scholarly journals Insomnia in patients with migraine

2019 ◽  
Vol 11 (2) ◽  
pp. 22-29
Author(s):  
E. M. Evdokimova ◽  
G. R. Tabeeva
Keyword(s):  
Sleep Disorders ◽  
Biological Rhythms ◽  
Underlying Disease ◽  
Early Morning ◽  
Study Participation ◽  
Sleep Diaries ◽  
Prospective Comparative Study ◽  
Group 2 ◽  
Chronic Course ◽  
Group 1

Objective: to evaluate the significance of insomnia and chronobiological patterns in the development of headache (HA) attacks for the formation of clinical features of migraine and for the elaboration of strategies for its prevention.Patients and methods. A prospective comparative study was conducted in 60 patients aged 18–65 years who were diagnosed as having migraine (with or without aura) with comorbid sleep disorder. Group 1 consisted of 30 patients with migraine and insomnia; Group 2 comprised 30 patients with migraine without insomnia. The study participation included four visits to a physician for 12 months.Results and discussion. Persistent sleep disorders in patients with migraine were shown to worsen the course of the underlying disease: HA attacks had a greater intensity, mainly left-sided localization and a longer duration. Group 1 patients were observed to have a chronic course of the disease with a frequency of ≥8 attacks per month in 33% of cases. Analysis of biological rhythms revealed that individuals with evening and mildly evening chronotypes were characterized by the greatest changes in the sleep-wake cycle, by sleep deprivation and its reduced efficiency. Analysis of the data of HA and sleep diaries kept by the patients for 12 months showed that Group 1 had four peaks of the daily distribution of HA attacks; 13.4% of attacks occurred during sleep and early morning.Conclusion. The coexistence of sleep disorders and HA is not only manifested as the overlapping of clinical manifestation, but also largely determines their natural course and prognosis, i.e. their progression into a chronic form. Therefore, it is imperative to identify sleep disorders in migraines, since their correction is effective and, in most cases, allows chronic HA to progress to an episodic form.

scholarly journals Reduction of the Risk of Relapse of Symptoms When Using Esophagoprotector in Patients Requiring Temporary Cancellation of Antisecretory Therapy

2021 ◽  
Vol 17 (16) ◽  
pp. 26-30
Author(s):  
Yu.A. Kucheryavy ◽  
◽  
P.R. Movtaeva ◽  
D.N. Andreev ◽  
R.I. Shaburov ◽  
...  
Keyword(s):  
Comparative Study ◽  
Underlying Disease ◽  
On Demand ◽  
Long Time ◽  
Prospective Comparative Study ◽  
Group 2 ◽  
Significant Regression ◽  
Risk Of Relapse ◽  
Group 1

Objective: to evaluate the effectiveness of an esophagoprotector in reducing the risk of recurrent symptoms of gastroesophageal reflux disease (GERD) in patients who requiring temporary cancellation of therapy with proton pump inhibitors (PPIs). Material and methods. For the prospective comparative study there were selectively chose patients who had been taking PPIs for a long time (at least one month) for the underlying disease and who required temporary discontinuation of antisecretory therapy due to objective medical reasons. The study included patients with endoscopically and/or pH-metrically verified GERD, as well as histologically verified Barrett's esophagus. In the process of randomization of patients, two equal groups were formed, depending on the therapy received at the time of PPI withdrawal: group 1 received antacids on demand, group 2 received antacids on demand, as well as the esophagoprotector Alfasoxx at a dose of 10 ml four times a day (after each meal and at night). The follow-up period was two weeks. The patients recorded episodes of heartburn in their personal diaries. Results. The study included 60 patients (28 men and 32 women). The average age of the examined patients was 43.1 ± 5.3 years. By the end of the two-week follow-up period, the frequency of recurrent symptoms in group 1 was 36.7%, while in group 2 it was 13.3%. The use of the esophagoprotector Alfasoxx contributed to the significant regression of the risk of heartburn recurrence (odds ratio 0.2657; 95% confidence interval (CI) 0.07328-0.9637; p = 0.0438) in comparison with the group of patients who received only antacids in the on-demand mode. When analyzing the population of patients who had relapsed symptoms, it was demonstrated that the average number of heartburn episodes in group 1 was 6.18 (95% CI 4,1930-8,1706), and in group 2 – 4.50 (95% CI 0,7121-8,2879). Conclusion. This prospective comparative study demonstrated that the use of the esophagoprotector Alfasoxx helps to reduce the risk of relapse of GERD symptoms in patients requiring temporary cancellation of PPI therapy.

