scholarly journals DYNAMICS OF CLINICAL AND BIOCHEMICAL INDICATORS OF BLOOD IN CORRECTION OF PAIN SYNDROME WITH "GABAPENTIN" AND "FLEXOPROFEN"

2021 ◽  
Vol 245 (1) ◽  
pp. 76-82
Author(s):  
S.D. Klyukin ◽  
◽  
V.V. Salautin ◽  
N.A. Pudovkin ◽  
S.E. Salautina ◽  
...  
Keyword(s):  
Sodium Chloride ◽  
Side Effects ◽  
Diagnostic Marker ◽  
Pain Syndrome ◽  
Optimal Dose ◽  
Control Group ◽  
Therapeutic Effectiveness ◽  
Clinical Indicators ◽  
Biochemical Indicators ◽  
Experimental Group

The aim of this work was to study the dynamics of clinical indicators biohimicheskogo serum carnivores in the relief of pain drugs, "Gabapentin" and "Flexiprobe». For the study, a control group and two experimental groups were formed on the principle of pairs of analogues of 34 animals (17 dogs and 17 cats) in each. Intact animals (n=34, dogs-17, cats-17) were intramuscularly adminis-tered the drug "Sodium chloride 0.9 %" at a dose of 1 ml/kg at intervals of 24 hours for 7 days. An-imals of the experimental groups with pain syndrome were treated according to the following scheme: in the first experimental group (n=34, dogs-17, cats-17), the drug "Gabapentin" was used orally or rectally as a drug for the correction of pain syndrome in a dose of 10-60 mg/kg at intervals of 24 hours for 7 days, the optimal dose was selected depending on the type and severity of pain. In the second experimental group (n=34, dogs-17 heads, cats-17 heads), the drug "Flexoprofen" was administered subcutaneously or intramuscularly at a dose of 2 mg/kg at intervals of 24 hours for 7 days to correct the pain syndrome. The diagnostic marker of pain syndrome is a violation of electro-lyte metabolism in the blood serum in dogs and cats, characterized by a significant increase in sodi-um levels from 138.2±3.7 mmol/l to 194 ±4.2 mmol/l and a decrease in calcium levels to 2.4±0.7 mmol/l in dogs and 2.3±0.8 mmol/l in cats. The maximum therapeutic effectiveness of drugs with the least number of side effects is achieved by multimodal use of the drugs "Gabapentin"and " Flexoprofen".

scholarly journals AB0347 INCREASING TO OPTIMAL METHOTREXATE DOSE MIGHT BE A BETTER TRADITIONAL DMARD STRATEGY IN RA TREATMENTS: A RANDOMIZED CASE-CONTROL TRIAL OF HAKKA PEOPLE IN SOUTHERN CHINA

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1473.1-1473
Author(s):  
D. Lin ◽  
Y. Wen ◽  
Y. Zhang ◽  
Q. Chen ◽  
Y. Pan ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Folic Acid ◽  
Side Effects ◽  
Oral Dose ◽  
Optimal Dose ◽  
Chinese Patients ◽  
Control Group ◽  
Average Weight ◽  
Methotrexate Dose ◽  
Experimental Group

