scholarly journals Impact of age to ferritin and neutrophil‐lymphocyte ratio as biomarkers for intensive care requirement and mortality risk in COVID‐19 patients in Makassar, Indonesia

2021 ◽  
Vol 9 (10) ◽  
Author(s):  
Haerani Rasyid ◽  
Alvin Sangkereng ◽  
Tutik Harjianti ◽  
Audrey S. Soetjipto
Keyword(s):  
Intensive Care ◽  
Mortality Risk ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Care Requirement

scholarly journals The Effects of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Prognostic Markers in Determining the Mortality in Patients Diagnosed With Pneumonia in Intensive Care

2021 ◽  
Author(s):  
Ömer Faruk Altaş ◽  
Mehmet Kızılkaya
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Mortality Risk ◽  
Demographic Data ◽  
Apache Ii ◽  
Prognostic Scores ◽  
Characteristic Analysis ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Point Increase

Objective: In this study, we aimed to reveal the level of predicting mortality of the Neutrophil/Lymphocyte (NLR) and Platelet/Lymphocyte Ratios (TLR) calculated in patients hospitalized with the diagnosis of pneumonia in the intensive care unit when compared with other prognostic scores. Method: The hospital records of 112 patients who were admitted to the intensive care unit between January 2015 and January 2018 and met the inclusion criteria were retrospectively reviewed. The patients’ demographic data, the NLR and PLR levels, and the APACHE II (Acute Physiology and Chronic Health Evaluation II) and SOFA (Sequential Organ Failure Assessment) scores were calculated from the patient files. Results: Of the 112 patients examined, 70 were males. The risk analysis showed that the male gender had 2.7 times higher risk of mortality. The NLR, PLR, APACHE II, and SOFA values were found statistically significant in predicting mortality (p<0.001). An evaluation of the risk ratios demonstrated that each one point increase in the NLR increased the mortality risk by 5%, and each one point increase in the SOFA score increased the mortality risk by 13% (p<0.05). In the ROC (receiver operating characteristic) analysis, the NLR assessment proved to be the most powerful, most specific, and sensitive test. The cut-off values were 11.3 for the NLR, 227 for the PLR, 29.8 for the APACHE II scores, and 5.5 for the SOFA scores. Conclusion: We believe that NLR and PLR are strong and independent predictors of mortality that can be easily and cost-effectively tested.

scholarly journals Neutrophil-lymphocyte ratio in the early diagnosis of sepsis in an intensive care unit: a case-control study

2019 ◽  
Vol 31 (1) ◽  
Author(s):  
Eduarda Cristina Martins ◽  
Lilian da Fe Silveira ◽  
Karin Viegas ◽  
Andrea Diez Beck ◽  
Geferson Fioravantti Júnior ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Early Diagnosis ◽  
Case Control Study ◽  
Case Control ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Control Study

scholarly journals Is the Neutrophil/Lymphocyte Ratio a Marker of Mortality in ARDS Patients Followed in Pulmonary Intensive Care Unit?

2019 ◽  
Vol 20 (-1) ◽  
pp. 9-9
Author(s):  
Nazli Deniz Atik ◽  
◽  
Esra Bahcivan ◽  
Pervin Korkmaz Ekren ◽  
Funda Elmas Uysal ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio

scholarly journals Neutrophil-Lymphocyte Ratio as a Potential Biomarker for Delirium in the Intensive Care Unit

2021 ◽  
Vol 12 ◽  
Author(s):  
Chai Lee Seo ◽  
Jin Young Park ◽  
Jaesub Park ◽  
Hesun Erin Kim ◽  
Jaehwa Cho ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Early Detection ◽  
Inflammatory Markers ◽  
Inflammatory Marker ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Icu Admission ◽  
Potential Biomarker ◽  
Significant Difference

Background: Recognition and early detection of delirium in the intensive care unit (ICU) is essential to improve ICU outcomes. To date, neutrophil-lymphocyte ratio (NLR), one of inflammatory markers, has been proposed as a potential biomarker for brain disorders related to neuroinflammation. This study aimed to investigate whether NLR could be utilized in early detection of delirium in the ICU.Methods: Of 10,144 patients who admitted to the ICU, 1,112 delirium patients (DE) were included in the current study. To compare among inflammatory markers, NLR, C-reactive protein (CRP), and white blood cell (WBC) counts were obtained: the mean NLR, CRP levels, and WBC counts between the initial day of ICU admission and the day of initial delirium onset within DE were examined. The inflammatory marker of 1,272 non-delirium patients (ND) were also comparatively measured as a supplement. Further comparisons included a subgroup analysis based on delirium subtypes (non-hypoactive vs. hypoactive) or admission types (elective vs. emergent).Results: The NLR and CRP levels in DE increased on the day of delirium onset compared to the initial admission day. ND also showed increased CRP levels on the sixth day (the closest day to average delirium onset day among DE) of ICU admission compared to baseline, while NLR in ND did not show significant difference over time. In further analyses, the CRP level of the non-hypoactive group was more increased than that of the hypoactive group during the delirium onset. NLR, however, was more significantly increased in patients with elective admission than in those with emergent admission.Conclusion: Elevation of NLR was more closely linked to the onset of delirium compared to other inflammatory markers, indicating that NLR may play a role in early detection of delirium.

scholarly journals THE COMPATIBILITY OF NEUTROPHIL TO LYMPHOCYTE COUNT RATIO WITH SERUM PROCALCITONIN AS BACTERIAL INFECTION MARKERS IN SEPSIS PATIENTS

2019 ◽  
Vol 25 (1) ◽  
pp. 58
Author(s):  
Elvinawaty Elvinawaty ◽  
Hanifah Maani ◽  
Zelly Dia Rofinda ◽  
Husni Husni
Keyword(s):  
Intensive Care ◽  
Bacterial Infection ◽  
Lymphocyte Count ◽  
Bacterial Infections ◽  
Statistical Significance ◽  
Clinical Signs ◽  
Public Hospitals ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Kappa Test

Bacterial infections and sepsis remain significant causes of morbidity and mortality in critical cases in Intensive Care Units (ICU) around the world. A quick and accurate diagnosis for sepsis is a challenge for clinicians and laboratory. The problem of an existing marker for sepsis with high sensitivity and specificity is still not satisfactory. Serum procalcitonin test is still widely used but cannot be supported by hospital laboratories especially in the regional public hospitals and needs more cost. Neutrophil-lymphocyte ratio is a potential index, easy, fast and cheap for bacteremia in patients with sepsis. This study aimed to determine the agreement of neutrophil-lymphocyte ratio with serum procalcitonin as a bacterial infection marker in sepsis patients. This study was an observational, analytical study with a cross-sectional design of 30 patients who had been diagnosed as sepsis by clinicians based on clinical signs of sepsis in the Intensive Care Unit of the Dr. M. Djamil Hospital Padang. The study was conducted from February to July 2016. Neutrophil and lymphocyte count was performed by flow cytometry method and procalcitonin test with Enzyme Linked Fluorescent Assay (ELFA). Results were analyzed by Kappa test with a statistical significance if p < 0.05. There were 30 subjects, consisting of 15 females (50%) and 15 males (50%) with the age mean of 48 years. Based on the Kappa test, the value obtained was kappa=0.634 (p=0.001) for the ratio neutrophil lymphocyte with procalcitonin. There was a substantial agreement between ratio neutrophil lymphocyte with procalcitonin test.

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