scholarly journals Antithyroid immunity in children with endemic goiter

1997 ◽  
Vol 43 (6) ◽  
pp. 22-25
Author(s):  
M. Yu. Svinarev ◽  
L. A. Lisenkova ◽  
G. M. Shub

Thyroid immunity is assessed in 246 children aged 6 to 16 living in a region with moderate iodine deficit (the Khvalynsk region of the Saratov district). A total of 203 children with endemic goiter of the first-third degree and 43 children with normal-sized thyroid were examined using the ultrasonic method, measurements of the blood levels of T3, T4, and TTH, estimation of the [(T3+T4)/TTH] index, and assessment of the urinary excretion of inorganic iodine. Serum autoantibodies to the microsomal antigen (MAg) and thyroglobulin (TG) were assayed by ELISA. Autoantibodies to MAg and/or TG were detected in 10.8%) of children with endemic goiter and 2.3%o of those without enlargement of the thyroid. The rate of detection of autoantibodies increases with age (p<0.05) and is parallel with increase in the size of the thyroid (up to 21.1%o in third- degree goiter, p<0.02). Autoantibodies were detected much more often in children with various echographically detected dijfuse changes in the thyroid structure (from 17.8 to 42.9%o vs. 8.6% in cases with the intact structure of the organ). Serum TTH level was reliably increased and the thyroid index decreased in “seropositive” children (p<0.01). The findings confirm the relationship between inadequate consumption of iodine and immunological reactivity of children and demonstrate certain regularities in the development of autoimmune disorders in children with endemic goiter.

2013 ◽  
Vol 112 (1-3) ◽  
pp. 49-55 ◽  
Author(s):  
Tao Ma ◽  
Kaidong Deng ◽  
Chenggang Jiang ◽  
Yan Tu ◽  
Naifeng Zhang ◽  
...  

2021 ◽  
pp. 50-57
Author(s):  
A. N. Kireev ◽  
M. A. Kireeva

The article provides a review and analysis of the defect identification method for determining the size of discontinuities when diagnosing various machine parts and units by the manual ultrasonic method. This method makes it possible to determine the equivalent size of discontinuities of various types without using standard samples of an enterprise: point planar and volumetric; extended planar and volumetric. The method is based on the use of the relationship between the amplitude and time characteristics of the echo signal from the discontinuity and the backside signal in the object being diagnosed and the equivalent size of the discontinuity. The article presents the mathematical apparatus for the implementation of this method. Also presented is a software product that allows you to automate calculations when using this defect identification method. The article contains experimental studies of the method for determining the equivalent dimensions of discontinuities of various types, which have shown its high reliability. The maximum value of the relative error in determining the equivalent size of a point planar discontinuity was 2.867 %. The maximum value of the relative error in determining the equivalent size of a point volumetric discontinuity was 1.986 %. The maximum value of the relative error in determining the transverse equivalent size of an extended planar discontinuity was 0.667 %. The maximum value of the relative error in determining the transverse equivalent size of an extended volumetric discontinuity was 1.95 %.


PEDIATRICS ◽  
1969 ◽  
Vol 44 (6) ◽  
pp. 1014-1016
Author(s):  
Aaron Nisenson

Four cases of extensive seborrheic dermatitis or Leiner's disease are presented which dramatically improved after the nursing mother was given injections of biotin. The relationship between seborrheic dermatitis in infants and biotin deficiency is discussed and the literature reviewed. From this review it appears that breast milk is deficient in biotin in comparison to cow's milk. The deficiency is further aggravated by poor maternal nutrition. Infection and diarrhea in the infant may also contribute to low blood levels of biotin. On the basis of this limited experience, injections of biotin to the nursing mother appear to be a useful treatment for the breast-fed infant with extensive seborrheic dermatitis.


2010 ◽  
pp. 431-442
Author(s):  
T Navrátil ◽  
E Kohlíková ◽  
M Petr ◽  
D Pelclová ◽  
M Heyrovský ◽  
...  

The administration of creatine (5 g/day for one month) to 11 young active sportsmen affected their urinary excretion of creatine, creatinine, and thiodiglycolic acid (TDGA) as well as blood levels of homocysteine, vitamin B12 and folates. The probands were divided into four groups, according to the amount of creatine found in urine, and of folates and vitamin B12 determined in blood. The changes of folates and vitamin B12 were mutually reciprocal. Each group utilized CR as donor of one- and two-carbon (1C and 2C) units by means of homocysteine (HoCySH), folates, and vitamin B12, in different metabolic pathways. In 10 men the creatine administration was accompanied by an increase of HoCySH level in blood, while in the last man, with accidentally discovered hyperhomocysteinemia, the HoCySH level dropped by 50 %. Differences between initial and terminal TDGA levels indicate that creatine affects equilibria of redox processes. Creatinine excretion into urine changed in the dependence on the extent of metabolic disturbances.


1998 ◽  
Vol 1998 ◽  
pp. 80-80
Author(s):  
F. Herrera Gomez ◽  
F. D. Deb Hovell ◽  
C. A. Sandoval Castro

Studies in the use of the purine derivatives technique in ruminants have been stimulated by the possible use of this technique as an estimator of the rumen microbial-N supplied to the host animal. The recovery factor influences the estimation of the total purines absorbed and therefore the microbial-N supply. The relationship between exogenous purine input and urinary excretion and recovery has been studied using cattle maintained with the intragastric infusion technique (Orskov et al., 1979). The urinary recovery of exogenous purines has been estimated to be 0.77-0.85 (Chen et al., 1990a, Verbic et al., 1990), and this relationship has been assumed to be applicable to normal feeding situations. To our knowledge there is no data to support or reject this approach. This study examined the urinary recovery of exogenous allantoin input in steers under normal feeding conditions.


2009 ◽  
Vol 27 (6) ◽  
pp. 689-697 ◽  
Author(s):  
Oliver Fricke ◽  
Christof Land ◽  
Ralf Beccard ◽  
Oliver Semler ◽  
Angelika Stabrey ◽  
...  

1974 ◽  
Vol 46 (6) ◽  
pp. 715-727
Author(s):  
C. W. Crane ◽  
F. A. Jenner ◽  
R. J. Pollitt

1. The time-course of urinary excretion of [15N]urea and [15N]argininosuccinate or [15N]arginine after an oral dose of [15N]ammonium lactate has been followed in patients with argininosuccinic aciduria and cystine-lysinuria respectively. The labelled argininosuccinate and arginine appeared more slowly than expected on simple precursor-product models. 2. In the patient with argininosuccinic aciduria, simultaneous ingestion of [15N]-ammonium lactate and [carbamoyl-14C]citrulline gave very different ratios of labelling with the two isotopes for urinary urea and argininosuccinate. Urinary argininosuccinate had not been in equilibrium with the urea precursor in this patient, but the plasma [14C]citrulline bore a reasonable precursor-product relationship to the urinary [14C]argininosuccinate. 3. Intravenous [guanidino-14C]arginine given to the patient with argininosuccinic aciduria resulted in a much higher degree of labelling of the plasma globulins than the albumin. This is consistent with a considerable turnover of hepatic arginine, as would be expected with a functioning Krebs-Henseleit urea cycle. 4. These results can be explained with a compartmentation model in which most of the urea is synthesized in the liver, but most of the urinary argininosuccinate is peripheral in origin.


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