scholarly journals Draft of the clinical recommendations for diagnosis and treatment of hypothyroidism

2021 ◽  
Vol 17 (1) ◽  
pp. 4-13
Author(s):  
V. V. Fadeev ◽  
T. B. Morgunova ◽  
G. A. Melnichenko ◽  
I. I. Dedov
Keyword(s):  
Pregnant Women ◽  
Autoimmune Thyroiditis ◽  
Clinical Guidelines ◽  
Radioactive Iodine ◽  
Primary Hypothyroidism ◽  
Diagnosis And Treatment ◽  
Clinical Recommendations ◽  
Chronic Autoimmune Thyroiditis ◽  
Endocrine Diseases

Hypothyroidism is one of the most common endocrine diseases. More than 99% of all cases of hypothyroidism in adults are due to primary hypothyroidism. Most often, hypothyroidism develops because of chronic autoimmune thyroiditis, as well as after medical manipulations (iatrogenic hypothyroidism) — postoperative or as a result of therapy with radioactive iodine. The article presents a draft of clinical guidelines for the diagnosis and treatment of hypothyroidism in different groups of patients, including pregnant women.

scholarly journals NON-MALIGNANT DISEASES OF THE ENDOCRINE SYSTEM THROUGH 30 YEARS AFTER CHERNOBYL ACCIDENT

2016 ◽  
Vol 57 (3) ◽  
pp. 22-32
Author(s):  
O. V. Kaminskyi ◽  
O. V. Kopilova ◽  
D. Y. Afanasyev ◽  
O. V. Pronin ◽  
N. S. Dombrovskaya
Keyword(s):  
Autoimmune Thyroiditis ◽  
Chernobyl Accident ◽  
Nodular Goiter ◽  
Primary Hypothyroidism ◽  
Critical Groups ◽  
Control Group ◽  
Exclusion Zone ◽  
Chronic Autoimmune Thyroiditis ◽  
Endocrine Diseases ◽  
Toxic Goiter

A retrospective analysis of data 1992–2014 years shows that the prevalence of thyroid patology in people affected by the Chernobyl accident is 40.3 %, in emergency workers — 35.4 %, in those whowere evacuated from the exclusion zone — 27.2 %, in residents of radiation contaminated areas — 28.6 %. It’s significantly higher (p < 0.0001) than in the general Ukrainian population (3.9 %). The most common non-malignant endocrine diseases in individuals who have suffered as a result of the Chernobyl accident were: nodular goiter — 14.4 %, chronic autoimmune thyroiditis 8 %, preobese/obesity 41.9 %/36.8 %, pre-diabetes/diabetes 15.5 %/21.4 %. The most common non-malignant endocrine diseases liquidators of the Chernobyl accident were nodular goiter — 21.8 %, chronic autoimmune thyroiditis — 12.9 %, pre-obese/obesity — 41.7 %/33.6 %, prediabetes/diabetes — 8.6 %/12.2 %. Critical groups were children evacuated from the 30 km exclusion zone and irradiated at the age of 3–6 years. They had diffuse toxic goiter in 43.7 %, chronic autoimmune thyroiditis — 1.7 %, primary hypothyroidism — 0.96 %, nodular goiter — 2.3 %, and the peak prevalence of chronic autoimmune thyroiditis occurred in 2001–2003. An active period of their puberty. Among children who were born from irradiated parents (first generation), thyroid disease was detected in 42.6 %, it exceeded the rate in the control group, chronic autoimmune thyroiditis diagnosed significantly less frequently — at 0.45 %, diffuse toxic goiter in 9.5–13.8 %, nodular goiter at 1.7 %. Non-malignant endocrine pathology in exposed adults and children is common, occurs in 3–53 % of individuals, occurs in the majority of victims in 10–15 years after exposure to the radiation factor in the result of technogenic accident or incident, it continues to grow slowly in 30 years.

scholarly journals Clinical recommendations of the Russian Association of Endocrinologists for the diagnosis and treatment of autoimmune thyroiditis in children

