Clinical Profile and Visual Outcome of Optic Neuritis Patients in Mysore Medical College and Research Institute, India

BACKGROUND Blindness is a major health problem worldwide and India has been an epicenter in the number of blindness cases. The causes of blindness, natural history differs between western countries and India. When it comes to optic neuritis the pattern in developing countries is different than developed countries. Multiple sclerosis is one of the major causes of disability disease in US and one of the most common early manifestations is optic neuritis. Early identification and early management have shown promises in reducing ocular morbidity as well as neurological morbidity and recurrences. But the trend of optic neuritis in India is very different and not many studies have been conducted to know about this disease and its causes in this geographical region. We wanted to evaluate the clinical profile and visual outcome of optic neuritis in India. METHODS It was a prospective study done for a duration of 10.8 +/- 8.4 months in which all patients clinically diagnosed with optic neuritis were studied. Thirty patients were included in the study. They were followed up and visual parameters were assessed and thus clinical profiling and visual outcomes were done. RESULTS Mean age was 39.3667 ± 14.03563 years. Female preponderance was seen (63.33 % of cases). Retrobulbar neuritis (56.7 % of eyes) was more common than papillitis (43.33 % of eyes) but papillitis was a more common presentation in males (73.7 %). Bilateral presentation was seen in 23.33 % cases. All patients complained of DOV but pain on ocular movements were complained by 36.66 % patients. Baseline median logMAR visual acuity (VA) was 1.17 ± 0.8, which improved to 1.6 ± 0.6, within one week and 0.79 +/- 0.6 within one month improving to 0.55 +/- 0.6 in three months. Approximately 64.68 % of eyes retained VA of or 6/18 or more. Colour vision recovery was noted in 39.86 %. Demyelinating lesions in the brain were present in 2 patients, one of which was already diagnosed as MS. One case on follow up was eventually diagnosed as multiple sclerosis. CONCLUSIONS In Indian scenario the profile of optic neuritis is different. Here incidence of papillitis is more or equal to that of retrobulbar optic neuritis, visual recovery is poor, causes being more of infectious or idiopathic and less recurrence rate. KEY WORDS Optic Neuritis, Clinical Profile, Visual Outcome, Developing Countries Ontt

Download Full-text

Demographic pattern, clinical profile and visual outcome of patients with optic neuritis in a tertiary level eye care center of eastern Nepal

Health Renaissance ◽

10.3126/hren.v11i3.9641 ◽

2014 ◽

Vol 11 (3) ◽

pp. 250-253

Author(s):

BG Shrestha ◽

M Sharma ◽

P Lavaju ◽

SM Pokharel ◽

N Agrawal ◽

...

Keyword(s):

Visual Acuity ◽

Optic Neuritis ◽

Care Center ◽

Visual Outcome ◽

Clinical Profile ◽

Response To Treatment ◽

Female Ratio ◽

History Of ◽

Intravenous Steroids ◽

Time Of Presentation

Introduction: Optic neuritis is one of the common causes of sudden visual impairment. Early diagnosis and treatment with intravenous steroids can hasten visual recovery. Objective: To analyze the demographic pattern, clinical profile, and response to treatment with pulse methylprednisolone in patients presenting with optic neuritis. Methods: A hospital based retrospective analysis of records of patients with optic neuritis presenting at BPKIHS between April 2010 to February 2012 was carried out. Demographic pattern, clinical profile and visual outcome at the time of presentation and discharge were recorded. Results: Thirty-five patients (44 eyes) presented with optic neuritis. A total of 33 eyes (75%) had papillitis and 11 eyes (25%) had retrobulbar optic neuritis. Male to female ratio was 2.18:1. The mean age at presentation was 31.20 ± 17.07 years. Diminution of vision was the commonest mode of presentation. Bilateral involvement was seen in 9 patients (25.71%). The 38 eyes (86.36%) had abnormal pupillary reaction. Eight patients (22.85%) had preceeding history of trauma, 1 (2.85%) had ethmoidal sinusitis and 1 (2.85%) otitis media. At the time of discharge 32 eyes (72.7%) showed recovery in visual acuity after pulse I.V. methylprednisolone therapy. Duration at presentation, visual acuity at presentation and diagnosis did not affect the final visual outcome (p=0.486, p=0.162 and p=0.122 respectively). Conclusion: Majority of patients presented with papillitis of idiopathic origin. Most of the cases were unilateral. Most patients with visual acuity of at least perception of light or better at the time of presentation improved after pulse I.V. methylprednisolone therapy. DOI: http://dx.doi.org/10.3126/hren.v11i3.9641 Health Renaissance 2013;11(3):250-253

