scholarly journals Hematological and immunological effects of gallium, indium, and arsenic in light emitting diodes manufacturing workers

2015 ◽  
Vol 3 (1) ◽  
pp. 41 ◽  
Author(s):  
Yen-Hsiung Liao
Keyword(s):  
Light Emitting Diodes ◽  
Venous Blood ◽  
Hemoglobin Concentration ◽  
Interferon Γ ◽  
Mean Corpuscular Hemoglobin ◽  
Light Emitting ◽  
Cell Counts ◽  
Exposed Workers ◽  
Ifn Γ ◽  
White Blood Cell Counts

<p><strong>Purpose:</strong> To determine whether hematological and immunological changes occur in manufacturing workers in association with gallium, indium, and arsenic biomarkers in light-emitting diodes.</p><p><strong>Methods:</strong> 91exposed light-emitting diodes, workers and 24 referents were monitored for whole blood and urine levels of gallium, indium, and arsenic. Venous blood was also collected for routine and immunological analyses.</p><p><strong>Results:</strong> The mean levels of blood in, urine Ga, urine as, and mean corpuscular hemoglobin concentration (MCHC) in the exposed workers were significantly than in referents. The values of mean corpuscular volume (MCV), white blood cell counts (WBCs), neutrophils, lymphocytes, interferon-γ (IFN-γ), and IgG in the exposed workers were lower than in referents. Combined exposure to Ga, In, and As showed a significant change in trends of decreased MCV, WBCs, neutrophils, lymphocytes, IFN,γ, and IgG value, after adjusting for appropriate confounders.</p><p><strong>Conclusion:</strong> These findings indicated that heavier exposed to Ga, In, and As may suppress hematological and immunological variables.</p>

Toxicopathological effects of lambda-cyhalothrin in female rabbits (Oryctolagus cuniculus)

2010 ◽  
Vol 30 (7) ◽  
pp. 591-602 ◽  
Author(s):  
Abdul Basir ◽  
Ahrar Khan ◽  
Riaz Mustafa ◽  
Muhammad Zargham Khan ◽  
Farzana Rizvi ◽  
...  
Keyword(s):  
Blood Cell ◽  
Oryctolagus Cuniculus ◽  
Hemoglobin Concentration ◽  
Control Group ◽  
Mean Corpuscular Hemoglobin ◽  
Dependent Manner ◽  
Cell Counts ◽  
Lambda Cyhalothrin ◽  
Group A ◽  
Dose Dependent

The aim of this study was to investigate effects of lambda-cyhalothrin (LCT) on clinical, hematological, biochemical and pathological alterations in rabbits (Oryctolagus cuniculus). New Zealand white female rabbits (n = 24) of 4-5 months age having 997.92 ± 32.83 g weight were divided into four equal groups. Group A (control) received normal saline intraperitoneally (ip). Animals in groups B, C and D were treated with LCT 1.0, 4.0 and 8.0 mg/kg bw ip. Each group received seven consecutive doses at an interval of 48 hours. Blood and serum samples were collected at an interval of 96 hours. Blood analysis revealed a significant (p < 0.05) decrease in red blood cell and white blood cell counts, hemoglobin concentration and lymphocytes, while mean corpuscular hemoglobin concentration, mean corpuscular volume, neutrophils, monocytes and eosinophils were increased. Serum biochemical analysis revealed significant (p < 0.05) decrease in serum total proteins and serum albumin, while an increase was seen in serum alanine aminotransferase and aspartate aminotransferase activities compared with the control group. Serum globulin values varied non-significantly in all treatment groups as compared to control group. A dose-dependent increase in the incidence of micronucleated polychromatic erythrocyte was observed. All gross and histopathological lesions observed in LCT-treated rabbits were dose-dependent. Liver of the treated rabbits exhibited extensive perihepatitis, hyperplasia of bile duct, necrosis, hemorrhages and congestion. In lungs, there were hemorrhages, thickened alveolar walls, congestion, emphysema, collapsed alveoli and accumulation of extensive inflammatory cells. Kidneys were congested and hemorrhagic whereas renal parenchyma and stroma were normal. Microscopically, heart showed congestion of blood vessels and nuclear pyknosis, myodegeneration. It was concluded from the study that LCT produced toxicopathological alterations in rabbits in a dose-dependent manner. On the basis of the results, it can be suggested that overdosing of LCT be avoided while treating animals for ectoparasites.