Background:The optimal methotrexate (MTX) dose is defined as 0.3mg/kg/week or ≥ 20mg/week at 6 months. [1] Considering average weight of Chinese, [2] the optimal MTX should be >15mg/w. However, not more than 30% in 25191 RA cases ever had MTX treatment in CREDIT (Chinese Registry of Rheumatoid arthritis). [3] The biggest concern is side effects of MTX. Our study is to investigate whether increasing MTX would get better results accompanied with more side effects to Chinese people.Objectives:Hakka people have the purest genes of the majority people-Han in China. It is planned to recruit 160 RA patients in Meizhou, where is a gathering place of Hakka people.Methods:The RA volunteers had no relief with 10 mg/w oral dose of MTX with/without other 1-2 inadequate dose of DMARDs for at least 3 months. They were randomly divided into 1:1 groups*. The experimental group would be treated with original DMARDs and incremental MTX (gradually increased to the optimal oral dose (0.3 mg/k/w) in the first 12 weeks and folic acid (the dose adjusted on demand with range from 5 mg/w to 5mg tid). While the control group would be treated with original MTX dose(10mg/w) but incremental original DMARDs(gradually increased to the maximum dose in the first 12 weeks). The two groups would keep the treatment at 12thweek last to the 36thweek, and the efficacy and safety indexes would be evaluated during the whole study.Results:1)We planned to recruit 160 RA patients in our study. 46 Hakka RA patients were enrolled in the study so far. 2 of 46 finished the 24thweek visit and 24 finished the 36thweek visit. The average age is 54.2± 9.3 years old, the average weight is 59.1±11.1kg, and the female to male ratio is 41:5.2)The average Folic acid dose is 14.4±9.5mg/w in the experimental group at the 12thweek.3)The morning stiffness time, PGA, PhGA, HAQ, DAS28 were better in experimental group after 12 weeks though slightly worse during 0-12 weeks. 100%(12) patients in experimental group, while 66.67%(8/12) in control group reach ACR20.4) Only 1 case(5.9%,1/23)had adverse event while 6 cases (26%,6/23) occurred adverse events. All events were mild level. 1 case (4.2%,1/23) in control group withdrew from the study because the disease was getting worse during 0-24 weeks.Conclusion:Hakka patients in China might have better outcomes due to increasing MTX to the 0.3mg/kg/w dose than increasing the other DMARDs. Therefore, We recommended the Chinses patients choose MTX as first incremental DMARD. The appropriate dose of Folic acid plus with the optimal dose of MTX in our study is higher than previous studies (such as 13.0±4.8mg/w reported by Gaujoux-Viala, 2018[1]). We recommended Chinese patients take 15mg/w folic acid to prevent MTX side effects in view of lower folic acid level in Chinese population.[3]References:[1]Gaujoux-Viala C, Rincheval N, Dougados M, et al. Optimal methotrexate dose is associated with better clinical outcomes than non-optimal dose in daily practice: results from the ESPOIR early arthritis cohort. Ann Rheum Dis. 2017 Dec;76(12):2054-2060.[2]Nan Jiang, Mengtao Li, Yanhong Wang, et al. Baseline characteristics and treatments among patients with rheumatoid arthritis: the CREDIT study in China, 2016-2018. Ann Rheum Dis. 2019 Jun; 78 (Suppl 2) 1404-1405.[3]He Y, Pan A, Hu FB,et al. Folic acid supplementation, birth defects, and adverse pregnancy outcomes in Chinese women: a population-based mega-cohort study, Lancet, 2016 Oct,Volume 388, Number 1, pp. S91-S91-(1)Disclosure of Interests:None declared

The use of poly additive Nabicat in the feeding of laying hens

2020 ◽  
pp. 44-55
Author(s):  
S. Nikolaev ◽  
L. Andreenko
Keyword(s):  
Laying Hens ◽  
Optimal Dose ◽  
Control Group ◽  
Nutrient Metabolism ◽  
Volgograd Region ◽  
Mineral Components ◽  
Environmentally Safe ◽  
Experimental Group ◽  
Poultry Farming

In modern poultry farming the most urgent tasks are to search for and test new environmentally safe feed and economically justifi ed additives that stimulate productivity, positively aff ect the health of poultry, and consequently increase the livability of livestock and other important zootechnical traits. In order to maintain physiologically normal processes of life, metabolism and increase the level of productivity of poultry it needs mineral components and their chelated compounds. The purpose of this work was to increase the egg productivity of poultry by using the silicon-containing poly additive Nabicat in feeding young hens and laying hens. The researches have been carried out on the poultry cross Highsex Brown under the environments in CJSC “Poultry Farm “Volzhskaya” in the Sredneakhtubinsky area in the Volgograd region. In this paper, The optimal dose of the introduction of the silicon-containing poly additive Nabicat in the diets of young and laying hens of the cross Highsex Brown has been scientifi cally justifi ed and the biological value of using an organic form of silicon has been determined. The positive infl uence of the optimal dose of poly additive on growth, consumption, and digestibility, nutrient metabolism in the poultry body, as well as egg productivity and quality of the resulting egg has been revealed. Thus, the average egg productivity per 1 hen in the control group during the experiment period was 321,3 pcs., and in the 1st, 2nd and 3rd experimental groups it was 322,6 pcs., 325,8 and 325,7 pcs., which was higher than in the control group by 0,40 %, 1,40 and 1,37 %, respectively. The average egg weight in the 1st experimental group exceeded the control by 0,43 g or 0,68 %, in the 2nd experimental group by 1,16 g or 1,84 %, in the 3rd experimental group by 0,81 g or 1,28 %. The economic eff ectiveness of using the organic silicon additive in the composition of Nabicat poly additive in the feeding of laying hens has been proved. The economic eff ect due to the use of diff erent doses of the introduction of silicon-containing poly additive Nabicat in compound feed for laying hens of the 1st experimental group was 141,66 rubles, the 2nd experimental group 962,76 rubles, and the 3rd experimental group 821,89 rubles.