Download Full-text

Differences in clinical features between optic neuritis in neuromyelitis optica spectrum disorders and in multiple sclerosis

Multiple Sclerosis Journal - Experimental Translational and Clinical ◽

10.1177/2055217318791196 ◽

2018 ◽

Vol 4 (3) ◽

pp. 205521731879119 ◽

Cited By ~ 5

Author(s):

Jindapa Srikajon ◽

Sasitorn Siritho ◽

Chanon Ngamsombat ◽

Naraporn Prayoonwiwat ◽

Niphon Chirapapaisan ◽

...

Keyword(s):

Multiple Sclerosis ◽

Visual Acuity ◽

Optic Neuritis ◽

Neuromyelitis Optica ◽

Retrospective Chart Review ◽

Visual Outcome ◽

Neuromyelitis Optica Spectrum Disorders ◽

Fiber Layer ◽

Spectrum Disorders

Background Optic neuritis (ON) is one of the common manifestations both in neuromyelitis-optica spectrum disorders (NMOSD) and in multiple sclerosis (MS). Objectives The objective of this paper is to compare clinical presentations, laboratories and imaging findings in ON associated with MS and NMOSD. Methods A retrospective chart review was performed in patients presenting with ON in 59 NMOSD patients with 72 eyes’ involvement and 163 ON attacks, and 20 MS patients with 23 eyes’ involvement and 36 ON attacks. Results ON-NMOSD patients had recurrent ON more often and tended to have simultaneous bilateral ON involvement at their first ON attack. Individuals with ON-NMOSD revealed worse visual acuity at first ON attacks and also had poorer long-term visual outcome than those with ON-MS, with nearly half of ON-NMOSD patients still having LogMAR visual acuity ≥1 at their last follow-up ( p = 0.035). Significant thinner average retinal nerve fiber layer thickness was found in the ON-NMOSD group. We found no significant differences in segmentation location of the optic nerve lesions and the length of involvement between the two groups. Conclusions It was difficult to completely differentiate ON-NMOSD from ON-MS. ON-NMOSD patients, however, tended to have simultaneous bilateral ON involvement and poorer long-term visual outcome than individuals with ON-MS.

Download Full-text

Optic Neuritis: Visual Outcome and Risk Factors for the Development of Multiple Sclerosis in Western Turkey

Neuro-Ophthalmology ◽

10.3109/01658107.2011.580888 ◽

2011 ◽

Vol 35 (3) ◽

pp. 115-120

Author(s):

Nese Celebisoy ◽

Ayse Sagduyu Kocaman ◽

Halil Gulluoglu ◽

Ayse Nur Yuceyar ◽

Figen Gokcay ◽

...

Keyword(s):

Risk Factors ◽

Multiple Sclerosis ◽

Optic Neuritis ◽

Visual Outcome ◽

Western Turkey

Download Full-text

Adolescents: a paediatrician’s or an adult physician’s domain? clinical profile of Indian adolescents admitted in pediatric ward and those admitted in other than pediatric ward

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20200681 ◽

2020 ◽

Vol 7 (3) ◽

pp. 571

Author(s):

Snehal V. Patel ◽

Halak J. Vasavada ◽

Purvi R. Patel ◽

Nirav B. Rathod

Keyword(s):

