the Institute of Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital, Hingna

BACKGROUND Aesthetic concerns have plagued humans for ages, but now modern technology and science have presented us with various options to treat these concerns. One such aspect is gingival depigmentation which as a dentist, we often come across. A randomized controlled clinical trial was conducted to compare and evaluate the techniques of gingival depigmentation for the management of gingival hyperpigmentation. METHODS A total of 45 patients with gingival pigmentation were randomly allocated into 3 groups: Surgical scalpel (N = 15), Cryosurgery (N = 15) and 810nm Diode Laser (N = 15). Melanin pigmentation index (MPI), visual analogue scale (VAS), wound healing index (WHI) and colour intensity index were evaluated for all the groups at baseline, immediate postoperative, 1 week, 1 and 3 months postoperatively. Statistical analysis was done for the data obtained to test the significance between the variables. P value < 0.05 was considered significant. RESULTS MPI scores from baseline to the postoperative intervals were effective in the management of gingival hyperpigmentation without any statistically significant difference. Faster healing was noted with surgical scalpel than cryosurgery. VAS scores were higher for the surgical scalpel group and lower for the other groups. The colour intensity index, an increase in the red colour value and decrease in the blue colour value was indicative of effectiveness of all the three techniques in the management of gingival hyperpigmentation. CONCLUSIONS It can be concluded that all the three techniques are effective in the management of gingival hyperpigmentation. KEY WORDS Gingival Hyperpigmentation, Aesthetic, Cryosurgery, Surgical Scalpel, Laser

Download Full-text

Riluzole for treatment of men with methamphetamine dependence: A randomized, double-blind, placebo-controlled clinical trial

Journal of Psychopharmacology ◽

10.1177/0269881118817166 ◽

2018 ◽

Vol 33 (3) ◽

pp. 305-315 ◽

Cited By ~ 6

Author(s):

Mohammad-Hadi Farahzadi ◽

Ehsan Moazen-Zadeh ◽

Emran Razaghi ◽

Mohammad-Reza Zarrindast ◽

Reza Bidaki ◽

...

Keyword(s):

Clinical Trial ◽

Randomized Clinical Trials ◽

Specific Treatment ◽

Controlled Clinical Trial ◽

P Value ◽

Urine Test ◽

Double Blind ◽

Double Blind Placebo ◽

Methamphetamine Dependence ◽

Significant Difference

Background: Riluzole is a glutamate regulator and effective in treatment of neuropsychiatric conditions. Aims: We assessed riluzole for treatment of methamphetamine dependence. Methods: In this randomized, double-blind, placebo-controlled clinical trial, male outpatients with methamphetamine dependence who were 18–65 years old received either 50 mg riluzole ( n=34) or placebo ( n=54) twice daily for 12 weeks. Patients were excluded in case of comorbid serious medical conditions or neurologic disorders, comorbid psychiatric disorders other than methamphetamine dependence requiring specific treatment interventions, simultaneous positive urine test result for substances of abuse other than methamphetamine, smoking >3 days per week, simultaneous consumption of medications which are contraindicated or have interaction with riluzole. Results: Concerning primary outcomes, the cumulative mean number of attended weekly visits was higher in the riluzole arm compared with the placebo arm approaching a statistically significant difference (riluzole, median (range)=13.00 (2.00–13.00); placebo=4.00 (2.00–13.00); Mann-Whitney U=505.00, p-value=0.073), and the weekly measured rate of positive methamphetamine urine test results was significantly lower in the riluzole arm by the end of the study (riluzole=1 (5.00%), placebo=9 (45.00%), p-value=0.004). Patients in the riluzole arm experienced significantly greater improvement on all the craving, withdrawal, and depression measures regarding mean score changes from baseline to endpoint. No significant difference was detected between the two arms in terms of incidence of adverse events. Conclusion: Future randomized clinical trials are needed to investigate proper dosing strategy in a more inclusive sample.

Download Full-text

Effectivity of Esomeprazole Compared with Lansoprazole in the Treatment of Pediatric with Gastritis

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2021.7191 ◽

2021 ◽

Vol 9 (B) ◽

pp. 1424-1427

Author(s):

Fini Kollins ◽

Supriatmo Supriatmo ◽

Rina Saragih ◽

Ilhamd Ilhamd

Keyword(s):

