scholarly journals Distribution of endothelial NO synthase gene alleles and locus D6S392 near Mn-dependent superox ide dismutase gene in patients with type I diabetes with diabetic nephropathy

2001 ◽  
Vol 47 (3) ◽  
pp. 15-18
Author(s):  
O. Ye. Voronko ◽  
D. A. Chistyakov ◽  
К. V. Savostyanov ◽  
L. A. Chugunova ◽  
M. Sh. Shamkhalova ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Type I Diabetes ◽  
Insulin Dependent Diabetes Mellitus ◽  
No Synthase ◽  
Dependent Diabetes Mellitus ◽  
Type I ◽  
Mitochondrial Superoxide ◽  
Nos3 Gene ◽  
Insulin Dependent ◽  
Mitochondrial Superoxide Dismutase

Distribution of alleles and genotypes of microsatellite D6S392 neighboring mitochondrial superoxide dismutase (SOD2) gene and of two polymorphous markers (minisatellite ecNOS4a/4b and mutation in codone 298: replacement of glutamic acid (Glu) with asparaginic (Asp) acid) was studied in patients with insulin dependent diabetes mellitus (IDDM) with and without diabetic nephropathy (DN) (36 and 56 patients, respectively). Distribution of locus D6S392 alleles and polymorphous marker Glu298Asp was virtually the same in both groups. Differences were observed for minisatellite ecNOS4a/4b. In DN patients the content of allele 4a and of genotype 4a/4b is increased in comparison with patients without DN (38.9 vs. 22.3%, p < 0.02, and 61.1 vs. 41.7%, p < 0.05, respectively). Decrease in the percent age of 4b/4b genotype and allele 4b in DN patients are also significant (30.6 vs. 57.1%, p < 0.02, and 61.1 vs. 77.1%, p < 0.02). Hence, polymorphous site ecNOS4b/4a of NOS3 gene is associated with DN development in patients with IDDM living in Moscow.

scholarly journals Mechanisms of membranoreceptor function disturbances in pregnant patients with insulin-dependent diabetes mellitus

1994 ◽  
Vol 40 (4) ◽  
pp. 4-7 ◽  
Author(s):  
N P Mikaelyan ◽  
Yu. A. Knyazev ◽  
A. G. Maxina ◽  
V. A. Petrukhin
Keyword(s):  
Diabetes Mellitus ◽  
Type I Diabetes ◽  
Glucose Consumption ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Binding ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Type I ◽  
Functional Changes ◽  
Insulin Dependent

Studies of membranoreceptor system in patients with insulin-dependent diabetes mellitus revealed that insulin resistance in pregnant patients with type I diabetes is caused by disordered cellular sensitivity to threshold physiological and submaximal insulin doses, whereas the maximal doses of the hormone normalize glucose consumption by the cells. High insulin doses intensify lipid peroxidation, normalize the status of membranous proteins, reduce the number of thiol groups, reduce AOA level in membranes, and, hence, reduce membranous capacity to bind active peroxide radicals. Structural and functional changes in red cell membranes are associated with reduced affinity of insulin receptors, reduction in the number of insulin-binding sites in membranes, this disordering intracellular effects of insulin.

scholarly journals ADAPTIVE CAPACITY IMPAIRMENT IN CHILDREN WITH INSULIN-DEPENDENT DIABETES MELLITUS AS SHOWN BY TIME INTERVAL ASSESSMENT

2021 ◽  
Vol 14 (5) ◽  
pp. 112-116
Author(s):  
YURI V. BYKOV ◽  
◽  
VLADIMIR A. BATURIN ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Type I Diabetes ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Control Group ◽  
Study Group ◽  
Type I ◽  
Level Of Consciousness ◽  
Insulin Dependent

Aim. The aim of the study was to diagnose and study the severity of impaired adaptive capacity in children with insulin-dependent diabetes mellitus using the method of assessment of time intervals. Material and methods. The study included 54 adolescents, aged 14 to 18 years. 27 adolescents with type I diabetes mellitus, who were urgently hospitalized in the intensive care unit in a serious condition, constituted the study group, the other 27 adolescents who were hospitalized for planned surgical intervention constituted the control group (conditionally healthy children). The diagnosis of type I diabetes mellitus was confirmed by clinical and laboratory data (hyperglycemia, ketoacidosis, impaired level of consciousness (deafening-sore). Study protocol: psychophysiological testing in adolescents was performed using the original «Rhythm» program, which presented patients with a reference sequence of sound signals and pauses between them, after which the patients played back the sound sequence using a personal computer. Adolescents in the study group were tested after diabetic ketoacidosis had subsided, glycemia had stabilized, and the level of consciousness had normalized (3–5 days after admission). The control group was tested upon admission to thehospital for planned treatment. Significance of the total index of deviations from the specified reference was determined using Student’s t-criterion. Results and discussion. Significant adaptation disorders were detected both in the study group and in the control group. However, in children with diabetes mellitus these disorders were more pronounced due to a greater shortening of the total duration of the cycle, as well as a greater aggregate index of deviations from the duration of set signals and pauses as compared to the «reference standard». Conclusion. The findings support the hypothesis that impaired adaptation mechanisms as a manifestation of desynchronization of biological rhythms may lie in the mechanism of insulin-dependent diabetes mellitus development.

