Regulation of cell signaling pathways by Schisandrin in different cancers: Opting for "Swiss Army Knife" instead of "Blunderbuss"

There has been an exponential growth in the field of molecular oncology and cutting-edge research has enabled us to develop a better understanding of therapeutically challenging nature of cancer. Based on the mechanistic insights garnered from decades of research, puzzling mysteries of multifaceted nature of cancer have been solved to a greater extent. Our rapidly evolving knowledge about deregulated oncogenic cell signaling pathways has allowed us to dissect different oncogenic transduction cascades which play critical role in cancer onset, progression and metastasis. Pharmacological targeting of deregulated pathways has attracted greater than ever attention in the recent years. Henceforth, discovery and identification of high-quality biologically active chemicals and products is gaining considerable momentum. There has been an explosion in the dimension of natural product research because of tremendous potential of chemopreventive and pharmaceutical significance of natural products. Schisandrin is mainly obtained from Schisandra chinensis. Schisandrin has been shown to be effective against different cancers because of its ability to inhibit/prevent cancer via modulation of different cell signaling pathways. Importantly, regulation of non-coding RNAs by schisandrin is an exciting area of research that still needs detailed and comprehensive research. However, we still have unresolved questions about pharmacological properties of schisandrin mainly in context of its regulatory role in TGF/SMAD, SHH/GLI, NOTCH and Hippo pathways.

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Role of non-coding RNAs as novel biomarkers for detection of colorectal cancer progression through interaction with the cell signaling pathways

Gene ◽

10.1016/j.gene.2020.144796 ◽

2020 ◽

Vol 753 ◽

pp. 144796 ◽

Cited By ~ 3

Author(s):

Mohadeseh Esmaeili ◽

Maryam Keshani ◽

Mehrdad Vakilian ◽

Maryam Esmaeili ◽

Maryam Peymani ◽

...

Keyword(s):

Colorectal Cancer ◽

Cell Signaling ◽

Signaling Pathways ◽

Cancer Progression ◽

Novel Biomarkers ◽

Non Coding Rnas ◽

Colorectal Cancer Progression ◽

Cell Signaling Pathways

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Realizing the Potential of Blueberry as Natural Inhibitor of Metastasis and Powerful Apoptosis Inducer: Tapping the Treasure Trove for Effective Regulation of Cell Signaling Pathways

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520620666200311103206 ◽

2020 ◽

Vol 20 (15) ◽

pp. 1780-1786

Author(s):

Sundas Fayyaz ◽

Rukset Attar ◽

Baojun Xu ◽

Uteuliyev Y. Sabitaliyevich ◽

Aima Adylova ◽

...

Keyword(s):

Clinical Trials ◽

Cell Signaling ◽

Signaling Pathways ◽

Scientific Evidence ◽

Biologically Active ◽

Bioactive Constituents ◽

Active Components ◽

Laboratory Findings ◽

Significant Information ◽

Cell Signaling Pathways

Blueberries belong to the genus Vaccinium of the family Ericaceae. Rapidly accumulating experimentally verified data is uncovering the tremendous pharmacological properties of biologically active constituents of blueberries against different diseases. Our rapidly evolving knowledge about the multifaceted nature of cancer has opened new horizons to search for different strategies to target multiple effectors of oncogenic networks to effectively inhibit cancer onset and progression. Excitingly, whole blueberry powder and various bioactive constituents (pterostilbene, malvidin-3-galactoside) of blueberries have been shown to efficiently inhibit metastasis in animal models. These results are encouraging and future studies must focus on the identification of cell signaling pathways effectively modulated by blueberries in different cancers. It seems exciting to note that researchers are focusing on metastasis inhibitory effects of blueberry; however, to reap full benefits, it is necessary to take a step back and critically re-interpret the mechanisms used by active components of blueberry to inhibit or prevent metastasis. JAK/STAT, TGF/SMAD, Notch, SHH/GLI, and Wnt/ β-Catenin have been shown to be directly involved in the regulation of metastasis. However, because of limited studies, it is difficult to critically assess the true potential of blueberry. Loss of apoptosis, metastasis and deregulation of signaling pathways are branching trajectories of molecular oncology. Accordingly, we have to emphasize on these essential facets to realistically claim blueberry as "Superfood". Different clinical trials have been conducted to gather clinical evidence about the chemopreventive role of blueberry or its bioactive components in cancer patients. But it seems clear that because of the lack of sufficient proof-of-concept studies, we cannot extract significant information about the transition of blueberry into the next phases of clinical trials. Overview of the existing scientific evidence revealed visible knowledge gaps and a better understanding of the targets of blueberry will be helpful in efficient and meaningful translation of laboratory findings to clinically effective therapeutics.