scholarly journals The economic efficiency of the use of mixed ligand complexes of Zinc, Manganese and Cobalt in the rations of highlyproductive cows of the Ukrain-ian Red-Spotted Dairy breed

2021 ◽  
Vol 23 (95) ◽  
pp. 82-86
Author(s):  
Yu. G. Kropyvka ◽  
V. S. Bomko ◽  
S. Y. Kropyvka
Keyword(s):  
Economic Efficiency ◽  
Economic Effect ◽  
Optimal Dose ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Control Group ◽  
Feed Mixture ◽  
Set Up ◽  
Experimental Group ◽  
Dairy Breed

The article deals with the results of research on the economic efficiency of the use of mixed ligand complexes of Zinc, Manganese and Cobalt in the feeding rations of highlyproductive cows of Ukrainian Red-Spotted Dairy breed in the first 100 days of lactation. The research was performed on five groups (one control and four experimental) of analogous cows in the conditions of ALC “Terezyne” Bila Tserkva district of Kyiv region. The control was the optimal dose of mixed ligand complexes of Zinc, Manganese and Cobalt, which was previously established with a concentration of 1 kg of dry matter (DM) of the feed mixture (FM), mg: Zinc – 60.8; Manganese – 60.8 and Cobalt – 0.78. For the 2nd experimental group, the concentration of these trace elements was increased by 10 %, and in the 3rd, 4th and 5th experimental groups – on the contrary, the concentration of Zinc, Manganese and Cobalt in 1 kg of DM of feed mixture was reduced by 10 %, 20 and 30 %, respectively, compared with the control. The best results on milk yield of natural and basic fat content were got from cows of the 4th experimental group, where the concentration of Zinc, Manganese and Cobalt due to their mixed ligand complexes in 1 kg of DM of feed mixture was, mg: Zinc – 48.6; Manganese – 48.6; Cobalt – 0.62. The cost of products got from experimental cows ranged from UAH 12702.3 up to UAH 13783.7 and it was the highest in the 4th experimental group. It was set up that for cows of Ukrainian Red-Spotted Dairy breed in the first 100 days of lactation the most economically advantageous was the dose of mixed ligand complexes, in which the concentration of Zinc and Manganese was 48.6 mg, and Cobalt – 0.62 mg/kg DM, which allowed to obtain a profit of 14.37 % more than in the control group. Doses of mixed ligand complexes with a concentration of Zinc and Manganese – 66.9 mg; 54.7 and 42.6 mg, and Cobalt – 0.86 mg; 0.7 and 0.55 mg/kg CF gave a much lower economic effect. Additional profit in the 2nd experimental group amounted to UAH 66.8 or 1.34 %; in the 3rd – UAH 95.6 or 1.92 % and in the 5th – UAH 561.6 or 11.28 %, compared with the control group.