Clinical Trial ◽

Abdominal Pain ◽

Treatment Group ◽

Pediatric Patients ◽

Controlled Clinical Trial ◽

P Value ◽

Test Results ◽

Initial Symptoms ◽

Significant Difference ◽

Single Blind

BACKGROUND: The administration of proton pump inhibitor (PPI) therapy in pediatric patients has also increased dramatically during the last three decades. Clinical trials comparison of esomeprazole and lansoprazole for pediatric were limited. AIM: This study focused on comparing the effectivity of Esomeprazole with lansoprazole for healing gastritis symptoms in pediatric patients. METHODS: A randomized and single blind (assessors) controlled clinical trial was done at H. Adam Malik hospital at Medan. Patients that complied with study’s criteria and signed informed consent were collected information about the symptoms. Confirmation diagnosis of g astritis by gastroscopy, then randomized into lansoprazole treatment group (15 mg if < 30 kg and 30 mg if > 30 kg) or esomeprazole treatment group (0,4–0,8 mg per Kg body weight). Medication for both groups will be given orally for 14 day s, then evaluated for the initial symptoms. p -value of this study was calculated with the χ2 test. RESULTS: Fifty two patients confirmed gastritis were enrolled in this study; 27 patients received lansoprazole and 25 patients received esomeprazole. There was no difference of effectivity between the two groups for vomiting, hematemesis, and nausea. Lansoprazole treatment for 14 days has a significant difference for abdominal pain recovery from esomeprazole treatment. The lansoprazole groups have 92% free of abdominal pain compared to the esomeprazole group for only 66% free of abdominal pain. CONCLUSION: There was no significant difference between lansoprazole and esomeprazole therapy.

Download Full-text

Serum Osteopontin and its Relation to Colorectal Carcinoma in Egyptian Patient

QJM ◽

10.1093/qjmed/hcab100 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Mohamed Abd Elmoghny Mostafa ◽

Hany Haron Kayser ◽

Ahmed Samir Allam ◽

Abanoub Refaat Saeed Hakim

Keyword(s):

Colorectal Cancer ◽

Clinical Trial ◽

Colorectal Carcinoma ◽

Dietary Habits ◽

Control Group ◽

Controlled Clinical Trial ◽

P Value ◽

Ageing Population ◽

Significant Difference ◽

Egyptian Patient

Abstract Background Colorectal cancer had a low incidence several decades ago. However, it has become a predominant cancer and now accounts for approximately 10% of cancer-related mortality in western countries. The ‘rise’ of colorectal cancer in developed countries can be attributed to the increasingly ageing population, unfavourable modern dietary habits and an increase in risk factors such as smoking, low physical exercise and obesity. Objectives The aim of this study to evaluate the role of serum level of osteopontin in prediction of Colorectal Carcinomain in correlation with tissue histopathology which it is the gold standard test in Egyptian patient. Patients and Methods The study was a Randomized controlled clinical trial. Which is a prospective, random, clinical trial conducted at Ain Shams University Hospitals at endoscopic unit on patients who refered for colonscopy. This study was conducted on 80 patients who were divided into 2 groups: Group A: 40 patients diagnosed as Colorectal Carcinoma as a patient group, Group B: 40 patients with age and sex matched control group who have normal colonscopy. Results There was statistically significant difference between CRC patients and normal colonscopic patients regarding the level ofosteopontin being higher in CRC patients (P value = 0.000). Also ROC curve for osteopontin in prediction of CRC showed the best cut of value >12 ng/ml with area under the curve (AUC) = 0.889, sensitivity =85%, specificity =77.5% with positive predictive value =79.1% Conclusion Serum Osteopontin (OPN) level is higher in patients with CRC than patients with normal colonscopy, so it can be used as a diagnostic marker for HCC.

Download Full-text

The effect of granisetron, ondansetron, and pethidine in preventing postoperative shivering: controlled clinical trial

10.21203/rs.2.19384/v1 ◽

2019 ◽

Author(s):

Masood Entezariasl ◽

Hamed Zandian ◽

Khatereh Isazadehfar

Keyword(s):

