Clinical and economic analysis of the modern strategies for treating metabolic syndrome

Objective. The objective of this study was to identify the ways to optimize therapy for metabolic syndrome through complex clinical and economic analysis. Methods. Sixty patients with metabolic syndrome were included in the study. The study group (30 subjects with the mean age of 41.0?11 years, 23 females (76.7%), 7 males (23.3%)) received pharmacotherapy for obesity (orlistat) and insulin resistance (metformin), lipid-lowering therapy and antihypertensive therapy, if needed. The control group (30 patients with the mean age of 43.4?9.5 years, 26 females (86.7%), 4 males (13.3%)) received lipid-lowering and antihypertensive therapy, if needed. All patients underwent clinical and laboratory examination, assessment of depression (Beck Depression Inventory) and evaluation of the quality of life using the SF-36 questionnaire at admission to the study and after 6 months of therapy. Complex clinical and economic analyses, including cost-effectiveness and cost-utility analyses and calculation of such indices as ?the incremental cost-effectiveness ratio? (ICER), LYG, QALY and ?net monetary benefit? (NMB), were conducted based on the results obtained. Results. Improvement of clinical and laboratory indicators and quality of life in the study group was more significant than that in the control group. The direct medical costs were 33,440.40 RUB for the study group and 18,878.50 RUB for the control group (for 6 months of therapy). The control group CER was 4,016.70, while the study group CER was 3,125.30; ICER was 2,430.90 RUB. LYG was equal to 0.7 and 2.3 years for the control and the study groups, respectively. The QALY measure for the control and study groups was 8.63 and 9.45, respectively. The weighted average total costs for the intended period of living was 498,745.00 RUB for the control group and 457,866.00 RUB for the study group. The control group CUR was 57,792.00 and 54,902.00 RUB/QALY without and with discounting, respectively, while in the study group they were 48,451.00 and 46,029.00 RUB/QALY, respectively. The NMB for the control group amounted to 10,790,910.00 and 10,815,840.00 RUB without and with discounting, respectively, while for the study group the values were 11,904,500.00 and 11,927,390.00 RUB. Conclusions. The results of clinical and economic analysis show that treatment of the metabolic syndrome, including pharmacotherapy of obesity and insulin resistance, should be prioritized over mere medical advisory and lifestyle modifications.

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The ımportance of art therapy ın the qualıty of lıfe ın hemodıalysıs patıents

Ukrainian Journal of Nephrology and Dialysis ◽

10.31450/ukrjnd.1(69).2021.04 ◽

2020 ◽

pp. 27-33

Author(s):

Ergün Parmaksız ◽

Hüseyin Demirbilek

Keyword(s):

Quality Of Life ◽

Hemodialysis Patients ◽

Control Group ◽

Study Group ◽

State Trait Anxiety Inventory ◽

Important Place ◽

Before And After ◽

Avoidance Measures ◽

The Mean

Dialysis causes many psycho-social problems in patients with chronic renal failure and decreases their quality of life by increasing their anxiety. We aimed to determine the influence of artistic activities on quality of life and reducing or eliminating dialysis anxiety.Methods. Among 180 hemodialysis patients, 8 patients were randomly selected as a study group and 8 patients as a control group. We performed our theater rehearsals in 16 sessions, two hours per week. State-Trait Anxiety Inventory (STAI), STAII and Social Anxiety Scales (SAS) were employed in both groups before and after the play. Results. The means of the eighth-month SAS fear and avoidance measures of the study group were found to be significantly lower than the control group and significantly lower than the baseline. The mean difference of the initial eighth-month SAS fear and avoidance in the study group was statistically significantly higher than the control group.Initial and eighth month SAS fear and avoidance difference averages of the study group were found statistically significantly higher than the control group.Conclusions. We determined that the therapies to be done with art have an important place in relieving or reducing anxiety in hemodialysis patients. In addition, it was the opinion that our patients would make positive contributions to their quality of life. However, further studies are needed to demonstrate whether theater rehearsals reduce anxiety in hemodialysis patients.

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Comparative analysis of use of triamcinolone and placebo in treatment of persistent allergic rhinitis

Russian otorhinolaryngology ◽

10.18692/1810-4800-2021-1-61-64 ◽

2021 ◽

Vol 20 (1) ◽

pp. 61-64

Author(s):

A. Kh. Nazanyan ◽

◽

S. L. Manasyan ◽

A. A. Avakyan ◽

A. K. Shukuryan ◽

...