THE APPLICATION OF STATISTICAL METHODS IN EVALUATING THE RESULTS OF CLINICAL FINDINGS OF THE DRUG BOVHUALONIDASE AZOXIMER IN CATS WITH UROLOGICAL DISEASES

2020 ◽  
pp. 212-218
Author(s):  
А. V. Nazarova ◽  
◽  
B. S. Semenov ◽  
Т. Sh. Kuznetsova ◽  
◽  
...  
Keyword(s):  
Relative Risk ◽  
Side Effects ◽  
Risk Reduction ◽  
Absolute Risk ◽  
Control Group ◽  
Control Groups ◽  
Saint Petersburg ◽  
Number Of Patients ◽  
And Control ◽  
Experimental Group

In the period from November 2018 to August 2020, we conducted a randomized blind placebo-controlled confirmatory clinical trial in parallel groups on the basis of network of veterinary clinics in Saint Petersburg and Saint Petersburg state university of veterinary medicine. The purpose of the study: to evaluate the effectiveness of Bovhualonidaze azoximer(BA) in patients subjected to surgical intervention on the urethra and bladder, to prevent postoperative complications and relapses of the underlying disease. The frequency of complications was taken as an indicator of effectiveness. 80 cats were evaluated according to the criteria for inclusion in the study, after evaluation and randomization, 53 patients (24 and 29 cats in the experimental and control groups, respectively) who had indications for surgery on the urethra and/or bladder were included in the study. After the withdrawal of some patients, 38 cats were analyzed (17 and 23 cats in the experimental and control groups, respectively). Animals in the experimental group received BA drugs in addition to conventional therapy, and animals in the control group received placebo. The rate of complications in the experimental group was 11.8 %, in the control group-61.9 %. The relative risk was 19.0 %, and the relative risk reduction was 80.9 %. The chance of developing complications in the animals of the experimental group is 12.2 times lower than in animals of the control group.. Absolute risk reduction — 50.1 %, and the number of patients to be treated — 2 patients. The confidence interval for the risk of side effects of BA drugs in cats was 0.0-10.1 %. Based on the results of our clinical study, we proved that the use of BA drugs is effective for preventing complications during surgical interventions on the urethra and bladder, and the risk of side effects when using BA drugs in cats is insignificant

Effectiveness of anti-stress drug use in the feeding of pigs

2020 ◽  
pp. 34-42
Author(s):  
S. I. Nikolaev ◽  
O. V. Korneeva ◽  
V. V. Shkalenko ◽  
A. K. Karapetyan ◽  
L. A. Syuliev
Keyword(s):  
Live Weight ◽  
Control Group ◽  
Clinical Indicators ◽  
Slaughter Weight ◽  
Young Pigs ◽  
Volgograd Region ◽  
The Difference ◽  
Productive Traits ◽  
Experimental Group

The experiment has been carried out on a crossbred stock of young pigs in the period 2015–2017 under the conditions of JSC CHC “Krasnodonskoe” in the Ilovlinsky district in the Volgograd region. The purpose of the research was to study the effectiveness of the effect of the anti-stress drug Feed-Food Magic Antistress Mix in intensive pig rearing on the productive traits and quality of the products obtained, as well as the estimated economic indicators. In order to conduct a scientific and economic experiment at the age of 60 days young pigs were divided into 2 experimental groups (control and experimental) according to the principle of pair analogs. Each group contained 25 heads. The difference between the control and experimental groups was that the animals in the control group have received the main diet, and the experimental group has received the anti-stress drug Feed-Food Magic Antistress Mix in addition to the main diet. In the experimental group of pigs when this drug was administered in the age 180 days the live weight parameter was higher than in the control group by 1,55 kg. Clinical indicators of young pigs were within the physiological norm. The pre-slaughter weight in the experimental group has increased by 4,86 % compared to the control group. Due to the use of an anti-stress drug the slaughter weight of animals in the experimental group has increased by 6,69 %. In comparison with the control group the slaughter yield in the experimental group has increased by 1,18 %, in which this indicator was at the level of 67,62 %. The morphological composition of carcasses in animals of the experimental group was also improved. Meat yield has increased by 0,95 %. The yield of fat and bones has decreased by 0,59 and 0,36 %. The weight of internal organs was also superior in the experimental group of pigs. Due to the use of the anti-stress drug the level of profitability in the experimental group of animals has increased by 11,69 %.

scholarly journals Short - Term Effects of Eccentric Hip Abductors and Lateral Rotators Strengthening In Sedentary People with Patellofemoral Pain Syndrome on Pain and Function : A Randomized Control Trail