Infectious Diseases ◽

Tertiary Care ◽

General Medicine ◽

Developed Countries ◽

Clinical Profile ◽

Late Adolescents ◽

Pediatric Ward ◽

Indian Adolescents ◽

Surgical Ward ◽

A Prospective Study

Background: Study of the clinical profile and no. of admissions of adolescents admitted in pediatric ward and other than Pediatric ward.Methods: A Prospective Study, conducted during August 2018 to March 2019, at a tertiary care teaching hospital, including age group 10-19 years.Results: Out of 1645, highest adolescents’ admissions 749 (46.37%) were to medical ward, 2nd highest in the Pediatric ward which was 317 (19.6%), followed by general surgical ward which was 312(19.3%). Highest among late adolescents, infectious diseases were still the leading cause of hospitalization of adolescents as it constituted 68.4% (902) of admissions to other than pediatric ward followed by surgical cause[135(10.2%)] followed by accidents [5%(66)].Conclusions: Infectious diseases are more common in adolescents compared to developed countries. The shift in hospitalisation of adolescents from pediatrics to general medicine at about 14 years is illustrated in present study and reflects the need of better implementation of clinical policy on the age divide.

Download Full-text

Epidemiology of bovine and human tuberculosis in the Federal Capital Territory of Nigeria, Abuja

Proceedings of the British Society of Animal Science ◽

10.1017/s1752756200011200 ◽

2005 ◽

Vol 2005 ◽

pp. 209-209

Author(s):

A. A. Abubakar ◽

P. H. Brooks ◽

S. U. Abdullahi ◽

A. C. Kudi ◽

O. Okaiyeto

Keyword(s):

Developing Countries ◽

Developed Countries ◽

Developing Nations ◽

Control Measures ◽

Major Health Problem ◽

Major Health ◽

Green Area ◽

Unpasteurized Milk ◽

The World ◽

Genus Mycobacterium

Tuberculosis (TB) is a chronic debilitating disease of man and animals caused by members of the genus Mycobacterium. TB is a major health problem with 8-9 million new cases a year in the world and 3 million deaths (WHO, 2002), and the majority of these are in developing nations. Infection due to due to M. bovis was once a major problem in developed countries but following eradication programmes, the incidence reduced to the extent that some areas are now free of the disease (Caffery, 1994). However, the infection continues in developing countries due to lack of rigorous control measures. In Nigeria there have been limited studies to determine the prevalence/relationship between bovine and human TB especially with the eating culture of ‘fura da nono’ i.e. unpasteurized milk. Abuja is the new capital of Nigeria with the population of 4 million continues to increase due to the influx of people from all states of the federation. The number of people diagnosed with TB is also on the increase. The semi forest vegetation of the Federal Capital Territory (FCT) also encourages migration of Fulani nomads in search of green area for their animals. The objective of this study was to determine the prevalence of bovine and human TB in the capital as well as to establish whether there is a link between animal and human TB.

Download Full-text

MRI of acute optic neuritis (ON) at the first episode: Can we predict the visual outcome and the development of multiple sclerosis (MS)?

La radiologia medica ◽

10.1007/s11547-019-01073-1 ◽

2019 ◽

Vol 124 (12) ◽

pp. 1296-1303 ◽

Cited By ~ 2

Author(s):

Michaela Cellina ◽

Chiara Floridi ◽

Cristina Rosti ◽

Marcello Orsi ◽

Marta Panzeri ◽

...