scholarly journals Blood Donation in Nigeria: Standard of the Donated Blood

2012 ◽  
Vol 4 (02) ◽  
pp. 094-097 ◽  
Author(s):  
Nwogoh Benedict ◽  
Awodu Omolade Augustina ◽  
Bazuaye Godwin Nosakhare
Keyword(s):  
Blood Donation ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Mean Cell Volume ◽  
Benin City ◽  
Cell Counts ◽  
Significant Difference ◽  
The Mean

ABSTRACT Objective: The objective was to determine the basic hematological parameters of remunerated blood donors in Benin City and to compare them with those of voluntary donors. Materials and Methods: This is a prospective study conducted in a tertiary health facility in Benin City. Pretransfusion samples were obtained from blood bags after gentle mixing and analyzed for hematological parameters. Samples were analyzed using the hematology autoanalyzer MODEL SYSMEX KN21. Result: A total of 215 samples were obtained comprising 160 remunerated (paid) and 55 voluntary donor samples. In the paid donors, the mean hemoglobin concentration (Hb) and hematocrit (HCT) 7.7±2.9 and 28.8±8.5 respectively. This was significantly lower than those of voluntary donors who had 13.9±1.2 and 42.2±3.3 with P < 0.001. The mean values of the red cell counts (RBC), white cell counts (WBC), mean cell volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were significantly lower in paid donors as P-values were <0.001. MCV was significantly low but not compared to the other parameters as P=0.04. There was no significant difference in the platelet count. Conclusion: Paid donors in Benin City have significantly lower hematological parameters than controls.

scholarly journals Hematological and serum biochemical findings in clinical cases of cattle naturally infected with lumpy skin disease

2015 ◽  
Vol 9 (03) ◽  
pp. 283-288 ◽  
Author(s):  
Sameeh M Abutarbush
Keyword(s):  
Skin Disease ◽  
Venous Blood ◽  
Hemoglobin Concentration ◽  
Viral Disease ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Creatinine Concentration ◽  
Blood Profile ◽  
Lumpy Skin Disease ◽  
Serum Biochemical

Introduction: Lumpy skin disease (LSD) is an acute viral disease of cattle that is currently emerging in the Middle East region and poses a serious threat to Europe and the rest of the world. The objective of this study was to describe hematological and serum biochemical findings associated with natural clinical infection of LSD in cattle. Methodology: A total of 129 animals clinically infected with LSD were enrolled in the study. Venous blood sample were collected from study animals, and hematological and serum biochemical parameters were measured. Results: Leukocytopenia was found in 8.7%, while leucocytosis was found in 18.2% of affected cattle. Decreased hematocrit concentration was seen in 18.3%. Most affected cattle had reduced mean corpuscular volume (43.7%), mean corpuscular hemoglobin (14.3%), and mean corpuscular hemoglobin concentration (11.5%). All cattle with abnormal platelets count had thrombocytopenia. Hyperfibrinogenemia, hyperproteinemia, and hyperalbuminemia were found in 69%, 59.6%, and 37.2% of affected cattle, respectively. Decreased creatinine concentration was seen in 65.8%. Hyperkalemia and hyperchloremia was found in 9.6% and 10.4% of the affected cattle, respectively. Conclusions: LSD appears to be associated with inflammatory leukogram, anemia, thrombocytopenia, hyperfibrinogenemia, hyperproteinemia, decreased creatinine concentration, hyperchloramia, and hyperkalemia. These are likely due to the associated severe inflammatory process and disease complications such as anorexia and reduced muscle mass. This is the first study that documents hematological and serum biochemical findings associated with LSD infection. Understanding the blood profile picture may give further insight to the pathogenesis of the disease and help in treatment of individual cattle.

