Serum levels of fibronectin in obese and non-obese women with polycystic ovary syndrome

2016 ◽  
Vol 62 (4) ◽  
pp. 27-31 ◽  
Author(s):  
Mogylnytska A. Liliya
Keyword(s):  
Endothelial Dysfunction ◽  
Serum Level ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Serum Levels ◽  
Control Group ◽  
Obese Women ◽  
Ovary Syndrome ◽  
Insulin Resistence ◽  
Relationship Of

Aim — to investigate serum level of fibronectin in obese and non-obese women with polycystic ovary syndrome (PCOS) as a marker of endothelial dysfunction, and the relationship of that factor to the endothelium-dependent dilatation and other risk factors for cardiovascular disease.Material and methods. We study 62 women: 45 — with PCOS (23 obese women, 22 — non-obese) and 20 — a control group. Serum level of fibronectin was determined by ELISA. Endothelium-dependent dilatation was measured by test of Celermajer. Data was presented as mean ± SD.Results. We found an elevation of serum level of fibronectin in obese women with PCOS compared to control (258,12±48,47 and 196,34±46,68 pmol/ml respectively; р<0,05), in non-obese women compared to control (227,62±35,36 and 196,34±46,68 pmol/ml respectively, р<0,05). Serum level of fibronectin in obese was higher than non-obese women (258,12±48,47 и 227,62±35,36 pmol/ml respectively, р<0,05). Also, there are a correlation between the serum levels of fibronectin and BMI, HOMA index, lipid metabolism, androgens in PCOS women obese and non-obese (p<0,05).Conclusion. Serum level of fibronectin is elevated in obese and non-obese women with PCOS. Hyperandrogenemia, dyslipidemia, insulin resistence, obesity appears to be significant factor to contributing elevation of fibronectin. The revealed change of fibronectin could reflect an endothelial dysfunction in PCOS.

scholarly journals The level of adhesion molecules in polycystic ovary syndrome

2021 ◽  
Vol 2 ◽  
pp. 57-63
Author(s):  
L.A. Mogylnytska
Keyword(s):  
Endothelial Dysfunction ◽  
Serum Level ◽  
Polycystic Ovary Syndrome ◽  
Adhesion Molecules ◽  
Polycystic Ovary ◽  
Control Group ◽  
Obese Women ◽  
Obese People ◽  
Ovary Syndrome ◽  
The Relationship

Polycystic ovary syndrome (PCOS) is characterized by dysfunction of the ovaries, hyperandrogenism and combination of metabolic disorders that increase the risk of developing cardiovascular diseases.The objective: of the investigation was to study the serum level of adhesion molecules (ICAM-1, VCAM-1 and E-selectin) in women with PCOS with different body weights as a marker of endothelial dysfunction, and their relationship with other factors of cardiovascular pathology.Materials and methods. 45 women with PCOS were examined, among whom a group of obese people – 23 women (age: 22,82±3,03 years, BMI 35,67±4,6) and a non-obese – 22 women (age: 22,81±2,03 years, BMI 22,35±2,16). The control group included 20 women aged 20,15±2,15 years, BMI 21,32±2,19. The serum level of ICAM-1, VCAM-1 and E-selectin was determined by the enzyme immunoassay. The significance of the differences of mean values was determined by the Student’s t-test. Correlation and multivariate regression analysis was used to assess the relationship between the studied factors,.Results. We revealed a significant increase of the serum level of adhesion molecules in obese and non-obese women with PCOS in comparison with women in the control group: ICAM-1 – +54,18%, +36,72%, respectively (p<0,0001), VCAM-1 – +50,76%, +36,33% respectively (p<0,0001), E-selectin – +40,24%, +29,56% respectively (p<0,0001). The concentration of these factors was higher in obese women with PCOS compared to non-obese women with PCOS: ICAM-I – +12,76% (p=0,04), VCAM-1 – +10,58% (p=0,009), E-selectin – +8,24% (p=0,03); p<0,05. The relationship was established between insulin content, HOMA and Caro index, lipid metabolism, hyperandrogenemia and an increase of serum level of adhesion molecules (p<0,01).Conclusions. As a result of our study, an increase of serum level of adhesion molecules in PCOS was revealed, both in combination with obesity and normal body weight, which may be a manifestation of endothelial dysfunction in this pathological condition. An increase in the content of ICAM-1, VCAM-1, E-selectin may be associated with insulin resistance, dyslipidemia and hyperandrogenism.