2016 ◽  
Vol 06 (01) ◽  
pp. 068-073
Author(s):  
Kavitha Shetty ◽  
Lawrence Mathias ◽  
Mahesh V. Hegde ◽  
Sukumar Shanmugam
Keyword(s):  
Statistical Significance ◽  
Pain Syndrome ◽  
Patellofemoral Pain ◽  
Control Group ◽  
Short Term ◽  
Strengthening Exercises ◽  
Post Test ◽  
Hip Abductor ◽  
And Function ◽  
Experimental Group

Abstract Purpose: To investigate the influence of additional eccentric strengthening to the hip abductor and lateral rotator musculature on pain and function in sedentary people with Patellofemoral pain syndrome (PFPS). Methods: 30 sedentary patients between 18 and 40 years of age, with a diagnosis of PFPS, all the subjects received treatment for a period of 4weeks and the subjects were randomly assigned to Control group (CG) and Experimental group (EG). The patients in the Control group (n = 15) performed a conventional knee-stretching and strengthening program, whereas, patients in the Experimental group (n = 15) performed the same exercises as those in the control group ,in addition received eccentric strengthening exercises for the hip abductors and lateral rotators. An 11-point numeric pain rating scale (NPRS), the Lower Extremity Functional Scale (LEFS) and the Anterior Knee Pain Scale (AKPS) were used as outcome measures during the baseline and at the end of 4weeks . Results: Statistics were retrieved using SPSS.16, paired 't' test was conducted to compare AKPS and LEFS values ,whereas, Mann- Whitney U test was used for NPRS value between the groups. After 4 weeks of treatment, the control group, pre and post-test value for AKPS (p<0.001),LEFS (P<0.001),NPRS (p<0.001) shows a statistical significance and even in the experimental group, pre and post-test value for AKPS (p<0.001),LEFS (P<0.001),NPRS (p<0.001) shows a statistical significance in pain and function, but comparing both the group experimental group is significantly more better AKPS (p=0.002),LEFS (P<0.001),NPRS (P<0.001) then a control group. Conclusion: short term Knee strengthening exercises supplemented by eccentric hip abductor and lateral rotator musculature–strengthening exercises were more effective than knee exercises alone in improving function and reducing pain in sedentary people with PFPS.

scholarly journals The effect of canine disimpaction performed with temporary anchorage devices (TADs) before comprehensive orthodontic treatment to avoid root resorption of adjacent teeth

2016 ◽  
Vol 21 (2) ◽  
pp. 65-72 ◽  
Author(s):  
Farzin Heravi ◽  
Hooman Shafaee ◽  
Ali Forouzanfar ◽  
Seyed Hossein Hoseini Zarch ◽  
Mohsen Merati
Keyword(s):  
Side Effects ◽  
Root Resorption ◽  
Clinical Success ◽  
Clinical Success Rate ◽  
Control Group ◽  
Vas Score ◽  
Impacted Canines ◽  
End Of Treatment ◽  
Treatment Volume ◽  
Experimental Group

ABSTRACT Objective: The aim of this study was to evaluate the movement of impacted canines away from the roots of neighboring teeth before full-mouth bracket placement, performed by means of TADs to decrease undesired side effects on adjacent teeth. Methods: The study sample consisted of 34 palatally impacted canines, being 19 in the experimental group and 15 in the control group. In the experimental group, before placement of brackets, the impacted canine was erupted by means of miniscrews. In the control group, after initiation of comprehensive orthodontics, canine disimpaction was performed by means of a cantilever spring soldered to a palatal bar. At the end of treatment, volume of lateral incisors and canine root resorption were measured and compared by means of a CBCT-derived tridimensional model. Visual Analogue Scale (VAS) score, bleeding on probing (BOP) and gingival index (GI) were recorded. Clinical success rate was also calculated. Results: The volume of root resorption of lateral teeth in the control group was significantly greater than in the experimental group (p < 0.001). At the end of treatment, VAS score, GI and BOP were not significantly different between the two groups. Conclusion: Based on our results, it seems that disimpaction of canines and moving them to the arch can be done successfully carried out with minimal side effects by means of skeletal anchorage.