scholarly journals Immunological Features of Pediatric Interstitial Pneumonia Due to Mycoplasma pneumoniae

2021 ◽  
Vol 9 ◽  
Author(s):  
Xuefeng Xu ◽  
Yuanjian Sheng ◽  
Li Yang ◽  
Haichun Zhou ◽  
Lanfang Tang ◽  
...  
Keyword(s):  
T Cells ◽  
Propensity Score ◽  
Interstitial Pneumonia ◽  
Mycoplasma Pneumoniae ◽  
Propensity Score Analysis ◽  
Interferon Γ ◽  
Lower Serum ◽  
Cell Counts ◽  
Score Analysis ◽  
Ifn Γ

Background: Inflammatory response, oxidative stress, and immunologic mechanism are involved in the pathogenesis of Mycoplasma pneumoniae pneumonia (MPP). However, the role of immune system of pediatric interstitial pneumonia due to M. pneumoniae infections remains poorly understood. The aim of this study was to analyze the immunologic features of pediatric interstitial pneumonia due to Mycoplasma pneumoniae (M. pneumoniae).Methods: A retrospective study was conducted on a primary cohort of children with MPP. Propensity score analysis was performed to match interstitial pneumonia and pulmonary consolidation children.Results: The clinical characteristics strongly associated with the development of interstitial pneumonia were boys, age &gt;5 years, wheezing history, hydrothorax free, lymphocytes (&gt;3.0 × 109/L), CD19+ (&gt;0.9 × 109/L), CD3+ (&gt;2.5 × 109/L), CD4+ (&gt;1.5 × 109/L), CD8+ (&gt;0.9 × 109/L), interleukin-6 (IL-6, &lt;30 pg/ml), IL-10 (&lt;6 pg/ml), and interferon-γ (IFN-γ, &lt;15 pg/ml). After propensity score analysis, children with interstitial pneumonia showed significantly higher CD19+, CD3+, and CD4+ T cell counts, and lower serum IL-6, IL-10, and IFN-γ levels. The final regression model showed that only CD4+ T cells (&gt;1.5 × 109/L, OR = 2.473), IFN-γ (&lt;15 pg/ml, OR = 2.250), and hydrothorax free (OR = 14.454) were correlated with the development of interstitial pneumonia among children with MPP.Conclusions: The M. pneumoniae-induced interstitial pneumonia showed increased CD4+ T cells and lower serum IFN-γ level. Specific immunologic profiles could be involved in the development of pediatric interstitial pneumonia due to M. pneumoniae infections.

Haematological profile in foals during the first year of life

2019 ◽  
Vol 184 (16) ◽  
pp. 503-503 ◽  
Author(s):  
Babak Faramarzi ◽  
Lon Rich
Keyword(s):  
Venous Blood ◽  
Reference Intervals ◽  
First Year ◽  
Cell Counts ◽  
Haematological Values ◽  
Haematological Profile ◽  
White Blood Cell Counts ◽  
First Year Of Life ◽  
Changes Over Time ◽  
Over Time

Foals’ haematological values change constantly during their first year of life. The use of updated age-based reference intervals (RIs) is imperative for providing accurate diagnosis and optimum care for sick foals. The authors' objective was to provide updated RIs for 13 haematological values in 2, 7, 14, 30, 90, 180 and 365-day-old foals and to investigate the changes over time in each measured value. Venous blood was collected at those ages from clinically healthy foals. Thirteen haematological values were analysed. The 95% RIs were reported using a bootstrapping method. Differences over time were examined using Friedman test. RIs for each of the measured values were calculated. Results showed noticeable trends in changes over time in several values. Nevertheless, white blood cell counts significantly increased between day 2 and day 90 (P=0.011) while lymphocyte counts increased from day 2 up to day 180 (P=0.033). The mean corpuscular haemoglobin and mean corpuscular volume (P=0.011) significantly decreased between day 2 and day 90. Normal haematological values in foals not only differ from those in adult horses but also change throughout the first year of life; thus, it is critical that clinicians use age-based RIs when treating sick foals.