scholarly journals Assessing the variability and predictability of adipokines (adiponectin, leptin, resistin and their ratios) in non-obese and obese women with anovulatory polycystic ovary syndrome

2019 ◽  
Author(s):  
Christian Obirikorang ◽  
William K.B.A. Owiredu ◽  
Sandra Adu-Afram ◽  
Emmanuel Acheampong ◽  
Evans Adu Asamoah ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Discriminatory Power ◽  
Control Group ◽  
Obese Women ◽  
Ovary Syndrome ◽  
And Control

Abstract Objectives: To assess variability and predictability of adiponectin, leptin, resistin and their ratios in non-obese and obese women with anovulatory polycystic ovary syndrome (aPCOS). Results: A total of 52 ovulatory controls (mean age=31.63±4.88 years, BMI=25.33±2.68 kg/m3); 54 non-obese [mean age=32.11±4.25 years, BMI=25.72±2.95 kg/m3] and 50 obese women with aPCOS [mean age= 33.64±4.14 years, BMI=39.19±2.99 kg/m3] were recruited. The aPCOS group had lower adiponectin [13.0(10.49-16.59) vs 18.42(15.72-19.92) µg/ml, p<0.0001], adiponectin: leptin ratio (A:L) [0.60(0.35-0.88) vs 1.19(0.92-1.37), p<0.0001], and adiponectin: resistin ratio (A:R) [0.30(0.21-0.43) vs 0.42(0.32-0.62), p<0.0001] but a higher leptin [20.02(14.54-26.80) vs 16.17(14.51-18.36) ng/ml, p<0.0001] and leptin: resistin ratio (L:R) [0.53(0.37-0.82) vs 0.40(0.27-0.48), p<0.0001] compared to the controls. The obese aPCOS group had lower adiponectin [11.04(5.66-13.25) vs 14.18(11.04-18.02), p<0.0001 and 18.42(15.72-19.92) µg/ml, p<0.0001], A:L [0.36(0.27-0.44) vs 0.78(0.61-1.16), p<0.0001 and 1.19(0.92-1.37), p<0.0001], and A:R [0.24(0.17-0.38) vs 0.40(0.23-0.58), p<0.0001 and 0.42(0.32-0.62), p<0.0001] but a higher leptin [26.80(14.28-32.09) vs 17.95(14.86-21.26), p<0.05 and 16.17(14.51-18.36) ng/ml, p<0.0001] and L:R [0.63(0.46-1.03) vs 0.41(0.30-0.61), p<0.0001 and 0.40(0.27-0.48), p<0.0001] compared to the non-obese aPCOS and control group, respectively. A:L showed the best discriminatory power in predicting aPCOS (AUC=0.83), followed by adiponectin alone (AUC=0.79), L:R and leptin alone (both AUC=0.69). Resistin alone had the poorest discriminatory power (AUC=0.48).

scholarly journals Polymorphic Variations in VDR Gene in Saudi Women with and Without Polycystic Ovary Syndrome (PCOS) and Significant Influence of Seven Polymorphic Sites on Anthropometric And Hormonal Parameters

2018 ◽  
Vol 37 (4) ◽  
pp. 415-425 ◽  
Author(s):  
Arwa Al Thomali ◽  
Maha H. Daghestani ◽  
Mazin H. Daghestani ◽  
Namik Kaya ◽  
Arjumand Warsy
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Serum Levels ◽  
Control Group ◽  
Ovary Syndrome ◽  
Vdr Gene ◽  
Saudi Women ◽  
Normal Controls ◽  
Genetic Analyzer

