S700 Early Proactive IFX Dose Optimization Negates the Impact of HLA-DQA1*05 on Anti-Drug Antibody Formation in Inflammatory Bowel Diseases

Inflammatory bowel diseases (IBD) are characterized by chronic dysregulation of immune homeostasis, epithelial demise, immune cell activation, and microbial translocation. Each of these processes leads to proinflammatory changes via the release of cytokines, damage-associated molecular patterns (DAMPs), and pathogen-associated molecular patterns (PAMPs), respectively. The impact of these noxious agents on the survival and function of the enteric nervous system (ENS) is poorly understood. Here, we show that in contrast to an expected decrease, experimental as well as clinical colitis causes an increase in the transcript levels of enteric neuronal and glial genes. Immunostaining revealed an elevated neuronal innervation of the inflamed regions of the gut mucosa. The increase was seen in models with overt damage to epithelial cells and models of T cell-induced colitis. Transcriptomic data from treatment naïve pediatric IBD patients also confirmed the increase in the neuroglial genes and were replicated on an independent adult IBD dataset. This induction in the neuroglial genes was transient as levels returned to normal upon the induction of remission in both mouse models as well as colitis patients. Our data highlight the dynamic and robust nature of the enteric nervous system in colitis and open novel questions on its regulation.

Download Full-text

Clinical approach to skin eruptions induced by anti-TNF agents among patients with inflammatory bowel diseases: insights from a multidisciplinary IBD-DERMA clinic

Therapeutic Advances in Gastroenterology ◽

10.1177/17562848211053112 ◽

2021 ◽

Vol 14 ◽

pp. 175628482110531

Author(s):

Henit Yanai ◽

Hadar Amir Barak ◽

Jacob E Ollech ◽

Irit Avni Biron ◽

Idan Goren ◽

...

Keyword(s):

Decision Making ◽

Shared Decision Making ◽

Inflammatory Bowel Diseases ◽

Clinical Approach ◽

Shared Decision ◽

Tertiary Referral Center ◽

Treatment Interruptions ◽

Bowel Diseases ◽

Inflammatory Bowel ◽

The Impact

Background and Aims: Skin eruptions are prevalent among patients with inflammatory bowel diseases (IBD), often associated with therapies and frequently leading to dermatological consults and treatment interruptions. We aimed to assess the impact of joint shared decision-making in a multidisciplinary (MDT) IBD-DERMA clinic. Methods: This retrospective cohort study assessed a consecutive group of patients with IBD who were referred for consultation in an MDT clinic at a tertiary referral center in Israel. Results: Over 1 year, 118 patients were evaluated in the MDT-IBD-DERMA clinic: 68 (57.6%) males; age – 35.2 ± 13.5 years, disease duration – 7.1 (interquartile range: 3.7–13.9) years; Crohn’s disease – 94/118 (79.6%). Skin eruption induced by an anti–tumor necrosis factor (TNF) were the most common diagnoses [46/118 (39%)], including psoriasiform dermatitis (PD) – 31/46 (67.4%) and inflammatory alopecia (IA) – 15/46 (32.6%). Of these, 18 patients (39.1%) continued the anti-TNF agent concomitantly with a topical or systemic anti-inflammatory agent to control the eruption. The remaining 28 patients (60.9%) discontinued the anti-TNF, of whom 16/28 (57.1%) switched to ustekinumab. These strategies effectively treated the majority [38/46 (82.6%)] of patients. Continuation of the anti-TNF was possible in a significantly higher proportion of patients with PD: 12/31 (38.7%) than only one in the IA group, p = 0.035. There was a higher switch to ustekinumab among the IA 7/15 (46.6%) compared with the PD 7/31 (22.6%) group, P = .09. Following IBD-DERMA advised intervention, IBD deteriorated in 9/4 6(19.5%) patients, 5/9 on ustekinumab (PD versus IA, P = NS). Conclusion: Shared decision-making in an integrated IBD-DERMA clinic allowed successful control of skin eruptions while preserving control of the underlying IBD in more than 80% of cases. Patients with IA profited from a switch to ustekinumab.

Download Full-text

The Impact of Matrix Metalloproteinases and Their Tissue Inhibitors in Inflammatory Bowel Diseases

Digestive Diseases ◽

10.1159/000336995 ◽

2012 ◽

Vol 30 (3) ◽

pp. 289-295 ◽

Cited By ~ 51

Author(s):

Gábor Lakatos ◽

István Hritz ◽

Mária Zsófia Varga ◽

Márk Juhász ◽

Pál Miheller ◽

...