scholarly journals Effect of bioactive compounds extracted from euphorbious plants on hematological and biochemical parameters of Channa punctatus

2011 ◽  
Vol 53 (5) ◽  
pp. 259-263 ◽  
Author(s):  
Jaya Shahi ◽  
Ajay Singh
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Hematological Parameters ◽  
Channa Punctatus ◽  
Mean Corpuscular Hemoglobin ◽  
Hematological Indices ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts ◽  
Sublethal Concentrations

Channa punctatus was exposed to four different concentrations of Rutin, Taraxerol and Apigenin. Changes in some hematological parameters of Channa punctatus were assessed to determine the influence of these compounds on test fish. Fish were exposed to sublethal concentrations (80% of LC50 of 24h) of these compounds for one week. Control fish were also administered for one week. Thereafter, blood samples were obtained from the control and experimental fish. Blood was assayed for selected hematological parameters (hematocrit, hemoglobin, red blood cell count, white blood cell count total plasma protein and plasma glucose concentration). The derived hematological indices of mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV) were calculated. Sublethal concentrations of these compounds caused a dose dependent decrease in hemoglobin values coupled with a decrease in hematocrit values and red blood cell counts are an obvious indication of anemia. The total white blood cell counts and the differential white blood cell counts were decreased except for the lymphocytes, where there was a slight increase. Plasma protein and glucose were also lower in exposed fish when compared with control. The hematological indices MCH, MCHC, MCV were also lowered. The result from this study reveals high mortality rate and deleterious consequences on the health of fish subjected to acute exposure of Rutin, Taraxerol and Apigenin and therefore, should not be used directly in aquaculture without having the proper knowledge.

scholarly journals Weight-length relationship, condition factor and blood parameters of farmed Cichla temensis Humboldt, 1821 (Cichlidae) in central Amazon

2011 ◽  
Vol 9 (1) ◽  
pp. 113-119 ◽  
Author(s):  
Marcos Tavares-Dias ◽  
Adriana Maria de Castro Monteiro ◽  
Elizabeth Gusmão Affonso ◽  
Kárlia Dalla Santa Amaral
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Condition Factor ◽  
Hemoglobin Concentration ◽  
Blood Parameters ◽  
Mean Corpuscular Hemoglobin ◽  
Central Amazon ◽  
Cell Parameters ◽  
Cell Counts ◽  
Length Relationship

Farming of native carnivore fish species has drawn attention due to their promising use in aquaculture. Among these species, tucunaré of the genus Cichla stand out, them being of high economical interest for sport fishing and Amazon's industry of ornamental fish. The present study describes the weight-length relationship (WLR), relative condition factor (Kn), red blood cell parameters, thrombocytes and leukocytes count of Cichla temensis Humboldt, 1821, farmed in central Amazon. Fish that underwent food training during fingerling culture received extruded ration containing 45% of crude protein during fattening, and had Kn with values from 0.925-1.199, which indicated good health condition during the culture. The equation obtained from the WLR was W = 0.0073Lt3.1435, indicating an isometric growth, which is the desirable for fish of fish farm. Red blood cell counts, total thrombocyte and leukocyte counts, hematocrit, hemoglobin concentration, mean corpuscular volume (MCV), concentration of mean corpuscular hemoglobin (MCHC), lymphocytes, monocytes and neutrophils had intra-specific variation. A significant (p<0.001) positive correlation of the red blood cells number with the hemoglobin concentration and hematocrit was found. These are the first sets of blood parameters for C. temensis and could be used as reference for comparison in further studies to evaluate the health status of this fish in different environments, because assessment of these parameters may be used as quick tool for diagnosing diseases, stress and malnutrition.