Keyword(s):

Quality Of Life ◽

Allergic Rhinitis ◽

Study Groups ◽

Control Group ◽

Study Group ◽

Persistent Allergic Rhinitis ◽

The Difference ◽

Double Blinded ◽

Better Than

The aim of the study was to determine the effect of triamcinolone monotherapy on the quality of life of patients with persistent allergic rhinitis. The study was placebo-controlled, randomized and double-blinded. The study included 46 patients in the study group and 24 patients in the control group, all were diagnosed with persistent allergic rhinitis for at least two years. Patients were examined twice after diagnosis was made. The study group was administered intramuscularly with 40 mg of triamcinolone once, while the control group was given placebo. To estimate the quality of life in both groups, a specially designed questionnaire was used, according to which the final scores were calculated. The triamcinolone group had a lower overall score on the questionnaire compared with the placebo group (p < 0.001). The difference between the scores at the beginning of the study and at the end of the first month for all indicators was statistically significant (p < 0,001). The difference in changes from the start of the study to the end of the first month (difference in treatment) between placebo and the study groups was statistically significant, in favour of the study group. Triamcinolone is a drug that improves the quality of life of patients treated for persistent allergic rhinitis, better than placebo.

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Effect of an Educational Intervention on Quality of Life and Sexual Function in Women with Endometriosis

International Journal of Studies in Nursing ◽

10.20849/ijsn.v3i2.452 ◽

2018 ◽

Vol 3 (2) ◽

pp. 127 ◽

Cited By ~ 1

Author(s):

Hend Abdallah EL Sayed ◽

Samia Abdel Hakeem Hanseen Aboud

Keyword(s):

Quality Of Life ◽

Sexual Function ◽

Educational Intervention ◽

University Hospital ◽

Control Group ◽

Study Group ◽

Significant Difference ◽

Quasi Experimental ◽

The Mean

Aim of the study was to investigate the effect of an educational intervention on quality of life and sexual function in women with endometriosis. Design: Quasi experimental time series research design. Setting: obstetrics and gynecology outpatient clinic affiliated to Benha University Hospital and Benha teaching Hospital. Sample: A purposive sample of 138 women diagnosed with endometriosis was eligible in the study and assigned equally into study and control groups. Tools for data collection: A structured interviewing questionnaire, Endometriosis Health Profile Questionnaire-30 and Sexual Health Outcomes in Women Questionnaire. Results: There was no statistically significant difference between both groups regarding demographic and obstetrical characteristics (p ˃ 0.05). Before implementation of educational intervention, the mean scores of total EHP-30 and SHOW-Q showed impaired quality of life and sexual function in the both groups (p ˃ 0.05). After one and two months of educational intervention implementation, mean total score of EHP-30 was significantly lowered in the study group compared with the control group. The mean scores of satisfaction, orgasm, and desire subscales were significantly higher in study group compared with control group. Whereas, the mean score of the pelvic problem interference subscale was significantly lower in study group compared with control group (p ≤ 0.001). Conclusion: The educational intervention about endometriosis has significant effect on the improvement of women's quality of life and sexual function. Recommendation: Provide health educational program for women with endometriosis to improve quality of life as well as sexual function.

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Comprehensive Stroke Education Program (CSEP) on Knowledge and Quality of Life among Patients with Stroke and Burden among Caregivers

Nursing and Health Care ◽

10.33805/2573-3877.142 ◽

2019 ◽

pp. 71-80

Author(s):

Baminidevi Nagarajan

Keyword(s):

Quality Of Life ◽

Controlled Trial ◽

World Health ◽

Control Group ◽

Study Group ◽

Level Of Knowledge ◽

The Mean ◽

Health Organization ◽

And Control

Stroke is a global health problem. Rehabilitation is a major part of patient care. The statistics on Cerebrovascular Accident (CVA) quoted by world health organization projects that nearly 15 million people suffer from stroke worldwide each year. Of these, 5 million die and another 5 million are permanently disabled. High blood pressure contributes to more than 12.7 million strokes worldwide. Study objectives were to determine the effectiveness of CSEP on knowledge and Quality of Life (QoL) among patients with stroke and to evaluate the effectiveness of CSEP on knowledge and burden among caregivers. This study was conducted at Sri Ramachandra Medical Centre (SRMC), Chennai-600 116. It is a 1675 bedded multi-specialty hospital. The pretest was conducted in neurology wards and the posttest was conducted at neurology OPD. Permission obtained from ethical committee. Randomized controlled trial research method was adopted. Sample size was 170 dyads (patient+caregiver) in those 85 dyads in each group were recruited by lottery method. Following pretest, CSEP was implemented to the study group dyads. Posttests were taken on 30th day, 90th day and 180th day at neurology OPD for both the groups. Comparison of mean scores of knowledge on stroke between the study and control group showed the level of knowledge found to be high among study group patients at p<0.001. The mean scores of ADL in the study group was statistically significant at p<0.05 level. The mean scores of Physical Component Summary (PCS) and Mental Component Summary (MCS) showed statistically significant at p<0.05. Overall mean scores of Stroke Specific Quality of Life (SSQOL) in the study group were found to be significant at p<0.01. Study group caregiver’s knowledge on stroke was statistically significant at p<0.01. The burden mean scores were higher among control group than the study group caregiver.