A COMPARATIVE STUDY TO EVALUATE THE OUTCOME OF PONSETI'S TECHNIQUE AND ACCELERATED PONSETI'S TECHNIQUE FOR CORRECTION OF CLUBFOOT

2021 ◽  
pp. 59-61
Author(s):  
Ashok Vidhyarthi ◽  
H.S. Varma ◽  
Rajeev Singh ◽  
Rajendra Thakur ◽  
Darwin Kumar Thakur
Keyword(s):  
Comparative Study ◽  
Ponseti Method ◽  
Congenital Deformity ◽  
Duration Of Treatment ◽  
Protocol Group ◽  
Pirani Score ◽  
Prospective Comparative Study ◽  
Group 2 ◽  
Accelerated Ponseti ◽  
Group 1

Introduction: Clubfoot is a common congenital deformity with incidence of1-6.8/1000 live births. Ponseti method is currently the gold standard for treatment of clubfoot which conventionally involves weekly plaster changes. A prospective comparative study was carried out at our hospital where we compared one group with weekly plaster change to other group with twice weekly plaster change, using the classical Ponseti protocol of manipulation. A total 50 feet (36 children ), divided into two Methods: groups, were randomly allocated to either Group 1 – 25 feet(accelerated Ponseti) or Group 2 – 25 feet (standard Ponseti). Group 2 underwent serial manipulations and casting once a week and Group 1 received manipulations and castings twice a week. Pirani score was documented at the time of presentation, after each cast, and at the time of removalof nal cast to assess the success of treatment ( Pirani score ≤1). A tota Results: l 43 feet (29 patients) underwent the entire course of treatment, while 7 patients discontinued the treatment during the course of the study. 14 patients, i.e, 21 feet were treated with Accelerated Ponseti Protocol (APP),i.e Group -1, and 15 patients, i.e, 22 feet were treated with Standard Ponseti Protocol (SPP), i.e Group-2. Mean duration of treatment from the rst cast to tenotomy in the accelerated ponseti protocol group was 20.57 ± 4.5 days (ranging from 12 to 29 days), and in standard ponseti protocol group was 39.66 ± 6.9 days (ranging from 29 to 51 days). Conclusion: Both the methods proved to be equally efcacious for the management of clubfoot in our study. However, the accelerated method had an overall shorter treatment duration making it convenient for the parents. As the patient is under direct observation of surgeons, complications, in any, are detected early and easily. Overall, the accelerated technique is more practical, benecial, and equally efcacious as standard ponseti technique, providing a more rapid correction of the deformity.

scholarly journals Loose knots and surgical site infections in abdominal surgeries (clean-contaminated and contaminated wounds)

2021 ◽  
Vol 8 (7) ◽  
pp. 2050
Author(s):  
Napa Madhusudhan ◽  
R. Prabhakar
Keyword(s):  
Wound Closure ◽  
Surgical Site Infections ◽  
Considerable Proportion ◽  
Intravenous Antibiotics ◽  
Vertical Mattress ◽  
Prospective Comparative Study ◽  
Group 2 ◽  
Clean Contaminated ◽  
Secondary Wound Closure ◽  
Group 1