SummaryBackground:This study was designed to evaluate the associations between vitamin D receptor (VDR) gene polymorphisms and biochemical characteristics of Saudi women with polycystic ovary syndrome (PCOS).Methods:Serum levels of LH, FSH, and Vitamin D were measured in 33 women: 16 patients and 17 normal controls (18 to 36 years). DNA was extracted and used for sequencing of the exons ofVDRgene using ABI PRISM 3730xi Genetic Analyzer.Results:Weight, BMI, Vit D, LH and FSH levels were higher in the PCOS patients compared to control group, where Vit D level correlated positively and significantly with FSH, in the control, but showed a negative and non-significant correlation in the PCOS patients. Sequencing results showed extensive polymorphisms in both groups, but the differences in the frequencies were not significant. Demographic and hormonal parameters were compared in the different genotypes of the SNPs. Significant differences were ob served in the values of the studied parameters in rs11168276, rs11168266, rs3858733, rs121909790, rs11168265 and rs731236. Vitamin D level was influenced significantly by the genotypes of rs11168265 (AA) (p=0.008), rs11168276 (AA; p=0.018) and rs731236 (CC; p=0.024).Conclusion:Vitamin D deficiency does not associate with PCOS in Saudi females. Several SNPs are identified in the VDR gene, in normal and PCOS females, but there is no difference in their frequencies between the two groups. The results show that polymorphism in VDR gene influences certain anthropometric and hormonal parameters in PCOS patients. Further detailed studies are required to confirm the associations between VDR and PCOS.

scholarly journals Serum levels of 3alpha-androstanediol glucuronide in hirsute and non hirsute women

1998 ◽  
pp. 421-424 ◽  
Author(s):  
L Falsetti ◽  
B Rosina ◽  
D De Fusco
Keyword(s):  
Body Mass Index ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Plasma Concentrations ◽  
Serum Levels ◽  
The Body ◽  
Control Group ◽  
Ovary Syndrome ◽  
Idiopathic Hirsutism ◽  
Androstanediol Glucuronide

This study has evaluated the behaviour of 3alpha-androstanediol glucuronide (3alpha-diol G) in 170 women of whom 85 had polycystic ovary syndrome (PCOS), 35 had idiopathic hirsutism (IH) and 50 had regular cycles (control group). Of the women with PCOS, 45 were hirsute (PCOS-H) and 40 were non hirsute (PCOS-NH). Women in the control group were not hirsute. Hirsutism was assessed by the same physician using the Ferriman-Gallway score. The body mass index (BMI) was estimated in all of the women. Plasma concentrations of 3alpha-diol G were elevated only in hirsute patients, both with PCOS and with IH. Even in PCOS-NH, concentrations of 3alpha-diol G were higher compared with controls (P < 0.001), but significantly lower (P < 0.001) than those of the PCOS-H and of the IH groups. The behaviour of 3alpha-diol G was not affected by BMI.

scholarly journals Visfatin and Resistin Serum Levels in Normal-Weight and Obese Women With Polycystic Ovary Syndrome

2014 ◽  
Vol 12 (3) ◽  
Author(s):  
Fatemeh Farshchian ◽  
Fahimeh Ramezani Tehrani ◽  
Houshang Amirrasouli ◽  
Hooman Rahimi Pour ◽  
Mehdi Hedayati ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Serum Levels ◽  
Normal Weight ◽  
Obese Women ◽  
Ovary Syndrome

scholarly journals Effects of metformin and ethinyl estradiol–cyproterone acetate on lipid levels in obese and non-obese women with polycystic ovary syndrome