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Regulation of cell signaling pathways by Wogonin in different cancers: Mechanistic review

Cellular and Molecular Biology ◽

10.14715/cmb/2021.67.2.1 ◽

2021 ◽

Vol 67 (2) ◽

pp. 1-7

Author(s):

Ghazala Butt ◽

Ulku Ozbey ◽

Durr-e-shahwar Malik ◽

Rukset Attar ◽

Lara Youssef ◽

...

Keyword(s):

Cell Signaling ◽

Signaling Pathways ◽

Drug Targets ◽

Conceptual Knowledge ◽

Scientific Evidence ◽

Oncogenic Signaling ◽

Natural Product Research ◽

Apoptotic Pathways ◽

Pharmacologically Active ◽

Cell Signaling Pathways

Natural products have historically been invaluable as a premium source of therapeutic agents. Recent advancements in genomics and structural biology have portrayed a high-resolution landscape of the diversity of proteins targeted by pharmacologically active products from natural sources. Natural product research has generated valuable wealth of information and cutting-edge research-works have leveraged our conceptual knowledge altogether to a new level. Wogonin (5,7-dihydroxy-8-methoxyflavone) is an O-methylated flavone and has attracted noteworthy appreciation because of its ability to pharmacologically target plethora of cell signaling pathways in different cancers. In this mini-review, we have gathered scattered pieces of available scientific evidence to summarize how wogonin pharmaceutically targeted Wnt/?-catenin, JAK/STAT, VEGF/VEGFR and TRAIL-driven apoptotic pathways in wide variety of cancers. We have also critically analyzed how wogonin prevented carcinogenesis and metastasis in tumor-bearing mice. Although researchers have uncovered pleiotropic role of wogonin in the regulation of different oncogenic signaling cascades but there are visible knowledge gaps in our understanding related to regulation of non-coding RNAs by wogonin. Future studies must converge on the unraveling of additional drug targets for wogonin to achieve a fuller and realistic understanding of the chemopreventive properties of wogonin.

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4-Hydroxy-Trans-2-Nonenal in the Regulation of Anti-Oxidative and Pro-Inflammatory Signaling Pathways

Oxidative Medicine and Cellular Longevity ◽

10.1155/2019/5937326 ◽

2019 ◽

Vol 2019 ◽

pp. 1-17 ◽

Cited By ~ 1

Author(s):

Himangshu Sonowal ◽

Kota V. Ramana

Keyword(s):

