Adjusting Anterior Thigh Muscle Measurements Using Ultrasound in Sarcopenia

2020 ◽  
pp. 1-2
Author(s):  
A.M. Ata ◽  
M. Kara ◽  
L. Özçakar
Keyword(s):  
Muscle Mass ◽  
Muscle Power ◽  
Thigh Muscle ◽  
Mass Measurements ◽  
Anterior Thigh ◽  
Age Related ◽  
Functional Assessments ◽  
And Performance ◽  
Fast Twitch ◽  
Regional Muscle

We have read with great interest the recently published article by Tsukasaki et al (1). We congratulate the authors for drawing attention to regional muscle mass measurements for evaluating sarcopenia. As they highlighted, age-related muscle loss occurs initially in the anterior thigh muscles that predominantly contain fast-twitch (type II) fibers (2). Therefore, regional muscle mass and functional assessments are important for the early diagnosis and follow-up of sarcopenia (2). In this regard, computed tomography (CT), magnetic resonance imaging, ultrasound (US) and dual-energy X-ray absorptiometry (DXA) techniques give opportunity for regional muscle mass measurements. Likewise, the authors compared the relationships among regional/total muscle mass measurements, muscle power, strength and performance tests. Although we agree with them in general, we would like to add further.

scholarly journals Physical activity in elderly

2015 ◽  
Vol 25 (4) ◽  
pp. 249 ◽  
Author(s):  
Jan Cvecka ◽  
Veronika Tirpakova ◽  
Milan Sedliak ◽  
Helmut Kern ◽  
Winfried Mayr ◽  
...  
Keyword(s):  
Physical Activity ◽  
Electrical Stimulation ◽  
Muscle Mass ◽  
Irreversible Process ◽  
Significant Decline ◽  
Positive Effects ◽  
Age Related ◽  
And Performance ◽  
And Function ◽  
Age Related Changes

Aging is a multifactorial irreversible process associated with significant decline in muscle mass and neuromuscular functions. One of the most efficient methods to counteract age-related changes in muscle mass and function is physical exercise. An alternative effective intervention to improve muscle structure and performance is electrical stimulation. In the present work we present the positive effects of physical activity in elderly and a study where the effects of a 8-week period of functional electrical stimulation and strength training with proprioceptive stimulation in elderly are compared.

Diminished overload-induced hypertrophy in aged fast-twitch skeletal muscle is associated with AMPK hyperphosphorylation

2005 ◽  
Vol 98 (2) ◽  
pp. 557-564 ◽  
Author(s):  
David M. Thomson ◽  
Scott E. Gordon
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Muscle Protein ◽  
Male Rats ◽  
Brown Norway ◽  
Ampk Phosphorylation ◽  
Age Related ◽  
Ampk Activity ◽  
Slow Twitch ◽  
Fast Twitch

Skeletal muscle mass declines with age, as does the potential for overload-induced fast-twitch skeletal muscle hypertrophy. Because 5′-AMP-activated protein kinase (AMPK) activity is thought to inhibit skeletal muscle protein synthesis and may therefore modulate muscle mass and hypertrophy, the purpose of this investigation was to examine AMPK phosphorylation status (a marker of AMPK activity) and its potential association with the attenuated overload-induced hypertrophy observed in aged skeletal muscle. One-week overload of fast-twitch plantaris and slow-twitch soleus muscles was achieved in young adult (8 mo; n = 7) and old (30 mo; n = 7) Fischer344 × Brown Norway male rats via unilateral gastrocnemius ablation. Significant ( P ≤ 0.05) age-related atrophy (as measured by total protein content) was noted in plantaris and soleus control (sham-operated) muscles. In fast-twitch plantaris muscles, percent hypertrophy with overload was significantly attenuated with age, whereas AMPK phosphorylation status as determined by Western blotting [phospho-AMPK (Thr172)/total AMPK] was significantly elevated with age (regardless of loading status). There was also a main effect of loading on AMPK phosphorylation status in plantaris muscles (overload > control). Moreover, a strong and significant negative correlation ( r = −0.82) was observed between AMPK phosphorylation status and percent hypertrophy in the overloaded plantaris muscles of all animals. In contrast to the plantaris, overload-induced hypertrophy of the slow-twitch soleus muscle was similar between ages, and AMPK phosphorylation in this muscle was also unaffected by age or overload. These data support the possibility that an age-related elevation in AMPK phosphorylation may partly contribute to the attenuated hypertrophic response observed with age in overloaded fast-twitch plantaris muscle.

scholarly journals The interaction between nutrition and exercise for promoting health and performance

2017 ◽  
Vol 77 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Oliver C. Witard ◽  
Derek Ball
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Metabolic Response ◽  
Healthy Ageing ◽  
Human Model ◽  
Health Issues ◽  
The Public ◽  
Non Invasive ◽  
Age Related ◽  
And Performance