Background: Surgical site infections (SSIs) are associated with high healthcare costs and worsen the post-operative course of a considerable proportion of general abdominal surgical patients. SSIs raise the risk of post-operative morbidity and mortality, necessitating hospitalization, intravenous antibiotics, and potentially surgical reintervention. The aim of the study was to compare the outcome of intermittent loose knots and the conventional vertical mattress suturing in patients undergoing abdominal surgeries.Methods: This prospective comparative study was done in patients undergoing emergency abdominal surgeries for any cause. Patients were divided into 2 groups- (a) group 1 (45 patients): intermittent loose knots between conventional vertical mattress sutures; (b) group 2 (45 patients): conventional vertical mattress suturing.Results: In this study, 31% of patients were in the 41-50 years age group, 53.3% of patients were male. Among various abdominal surgery opted, laparotomy was the most commonly performed procedure (47%). In this study, group 1 patients shown a decrease in wound gap, secondary wound closure and delayed wound approximation than group 2 patients.Conclusions: Loose knots in between conventional vertical mattress sutures are better than conventional vertical mattress suturing in terms of wound gap, secondary wound closure and delayed wound approximation.

Clinical and polysomnographic characteristics in patients with morning headache

2018 ◽  
pp. 42-48
Author(s):  
Thalyta Porto Fraga ◽  
Paulo Samandar Jalali ◽  
Paulo Sergio Faro Santos ◽  
Alan Chester Feitosa de Jesus
Keyword(s):  
Sleep Disorders ◽  
Clinical Characteristics ◽  
Statistical Significance ◽  
Sleep Onset ◽  
Normal Range ◽  
Morning Headache ◽  
Upper Respiratory ◽  
Group 2 ◽  
Restorative Sleep ◽  
Group 1

Background: The relation between headaches and sleep disorders are complex and heavily questioned. However, there is still controversy about this interrelationship. Objective: To describe the clinical and polysomnographic characteristics of patients with morning headache, and to compare them with patients without morning headaches. Methods: Prospective study between April and August 2009. One hundred and eight patients were included consecutively and by convenience. All patients were submitted to polysomnography and were distributed in the group with headache (group 1) or the group without headache (group 2). Results: Morning headache was reported by 33 (30.6%) patients, 17 (51.5%, p = 0.02) women. The clinical characteristics in the group of morning headache were 42.4% with disease in upper respiratory system, 72.7% with anxiety, 45% with headache in general, 54% with neurocognitive symptoms, 81.2% reported non restorative sleep and 60.6% had insomnia (all p< 0.05). Among the polysomnographic features surveyed, the only variable that showed statistical significance was wake after sleep onset. Almost 43% (vs. 20%) of patients with morning headaches were in normal range. Conclusions: It was not possible to conclude that the presence of the increase apnea/hypopnea indices, desaturation relevant and intermittent and disruption of sleep patterns are sufficient to modulate, by itself, the occurrence of morning headaches. Sleep disorders can act as a trigger for morning headaches in susceptible individuals with specific clinical profile

scholarly journals To Compare the Outcome of Estrogen and Betamethasone Cream in the Treatment of Labial Adhesion in Pre-pubertal Girls

2020 ◽  
Vol 43 (3) ◽  
pp. 161-164
Author(s):  
Gajendra Nath Mahato ◽  
Paritosh Kumar Palit ◽  
Md Hasanuzzaman
Keyword(s):  
Child Health ◽  
Adverse Effects ◽  
Vaginal Opening ◽  
Prospective Comparative Study ◽  
Previously Treated ◽  
The Difference ◽  
Group 2 ◽  
Labial Adhesion ◽  
Prepubertal Girls ◽  
Group 1