Cell Signaling ◽

Signaling Pathways ◽

Critical Role ◽

Aldehyde Group ◽

Hydroxyl Group ◽

Unsaturated Aldehyde ◽

Inflammatory Signaling ◽

Age Related ◽

Cell Signaling Pathways ◽

Reactive Molecule

Recent studies indicate that 4-hydroxy-trans-2-nonenal (HNE), a major oxidative stress triggered lipid peroxidation-derived aldehyde, plays a critical role in the pathophysiology of various human pathologies including metabolic syndrome, diabetes, cardiovascular, neurological, immunological, and age-related diseases and various types of cancer. HNE is the most abundant and toxic α, β-unsaturated aldehyde formed during the peroxidation of polyunsaturated fatty acids in a series of free radical-mediated reactions. The presence of an aldehyde group at C1, a double bond between C2 and C3 and a hydroxyl group at C4 makes HNE a highly reactive molecule. These strong reactive electrophilic groups favor the formation of HNE adducts with cellular macromolecules such as proteins and nucleic acids leading to the regulation of various cell signaling pathways and processes involved in cell proliferation, differentiation, and apoptosis. Many studies suggest that the cell-specific intracellular concentrations of HNE dictate the anti-oxidative and pro-inflammatory activities of this important molecule. In this review, we focused on how HNE could alter multiple anti-oxidative defense pathways and pro-inflammatory cytotoxic pathways by interacting with various cell-signaling intermediates.

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Recent updates on true potential of an anesthetic agent as a regulator of cell signaling pathways and non-coding RNAs in different cancers: Focusing on the brighter side of propofol

Gene ◽

10.1016/j.gene.2020.144452 ◽

2020 ◽

Vol 737 ◽

pp. 144452 ◽

Cited By ~ 2

Author(s):

Ammad Ahmad Farooqi ◽

Aima Adylova ◽

Uteuliyev Yerzhan Sabitaliyevich ◽

Rukset Attar ◽

Muhammad Imran Sohail ◽

...

Keyword(s):

Cell Signaling ◽

Signaling Pathways ◽

Anesthetic Agent ◽

Non Coding Rnas ◽

Cell Signaling Pathways

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Cell signaling pathways involved in enhanced cardiac repair mediated by TGF-β treated amnion epithelial cells

The Thoracic and Cardiovascular Surgeon ◽

10.1055/s-0032-1332323 ◽

2013 ◽

Vol 61 (S 01) ◽

Author(s):

R Roy ◽

A Brodarac ◽

H Stachelscheid ◽

YH Choi ◽

R Hetzer ◽

...

Keyword(s):

Epithelial Cells ◽

Cell Signaling ◽

Signaling Pathways ◽

Cardiac Repair ◽

Cell Signaling Pathways ◽

Amnion Epithelial Cells

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MicroRNAs and Oxidative Stress: An Intriguing Crosstalk to Be Exploited in the Management of Type 2 Diabetes

Antioxidants ◽

10.3390/antiox10050802 ◽

2021 ◽

Vol 10 (5) ◽

pp. 802

Author(s):

Teresa Vezza ◽

Aranzazu M. de Marañón ◽

Francisco Canet ◽

Pedro Díaz-Pozo ◽

Miguel Marti ◽

...

Keyword(s):

Oxidative Stress ◽

Type 2 Diabetes ◽

Signaling Pathways ◽

Current Knowledge ◽

Critical Role ◽

Cell Dysfunction ◽

Non Coding Rnas ◽

And Oxidative Stress ◽

Molecular Crosstalk

Type 2 diabetes is a chronic disease widespread throughout the world, with significant human, social, and economic costs. Its multifactorial etiology leads to persistent hyperglycemia, impaired carbohydrate and fat metabolism, chronic inflammation, and defects in insulin secretion or insulin action, or both. Emerging evidence reveals that oxidative stress has a critical role in the development of type 2 diabetes. Overproduction of reactive oxygen species can promote an imbalance between the production and neutralization of antioxidant defence systems, thus favoring lipid accumulation, cellular stress, and the activation of cytosolic signaling pathways, and inducing β-cell dysfunction, insulin resistance, and tissue inflammation. Over the last few years, microRNAs (miRNAs) have attracted growing attention as important mediators of diverse aspects of oxidative stress. These small endogenous non-coding RNAs of 19–24 nucleotides act as negative regulators of gene expression, including the modulation of redox signaling pathways. The present review aims to provide an overview of the current knowledge concerning the molecular crosstalk that takes place between oxidative stress and microRNAs in the physiopathology of type 2 diabetes, with a special emphasis on its potential as a therapeutic target.

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