scholarly journals THE MOLECULAR MECHANISM OF LACTOFERRIN INFLUENCE ON BONE FORMATION

2016 ◽  
Vol 19 (3) ◽  
pp. 12-22
Author(s):  
P E Sadchikov ◽  
I L Goldman ◽  
S V Razin ◽  
A D Chernousov ◽  
L I Alekseeva ◽  
...  

In present critical review of systematized materials on the breakthrough achievements of the last decade - the discovery of the effect of protein lactoferrin (LF) on bone formation. It is shownthat LF increases the number of osteoblasts, stimulate their proliferation and differentiation, and prevents their destruction. Action of LF exceeds that of many other previously established bone-forming factors. LF increases the ability of osteoblasts to synthesize and mineralize bone matrix. Apparently, the effect of LF on bone anabolism ensured by the presence of specific receptors on osteoblasts. It was found that LF also inhibits the formation of osteoclasts. Experimental studies have demonstrated that LF prevents the destruction of bone tissue in ovariectomizedanimals and, thus, developing the type of postmenstrual osteoporosis in women. We get the first clinical studies demonstrating an increase in the period of healing of bone injuries while reducing the level of endogenous LF. Since molecular research establishes that the expression of the LF gene is regulated by estrogen, which reduces the development of postmenopausal osteoporosis (PMO) in women, there is a need to further investigate the relationship of these processes, which will help to create a basis for the management of bone formation.

1916 ◽  
Vol 29 (7) ◽  
pp. 798
Author(s):  
C. P. Curtis ◽  
Paul E. Bowers

2021 ◽  
Vol 1022 ◽  
pp. 181-193
Author(s):  
Dmitry M. Rozhkov ◽  
Evgenia V. Eltoshkina ◽  
Petr I. Ilyin ◽  
Olga A. Svirbutovich

The article presents the results of experimental studies to determine the relationship between the electrolysis modes and the properties of electroplating coatings for mathematical modeling of the dynamics of the electrolytic process (MDEP), described by a system of ordinary differential equations due to the complex relationship of the kinetics of chemical reactions, hydrodynamics and mass transfer in the electrolyte flow, the kinematics of electrode plates, and the influence of the electric field of the "anode-cathode" pair on all these processes. At the same time, the experimental base was a series of full-scale experiments to restore the seats of the root supports of cylinder blocks with electroplated coatings. The final result of the research is the procedure for constructing an optimal resource-saving mode of electroplating, which is a zinc-iron alloy.


1987 ◽  
Vol 51 (3) ◽  
pp. 15-33 ◽  
Author(s):  
Orville C. Walker ◽  
Robert W. Ruekert

The authors review and integrate various theoretical perspectives, normative statements, and pieces of empirical evidence about the organizational structures and processes best suited for implementing different types of business strategies. Particular emphasis is given to the relationship of different types of structure, processes, and policies involved in the performance of marketing activities to the overall performance of different business strategies. Several specific research propositions are developed.


Author(s):  
David L. Streiner ◽  
Geoffrey R. Norman ◽  
John Cairney

Although the goal of many clinical assessments and research studies is to measure how much people change between two occasions, the measurement of change is fraught with conceptual and methodological difficulties. One of the difficulties is that there are (at least) two different reasons to measure change: to determine if intervention had any effect, and to identify the correlates of change. These two goals work against each other, because the former requires there to be little difference in the amount of change among people in the same group, while the latter depends on inter-individual differences. The chapter also discusses various biases that exist when people are asked directly how much they think they have changed. This chapter addresses the issues of the relationship of change to the reliability of the scale, difficulties of measuring change in experimental and quasi-experimental studies, and new approaches to measuring change, such as growth curve analysis.


2020 ◽  
Vol 164 ◽  
pp. 14004
Author(s):  
Alexandr Dykha ◽  
Volodymyr Kukhar ◽  
Viktor Artiukh ◽  
Maxim Aleksandrovskiy

Research was conducted to determine the effect of lubricants on stress and strain in the contact of metal surfaces. Experiments were carried out on the introduction of a fixed and moving indenter in contact with a dry and lubricated surface.The steel spherical specimen was pressed into a lubricated and dry metal surface. The microstructures of the structure of the surface layer are studied under various conditions of deformation. The diagrams of the relative deformation of the surface layers are constructed. The mechanism of the formation and distribution of internal stresses for dry and greased contact is described. Experimental studies of the introduction of a moving steel indenter into a lubricated surface have been carried out. The relationship of the deformation mechanisms of lubricated surfaces with their wear resistance is determined. The results obtained are recommended for predicting the durability of lubricated friction units according to the criterion of contact strength.


Injury ◽  
2007 ◽  
Vol 38 ◽  
pp. S13-S21 ◽  
Author(s):  
Georgios I. Drosos ◽  
Konstantinos I. Kazakos ◽  
Pavlos Kouzoumpasis ◽  
Dionisios-Alexandros Verettas

1977 ◽  
Vol 1 (3) ◽  
pp. 229-246 ◽  
Author(s):  
Rebecca Oxford Manley

This article is a critical review of studies concerning the relationship of parental warmth and hostility to sex-related differences in children's achievement orientation. Parental warmth seemed to operate differently upon girls' and boys' achievement orientation in most of the studies cited. Moderate but not high maternal warmth and even slight hostility were related to strong achievement∗ orientation in girls, while high maternal nurturance and affection were associated with strong achievement orientation in boys. However, the article warns against assuming a simple causal relationship between parental warmth and sex-related differences in children's achievement orientation. Achievement theories, two main parental dimensions, and future research directions are also discussed.


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