2005 ◽  
Vol 152 (2) ◽  
pp. 269-275 ◽  
Author(s):  
K Rautio ◽  
J S Tapanainen ◽  
A Ruokonen ◽  
L C Morin-Papunen
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Ethinyl Estradiol ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Lipoprotein Cholesterol ◽  
Metformin Treatment ◽  
Obese Women ◽  
Ovary Syndrome ◽  
Cholesterol Ratio

Objective: Women with polycystic ovary syndrome (PCOS) exhibit risk factors for cardiovascular diseases such as abdominal obesity, insulin resistance and dyslipidemia. Insulin sensitizers, especially metformin, have been shown to improve these metabolic disturbances, but there are only a few studies on their effects on serum lipids in polycystic ovary syndrome. Methods: Thirty-five women with PCOS (18 obese and 17 non-obese) were randomized to 6-month treatments with metformin or ethinyl estradiol–cyproterone acetate oral contraceptive pills. Results: In the whole-study population (non-obese and obese women) serum levels of high-density lipoprotein cholesterol increased from 1.4±0.2 to 1.6±0.1 mmol/l (means ±s.e. throughout) at 3 and 6 months (P < 0.001), the total cholesterol:high-density lipoprotein cholesterol ratio decreased significantly from 3.8±0.3 to 3.3±0.2 at 6 months (P < 0.001) and a similar trend was observed in serum triglyceride levels during metformin treatment. In the oral contraceptive group, serum levels of total cholesterol increased from 4.9±0.3 to 5.4±0.3 mmol/l (P < 0.05), high-density lipoprotein cholesterol increased from 1.2±0.1 to 1.5±0.1 mmol/l (P < 0.001), the total cholesterol:high-density lipoprotein cholesterol ratio decreased from 4.6±0.4 to 3.7±0.2 (P < 0.001) and triglycerides increased from 1.3±0.1 to 1.9±0.2 mmol/l at 6 months of treatment (P < 0.001). Serum low-density lipoprotein cholesterol levels remained unchanged during both treatments. Milder but similar changes in the subgroups of obese and non-obese women were observed during both treatments. Moreover, in the whole-study population both systolic (P = 0.02) and diastolic (P = 0.05) blood pressures decreased over the 6 months of metformin treatment. Conclusion: In women with PCOS, metformin treatment had beneficial effects on lipid profile and blood pressure, and therefore it could be useful in the prevention of cardiovascular complications in these women.

scholarly journals Association between Interleukin-32 and Interleukin-17A Single Nucleotide Polymorphisms and Serum Levels with Polycystic Ovary Syndrome

2019 ◽  
Author(s):  
Fatemeh Hesampour ◽  
Bahia Namavar Jahromi ◽  
Foroozan Tahmasebi ◽  
Behrouz Gharesi-Fard
Keyword(s):  
Serum Level ◽  
Single Nucleotide Polymorphisms ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Serum Levels ◽  
Nucleotide Polymorphisms ◽  
Iranian Women ◽  
Ovary Syndrome ◽  
Single Nucleotide ◽  
Interleukin 17A

Polycystic ovary syndrome (PCOS) is correlated with low-grade chronic inflammation. Interleukin-17A (IL-17A) and Interleukin-32 (IL-32) are two members of the pro-inflammatory cytokines which act as significant components of the immune system during certain inflammatory diseases. Along with immunological processes, genetic factors play major roles in predisposition to PCOS. There are myriad single nucleotide polymorphisms (SNPs) within IL-17A and IL-32 genes that may affect their production and the susceptibility of individuals to PCOS. The objective of the present research was to investigate the association between IL-17A (rs2275913) and IL-32 (rs9927163, rs4786370) SNPs, and also their serum levels with susceptibility to PCOS in a group of Iranian women. In this case-control study, 150 PCOS patients (mean age of 29.1 years) and 150 healthy women (mean age of 26.1 years) were analyzed in terms of IL-17A and IL-32 SNPs via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Furthermore, serum levels of IL-17A and IL-32 cytokines were measured through the use of ELISA method. There were significant differences between PCOS and healthy women regarding IL-17A rs2275913 alleles, genotypes frequencies (p=0.005, and 0.01, respectively) and the allelic distribution of IL-32 rs9927163 SNP (p=0.03). Additionally, significant differences were indicated between two groups concerning the AG genotype against AA+GG genotypes (p=0.009) and the GG genotype against AA+AG genotypes (p=0.006) in IL-17A rs2275913 SNP. In the matter of IL-32 gene SNPs, GC haplotype frequency was significantly different between patients and controls (p=0.05). Furthermore, IL-32 serum level was not significantly different between the two studied groups and the serum level of IL-17A was not detectable. In conclusion, IL-17A and IL-32 SNPs might be associated with predisposition to PCOS in Iranian women.