Blood Pressure ◽

Clinical Trial ◽

Controlled Clinical Trial ◽

P Value ◽

Anesthesia Induction ◽

Central Temperature ◽

Significant Difference ◽

The Mean ◽

The Difference ◽

Peripheral Temperature

Abstract Background: recently, use of HT35 receptor antagonists to prevent postoperative shivering has attracted a great deal of attention. Therefore, the present study was conducted with the aim of investigating the effectiveness of granisetron as an HT35 antagonist when compared with ondansetron and pethidine in preventing postoperative shivering. Methods: in this triple blind random clinical trial study, 90 patients 18-50 years of age with ASA Class I and II undergoing general anesthesia were randomly assigned into one of the three drug groups: O (4-mg ondansetron), G (40 μg/kg of granisetron), and P (25 mg pethidine), immediately before induction of anesthesia. After anesthesia induction, at the end of the surgery, after the entrance and after leaving the recovery state, central temperature, peripheral temperature, systolic blood pressure, diastolic blood pressure, heart rate, and shivering were measured and recorded. P-value less than 0.05 was considered statistically significant. Results: in the pethidine, ondansetron, and granisetron groups, 4 (13.3%), 3 (10%), and 10 (33.3%) of patients experienced shivering during recovery, where the difference between the ondansetron and granisetron groups was significant (p-value=0.02). The variations in the mean arterial pressure during the investigation stages were not significant only in the ondansetron group (p>0.05). At the beginning of recovery, the reduction of peripheral temperature was significantly lower in the ondansetron group (p<0.05), while reduction of the central temperature was higher in the granisetron group (p<0.05). By the end of the recovery, the changes in the peripheral temperature across the three groups were consistent with the changes at the beginning of recovery, but no significant difference was observed variations of the central temperature across the three groups. Conclusion: Granisetron was not found to be much effective in preventing postoperative shivering. Ondansetron and pethidine were equally effective in preventing postoperative shivering. Ondansetron also causes less hemodynamic changes compared to other drugs, while granisetron is more effective in terms of preventing nausea and vomiting

Download Full-text

Atorvastatin and standard treatment of Helicobacter pylori: Single Blinded Randomized Controlled Clinical Trial

10.1101/2020.05.29.20117200 ◽

2020 ◽

Author(s):

Mohammad Reza Mohammad Hoseini Azar ◽

Parham Portaghali ◽

Ali Jafari ◽

Amin Sedokani

Keyword(s):

Clinical Trial ◽

Helicobacter Pylori ◽

Standard Treatment ◽

Intervention Group ◽

Control Group ◽

Controlled Clinical Trial ◽

P Value ◽

Bismuth Subcitrate ◽

Significant Difference ◽

H Pylori

AbstractBackgroundConsidering the increase in drug resistance over time to Helicobacter pylori treatment relying on the anti-inflammatory and antibacterial effects of atorvastatin to increase the success rate of H. pylori eradication, we examined the effect of adding atorvastatin to standard treatment of H. pylori eradication.Materials and MethodsA total of 186 symptomatic patients who had been diagnosed with Helicobacter pylori infection and tested for H. pylori eradication were examined by a pathological response or positive urea breath test. Patients who received atorvastatin in addition to standard treatment were also identified based on a table of random numbers. Standard treatment included a 240mg bismuth subcitrate tablet, a 40mg pantoprazole tablet, a 500mg metronidazole tablet, and 2 capsules of 500mg amoxicillin, all taken BID for 14 days. After 4 weeks of treatment, all patients underwent stool testing for H. pylori fecal antigen. If the test was positive, the request was considered a failure of treatment, and if the test was negative, it was considered a successful eradication of H. pylori. The clinical trial registration code for this study is IRCT20190823044589N1.ResultsThe eradication rate of H. pylori was 80% in the control group and 80.9% in the intervention group, which did not show a statistically significant difference between the two groups (P-value = 0.971).ConclusionAdding atorvastatin to 4-drug regimen of PPI, bismuth subcitrate, amoxicillin, and metronidazole as the first line of treatment for H. pylori eradication is ineffective.

Download Full-text

The effect of transcutaneous auricular stimulation on anxiety before colposcopy: A randomized clinical trial

Acta Facultatis Medicae Naissensis ◽

10.5937/afmnai2004405j ◽

2020 ◽

Vol 37 (4) ◽

pp. 405-415

Author(s):

Samaneh Jouya ◽

Nahid Golmakani

Keyword(s):

Clinical Trial ◽

State Anxiety ◽

Intervention Group ◽

Routine Care ◽

T Test ◽

Anxiety Level ◽

Control Group ◽

Controlled Clinical Trial ◽

P Value ◽

Significant Difference

Women experience a high level of anxiety and negative emotional responses during colposcopy, which results in women's' unwillingness to return for follow-up. Transcutaneous auricular stimulation may be useful in reducing anxiety. Therefore, the aim of this study was to determine the effect of transcutaneous auricular stimulation on anxiety before colposcopy. This randomized controlled clinical trial study was performed on 65 female candidates for colposcopy who were referred to Ghaem Hospital, Mashhad, Iran, in 2017. Women were randomized into one of the two groups. In the intervention group, a pointer Excel device was used for forty minutes before colposcopy; electrical stimulation at 4 points (Shenmen, relaxation, tranquillizer and endocrine) was performed on ears, with the frequency of 2 Hz for 30 seconds at each point. Women received routine care in the control group. The anxiety level was assessed by Spielberger Questionnaire before intervention and also 40 minutes after intervention. Data analysis was performed using the t-test, paired t-test, and MannWhitney test in SPSS software, version16. P value less than 0.05 was considered significant. After intervention, the state anxiety score was 43.9 ± 9.19 in the control group and 54.3 ± 9.07 in the intervention group, and the difference between the two groups was statistically significant (P = 0.00), while there was no significant difference in the level of trait anxiety in the two groups (P = 0.21). Regarding the reduction of state anxiety level after intervention, transcutaneous auricular stimulation is recommended as a suitable method to reduce anxiety of patients who are candidates for colposcopy.