Background: Labial adhesion is a condition of prepubertal girls where the labia are fused over the vaginal opening and/or urethra. Objective: The purpose of the study was to compare the outcome of estrogen and betamethasone cream in the treatment of labial adhesion. Materials and methods: This prospective comparative study was conducted among 100 pre-pubertal girls with labial adhesion where at least 50% vaginal opening was fused. Patients previously treated with estrogen or betamethasone for labial adhesion was excluded from the study. Fifty patients were treated with betamethasone cream (group 1) and fifty patients with estrogen cream (group 2) after randomization. All patients were followed at 3rd week, 6th week, 3rd month, 6th month and then release of adhesion and adverse effects were noted. Results: Within 3 weeks no adhesion was found in 84.0% participants in group 1 and 64.0% participants in group 2, which showed significant statistical differences (p=0.023). Within 6 months recurrence of adhesion was found in 2.2% participants in group 1 and 23.4% in group 2, which also showed highly significant statistical differences (p=0.004). Success rate was 90.0% and 72.0% within 6 months in group 1 and in group 2 respectively and the difference was statistically significant (p=0.022). Conclusion: Betamethasone cream appears to be a superior agent in terms of effectiveness, safety and cost than estrogen cream in the treatment of labial adhesion in pre-pubertal girls. Bangladesh J Child Health 2019; VOL 43 (3) :161-164

Invasive aspergillosis in adult patients with rheumatic diseases

2020 ◽  
Vol 14 (4) ◽  
pp. 16-22
Author(s):  
V. I. Mazurov ◽  
A. M. Lila ◽  
O. V. Shadrivova ◽  
M. S. Tonkoshkur ◽  
M. S. Shostak ◽  
...  
Keyword(s):  
Risk Factors ◽  
Respiratory Failure ◽  
Invasive Aspergillosis ◽  
Rheumatic Diseases ◽  
Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Underlying Disease ◽  
Control Group ◽  
Group 2 ◽  
Group 1

Objective: to study risk factors for invasive aspergillosis (IA), its etiology, clinical manifestations, and treatment efficiency in patients with rheumatic diseases (RD).Patients and methods. The first study of proven and probable IA (EORT/MSGERC, 2019) was conducted in 18 patients with RD, who accounted for 3% of all adult IA patients (n=699) included in the 1998–2020 registry of the Department of Clinical Mycology, Allergology, and Immunology, I.I. Mechnikov North-Western State Medical University (Group 1). This group comprised 56% women; the median age was 59 [21; 75] years. Group 2 (a comparison group) included 610 adult hematology patients with IA (median age, 45 [18; 79] years; 42% women). A prospective case-control study was conducted to identify risk factors for IA in patients with RD: 36 rheumatic patients without IA (median age, 58 (18–79) years; 61% women) (a control group).Results and discussion. Patients with RD were found to often develop IA in the presence of anti-neutrophilic cytoplasmic antibody-associated vasculitis (granulomatosis with polyangiitis and microscopic polyangiitis) and systemic lupus erythematosus (50 and 16%, respectively). It was shown for the first time that the likelihood of IA in patients with RD increases with prolonged (median 14 days) lymphocytopenia during RD treatment (odds ratio 13.0; 95% confidence interval, 3.3–50.3). The main causative agents of IA were A. fumigatus (50%) and A. niger (29%). IA was more severe in Group 1 than in Group 2: in the resuscitation and intensive care units, there were 44 and 18%, respectively (p=0.01). Group 1 versus Group 2 more frequently had respiratory failure (61 and 37%, respectively; p=0.03), hemoptysis (28 and 7%; p=0.0001), chest pain (17 and 7%; p=0.04), and cardiac involvement (11 and 1%; p=0.0001), and less frequently had fever (67 and 85%; p=0.01). The common site of IA was the lung (83%); the characteristic feature detected by computed tomography (CT) is pulmonary cavitation (44%). Antifungal therapy was used in 89% of Group 1 patients; the overall 12-week survival was 69%.Conclusion. In patients with RD, it is difficult to differentiate between the progression of the underlying disease, adverse drug reactions, infectious complications, or a combination of these disorders due to the similarity of their clinical manifestations. When RD patients with infectious syndrome and respiratory failure develop prolonged lymphocytopenia during combination therapy, AI should be suspected and lung CT, bronchoscopy, and mycological examination of the material obtained by bronchoalveolar lavage be done.

