scholarly journals Relationships between morphological indicators of the tibia and soft tissues lesions and some biochemical blood indicators in patients with traumatic osteomyelitis

Pathologia ◽  
2021 ◽  
Vol 18 (2) ◽  
pp. 218-228
Author(s):  
V. V. Hryhorovskyi ◽  
S. Mahomedov ◽  
M. P. Hrytsai ◽  
V. P. Tsokalo ◽  
T. A. Kuzub ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Blood Serum ◽  
Soft Tissues ◽  
Clinical Indicators ◽  
Association Coefficient ◽  
Biochemical Indicators ◽  
Bone Fragments ◽  
Definition Of ◽  
Pathological Focus ◽  
Severity Degree

Aim. Research aim was to find statistical differences of biochemical indicators of blood and morphometric indicators of crural tissue lesion and relationships between them in patients with traumatic osteomyelitis of the tibia with trophic disturbances in extremity. Material and methods. The work material includes data from 28 patients with traumatic osteomyelitis which was combined with trophic tissue disturbances of different manifestation degree. The levels of procalcitonin, lactate dehydrogenase and acetylcholinesterase of blood serum were estimated. In crural tissues quantitative biochemical, gradual morphometric indicators, frequencies of occurrence of different manifestation degree cases and relationships “clinic – biochemistry – pathomorphology” were defined histologically. Results. Average values of procalcitonin, lactate dehydrogenase and acetylcholinesterase in patients with traumatic osteomyelitis of the tibia, combined with trophic disturbances in crural tissues, are significantly higher, than average values of these indicators in intact donors. In the majority of the patients with chronic traumatic osteomyelitis in crural tissues pathological changes were found out, which by clinical estimations are considered as trophic disturbances. They represent a combination of discirculatory, ischemic-necro­tic, exsudative, productive-inflammatory, and also reparative processes which in total create a composite picture of complex lesion and can persist for many years. As closest relations, according to values of association coefficient, concerning certain biochemical indicators, can be noted such clinical indicators: “degree of bone fragments non-consolidation” and “severity of trophic disturbances in bone tissue (by clinical estimation)”, concerning defined morphometric indicators – such biochemical indicators: “level of procalcitonin” and “level of lactate dehydrogenase” in blood serum. Among morphometric lesion indicators the closest relations concerning biochemical indicators were revealed: in bones – “the form of the pathological focus of traumatic osteomyelitis” and “presence of sequesters”, in soft tissues – “exsudative inflammation in internal membrane of a focus capsule”. Conclusions. In chronic traumatic osteomyelitis combined with trophic disturbances of crural tissues, there are relationships between some clinical, biochemical and morphological indicators of the extremity tissues condition. A deviation of metabolism indicators from norm can serve as biochemical markers in definition of severity degree and efficiency of treatment in patients.

Decrease in proven ventriculitis by reducing the frequency of cerebrospinal fluid sampling from extraventricular drains

2011 ◽  
Vol 115 (5) ◽  
pp. 1040-1046 ◽  
Author(s):  
Teresa A. Williams ◽  
Gavin D. Leslie ◽  
Geoffrey J. Dobb ◽  
Brigit Roberts ◽  
Peter Vernon van Heerden
Keyword(s):  
Head Injuries ◽  
Tertiary Hospital ◽  
Sampling Frequency ◽  
Apache Ii Score ◽  
Optimum Frequency ◽  
Clinical Indicators ◽  
Historical Comparison ◽  
Institutional Ethics ◽  
Daily Sampling ◽  
Definition Of