Keyword(s):

Multiple Sclerosis ◽

Optic Neuritis ◽

Visual Outcome ◽

First Episode ◽

Acute Optic Neuritis

Download Full-text

Progression of Optic Neuritis to Multiple Sclerosis: A Prospective Study in an Italian Population

Neuroepidemiology ◽

10.1159/000110256 ◽

1991 ◽

Vol 10 (3) ◽

pp. 117-121 ◽

Cited By ~ 2

Author(s):

G. Mapelli ◽

M. Pavoni ◽

P. De Palma ◽

R. Modestino ◽

V. Pavoni

Keyword(s):

Multiple Sclerosis ◽

Optic Neuritis ◽

Prospective Study ◽

Italian Population ◽

A Prospective Study

Download Full-text

Clinical Profile of Bilateral Optic Neuritis

Jurnal Kesehatan Andalas ◽

10.25077/jka.v7i0.767 ◽

2018 ◽

Vol 7 ◽

pp. 29

Author(s):

M. Hidayat

Keyword(s):

Multiple Sclerosis ◽

Optic Neuritis ◽

Clinical Profile

Neuritis optik adalah istilah yang digunakan untuk merujuk suatu peradangan pada saraf optik. Neuritis optik bilateral pada orang dewasa jarang terjadi, terutama pada individu tanpa adanya kelainan sistemik inflamasi atau autoimun. Tujuan: Untuk menggambarkan profil klinis neuritis optik bilateral akut pada orang dewasa, efek terapi kortikosteroid intravena serta waktu pemulihan visus. Metode: Kami melakukan tinjauan retrospektif terhadap rekam medis pasien yang merujuk ke klinik neuro-ophthalmologi di Rumah Sakit M. Djamil dengan neuritis optik bilateral akut dari Januari 2016 sampai April 2017. Kriteria eksklusi mencakup multiple sclerosis atau myelopathy sebelumnya, kelainan sistemik yang dikenal atau pengobatan yang terkait dengan neuropati optik, uveitis, atau neoplasma. Pasien mendapatkan metilprednisolon intravena yang diikuti oleh tappering off metilprednisolon oral. Ketajaman visual, lapang pandang, penemuan oftalmoskopi, dan evaluasi neurologis dicatat pada awal dan pada 1 bulan atau 3 bulan. Hasil: Sembilan pasien dari 4 pria dan 5 wanita, dengan rentang usia 22-41 tahun, memiliki penglihatan bilateral yang menurun, 6 dengan rasa sakit pada menggerakan mata. Semua pasien memiliki evaluasi neurologis normal, dengan ketajaman penglihatan mulai dari penghitungan jari sampai gerakan tangan dan berbagai pola lapang pandang. Kedua saraf optik menunjukkan temuan ophthalmoscopy yang tidak normal. Setelah terapi kortikosteroid rata-rata 2 minggu, semua pasien menunjukkan perbaikan pada ketajaman penglihatan, bidang visual, dan temuan oftalmoskopi. Tidak ada pasien yang mengalami masalah neurologis selama follow-up dengan rata-rata 3 bulan. Kesimpulan: Neuritis optik bilateral idiopatik jarang terjadi pada orang dewasa. Terapi kortikosteroid menunjukkan hasil visual yang baik.

Download Full-text

Rheumatic Fever and Antibody Response to Group A Streptococcal Infections

Nepalese Heart Journal ◽

10.3126/njh.v6i1.18597 ◽

2017 ◽

Vol 6 (1) ◽

pp. 58-61

Author(s):

Ganesh Prasad Neupane ◽

R Makaju ◽

R Koju

Keyword(s):

Developing Countries ◽

Heart Disease ◽

Rheumatic Fever ◽

Cause Of Death ◽

Structural Heart Disease ◽

Developed Countries ◽

Common Disease ◽

Major Health Problem ◽

Group A ◽

Clinically Significant

Rheumatic fever is non-suppurative sequel of group A streptococcal infection. It is a multifocal inflammatory disease, affecting primarily the heart, joints, skin and central nervous system occurring in 0.1% to 3% after untreated pharyngitis. It was a major cause of death and a common cause of chronic structural heart disease in children until 1960. It has declined in developed countries due to advent of penicillin and improved social conditions. Rheumatic fever is very common disease among children in developing countries till date. Rheumatic fever and its clinically significant sequel, rheumatic heart disease, continue to be a major health problem in developing countries like Nepal. Rheumatic fever is still a major cause of death and heart disease.

Download Full-text