scholarly journals Levels of Trace Elements in Erythrocytes as Endocrine Disruptors in Obese and Nonobese Women with Polycystic Ovary Syndrome

2022 ◽  
Vol 19 (2) ◽  
pp. 976
Author(s):  
Kamila Pokorska-Niewiada ◽  
Agnieszka Brodowska ◽  
Jacek Brodowski ◽  
Małgorzata Szczuko
Keyword(s):  
Trace Elements ◽  
Polycystic Ovary Syndrome ◽  
Inductively Coupled Plasma ◽  
Polycystic Ovary ◽  
Atomic Emission ◽  
Thyroid Stimulating Hormone ◽  
Control Group ◽  
Obese Women ◽  
Ovary Syndrome ◽  
Inductively Coupled

Introduction: Polycystic ovary syndrome (PCOS) is one of the most commonly recognized endocrinopathies in women. The literature lacks clear data that allow any meaningful conclusions to be drawn about the influence of trace elements in erythrocytes on the biochemical parameters of PCOS. Materials and methods: This study was conducted among 47 women meeting the Rotterdam criteria for the diagnosis of polycystic ovary syndrome. The research groups included women with PCOS with different BMI values (body mass index): obese women with PCOS (PCOS with BMI ≥ 30, mean BMI index 35.4 ± 4.4 kg/m2), nonobese PCOS women (PCOS with BMI < 30, mean BMI index 25.2 ± 2.8 kg/m2), and healthy control group (CG) with a mean BMI of 23.57 ± 0.9 kg/m2. The contents of trace elements in erythrocytes were determined with an inductively coupled plasma atomic emission spectrometer. Results: The only trace element showing significant differences in concentration between the studied groups was nickel (Ni). The level of nickel in the obese women with PCOS (BMI ≥ 30) was significantly higher than in nonobese women (BMI < 30). The content of other trace elements in erythrocytes did not differ significantly between the studied groups. Several significant correlations were found within each of the studied PCOS groups: in the group of obese women, the content of zinc (Zn) in erythrocytes positively correlated with prolactin, the content of magnesium (Mg) positively correlated with testosterone, and the content of manganese (Mn) negatively correlated with thyroid-stimulating hormone. In the group of nonobese women, Zn content correlated positively with testosterone, Ni with luteinizing hormone (LH) and estradiol, and Mg negatively correlated with estradiol. Conclusions: The relationship between the level of trace elements and the level of hormones suggests that, in obese women with PCOS, nickel may play a role in inhibiting the processes of folliculogenesis and ovulation. Research on trace elements and their relationship to ovulatory cycles and the development of PCOS may contribute to reducing the consequences of PCOS and, therefore, should be extended.

No relationship between osteoprotegerin concentrations and endothelial dysfunction in non-obese women with and without polycystic ovary syndrome

2014 ◽  
Vol 291 (5) ◽  
pp. 1075-1080 ◽  
Author(s):  
Remzi Abali ◽  
Nicel Tasdemir ◽  
Seref Alpsoy ◽  
Ufuk Göker Tasdemir ◽  
Savas Guzel ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Obese Women ◽  
Ovary Syndrome
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