Object Ventriculitis associated with extraventricular drains (EVD) increases rates of morbidity and mortality as well as costs. Surveillance samples of CSF are taken routinely from EVD, but there is no consensus on the optimum frequency of sampling. The goal of this study was to assess whether the incidence of ventriculitis changed when CSF sampling frequency was reduced once every 3 days. Methods After receiving institutional ethics committee approval for their project, the authors compared a prospective sample of EVD-treated patients (admitted 2008–2009) and a historical comparison group (admitted 2005–2007) at two tertiary hospital ICUs. A broad definition of ventriculitis included suspected ventriculitis (that is, treated with antibiotics for ventriculitis) and proven ventriculitis (positive CSF culture). Adult ICU patients with no preexisting neurological infection were enrolled in the study. After staff was provided with an education package, sampling of CSF was changed from daily to once every 3 days. All other management of the EVD remained unchanged. More frequent sampling was permitted if clinically indicated during the third daily sampling phase. Results Two hundred seven patients were recruited during the daily sampling phase and 176 patients when sampling was reduced to once every 3 days. The Acute Physiology and Chronic Health Evaluation (APACHE) II score was lower for the daily sampling group than for the every-3rd-day group (18.6 vs 20.3, respectively; p < 0.01), but there was no difference in mean age (47 and 45 years, respectively; p = 0.14), male or female sex (61% and 59%, respectively; p = 0.68), or median EVD duration in the ICU (4.9 and 5.8 days, respectively; p = 0.14). Most patients were admitted with subarachnoid hemorrhage (42% in the daily group and 33% in the every-3rd-day group) or traumatic head injuries (29% and 36%, respectively). The incidence of ventriculitis decreased from 17% to 11% overall and for proven ventriculitis from 10% to 3% once sampling frequency was reduced. Sampling of CSF once every 3 days was independently associated with ventriculitis (OR 0.44, 95% CI 0.22–0.88, p = 0.02). Conclusions Reducing the frequency of CSF sampling to once every 3 days was associated with a significant decrease in the incidence of ventriculitis. The authors suggest that CSF sampling should therefore be performed once every 3 days in the absence of clinical indicators of ventriculitis. Reducing frequency of CSF sampling from EVDs decreased proven ventriculitis.

scholarly journals Magnetic resonance imaging in traumatic injuries of the ankle joint in children

2020 ◽  
Vol 24 (4) ◽  
pp. 266-271
Author(s):  
N. Yu. Serova ◽  
T. A. Akhadov ◽  
I. A. Melnikov ◽  
O. V. Bozhko ◽  
N. A. Semenova ◽  
...  
Keyword(s):  
Ankle Joint ◽  
Soft Tissues ◽  
Diagnostic Value ◽  
Ankle Injuries ◽  
Deltoid Ligament ◽  
Anterior Talofibular Ligament ◽  
Mri Findings ◽  
Traumatic Injuries ◽  
Sport Activities ◽  
Bone Fragments

Introduction. Sprain of the ankle joint is one of the most common injuries in children during sport activities. Purpose. To define MRI diagnostic value in ankle joint injuries. Material and methods. 30 patients , 18 boys and 12 girls aged 8-17 ( average age 14.6 years), were enrolled into the study. 20 of them (66.7%) were 12-14 years old, 3 (10%) - < 10 years old and 7 (23.3 %) - > 14 years old. A Philips AchievadStream 3.0 Tesla scanner was used for MRI examination. Results. MRI findings showed that 17 (56.7%) patients had damage of the anterior talofibular ligament; 8 patients had avulsion of bone fragments of the lateral ankle; 9 patients (30.0%) had partial deltoid ligament injuries. Complete rupture of ligaments was rare and was seen only in two patients (6.7%). Conclusion. MRI is a method of choice in assessing ankle injuries due to high contrast of soft tissues, high resolution and multi-planar potentials. MRI is especially useful in examining soft ankle tissue structures such as tendons, ligaments, nerves and fascia, as well as in revealing hidden / subtle bone damage.

Retrospective registry evaluating the PSA flare phenomenon with cabazitaxel in metastatic castration-resistant prostate cancer (mCRPC).

2013 ◽  
Vol 31 (6_suppl) ◽  
pp. 122-122 ◽  
Author(s):  
Antoine Angelergues ◽  
Florence Mercier ◽  
Aude Flechon ◽  
Aline Guillot ◽  
Sylvestre Le Moulec ◽  
...  
Keyword(s):  
Soft Tissues ◽  
Progression Free Survival ◽  
Median Number ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant ◽  
Response Table ◽  
C Cycle ◽  
Psa Response ◽  
Definition Of ◽  
Early Rise