Keyword(s):

Matrix Metalloproteinases ◽

Inflammatory Bowel Diseases ◽

Tissue Inhibitors ◽

Bowel Diseases ◽

Inflammatory Bowel ◽

The Impact

Download Full-text

Methotrexate for Inflammatory Bowel Diseases - New Developments

Digestive Diseases ◽

10.1159/000443129 ◽

2016 ◽

Vol 34 (1-2) ◽

pp. 140-146 ◽

Cited By ~ 9

Author(s):

Hans H. Herfarth

Keyword(s):

Ulcerative Colitis ◽

Crohn’S Disease ◽

Inflammatory Bowel Diseases ◽

Antibody Formation ◽

Clinical Effectiveness ◽

New Developments ◽

The Past ◽

Steroid Dependent ◽

Bowel Diseases ◽

Inflammatory Bowel

Methotrexate (MTX) is an established therapy for patients with steroid-dependent Crohn's disease (CD). MTX is also frequently used in combination with anti-TNF agents to suppress anti-drug antibody formation. It has been suggested in the past that MTX lacks any clinical effectiveness in patients with ulcerative colitis (UC); however, newer data at least partially contradict this assumption. The following review will discuss recent data for the use of MTX in CD, UC and in combination with anti-TNF agents.

Download Full-text

605 THE IMPACT OF FUT2 LOSS-OF-FUNCTION MUTATION ON THE PATHOGENESIS OF INFLAMMATORY BOWEL DISEASES MEDIATED BY THE GUT MICROBIOME

Gastroenterology ◽

10.1016/s0016-5085(21)01037-4 ◽

2021 ◽

Vol 160 (6) ◽

pp. S-119

Author(s):

Sijing Cheng ◽

Jun Hu ◽

Xianrui Wu ◽

Na Jiao ◽

Yichen Li ◽

...

Keyword(s):

Inflammatory Bowel Diseases ◽

Gut Microbiome ◽

Loss Of Function ◽

Bowel Diseases ◽

Inflammatory Bowel ◽

The Impact

Download Full-text

Inflammatory bowel disease is an independent risk factor for male erectile dysfunction

10.31083/jomh.2021.095 ◽

2021 ◽

pp. 1

Keyword(s):

Risk Factors ◽

Erectile Dysfunction ◽

Inflammatory Bowel Diseases ◽

Psychological Status ◽

Psychological State ◽

Pelvic Surgery ◽

Depression Status ◽

Bowel Diseases ◽

Inflammatory Bowel ◽

The Impact

Background and objective: Inflammatory bowel diseases (IBD) are chronic diseases involving the gastrointestinal system, including ulcerative colitis (UC) and Crohn's disease (CD). Studies have shown a relationship between inflammatory bowel diseases and sexual dysfunction in men but it has been reported that this is due to surgery or the patient's psychological state. In our study, we aimed to assess the impact of IBD on the sexual functioning of male patients who has no previous pelvic surgery by evaluating the depression status of the patients. Materials and methods: The 334 patients who were followed up in our gastroenterology outpatient clinic between January 2021 and March 2021 were included in the study and they were divided into 2 groups as with (n = 146) and without IBD (n = 188). None of the patients had a history of pelvic surgery or pelvic radiotherapy due to IBD or any other disease. The two groups were compared in terms of demographic data, comorbidities, sexual function, depression status and blood tests. International Index of Erectile Function (IIEF) was used in the evaluation of sexual functions, and the Beck Depression Inventory (BDI) was used in the evaluation of depression. Risk factors for erectile dysfunction (ED) were determined. Results: The mean Beck depression test scores of the two groups were found to be similar (p = 0.361). ED was detected in 52.7% of patients with IBD and 32.4% of patients without IBD (p < 0.0001). In multivariate regression analysis, age (p = 0.008), smoking (p < 0.001), presence of diabetes mellitus (p = 0.02) and presence of IBD (p < 0.001) were determined as independent risk factors for ED. Conclusion: Inflammatory bowel diseases can cause ED regardless of the pelvic surgery performed and the psychological status that occur in these patients.

Download Full-text

P225 Impact of Inflammatory Bowel Diseases on patients working life

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjab076.351 ◽

2021 ◽

Vol 15 (Supplement_1) ◽

pp. S277-S277

Author(s):

N Sahar ◽

W Dahmani ◽

E Nour ◽

H Aya ◽

B A Wafa ◽

...