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Integrated approach in the treatment of metabolic syndrome

Obesity and metabolism ◽

10.14341/omet2014132-37 ◽

2014 ◽

Vol 11 (1) ◽

pp. 32-37 ◽

Cited By ~ 2

Author(s):

V A Uchamprina ◽

T I Romantsova ◽

M F Kalashnikova

Keyword(s):

Quality Of Life ◽

Insulin Resistance ◽

Blood Pressure ◽

Metabolic Syndrome ◽

Clinical Outcomes ◽

Antihypertensive Therapy ◽

Standard Therapy ◽

Integrated Approach ◽

Study Group

The Goal of this study was to investigate the efficacy of the integrated approach for the treatment of metabolic syndrome (MS) aiming to correct all of its components versus standard therapy using clinical outcomes (BMI, waist circumference, blood pressure, lipid levels), assessment of psychological status (Beck Depression Inventory), and quality of life (SF-36). Methods: A total of 60 patients with MS were included in the study. The study group (30 subjects mean age 41.0±11 years, women - 23 (76.7%), men - 7 (23.3%)) received the complex therapy of MS - pharmacotherapy of obesity (orlistat) and insulin resistance (metformin), lipid-lowering therapy (statins or fibrates), antihypertensive therapy. Control group (30 patients mean age 43.4±9.5 years, women - 26 (86.7%), men - 4 (13.3%)) was treated with statins or fibrates and received antihypertensive therapy when needed. At the inclusion in the study and after 6 months of therapy all patients underwent clinical and laboratory investigation, assessment of depression and quality of life. Results: We found a more significant reduction of all clinical outcomes (body weight, blood pressure, improvement in glucose and lipid metabolism), a significant decrease in the prevalence and severity of the depression, and an improvement in the quality of life in patients of study group compared with standard therapy. Conclusion: Complex treatment of the MS, including pharmacotherapy of obesity (orlistat, Xenical) and insulin resistance (metformin, Glucophage) is characterized by a greater clinical efficacy compared with standard therapy.

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Analysis of the Impact of Personalized Nursing Service and Hospice Care on the Quality of Life of Elderly Cancer Patients

Tobacco Regulatory Science ◽

10.18001/trs.7.4.24 ◽

2021 ◽

Vol 7 (4) ◽

pp. 469-473

Author(s):

Ting Fang ◽

Nian Wang ◽

Meng Chen ◽

Hongmei Ma

Keyword(s):

Quality Of Life ◽

Cancer Patients ◽

Advanced Cancer ◽

Hospice Care ◽

Pain Treatment ◽

Control Group ◽

Study Group ◽

The Difference ◽

The Impact

Objective Explore the impact of personalized nursing services and hospice care on the quality of life of elderly patients with advanced cancer. Method We selected 80 elderly cancer patients admitted to our hospital from September 2020 to May 2021, and divided these patients into a study group and a control group using a random number table method. The patients in the control group used conventional nursing methods to treat and care for the patients, and the patients in the study group used hospice care measures and combined personalized nursing measures. The quality of life and pain treatment effects of the two groups of patients before and after treatment were compared. Result Before treatment, the quality-of-life scores of the two groups of patients were low, and there was no statistical difference (P>0.05); After treatment, the quality of life of the two groups of patients improved, but compared with the control group, the improvement was more obvious in the study group, and the difference was statistically significant (P<0.05). In terms of pain treatment effect, the total effective rate of pain treatment in the study group was 87.5%, which was significantly better than the 62.5% in the control group. The difference was statistically significant (P<0.05). Conclusion Personalized nursing services and hospice care are conducive to improving the survival and treatment of elderly patients with advanced cancer, and can be used as a clinical application program for the care of advanced cancer patients.