scholarly journals INTESTINAL ANASTOMOSIS

2010 ◽  
Vol 17 (02) ◽  
pp. 232-234
Author(s):  
RANA ASRAR AHMAD KHAN ◽  
Mohammad Dilawaiz ◽  
FAKHAR HAMEED ◽  
Ch. Mohammad Akram ◽  
BASHIR AHMED
Keyword(s):  
Cost Effectiveness ◽  
Double Layer ◽  
Intestinal Anastomosis ◽  
Single Layer ◽  
Cost Effective ◽  
Continuous Layer ◽  
Prospective Comparative Study ◽  
The Difference ◽  
Group 2 ◽  
Group 1

Objective: To evaluate the safety and cost effectiveness of single layer interrupted intestinal anastomosis in comparison with the double layer conventional method of intestinal anastomosis. Study Design : Prospective comparative study. Period & Setting: Surgical unit 4 DHQ hospital Faisalabad operated by single team during 12 months starting from Feb. 2007 to Jan. 2008. Materials and Methods: The cases were assigned to the two techniques, each being applied on alternate patient, single layer extra mucosal interrupted anastomosis anddouble layer anastomosis. In group 1 we used black silk 3/0 and in double layer we used vicryl 3/0 for inner continuous layer and black silk 3/0 for outer continuous layer. Comparison between two techniques was done on the bases of procedure time, cost effectiveness, morbidity in terms of rate of leakage/. Results: Average time for the construction of the single layer anastomosis was 20 minutes and in double layer was 35 minutes, the difference in average time is statistically significant (p<.001) while average duration of stay was 168 hrs and 216 hrs in group 1 and 2 respectively (p<.001). Leakage rate was double (12%) in group 2 while 6% in group 1. Moreover structure material consumption was more in two layered technique and longer stay added to that lead to more hospital expenses on two layered technique. Conclusion: Anastomosis usinga single layer interrupted extra mucosal technique was faster to perform, cost effective, less likely to leak and as strong as a 2-layer anastomosis.

scholarly journals Urolithiasis is associated with low serum testosterone levels in men

2015 ◽  
Vol 87 (1) ◽  
pp. 83 ◽  
Author(s):  
Alper Otunctemur ◽  
Emin Ozbek ◽  
Suleyman Sami Cakir ◽  
Murat Dursun ◽  
Emre Can Polat ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Stone Formation ◽  
Serum Testosterone ◽  
Early Morning ◽  
Stone Disease ◽  
Chi Square ◽  
Testosterone Levels ◽  
History Of ◽  
Group 2 ◽  
Group 1

Objective: To evaluate the relationship among urolithiasis, metabolic syndrome (MetS) and serum testosterone (T) level in men. Material and Methods: 513 men older than 18 years were enrolled in this study: 313 of the subjects had a history of stones (group 1) and 200 had no history of stones (controls, group 2). Early morning T levels were recorded and anthropometric measurements were invastigated to evaluate MetS. Analyses were completed using chi-square tests. Result: Serum T level was lower in stone forming patients than coltrol subjects and 161 (%51.4) men in group 1 and 92 (%46) men in group 2 were diagnosed with metabolic syndrome. T level was found lower limit (&lt; 285 ng/dl) in the MetS and urolithiasis group (p 0.002, OR 2.71). Conclusions: We found low testosterone levels in the patients with stone disease and prevalance of the MetS in men with urolithiasis was higher than in men without stone disease. Our findings show that levels of testosterone had no effect on stone formation, but the factors that cause stone formation can have an effect on the level of testosterone.

scholarly journals Does the power of the laser devices matter for a successful HoLEP procedure? A prospective comparative study