Download Full-text

The effect of oat bran consumption on gestational diabetes: a randomized controlled clinical trial

BMC Endocrine Disorders ◽

10.1186/s12902-021-00731-8 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Zahra Barati ◽

Mina Iravani ◽

Majid Karandish ◽

Mohammad Hosein Haghighizadeh ◽

Sara Masihi

Keyword(s):

Clinical Trial ◽

Blood Glucose ◽

Gestational Diabetes ◽

Fasting Blood Glucose ◽

Intervention Group ◽

Control Group ◽

Controlled Clinical Trial ◽

Standard Diet ◽

Oat Bran ◽

Significant Difference

Abstract Background Gestational diabetes is the most common medical complication in pregnancy, and it has many side effects for the mother and the fetus. The aim of this study was to evaluate the effect of oat bran consumption on gestational diabetes. Methods This study is a randomized clinical trial that was performed on 112 women with gestational diabetes treated with diet. Participants were randomly divided into two groups of 56. Participants in both groups were given a diet for gestational diabetes. In addition to the diet, the intervention group received 30 g of oat bran daily for 4 weeks at lunch and dinner. Tests of fasting blood glucose and two-hour postprandial (2hpp) glucose were taken from both groups: before the intervention, and 2 and 4 weeks after the start of the intervention. Data analysis was performed using SPSS statistical software (version 22) using independent t-test, as well as Chi-square and Mann-Whitney tests. P values less than 0.05 were considered statistically significant. Results There was no statistically significant difference between the two groups in terms of mean blood glucose before the intervention, while 2 and 4 weeks after the intervention, mean fasting blood glucose and two-hour postprandial (2hpp) glucose decreased significantly in the intervention group compared with the control group (P < 0.001). Conclusion Based on the results of this study, the addition of oat bran to the standard diet for pregnant women with gestational diabetes reduced fasting blood glucose and two-hour postprandial (2hpp) glucose. More detailed studies with higher sample sizes are recommended to prove the effectiveness of this valuable dietary supplement. Trial registration IRCT registration number:IRCT20191220045828N1. Registration date: 2020-04-18. Registered while recruiting.

Download Full-text

Standard versus Endocuff versus cap-assisted colonoscopy for adenoma detection: A randomised controlled clinical trial

United European Gastroenterology Journal ◽

10.1177/2050640620982952 ◽

2020 ◽

pp. 205064062098295

Author(s):

Martin Floer ◽

Laura Tschaikowski ◽

Michael Schepke ◽

Radoslaw Kempinski ◽

Katarzyna Neubauer ◽

...

Keyword(s):

Clinical Trial ◽

Cancer Screening ◽

Controlled Clinical Trial ◽

Polyp Detection ◽

Withdrawal Time ◽

Adenoma Detection ◽

Significant Difference ◽

Randomised Controlled Clinical Trial ◽

Randomised Controlled ◽

Standard Colonoscopy

Background and aims Adenoma detection rate (ADR) in colon cancer screening is most important for cancer prophylaxis. This work is the first three-armed randomised controlled clinical trial aimed at comparing a head-to-head setting standard colonoscopy (SC) with Endocuff-assisted colonoscopy (EC) and cap-assisted colonoscopy (CAC) for improvement of ADR. Methods Patients from Poland and Germany with independent indication for colonoscopy were randomised into three arms of this trial: EC, CAC and SC. Exclusion criteria were age <18 years, active Crohn’s disease or ulcerative colitis, known stenosis and post-colonic resection status. Results A total of 585 patients (195 SC, 189 EC and 186 CAC) were enrolled in this study. Indications were not different between the groups (colorectal cancer screening 51%, diagnostic colonoscopy in 31% and post polypectomy follow-up in 18%; p=0.94). Withdrawal time was a mean of seven minutes in all groups ( p=0.658), and bowel preparation did not differ between the groups. The time to reach the caecum was significantly reduced when using the cap (a mean of six minutes for CAC vs. seven minutes for SC; p=0.0001). There was no significant difference in the primary outcome of the ADR between the groups (EC 32%, CAC 30%, SC 30%; p=0.815). EC proved to be superior (EC vs. SC) in the sigmoid colon and transverse colon for polyp detection. Conclusion The use of EC increased the total number of polyps seen during colonoscopy. In contrast to recent studies, no significant improvement of the ADR was detected.

