The Impact of Body Mass Index and Insulin Resistance on IVF Outcomes of Polycystic Ovary Syndrome

The objective of this study is to explore how hyperinsulinemia and insulin resistance relate to the clinical, endocrine and metabolic factors in the infertile women with polycystic ovary syndrome. This study was conducted on 121 consecutive infertile women with polycystic ovary syndrome attending the Infertility unit from January 2017 to December 2017. They were divided into two groups: insulin resistant and insulin sensitive. There was significant difference in body mass index and waist circumference between the two groups. Serum lipids were not associated with insulin resistance. Hyperinsulinemia was significantly associated with metabolic syndrome. Reducing body mass index and waist circumference may improve insulin resistance in infertile women with polycystic ovary syndrome. Screening the infertile women with polycystic ovary syndrome for hyperinsulinemia and insulin resistance and subsequent counseling is recommended to address the long-term risks of metabolic syndrome.

Download Full-text

Prevalence of insulin resistance among American women with polycystic ovary syndrome (PCOS) as a function of body mass index (BMI)

Fertility and Sterility ◽

10.1016/j.fertnstert.2007.07.262 ◽

2007 ◽

Vol 88 ◽

pp. S78-S79

Author(s):

M.H. Dahan ◽

F. Abbasi ◽

G. Reaven

Keyword(s):

Insulin Resistance ◽

Body Mass Index ◽

Polycystic Ovary Syndrome ◽

Body Mass ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

American Women

Download Full-text

Impact of body mass index on blood pressure levels in patients with polycystic ovary syndrome

Arquivos Brasileiros de Endocrinologia & Metabologia ◽

10.1590/s0004-27302007000700013 ◽

2007 ◽

Vol 51 (7) ◽

pp. 1104-1109 ◽

Cited By ~ 10

Author(s):

Cristiano R.G. Barcellos ◽

Michelle P. Rocha ◽

Sylvia A.Y. Hayashida ◽

Décio Mion Junior ◽

Silvia G. Lage ◽

...

Keyword(s):

Blood Pressure ◽

Body Mass Index ◽

Polycystic Ovary Syndrome ◽

Body Mass ◽

Polycystic Ovary ◽

Present Moment ◽

Model Assessment ◽

Ovary Syndrome ◽

Significant Difference ◽

The Impact

As there is controversy about the prevalence of hypertension in patients with polycystic ovary syndrome (PCOS) and, up to the present moment, no studies have evaluated the impact of body mass index (BMI) on blood pressure levels (BP) in these patients, we studied retrospectively sixty-nine patients with PCOS, with BMI of 29.0 ± 6.7 kg/m² and aged 25.6 ± 5.6 yr, subdivided into three groups according to BMI (normal, overweight and obese) and evaluated regarding BP (mercury sphygmomanometer), basal hormonal profile, fasting glucose, and insulin sensitivity (HOMA-IR). Mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) were normal (118.1 ± 17.0 and 74.7 ± 11.5 mmHg, respectively), with a hypertension prevalence of 20.3%. Of these patients, 78.6% were obese and 21.4% were overweight. When the groups were compared according to BMI, a significant increase in SBP and DBP was observed (higher in overweight and obese patients for SBP and higher in obese for DBP), as well as a significant progressive increase in glucose, insulin, homeostatic model assessment, and a significant progressive decline in LH levels. When the patients were subdivided as normotensive or hypertensive, a significant difference was observed only for BMI (28.2 ± 6.1 and 34.7 ± 8.6 kg/m², respectively; p = 0.007). In conclusion, we observed a significant and progressive impact of BMI on blood pressure levels in our patients with polycystic ovary syndrome.

Download Full-text

Relationship of body mass index and insulin resistance to degree of hirsutism in polycystic ovary syndrome (PCOS)

Fertility and Sterility ◽

10.1016/j.fertnstert.2012.07.773 ◽

2012 ◽

Vol 98 (3) ◽

pp. S214

Author(s):

E.I. Lewis ◽

T. Hartshorn ◽

C. Holschneider ◽

K.M. Brennan

Keyword(s):

Insulin Resistance ◽

Body Mass Index ◽

Polycystic Ovary Syndrome ◽

Body Mass ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Relationship Of

Download Full-text

Heterogenous origins of hyperandrogenism in the polycystic ovary syndrome in relation to body mass index and insulin resistance

Gynecological Endocrinology ◽

10.1080/09513590.2017.1393062 ◽

2017 ◽

Vol 34 (3) ◽

pp. 238-242 ◽

Cited By ~ 2

Author(s):

Shalini Patlolla ◽

Suresh Vaikkakara ◽

Alok Sachan ◽

Ashok Venkatanarasu ◽

Bharath Bachimanchi ◽

...

Keyword(s):

Insulin Resistance ◽

Body Mass Index ◽

Polycystic Ovary Syndrome ◽

Body Mass ◽

Polycystic Ovary ◽

Ovary Syndrome

Download Full-text

Endothelial function in young women with polycystic ovary syndrome (PCOS): Implications of body mass index (BMI) and insulin resistance

Obesity Research & Clinical Practice ◽

10.1016/j.orcp.2009.08.001 ◽

2010 ◽

Vol 4 (1) ◽

pp. e49-e56 ◽

Cited By ~ 6

Author(s):

Ghada El-Kannishy ◽

Shaheer Kamal ◽

Amany Mousa ◽

Omayma Saleh ◽

Adel El Badrawy ◽

...