2003 ◽  
Vol 49 (6) ◽  
pp. 51
Author(s):  
E. P. Kasatkina ◽  
M. I. Martynova ◽  
V. A. Peterkova ◽  
L. N. Samsonova ◽  
L. V. Sapelkina ◽  
...  
Keyword(s):  
Autoimmune Thyroiditis ◽  
Diagnosis And Treatment ◽  
Clinical Recommendations ◽  
Russian Association

The article is devoted to the clinical recommendations of the Russian Association of Endocrinologists for the diagnosis and treatment of autoimmune thyroiditis in children

scholarly journals “Vitamin D Deficiency Is More Common in Women with Autoimmune Thyroiditis: A Retrospective Study”

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Nino Turashvili ◽  
Lali Javashvili ◽  
Elene Giorgadze
Keyword(s):  
Vitamin D ◽  
Retrospective Study ◽  
Vitamin D Deficiency ◽  
Autoimmune Thyroiditis ◽  
Thyroid Stimulating Hormone ◽  
Primary Hypothyroidism ◽  
Thyroid Autoantibody ◽  
Chronic Autoimmune Thyroiditis ◽  
Antithyroglobulin Antibodies ◽  
Stimulating Hormone

Background. Vitamin D is a hormone that is mainly produced in the skin upon ultraviolet B radiation exposure and has important influence on various organs. In recent years, data have been collected that vitamin D deficiency plays an important role in the development of various nonskeletal diseases, including autoimmune diseases. Chronic autoimmune thyroiditis (Hashimoto’s thyroiditis) is one of the most common organ-specific autoimmune endocrine diseases. It is characterized by increased level of antithyroid peroxidase and/or antithyroglobulin antibodies in blood, which often leads to thyroid dysfunction and structural changes of the gland. There is an opinion that vitamin D deficiency may be considered as an important risk factor for development of chronic autoimmune thyroiditis, but data of various small studies are controversial. Despite the fact that Georgia is a sunny country, vitamin D deficiency is a widespread problem here. Thyroid diseases, including the chronic autoimmune thyroiditis, are also very common in Georgia. The aim of our research was to compare the level of vitamin D between the patients with chronic autoimmune thyroiditis and the healthy subjects. Methods. This retrospective study enrolled subjects, who were 18–70 years old and visited the clinics “Cortex” and “National Institute of Endocrinology” in 2018 or in 2019 from mid-spring to mid-summer. Data of thyroid-stimulating hormone, free thyroxine, antithyroid peroxidase antibodies, antithyroglobulin antibodies, thyroid ultrasonography, and 25(OH) vitamin D were retrospectively analysed based on medical history. In total, data of 1295 patients were collected. The statistical processing of data was performed through the SPSS 20 program. Results. The negative association between thyroid-stimulating hormone, antithyroid peroxidase antibodies, antithyroglobulin antibodies, heterogeneous parenchyma of thyroid gland, and vitamin D was found in women. Statistically significant association was not detected in men. Conclusions. Serum vitamin D is lower in women with autoimmune thyroiditis and primary hypothyroidism. Further studies are needed to evaluate the influence of vitamin D supplementation on thyroid autoantibody positivity or primary hypothyroidism.

scholarly journals Clinical recommendations of the Russian Association of Endocrinologists for the diagnosis and treatment of autoimmune thyroiditis in adults

2003 ◽  
Vol 49 (6) ◽  
pp. 50-50 ◽  
Author(s):  
I. I. Dedov ◽  
G. A. Melnichenko ◽  
G. A. Gerasimov ◽  
V. V. Fadeev ◽  
N. A. Petunina ◽  
...  
Keyword(s):  
Autoimmune Thyroiditis ◽  
Diagnosis And Treatment ◽  
Clinical Recommendations ◽  
Russian Association

The article is devoted to the clinical recommendations of the Russian Association of Endocrinologists for the diagnosis and treatment of autoimmune thyroiditis in adults

scholarly journals Treatment of aseptic osteonecrosis of the talus. A draft of clinical guidelines