2021 ◽  
Author(s):  
Zafer Tokatli ◽  
Mehmet Ferhat ◽  
Muhammed Ibis ◽  
Gulcin Turkmen Sariyildiz ◽  
Atilla Elhan ◽  
...  
Keyword(s):  
Comparative Study ◽  
High Power ◽  
Antithrombotic Therapy ◽  
Functional Results ◽  
Holmium Laser ◽  
Prospective Comparative Study ◽  
Group 2 ◽  
Laser Devices ◽  
Group 1 ◽  
Comparative Manner

Background: To evaluate the efficiency and safety of medium power (MP) holmium laser devices in the enucleation of the enlarged prostate (HoLEP) adenomas compared to high power (HP) laser devices. Methods: Based on the device power used, a total of 120 patients were divided randomly into two groups. While patients in Group 1 were treated with a MP device (50 W) at 39.6-W (2.2J / 18Hz ), patients in Group 2 were treated with HP (100W) device at 42W (1.2J / 35Hz). Peri- and postoperative parameters were well evaluated in both groups with an emphasis on enucleation efficiency and hemoglobin decrease in a comparative manner. Results: Peri- and postoperative parameters as well as functional results were similar in the two groups. The median enucleation efficiency (EE) values in Group 1 and Group 2 were 1.15 (IQR: 0.33-2.2) and 1.11 (IQR: 0.4-2.8), respectively (p=0.775). Hemoglobin decrease values in Group 1 and Group 2 were 1.3 (IQR: 0.1-4) and 1.4 (IQR: 0.4-3.1), respectively (p=0.736). Significant improve in the postoperative functional parameters were noted again in both groups. Conclusion: Our results indicate well that similar to the HP laser devices, effective and safe removal of the enlarged prostate adenomas with MP laser devices (50W) is possible without any technical difficulties, even in patients receiving antithrombotic therapy.

scholarly journals Functional Outcomes of 24-Hour Thumb Immobilization in Healthy Volunteers: Prospective Comparative Study

2017 ◽  
Vol 06 (03) ◽  
pp. 201-205
Author(s):  
Raghuveer Muppavarapu ◽  
Lyubov Tsytsikova ◽  
Poonam Dalwadi ◽  
Charles Cassidy ◽  
Michael Gottschalk
Keyword(s):  
Comparative Study ◽  
Healthy Volunteers ◽  
Functional Outcome ◽  
Measurement Information ◽  
Dominant Hand ◽  
Significant Difference ◽  
Patient Reported ◽  
Prospective Comparative Study ◽  
Group 2 ◽  
Group 1

Background Immobilization is often needed for the treatment of wrist and hand injuries. The current best method of immobilization for several types of injuries has yet to be elucidated with little being reported on the functional differences of each type of immobilization. Purpose The purpose of this study is to compare the functional outcome between healthy young volunteers with a 24-hour short arm cast (SAC) versus thumb spica cast (TSC) immobilization. Methods A total of 50 healthy volunteers completed a baseline typing assessment and a Patient-Reported Outcomes Measurement Information System (PROMIS) upper extremity functional scoring assessment. Participants in group 1 were randomly initially assigned to a TSC of their dominant hand followed by an SAC, whereas participants in group 2 were randomly initially assigned to a TSC of their nondominant hand followed by an SAC. The volunteers completed the typing assessment and PROMIS assessment at the end of the 24-hour casting period. Results A total of 50 participants were enrolled in the study with 25 in group 1 and 25 in group 2. There was a 24.3-point difference between the average PROMIS score for participants with SAC compared with participants with TSC (93 vs. 68.7; p = 0.0001). There was a significant difference between the typing speed and accuracy of participants with SAC compared with participants with TSC (p = 0.0001). Conclusion There is a significant difference in functionality of a TSC immobilization versus an SAC immobilization according to the PROMIS functional outcome score and typing speed in a 24-hour casting period. SAC immobilization should be considered to have a possible similar effect in pathologic conditions instead of TSC immobilization given these findings even though a 24-hour period is not enough to provide adequate long-term conclusions. Level of Evidence I, prospective comparative study.

Sign in / Sign up

Export Citation Format

Share Document