Keyword(s):

Inflammatory Bowel Diseases ◽

Burden Of Illness ◽

Work Productivity ◽

Intestinal Resection ◽

Working Life ◽

Professional Activity ◽

Professional Career ◽

Bowel Diseases ◽

Inflammatory Bowel ◽

The Impact

Abstract Background Inflammatory bowel diseases (IBD) are a group of chronic disabling gastrointestinal disorders, consisting mainly of Crohn’s disease (CD) and ulcerative (UC). A substantial part of the burden of illness in these conditions relates to the functional impairment, particularly affecting the ability to work. The aims of this study were to determine the impact of IBD on the working life of patient and to identify factors associated with a decreased productivity at work in patients with IBD. Methods A cross-sectional study carried out at the Gastroenterology department of Sahloul University Hospital (CHU) over a period of 6 months. Patients with IBD (CD or UC) who present to the outpatient clinic or are hospitalized in the ward or day hospital were included. A questionnaire drawn up on the basis of qualitative studies on this subject is used to collect data on the professional career, the characteristics of the position held, difficulties encountered at work on a daily basis.The questionnaire will be accompanied by the “Work Productivity and Activity Impairment” (WPAI) work productivity score. Results Among the 82 patients included, 58 had Crohn disease (CD) and 24 had ulcerative colitis (UC). The sex ratio was 1.2 and the mean age of our patients was 33.5 ± 10.2 years. . The majority of UC patients had pancolic involvement (n = 18; 75%). Among the 58 patients followed for CD, 24 (41.4%) had anoperineallesions. Twenty-two patients (26.8%) had already undergone intestinal resection. Six patients (7.3%) were on prolonged sick leave. The majority of patients worked in the private sector (n = 68; 82.9%). Two patients (2.4%) had a fixed rate of work per night. No patient had a job requiring frequent travel. Sixty-two patients (75.6%) had a weekly hourly volume greater than 40 hours.In half of the cases, the discovery of the disease preceded the choice of a professional career; among the remaining patients, this choice was influenced by IBD in 4 cases (10, 5%). Sixteen patients (21.5%) had to skip work hours during the week preceding the interview. The average number of hours missed due to a specific IBD-related problem was 5 hours with extremes ranging from 3 to 10 hours per week. An overall decrease in productivity (BGP) greater than 50% was objectified in 16 patients (21%). The average rates of absenteeism, presenteeism and BGP were 10.49%, 71.25% and 74.14% respectively. The presence of anoperineallesions was the only variable associated with BGP (50% vs 13.3%; p = 0.044). Conclusion The impact of IBD on professional activity appears to be significant and requires special attention from both the gastroenterologists and the occupational physicians.

Download Full-text

Quality of Life Impact and Special Issues in Women with Inflammatory Bowel Diseases

10.21203/rs.3.rs-223640/v1 ◽

2021 ◽

Author(s):

Gabriel Constantinescu ◽

Gina Gheorghe ◽

Ecaterina Rinja ◽

Oana Plotogea ◽

Vasile Sandru ◽

...

Keyword(s):

Quality Of Life ◽

Inflammatory Bowel Diseases ◽

Standard Of Care ◽

Cross Sectional ◽

Men And Women ◽

Bowel Diseases ◽

Inflammatory Bowel ◽

The Impact ◽

Gender Specific

Abstract Background: The impact of inflammatory bowel diseases (IBD) on quality of life (QoL) of patients is significant and has important social and professional consequences. Methods: We aimed to describe the patients’ perspective regarding the impact of IBD on their overall QoL and to evaluate the differences between men and women. An observational cross-sectional study, that included 180 patients with IBD in clinical remission, was conducted. All the patients completed a number of 3 questionnaires in order to evaluate the general aspects of their QoL. A separate questionnaire was created regarding gender-specific issues in women with IBD encounter. Also, particular features such as the incidence of anemia and osteoporosis among IBD patients were documented. The data obtained were analyzed and compared between the two gender-classified groups. Results: According to the Short Inflammatory Bowel Disease Questionnaire (SIBDQ), patients had a general perception of a good QoL, but the impact was higher in women. Fatigue and tiredness were severely perceived almost to the same degree regardless of gender, whereas anxiety and unemployment were more present in men. No significant differences in women with IBD during active disease and during disease remission were found. Conclusions: The overall quality of life of IBD patients is affected in many aspects, leading to the deterioration of their social and professional lives, for both men and women, but some aspects remain gender-specific and require a personalized standard of care.

Download Full-text