scholarly journals ОЦІНКА ФАРМАКОЛОГІЧНОЇ ЕФЕКТИВНОСТІ ТРАУМЕЛЮ (AD US.VET) ТА ФОСФОРУ-ГОМАККОРД (AD US.VET) ПРИ БРОНХОПНЕВМОНІЇ СОБАК

2016 ◽  
Vol 18 (2(66)) ◽  
pp. 206-212
Author(s):  
Yu.O. Chubov ◽  
V.Yu. Kushnir
Keyword(s):  
Sodium Chloride ◽  
Research Work ◽  
Control Group ◽  
Control Groups ◽  
East European ◽  
The Third ◽  
Isotonic Sodium Chloride ◽  
Experimental Group ◽  
Tools And Methods

The mucous membrane of the respiratory tract is easily the immediate effects of the environment, while contact with air that is inhaled, so pneumonia is common in dogs. For the treatment of dogs, sick with  catarrhal bronchopneumonia there are a number of tools and methods, but they are not always effective. Moreover, many of these methods have long waiting period of action and significant side effects. Thet is why the purpose of our research  work was to find effective and biologically safe treatment of dogs, sick with catarrhal bronchopneumonia and installation pharmacological effectiveness of complex antihomotoxic preparations Traumel (ad us.vet) and Phosphor-Homakkord (ad us.vet). The material for the study were 40 dogs aged 1 to 3 years old, weighing 34 to 43 kg (German and East-European sheep-dog), sick with acute catarrhal bronchopneumonia. Each animal was subjected to clinical and hematology research. Sick animals were divided in to four groups: ten animals to each group. First and second – control groups, third and fourth – experimental groups. In the first group we used mukaltyn 0.5 g orally twice a day up to recovery, bitsillin 3 50 th. UA / kg once every three days by intramuscular injection, dissolving in 2 ml of isotonic sodium chloride and vitamin B12 1 ml once a day subcutaneously for 10 days. In the second control group instead of bitsillin-3 was used antibiotic combi-kell 1 ml per 10 kg weight of body subcutaneously once every three days up to recover.In the third and fourth groups we used the lymphotropic complex antihomotoxic therapy with using the homeopathic preparations Traumel and Phosphor-Homakkord in conjunction with traditional means. Thus, in the third group was used inside mukaltyn 0.5 g twice a day up to recovery, bitsillin 3 50 th.UA / kg once every three days vnutrishom'yazovo dissolving in 2 ml of isotonic sodium chloride lidasa intradermally 32 IU with 1 ml of 0.5% solution of novocaine 3 days in a row, then 3 times a week, Traumel regional lymphotropic three consecutive days to 1 ml intradermally, then every three days and Phosphor- Homakkord lymphotropic regionally 1 ml 1 every 3 days to recovery . In the fourth experimental group used the same treatment, but instead of bitsillin-3 was used Combi-Kell 1 ml / 10 kg subcutaneously once every three days to recover.The results of our researches show that using of complex anthyhomotoxic therapy is appropriate and therapeutically effective versus conventional therapy.So despite the fact that there are a wide number of preparations and methods for treatment of dogs, sick with catarrhal bronchopneumonia, they are not always effective. As shown by our researches, using of compex anthyhomotoxic lymphotropic with the preparations Traumel and Phosphor-Homakkord reduces the duration and improve the quality of treatment.

scholarly journals The Effects of 12-Weeks of Sensorimotor Exercise on Pain, Strength, Pelvic Drop, and Dynamic Knee Valgus in Males With Patellofemoral Pain Syndrome

2020 ◽  
Vol 10 (3) ◽  
pp. 159-168
Author(s):  
Ali Yalfani ◽  
◽  
Mohamadreza Ahmadi ◽  
Farzaneh Gandomi ◽  
◽  
...  
Keyword(s):  
Muscle Strength ◽  
Pain Syndrome ◽  
Patellofemoral Pain Syndrome ◽  
Quadriceps Muscle ◽  
Patellofemoral Pain ◽  
Control Group ◽  
Knee Valgus ◽  
Quadriceps Muscle Strength ◽  
Hip Abductor ◽  
Experimental Group