The theme of The Nutrition Society Spring Conference 2017 was on the interaction between nutrition and exercise for promoting healthy ageing, maintaining cognitive function and improving the metabolic health of the population. The importance of this theme is highlighted by the public health issues surrounding obesity, diabetes and the age-related loss of skeletal muscle mass (sarcopenia). The opening symposium provided a historical perspective of both invasive and non-invasive methodologies for measuring exercise energetics and energy balance. Data derived from these techniques underpin current understanding regarding the metabolic response to nutrition and exercise. Further symposia examined the importance of skeletal muscle for healthy ageing in older men and postmenopausal women. From a nutritional perspective, the potential for animal- v. plant-based protein sources to offset the age-related decline in muscle mass was discussed. The day concluded by discussing the link(s) between nutrition, exercise and brain function. Day 2 commenced with examples of applied equine research illustrating the link between nutrition/exercise and insulin resistance to those of a human model. The final symposium examined the combined role of nutrition and exercise in reducing risk of type 2 diabetes and dyslipidaemia. The overall conclusion from the meeting was that the interaction between diet and physical activity confers greater benefits to human health and performance than either component alone.

scholarly journals 970 Age-related Differences in Acute Skeletal Muscle Atrophy After Immobilisation: A Systematic Review

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
H Hodgson ◽  
M Wilkinson ◽  
A Howard
Keyword(s):  
Systematic Review ◽  
Muscle Mass ◽  
Muscle Atrophy ◽  
Older Persons ◽  
Convincing Evidence ◽  
Skeletal Muscle Atrophy ◽  
Mass Measurements ◽  
High Quality Research ◽  
Acute Setting ◽  
Age Related

Abstract Introduction Muscle atrophy is a recognised cause of morbidity and mortality. Whilst the association between loss of muscle mass and age is well established, it is controversial as to whether older adults’ atrophy at a different rate or are more susceptible to atrophy in the acute setting. The aim of this systematic review is to identify if there are any age-related differences in the rate of atrophy between older and younger persons. Method A systematic search of Medline, Embase and Cochrane databases in December 2020 was carried out. All studies whose design involved a period of immobilisation and a comparison between older and younger cohorts were included. Studies must have direct pre-and-post immobilisation muscle mass measurements, and the percentage change in muscle mass was extracted from each study. Results Searching revealed 1007 records, of which six articles met the inclusion and exclusion criteria. 150 participants were included; 136 (90.7%) were male, and 14 (9.3%) were female. Studies used immobilisation periods between five and 14 days, and measured muscle volume by MRI, DXA or CT. Three studies reported greater atrophy in the older group, and three studies reported greater atrophy in the younger group. Conclusions There is no convincing evidence of any differences between the rates of atrophy in older persons in comparison to younger persons. We highlight that the current literature is inconsistent and overall, there is a lack of high-quality research on the topic, with particular concern regarding the significant lack of literature regarding atrophy rates in women.

scholarly journals The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass

2020 ◽  
Author(s):  
Vanina Romanello ◽  
Marco Sandri
Keyword(s):  
Muscle Mass ◽  
Disease Onset ◽  
Premature Death ◽  
Poor Quality ◽  
Mitochondrial Network ◽  
Dynamic Coordination ◽  
Age Related ◽  
Muscle Changes ◽  
And Performance

Abstract The dynamic coordination of processes controlling the quality of the mitochondrial network is crucial to maintain the function of mitochondria in skeletal muscle. Changes of mitochondrial proteolytic system, dynamics (fusion/fission), and mitophagy induce pathways that affect muscle mass and performance. When muscle mass is lost, the risk of disease onset and premature death is dramatically increased. For instance, poor quality of muscles correlates with the onset progression of several age-related disorders such as diabetes, obesity, cancer, and aging sarcopenia. To date, there are no drug therapies to reverse muscle loss, and exercise remains the best approach to improve mitochondrial health and to slow atrophy in several diseases. This review will describe the principal mechanisms that control mitochondrial quality and the pathways that link mitochondrial dysfunction to muscle mass regulation.

scholarly journals Effects of Physiotherapy Interventions on the Function of the Locomotor System in Elder Age: View of Theory and Practice

2020 ◽  
Author(s):  
Boglárka Debity ◽  
Julianna Cseri
Keyword(s):  
Skeletal Muscle ◽  
Resistance Training ◽  
Bone Remodeling ◽  
Muscle Mass ◽  
Neural Control ◽  
Muscle Power ◽  
Relevant Literature ◽  
Balance Training ◽  
Locomotor System ◽  
And Performance

The aim of this chapter is to give an overview about the aging processes in the neural and muscuo-skeletal system at cellular and tissue level to highlight the demand for physiotherapy interventions. Searching the relevant literature published in the last decade, it was found that the loss of muscle mass (myofiber atrophy and decrease in the number of myofibers) is associated with decreased regeneration capacity of the skeletal muscle, deterioration of the neural control and bone remodeling as well as the impaired microcirculation leading to insufficient adaptation to the physical exercises. In the management of the aging-related deterioration of the skeletal muscle (sarcopenia), the first tool is the resistance training that improves the muscle mass and power as well as the functional outcomes regarding the mobility and physical performance. The endurance (aerobic) training improves the cardiovascular and respiratory status providing better blood supply to the skeletal muscle and exerts some effects directly to the skeletal muscle and bone (increases the mitochondrial functions, improves the bone remodeling). The combination of aerobic and resistance training seems to be more effective against the sarcopenia and osteopenia. The balance training gives additional benefits, so (together with increased muscle power and performance) improves the quality of life.

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