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The effects of breathing exercises on respiratory functions, functional capacity and quality of life in vehicle spray painters

International Journal of Therapy and Rehabilitation ◽

10.12968/ijtr.2021.0092 ◽

2021 ◽

Vol 28 (12) ◽

pp. 1-8

Author(s):

Burak Yilmaz ◽

Cagtay Maden ◽

Begümhan Turhan

Keyword(s):

Quality Of Life ◽

Functional Capacity ◽

Control Group ◽

Study Group ◽

Breathing Exercises ◽

Sf 36 ◽

Significant Difference ◽

Before And After ◽

Respiratory Exercises

Background/aims Workers engaged in vehicle spray painting are at a risk of developing respiratory problems because of the solvents in the spray paints. Changes in respiratory functions and functional capacities caused by spray painting can be improved with respiratory exercises. The aim of this study was to examine the effects of respiratory exercises on the respiratory functions, functional capacity and quality of life in vehicle spray painters. Methods A total of 70 volunteers with similar characteristics participated in the study. The groups were divided into two groups randomly (35 study group, 35 control group). Respiratory functions (value of forced expiratory volume percentage in 1 second [FEV1]), forced vital capacity percentage [FVC], FEV1/FVC percentage, peak expiratory flow percentage [PEF (%)] and maximum voluntary ventilation percentage [MVV (%)]), functional capacity (6-Minute Walk Test) and quality of life (Short Form Health Survey [SF-36]) were evaluated. The study group undertook supervised breathing exercises 3 days a week for 6 weeks. The same exercises were given to the control group as a home programme. Home programmes were followed up by telephone calls. Evaluations were performed again after 6 weeks. Results In the study group, FEV1 (%) increased more than in the control group (P<0.05). The increase in PEF (%) was similar in both groups (P>0.05). In the study group, FEV1/FVC (%) and MVV (%) were significantly different before and after the intervention (P<0.05), but there was no difference in the control group (P>0.05). There was a greater increase in the study group than in the control group (P<0.05). 6-Minute Walk Test distance (m) before and after the intervention in both groups were similar (P>0.05). Before and after the intervention, a significant difference was found in the vitality and the social function domains of the SF-36 in the study group. In the comparisons of groups, a significant difference was found in the study group in the role-emotional, social function and bodily pain domains of the SF-36 after the intervention (P<0.05). Conclusions Breathing exercises can be recommended for vehicle spray painters to avoid an increase in respiratory resistance and to improve their quality of life.

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Intravesical Instillation of Sodium Hyaluronate (Cystistat®) for the Treatment of Patients with Radiation Cystitis-Randomized Clinical Trial

International Journal of Cancer Management ◽

10.5812/ijcm.108299 ◽

2020 ◽

Vol 13 (11) ◽

Author(s):

Farzad Allameh ◽

Abbas Basiri ◽

Saleh Ghiasy ◽

Atefeh Javadi ◽

Seyyed Ali Hojjati ◽

...

Keyword(s):

Quality Of Life ◽

Clinical Trial ◽

Hyaluronic Acid ◽

Sodium Hyaluronate ◽

Intravesical Instillation ◽

Control Group ◽

Radiation Cystitis ◽

Vas Score ◽

The Mean

Background: Radiotherapy (RT) is a choice to manage pelvic organ malignancies that can affect bladder; therefore, it causes radiation cystitis with some bothering urinary symptoms and decreasing the patient’s quality of life. Intravesical hyaluronic acid (HA) is an agent with promising results in some studies for cystitis, and Cystistat is a derivative of hyaluronic acid. Objectives: This clinical trial aimed at evaluating the effects of intravesical instillation of Cystistat on symptoms of radiation cystitis and quality of life (QOL). Methods: A total of 58 patients with radiation cystitis were randomized in 2 groups (case: 30, control: 28). One group received intravesical Cystistat, the other received normal saline weekly for up to 4 weeks and then monthly for up to 2 months. Hematuria, Visual Analog scale (VAS) and QOL based on King’s Health questionnaire were compared before and 3, 6 and 9 months after intravesical instillation. Results: The mean age of the patients was 63.93 ± 10.89 years old. The mean of each sub-category of QOL and total score of QOL, as well as, VAS score were significantly improved in comparison to the control group at each time of follow-ups (P < 0.05). Hematuria was significantly different in the 3rd, 6th and 9th month of follow-ups (P < 0.05). Conclusions: Findings showed that patients with radiation cystitis could significantly benefit from intravesical instillation of HA, their hematuria would be successfully resolved rather than control group in addition to lowering the VAS score, so their QOL would be improved.