Erythrocyte indices during a competitive marathon

1982 ◽  
Vol 52 (1) ◽  
pp. 168-172 ◽  
Author(s):  
M. A. Kolka ◽  
L. A. Stephenson ◽  
J. E. Wilkerson
Keyword(s):  
Water Vapor Pressure ◽  
Venous Blood ◽  
Plasma Osmolality ◽  
Hemoglobin Concentration ◽  
Ambient Air ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Indwelling Catheter ◽  
Weight Losses ◽  
Rbc Indices

Three adult male volunteers ran a competitive marathon (42.2 km) during which there was an average ambient air (dry bulb) temperature of 19.4 degree C, with an average ambient water vapor pressure of 9.5 Toor. Prior to and at 4.8-km (3-mi) intervals throughout the race, venous blood samples were drawn from an indwelling catheter in a peripheral arm vein. In each blood sample the total erythrocyte count (EC) was made, and whole blood hemoglobin concentration, hematocrit, and plasma osmolality were determined. From these measurements, the standard red blood cell (RBC) indices of mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were calculated. The three subjects completed the race in 191, 240, and 310 min, with weight losses averaging 5.4% of prerace body weight. EC linearly decreased below the prerace control levels of 5.69 X 10(6) RBC/mm3 for the first 14.5 km of the race, so that EC was 4.7% below control levels by this point. Subsequently, EC rose back to control levels by 19.3 km, where it remained for the rest of the race. MCHC, MCH, and calculated total RBC volume did not significantly change during the race. Plasma osmolality related to plasma osmolality. These data indicate the dynamic nature of erythrocyte number and volume during long-duration submaximal exercise, and the extraordinary ability of the human body to maintain RBC indices within narrow limits when confronted with a severe stress such as the marathon.

Role of interferon-γ in the evolution of murine bleomycin lung fibrosis

2003 ◽  
Vol 285 (6) ◽  
pp. L1255-L1262 ◽  
Author(s):  
Michael J. Segel ◽  
Gabriel Izbicki ◽  
Pazit Y. Cohen ◽  
Reuven Or ◽  
Thomas G. Christensen ◽  
...  
Keyword(s):  
Lung Injury ◽  
Lung Fibrosis ◽  
Time Course ◽  
Intratracheal Instillation ◽  
Interferon Γ ◽  
Mrna Levels ◽  
Wild Type ◽  
Cell Counts ◽  
Ifn Γ

IFN-γ production is upregulated in lung cells (LC) of bleomycin-treated C57BL/6 mice. The present study characterizes the time course, cellular source, and regulation of IFN-γ expression in bleomycin-induced lung injury. IFN-γ mRNA in LC from bleomycin-treated mice peaked 3 days after intratracheal instillation. IFN-γ protein levels were increased at 6 days, as was the percentage of LC expressing IFN-γ. CD4+, CD8+, and natural killer cells each contributed significantly to IFN-γ production. IL-12 mRNA levels were increased at 1 day in LC of bleomycin-treated mice. Anti-IL-12 and anti-IL-18 antibodies decreased IFN-γ production by these cells. To define the role of endogenous IFN-γ in the evolution of bleomycin lung injury, we compared the effect of bleomycin in mice with a targeted knockout mutation of the IFN-γ gene (IFN-γ knockout) and wild-type mice. At 14 days after intratracheal bleomycin, total bronchoalveolar lavage cell counts and lung hydroxyproline were decreased in IFN-γ knockouts compared with wild-type animals. There was no difference in morphometric parameters of fibrosis. Our data show that enhanced IFN-γ production in the lungs of bleomycin-treated mice is at least partly IL-12 and IL-18 dependent. Absence of IFN-γ in IFN-γ knockout mice does not increase pulmonary fibrosis. Endogenous IFN-γ may play a proinflammatory or profibrotic role in bleomycin-induced lung fibrosis.

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