Pittsburgh Insulin-Dependent Diabetes Mellitus Morbidity and Mortality Study: Physical Activity and Diabetic Complications

PEDIATRICS ◽  
1986 ◽  
Vol 78 (6) ◽  
pp. 1027-1033
Author(s):  
R. E. LaPorte ◽  
J. S. Dorman ◽  
N. Tajima ◽  
K. J. Cruickshanks ◽  
T. J. Orchard ◽  
...  
Keyword(s):  
Physical Activity ◽  
Diabetic Complications ◽  
Type I Diabetes ◽  
Health Effect ◽  
Team Sports ◽  
Macrovascular Disease ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
Type I ◽  
Insulin Dependent

The long-term health consequences of chronic physical activity for patients with type I diabetes are unknown. In the current study, the association of physical activity to diabetic complications was assessed in 696 type I diabetic individuals diagnosed between 1950 and 1964. Participation in team sports in high school or college was not associated with a decreased prevalence of severe retinopathy or blindness later in life. There was, however, a suggestion of a negative association between physical activity and both cardiovascular disease and overall mortality, ie, individuals who participated in team sports were somewhat less likely to report macrovascular disease at follow-up or to have died than nonparticipants. The relationship between physical activity and diabetic complications only appeared in male subjects. The results suggest that activity early in life by patients with type I diabetes does not appear to be associated with an adverse health effect and may, in fact, be beneficial.

Detection of autoantibodies to the 65-kD isoform of glutamate decarboxylase by radioimmunoassay

1994 ◽  
Vol 130 (6) ◽  
pp. 575-580 ◽  
Author(s):  
Fred Lühder ◽  
Klaus-Peter Woltanski ◽  
Ludwig Mauch ◽  
Heinz Haubruck ◽  
Klaus-Dieter Kohnert ◽  
...  
Keyword(s):  
High Risk ◽  
Glutamate Decarboxylase ◽  
Type I Diabetes ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
Diabetic Patients ◽  
Type I ◽  
Newly Diagnosed ◽  
Cross Sectional ◽  
Insulin Dependent

Lühder F, Woltanski K-P, Mauch L, Haubruck H, Kohnert K-D, Rjasanowski I, Michaelis D, Ziegler M. Detection of autoantibodies to the 65-kD isoform of glutamate decarboxylase by radioimmunoassay. Eur J Endocrinol 1994:130:575–80. ISSN 0804–4643 Autoantibodies (AAb) to glutamate decarboxylase (GAD) occur with a high prevalence in sera of newly diagnosed type I (insulin-dependent) diabetic patients. The aim of this study was to establish a GAD-AAb radioimmunoassay using 125I-labelled GAD65 and to evaluate this assay in a cross-sectional study with newly diagnosed type I diabetic patients (diabetes duration < 6 weeks). Furthermore, subjects at high risk of developing type I diabetes and individuals suffering from other autoimmune diseases were examined in this assay. For GAD-AAb detection, 125I-labelled GAD65 was incubated with 10 μl of human serum overnight on ice. Thirty of 51 (59%) type I diabetic patients but none of the 54 healthy blood donors tested were found to be positive. A displacement step using 100 000 g supernatant from rat brain containing or not containing GAD showed the specificity of the binding of 125I-GAD65. Concerning the individuals at high risk of developing diabetes, 9/12 (75%) islet cell antibody (ICA)-positive non-diabetic and 4/34 (12%) ICA-negative subjects with metabolic abnormalities were GAD-AAb positive. These results show the association between type I (insulin-dependent) diabetes mellitus and the occurrence of GAD65-AAb, which possibly predicts a risk of developing the disease. F Lühder, Department of Immunochemistry, Institute of Diabetes "Gerhardt Katsch", Greifswalder Str. I la, D-17495 Karlsburg, Germany

Hyperglycemia following Intralesional Corticosteroid Injection in a Patient with Type I Diabetes Mellitus

2014 ◽  
Vol 18 (4) ◽  
pp. 275-276 ◽  
Author(s):  
Patrick Fleming ◽  
Leah Drazek ◽  
James C. Shaw
Keyword(s):  
Diabetes Mellitus ◽  
Type I Diabetes ◽  
Corticosteroid Injection ◽  
Insulin Dependent Diabetes Mellitus ◽  
Local Effect ◽  
Dependent Diabetes Mellitus ◽  
Type I ◽  
Systemic Complications ◽  
Intralesional Corticosteroid ◽  
Insulin Dependent

Case Report: A 36-year-old woman with well-controlled type 1 diabetes mellitus reported hyperglycemia (plasma glucose peaked at 21.3 mmol/L) after her first injection with intralesional triamcinolone acetonide for alopecia areata. Conclusion: Intralesional corticosteroids are used to maximize local effect while presumably minimizing systemic complications. This adverse effect is an important consideration when treating patients with insulin-dependent diabetes mellitus, and it would be reasonable to counsel patients of such a possibility.

Resting parasympathetic status and cardiovascular response to orthostatic and behavioral challenges in type I insulin-dependent diabetes mellitus

1994 ◽  
Vol 1 (2) ◽  
pp. 137-162 ◽  
Author(s):  
Barry E. Hurwitz ◽  
Ruth E. Quilhan ◽  
Jennifer B. Marks ◽  
Neil Schneiderman ◽  
Robert F. Agramonte ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Response ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Type I ◽  
Behavioral Challenges ◽  
Insulin Dependent
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