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Effectiveness of Cognitive-Behavioral Therapy (CBT) on Quality of Life (QOL) and Worry in Patients with Generalized Anxiety Disorder (GAD)

International Journal of Indian Psychology ◽

10.25215/0202.021 ◽

2015 ◽

Vol 2 (2) ◽

Author(s):

Sheida Jabalameli ◽

Hamid Taher Neshat Doost ◽

Mohammad Bagher Kajbaf ◽

Hossein Molavi

Keyword(s):

Quality Of Life ◽

Anxiety Disorder ◽

Generalized Anxiety Disorder ◽

Behavioral Therapy ◽

Control Group ◽

Generalized Anxiety ◽

The Mean ◽

Experimental Group

Generalized Anxiety Disorder (GAD) is one of the most common anxiety disorders. It has been reported that psychological treatments like Cognitive-Behavioral Therapy (CBT) is effective for patients with GAD. The purpose of the present research was to investigate the effectiveness of CBT on Quality of Life (QOL) and worry in patients with GAD. A sample of 30 patients with GAD who had been referred to psychiatry offices in Isfahan, Iran were selected and assigned into an experimental group (n=15) and a control group (n=15) randomly. The experimental group received CBT in 8 weekly sessions. All participants completed the World Health Organization Quality Of Life-Brief (WHOQOL-BREF) questionnaire and the Penn State Worry Questionnaire (PSWQ) at pretest, posttest and follow up. The results of MANCOVA showed that the mean scores of QOL in the experimental group was significantly higher than the control group at the posttest and follow up (P<0.05) and the mean scores of worry in the experimental group was significantly lower than the control group at the posttest and follow up (P<0.05) It is concluded that CBT can be applied for the patients with GAD as a useful psychological treatment. In general, CBT can improve QOL and decrease worry in patients with GAD.

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Effects of Non-Pharmacological Treatment on Pain, Flexibility, Balance and Quality of Life in Women with Fibromyalgia: A Randomised Clinical Trial

Journal of Clinical Medicine ◽

10.3390/jcm10173826 ◽

2021 ◽

Vol 10 (17) ◽

pp. 3826

Author(s):

Juan Rodríguez-Mansilla ◽

Abel Mejías-Gil ◽

Elisa María Garrido-Ardila ◽

María Jiménez-Palomares ◽

Jesús Montanero-Fernández ◽

...

Keyword(s):

Quality Of Life ◽

Perceived Exertion ◽

Exercise Program ◽

Well Being ◽

Exercise Programme ◽

Secondary Outcome ◽

Control Group ◽

Static Balance ◽

The Mean

Background: The functional deficits in people with fibromyalgia can be related to the level of physical activity performed. This study investigated the effectiveness of an active exercise programme versus exercise for well-being improving pain, flexibility, static balance, perceived exertion and quality of life of women with fibromyalgia; Methods: A randomised, single-blind, controlled trial was conducted. A total of 141 of women diagnosed with fibromyalgia were enrolled and randomised to an active exercise program group (n = 47), where they performed physical active exercises, an exercise for well-being group (n = 47), which performed the Qi Gong exercises named ‘the twenty Wang Ziping figures for health and longevity’, and a control group (n = 47), which did not receive any intervention, for a period of 4 weeks. Measures were taken at baseline and after the treatment. The primary outcome measures were static balance and centre of gravity (Wii-Fit Nintendo ©), flexibility (test de Wells and Dillon), pain (Visual Analogue Scale) and quality of life (Spanish-Fibromyalgia Impact Questionnaire). The secondary outcome measure was the perceived exertion during activity (BORG Scale). Results: In total, 93 participants completed the study. The mean value of the age was 52.24 ± 6.19. The post intervention results showed statistically significant improvements in the exercise for well-being and the active exercise programme groups vs. the control group in relation to pain (p = 0.006 active exercise programme group, p = 0.001 exercise for well-being group), static balance (p < 0.001 active exercise programme group) and quality of life (p < 0.001 active exercise programme group, p = 0.002 exercise for well-being group). In addition, the mean scores related to perceived fatigue during the sessions were 6.30 ± 1.88 for the active exercise programme group and 5.52 ± 1.55 for the exercise for well-being group. These differences were not significant. Conclusions: The active exercise program and exercise for well-being improved flexibility, static balance, pain and quality of life of women with fibromyalgia. The participants of the active exercise programme achieved better results that those of the exercise for well-being.

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