2021 ◽  
Vol 27 (2) ◽  
pp. 153-162
Author(s):  
A.N. Torgashin ◽  
◽  
A.K. Mursalov ◽  
S.S. Rodionova ◽  
N.V. Zagorodniy ◽  
...  
Keyword(s):  
Clinical Guidelines ◽  
Treatment Options ◽  
Medical Professional ◽  
Diagnosis And Treatment ◽  
Disease Stage ◽  
Cochrane Library ◽  
Level Of Evidence ◽  
Non Profit ◽  
Clinical Recommendations ◽  
Aseptic Osteonecrosis

Clinical guidelines are an algorithm adapted for use in our country, based on the works systematized by the level of evidence, reflecting current approaches to the diagnosis and treatment of aseptic bone necrosis (osteonecrosis) of various localizations. Purpose of the study Creation of an algorithm for diagnosis and treatment of osteonecrosis based on the assessment of the evidence level of literature data. Material and methods The Guidelines are a systematized algorithm based on the level of evidence for the management of patients with osteonecrosis, reflecting current approaches to diagnosis, treatment and rehabilitation, which are based on literature data and the authors' own experience. Electronic databases of Medline, Embase, Web of Science, and Cochrane Library platforms were searched for related sources. Preference was given to the works with high levels of evidence. References to information sources are given in the order of their appearance in the text. The search depth was 50 years due to the availability of systematic literature reviews in the framework of previous international clinical guidelines. When specific medical procedures related to the diagnosis, conservative or surgical treatment of osteonecrosis were included in the clinical recommendations, their level of evidence was reliability, the appropriateness of their use, taking into account the unified scale for assessing the quality of evidence and the strength of the recommendations for application of medical technologies GRADE. Results The Guidelines reflect aspects of clinical, instrumental and laboratory examination of patients with osteonecrosis, treatment options depending on the location of the process and disease stage. Conclusion Clinical recommendations on the medical assistance to patients with aseptic osteonecrosis have been compiled according to the requirements imposed on clinical recommendations developed by medical professional non-profit institutions

SERUM THYROTROPHIN AND THE RESPONSE TO THYROTROPHIN RELEASING HORMONE IN SYMPTOMLESS AUTOIMMUNE THYROIDITIS AND IN BORDERLINE AND OVERT HYPOTHYROIDISM

1974 ◽  
Vol 75 (2) ◽  
pp. 274-285 ◽  
Author(s):  
A. Gordin ◽  
P. Saarinen ◽  
R. Pelkonen ◽  
B.-A. Lamberg
Keyword(s):  
Autoimmune Thyroiditis ◽  
Elevated Serum ◽  
Mean Value ◽  
Primary Hypothyroidism ◽  
Overt Hypothyroidism ◽  
Thyrotrophin Releasing Hormone ◽  
Releasing Hormone ◽  
The Mean ◽  
The Individual ◽  
Serum Tsh

ABSTRACT Serum thyrotrophin (TSH) was determined by the double-antibody radioimmunoassay in 58 patients with primary hypothyroidism and was found to be elevated in all but 2 patients, one of whom had overt and one clinically borderline hypothyroidism. Six (29%) out of 21 subjects with symptomless autoimmune thyroiditis (SAT) had an elevated serum TSH level. There was little correlation between the severity of the disease and the serum TSH values in individual cases. However, the mean serum TSH value in overt hypothyroidism (93.4 μU/ml) was significantly higher than the mean value both in clinically borderline hypothyroidism (34.4 μU/ml) and in SAT (8.8 μU/ml). The response to the thyrotrophin-releasing hormone (TRH) was increased in all 39 patients with overt or borderline hypothyroidism and in 9 (43 %) of the 21 subjects with SAT. The individual TRH response in these two groups showed a marked overlap, but the mean response was significantly higher in overt (149.5 μU/ml) or clinically borderline hypothyroidism (99.9 μU/ml) than in SAT (35.3 μU/ml). Thus a normal basal TSH level in connection with a normal response to TRH excludes primary hypothyroidism, but nevertheless not all patients with elevated TSH values or increased responses to TRH are clinically hypothyroid.

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