122 Background: PSA initial flare followed by a decrease is documented in up to 18% of mCRPC patients (pts) treated with docetaxel (D). There is no standard definition of this phenomenon, and its significance in terms of treatment efficacy and prognosis remains unclear. We evaluated the PSA flare incidence and characteristics with cabazitaxel (C), a new taxane developed to overcome D resistance, and its impact on outcome. Methods: A retrospective review of 84 consecutive pts (median 67 yrs) treated with C for mCRPC progressing during or after D was conducted in 8 French centers. Baseline characteristics, disease history, PSA values before and during C, overall survival (OS) and radiological or clinical progression-free survival (PFS) were collected. Results: At C initiation, most pts (84%) were ECOG 0-1, 59.5% had pain and 23.8% received ≥2 chemotherapy lines. Metastases were located in bone (92.9%), lymph nodes (48.8%) and visceral/soft tissues (9.5%). Median number of C cycles was 6 (range 2-14). Median OS and PFS from first C cycle were 16.4 and 6.7 months, respectively. Flare incidence, PFS and OS varied with the definition used (table). Definition [3] seems to us the most clinically relevant, and showed a close estimate of PFS compared to pts with immediate PSA decrease from baseline. We recommend to use this definition in clinical practice. Conclusions: PSA flare occurred in 16% pts treated with C and was associated with as good outcome as immediate responders. C should not be withdrawn prematurely in case of isolated initial PSA rise. This finding supports the PCWG 2 recommendation that early rise (prior to 12 weeks) with cytotoxics should be ignored in determining PSA response. [Table: see text]

Primitive Bone Fracturing: A Method of Research

1972 ◽  
Vol 37 (3) ◽  
pp. 369-382 ◽  
Author(s):  
Hind Sadek-Kooros
Keyword(s):  
Quantitative Analysis ◽  
Decision Theory ◽  
Annual Meeting ◽  
Bone Fractures ◽  
Weighted Sums ◽  
Fracture Patterns ◽  
Bone Fragments ◽  
Preliminary Study ◽  
Definition Of ◽  
And Function

AbstractA preliminary study of the form and fracture patterns of sheep metatarsals from Jaguar Cave is used to illustrate a method for the quantitative analysis of primitive bone fracturing techniques. Criteria of form, fracture, and function are defined and weighted, on the basis of experiments with green bone, and the aid of computers is enlisted to process the archaeological specimens via these criteria. The data is searched for: a. the definition of a technique of intentional fracture, b. the formation of classes of intentionally fractured and retouched bone fragments, and c. the identification of statistically perfect tools and not-tools, determined by higher or lower correlations of weighted sums. Conclusions are drawn from the analysis of the Jaguar Cave bone and bone from other early collections. The application of linear decision theory to the analysis of bone fractures was first attempted in a Ph.D. dissertation (Sadek-Kooros 1966), and a shorter version of the present paper was read at the Thirty-Fourth Annual Meeting of the Society for American Archaeology, on May 2, 1969.

scholarly journals Influence of active and passive smoking at pregnancy on expression of an oxidizing stress

2019 ◽  
pp. 236-239
Author(s):  
O. A. Chursina ◽  
O. D. Konstantinova ◽  
S. I. Krasikov ◽  
A. A. Petrova ◽  
N. I. Kolosova
Keyword(s):  
Blood Serum ◽  
Pregnant Women ◽  
Passive Smoking ◽  
Rapid Test ◽  
Superoxide Dismutases ◽  
Control Group ◽  
Active Smoking ◽  
Smoking During Pregnancy ◽  
Definition Of

Objective: definition of indicators of system prooksidanty-antioxidants at active and passive smoking during pregnancy. Material and methods. On the basis of city clinic for women 39 pregnant women on the term of a gestation of 37 weeks are examined. Questioning, rapid test for identification of a kotinin in urine, determination of level of a malon dialdehyde (MDA) and also activities superoxide dismutases (SOD) and catalases is carried out to bloods of surveyed. Patients are divided into 3 groups: I-of 11 smoking pregnant women subject to II-13 to passive smoking at pregnancy, III-control group of 15 women. Results. At patients of I and II groups substantial increase of level MDA in blood serum is noted. Reliable decrease of the activity of SOD of erythrocytes in the I group and insignificant decrease of the activity in II is taped. The indicator of catalase/SOD was statistically higher at active smoking. Conclusion. Active and passive smoking at pregnancy leads to change in prooxidatic and antioxidatic systems.