Keyword(s):

Insulin Resistance ◽

Body Mass Index ◽

Polycystic Ovary Syndrome ◽

Endothelial Function ◽

Body Mass ◽

Young Women ◽

Polycystic Ovary ◽

Ovary Syndrome

Download Full-text

Responses of Serum Androgen and Insulin Resistance to Metformin and Pioglitazone in Obese, Insulin-Resistant Women with Polycystic Ovary Syndrome

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2004-1965 ◽

2005 ◽

Vol 90 (3) ◽

pp. 1360-1365 ◽

Cited By ~ 140

Author(s):

C. Ortega-González ◽

S. Luna ◽

L. Hernández ◽

G. Crespo ◽

P. Aguayo ◽

...

Keyword(s):

Insulin Resistance ◽

Body Mass Index ◽

Body Weight ◽

Insulin Sensitivity ◽

Polycystic Ovary Syndrome ◽

Body Mass ◽

Polycystic Ovary ◽

Obese Women ◽

Ovary Syndrome ◽

Waist To Hip Ratio

Severe insulin resistance is a key abnormality in obese women with polycystic ovary syndrome (PCOS). The purpose of this study was to evaluate whether pioglitazone decreases insulin resistance (IR) and hyperandrogenism to the same extent as metformin in obese women with PCOS who have not received any previous treatment. Fifty-two women with PCOS were randomly allocated to receive either pioglitazone (30 mg/d, n = 25) or metformin (850 mg three times daily, n = 27) and were assessed before and after 6 months. Body weight, body mass index, and waist to hip ratio increased significantly (P ≤ 0.05) after pioglitazone treatment but not after metformin treatment. Fasting serum insulin concentration (P < 0.001 for both drugs) and the area under the insulin curve during a 2-h oral glucose tolerance test decreased after pioglitazone (P < 0.002) or metformin (P < 0.05) treatment. IR (homeostasis model of assessment-IR index) decreased and insulin sensitivity (elevation of the quantitative insulin sensitivity check index and the fasting glucose to insulin ratio) increased (P ≤ 0.008) after treatment with either drug. Hirsutism (P < 0.05) and serum concentrations of free testosterone (P < 0.02) and androstenedione (P < 0.01) declined to a similar extent after treatment with the drugs. Treatment with pioglitazone or metformin was associated with the occurrence of pregnancy (n = 5 and n = 3, respectively). These results suggest that pioglitazone is as effective as metformin in improving insulin sensitivity and hyperandrogenism, despite an increase in body weight, body mass index, and the waist to hip ratio associated with pioglitazone.

Download Full-text

Assessment of Psycho-emotional Distress Due to Age, Body Mass Index, and Marital Status in Polycystic Ovary Syndrome in North Indian Population

International Journal of Women s Health and Reproduction Sciences ◽

10.15296/ijwhr.2020.59 ◽

2020 ◽

Vol 8 (4) ◽

pp. 368-375

Author(s):

Fauzia Tabassum ◽

Hemali Heidi Sinha ◽

Kavita Dhar ◽

Chandra Jyoti ◽

Md Sayeed Akhtar ◽

...

Keyword(s):

Body Mass Index ◽

Body Weight ◽

Polycystic Ovary Syndrome ◽

Marital Status ◽

Body Mass ◽

Polycystic Ovary ◽

Reproductive Age ◽

Ovary Syndrome ◽

Significant Difference ◽

The Impact

Objectives: Polycystic ovary syndrome (PCOS) is a multifaceted endocrine disorder in reproductive age having a greater impact on health-related quality of life (HRQOL). The aim of this study was to find out PCOS demographics and its related HRQOL effects for improving psychological understanding in disease management. Materials and Methods: A prospective questionnaire-based study was conducted for a period of twelve months at All India Institute of Medical Sciences, Patna, India. The data of 100 PCOS cases were collected about socio-demographic status, clinical history, and dietary intake. Then, a validated PCOS questionnaire (PCOSQ) was used to observe the impact of PCOS symptoms on patients’ HRQOL. Results: The overall 57% and 48% of PCOS cases belonged to the age range of 20-30 years and had a body mass index (BMI) of >25-30, respectively. Based on the results, a significant difference was observed in the mean score of PCOSQ vs. marital status in PCOS cases with respect to emotion (P=0.039), body weight (P=0.002), and infertility (P=0.001). Furthermore, the result showed a significant difference in the domain of emotion (P=0.008), body hair (P=0.035), body weight (P<0.001), and infertility (P=0.018) among BMI group, and a high score was observed in the BMI group <18 in comparison to the other groups of BMI. Conclusions: In general, our findings indicated that infertility, emotions, and BMI had extremely higher impacts on the HRQOL of women suffering from PCOS although their educational status failed to affect HRQOL.

Download Full-text