Download Full-text

A randomized controlled clinical trial of the effect of supportive counseling on mental health in Iranian mothers of premature infants

BMC Pregnancy and Childbirth ◽

10.1186/s12884-020-03502-w ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Leila Seiiedi-Biarag ◽

Mojgan Mirghafourvand ◽

Khalil Esmaeilpour ◽

Shirin Hasanpour

Keyword(s):

Mental Health ◽

Clinical Trial ◽

Premature Infants ◽

Control Group ◽

Controlled Clinical Trial ◽

Randomized Controlled Clinical Trial ◽

Randomized Controlled ◽

Significant Difference ◽

Postpartum Bonding ◽

Supportive Counseling

Abstract Background Premature birth can affect maternal mental health. Considering that the mental health disorder in mothers may play a vital role in the growth and development of their children, therefore, this study was conducted to determine the effect of supportive counseling on mental health (primary outcome), mother-child bonding and infant anthropometric indices (secondary outcomes) in mothers of premature infants. Methods This randomized controlled clinical trial was carried out on 66 mothers with hospitalized neonates in the NICU of Alzahra hospital in Tabriz- Iran. Participants were randomly allocated into two groups of intervention (n = 34) and control (n = 32) through a block randomization method. The intervention group received 6 sessions of supportive counseling (45–60 minutes each session) by the researcher, and the control group received routine care. Questionnaires of Goldberg General Health and the postpartum bonding were completed before the intervention (first 72 hours postpartum) and 8 weeks postpartum. Also, the anthropometric index of newborns were measured at the same time. Results There was no statistically significant difference between the two groups in terms of socio-demographic characteristics. After the intervention, based on ANCOVA with adjusting the baseline score, mean score of mental health (AMD: -9.8; 95% Confident Interval (95% CI): -12.5 to -7.1; P < 0.001) and postpartum bonding (AMD: -10.0; 95% CI: -0.6 to 13.9; P < 0.001) in the counseling group was significantly lower than those of the control group; however, in terms of weight (P = 0.536), height (P = 0.429) and head circumference (P = 0.129), there was no significant difference between the two groups. Conclusions Supportive counseling may improve mental health and postpartum bonding in mothers of premature infants. Thus, it may be recommendable for health care providers to offer it to mothers. Trial registration Iranian Registry of Clinical Trials (IRCT): IRCT20120718010324N45. Date of registration: October 29, 2018.

Download Full-text

Intravenous paracetamol versus ketorolac for pain attenuation in patients with renal colic; a randomized, single blind and controlled clinical trial

Journal of Renal Injury Prevention ◽

10.34172/jrip.2020.10 ◽

2020 ◽

Vol 9 (2) ◽

pp. e10-e10

Author(s):

Arash Ardestani Zadeh ◽

Davood Arab ◽

Mohammadreza Moonesan ◽

Majid Mirmohammadkhani ◽

Pouya Morid

Keyword(s):

Clinical Trial ◽

Adverse Effects ◽

Renal Colic ◽

Vital Signs ◽

Analgesic Efficacy ◽

Controlled Clinical Trial ◽

Randomized Controlled ◽

Intravenous Paracetamol ◽

Significant Difference ◽

Single Blind

Introduction: Pain control is an essential care for patients with renal colic in emergency wards. Objectives: This study aimed to compare the analgesic efficacy of intravenous (IV) paracetamol (PC) versus ketorolac (KET) for patients with renal colic. Patients and Methods: In a randomized controlled clinical trial, 110 patients with renal colic referred to the emergency department of Kosar hospital, Semnan between October 2015 and June 2016 were selected. Eighty-eight patients were divided into two groups (44 patients in each group) of PC (1 g/IV) and KET (30 mg/IV). One patient in each group was excluded during the study. Vital signs and pain severity (measured by visual analogue scale [VAS]) of all patients were recorded at admission time 0, 20, 40 and 60 minutes after treatment. Then, the results were compared in two groups. Results: The results showed that at the time of 0, 20, 40 and 60 minutes after the administration of the PC and KET drugs, no significant difference was seen in severity of pain based on VAS score between the two groups (P<0.05). Moreover, there were no significant differences in the vital signs of two groups (P<0.05). No adverse effects were reported in each group. Conclusion: In conclusion, the use of IV-PC and KET in patients with renal colic had similar pain relieving effects without any adverse effects.

Download Full-text