scholarly journals THE DEVELOPMENT OF TOTAL COMPLEMENT ACTIVITY ASSAY BASED ON COMPLEMENT-DEPENDENT IMMUNE LIPOSOME LYSIS

2015 ◽  
Vol 69 (3-4) ◽  
pp. 24-30
Author(s):  
S. N. Skopinskaya ◽  
S. P. Yarkov ◽  
E. N. Khramov ◽  
A. V. Antashev
Keyword(s):  
Blood Serum ◽  
Activity Assay ◽  
Animal Blood ◽  
Complement Activity ◽  
Sheep Erythrocytes ◽  
Wide Range ◽  
Total Complement ◽  
Sulforhodamine 101 ◽  
Internal Volume ◽  
Definition Of

Background: The purpose of work was development of a fast and reproduced procedure for measurement of the total complement activity (ТСА) in human or animal blood serum. Materials and methods: Steady at storage liposomes preparations, which surface sensitized 2,4-DNP haptens, and the internal volume contains calceine or sulforhodamine 101 are obtained. Complement-dependent immune lysis of liposomes at presence of the anti-2,4-DNP immunoglobulines and complement preparations from animals are investigated. Results: It is shown that the degree of liposomes immune lysis depends on complement concentration in a wide range that can be used for definition of TCA level. Research of blood sera from patients has revealed correlation (r =0,793) between data received with the help of liposome immunolytic systems, and the data of nephelometric analysis with application of suspension sheep erythrocytes. Conclusion: The method allows to define total complement activity in blood serum in 15 minutes without separation of reaction components. This might be useful for measurement ТСА level at patients with various diseases and realization of scientific researches.

scholarly journals DYNAMICS OF CLINICAL AND BIOCHEMICAL INDICATORS OF BLOOD IN CORRECTION OF PAIN SYNDROME WITH "GABAPENTIN" AND "FLEXOPROFEN"

2021 ◽  
Vol 245 (1) ◽  
pp. 76-82
Author(s):  
S.D. Klyukin ◽  
◽  
V.V. Salautin ◽  
N.A. Pudovkin ◽  
S.E. Salautina ◽  
...  
Keyword(s):  
Sodium Chloride ◽  
Side Effects ◽  
Diagnostic Marker ◽  
Pain Syndrome ◽  
Optimal Dose ◽  
Control Group ◽  
Therapeutic Effectiveness ◽  
Clinical Indicators ◽  
Biochemical Indicators ◽  
Experimental Group

The aim of this work was to study the dynamics of clinical indicators biohimicheskogo serum carnivores in the relief of pain drugs, "Gabapentin" and "Flexiprobe». For the study, a control group and two experimental groups were formed on the principle of pairs of analogues of 34 animals (17 dogs and 17 cats) in each. Intact animals (n=34, dogs-17, cats-17) were intramuscularly adminis-tered the drug "Sodium chloride 0.9 %" at a dose of 1 ml/kg at intervals of 24 hours for 7 days. An-imals of the experimental groups with pain syndrome were treated according to the following scheme: in the first experimental group (n=34, dogs-17, cats-17), the drug "Gabapentin" was used orally or rectally as a drug for the correction of pain syndrome in a dose of 10-60 mg/kg at intervals of 24 hours for 7 days, the optimal dose was selected depending on the type and severity of pain. In the second experimental group (n=34, dogs-17 heads, cats-17 heads), the drug "Flexoprofen" was administered subcutaneously or intramuscularly at a dose of 2 mg/kg at intervals of 24 hours for 7 days to correct the pain syndrome. The diagnostic marker of pain syndrome is a violation of electro-lyte metabolism in the blood serum in dogs and cats, characterized by a significant increase in sodi-um levels from 138.2±3.7 mmol/l to 194 ±4.2 mmol/l and a decrease in calcium levels to 2.4±0.7 mmol/l in dogs and 2.3±0.8 mmol/l in cats. The maximum therapeutic effectiveness of drugs with the least number of side effects is achieved by multimodal use of the drugs "Gabapentin"and " Flexoprofen".

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