Purpose: Patellofemoral Pain Syndrome (PFPS) is among the most prevalent complaints observed in healthcare clinics. This group of patients encounters Pelvic Drop (PD) and Dynamic Knee Valgus (DNV); its’ causes have been reported as pain and decreased muscle strength. The current study aimed to explore the effects of a 12-week Sensorimotor Exercise (SME) on pain, strength, PD, and DNV in males with PFPS. Methods: This randomized double-blind clinical trial involved 32 patients with PFPS. The study samples were randomly divided into the experimental (n=16) and control (n=16) groups. To assess pain, the Visual Analogue Scale (VAS) was used. Moreover, quadriceps muscle strength was measured by the hip abductor hand dynamometer. To analyze PD and DNV, camera and Kinova software were used during stairs descent. The experimental group performed 12 weeks of SME for 3 one-hour weekly sessions. However, the control group received no therapeutic intervention during this time. The obtained data were analyzed in SPSS using Analysis of Covariance (ANCOVA).  Results: The data analysis results suggested that pain significantly reduced in the experimental group, compared to the control group, after twelve weeks of SME (P<0.001). Besides, quadriceps muscle strength (P<0.002) and hip abductor muscle strength (P<0.001) improved, and PD angle (P<0.002) and DNV (P<0.003) were reduced. Conclusion: SME reduced pain and facilitated the frequency and time of muscle activation. It also increased the strength of the gluteus medius muscle as the main stabilizer of the pelvis chain and led to a reduction in PD and DNV. Thus, SME could be used as a comprehensive protocol treatment to improve various disorders in patients with PFPS.

Effect of exercise during adjuvant chemotherapy for breast cancer.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 6524-6524
Author(s):  
Barbara K Haas ◽  
Cynthia R. C. Osborne ◽  
Svetislava J. Vukelja ◽  
Jennifer Selman ◽  
Trevor Davis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Peripheral Neuropathy ◽  
Side Effects ◽  
Outcome Measures ◽  
Treatment Plan ◽  
Exercise Program ◽  
Well Being ◽  
Control Group ◽  
Positive Effects ◽  
Experimental Group

6524 Background: In 2018, an estimated 266,120 women faced the challenge of living with breast cancer and approximately 40,920 died from their disease. Nearly 100% of these women experienced significant treatment related side effects that negatively impact quality of life (QOL). Exercise has repeatedly demonstrated to alleviate many of the side effects, improve QOL, and decrease cancer recurrence and mortality. In spite of this evidence, women do not maintain exercise during treatment for breast cancer. The purpose of this randomized controlled trial was to determine the effectiveness of exercising the day chemotherapy is administered on 1) the persistence with an exercise program, 2) side effects, and 3) QOL. Methods: Eligible women were randomly assigned to a control or experimental group. As part of their treatment plan, all participants were referred to one of 14 community-based exercise centers to exercise. Experimental group also exercised at one of two cancer centers each day chemotherapy was administered. Outcome measures include exercise retention and chemotherapy, completion; cancer-related fatigue, nausea/vomiting, peripheral neuropathy, weight gain, and QOL. Outcome measures were assessed prior to every second course of chemotherapy and 3- and 6-months post-chemotherapy. Results: 273 women with Stage I-III breast cancer receiving chemotherapy were enrolled in the study. The number of participants who withdrew from exercise was higher among those in the control group (n= 16; 12.4%) compared with those in the experimental group (n = 10; 6.9%). At cycle 5, those in the experimental group reported less motor peripheral neuropathy than those in the control group (p = .018) and higher physical well-being scores than those in the control group (p = .047). Conclusions: The highest impact of the intervention was on attrition from exercise. Since participants in both the control and experimental groups exercised throughout chemotherapy, it is not surprising that the groups performed comparably with regard to side effects and QOL. Given the positive effects exercise has demonstrated on persons receiving cancer treatment in numerous studies, having patients exercise in the cancer center on the day of chemotherapy is a significant step toward engaging persons receiving chemotherapy in an exercise program.

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