scholarly journals Estimating the economic impact of the 2014 Ebola virus outbreak in West Africa: an empirical approach

2019 ◽  
Vol 1 (1) ◽  
pp. 1
Author(s):  
Mohamed Jalloh
2021 ◽  
Vol 12 (1) ◽  
Author(s):  
T. R. W. Tipton ◽  
Y. Hall ◽  
J. A. Bore ◽  
A. White ◽  
L. S. Sibley ◽  
...  

AbstractZaireebolavirus (EBOV) is a highly pathogenic filovirus which can result in Ebola virus disease (EVD); a serious medical condition that presents as flu like symptoms but then often leads to more serious or fatal outcomes. The 2013–16 West Africa epidemic saw an unparalleled number of cases. Here we show characterisation and identification of T cell epitopes in surviving patients from Guinea to the EBOV glycoprotein. We perform interferon gamma (IFNγ) ELISpot using a glycoprotein peptide library to identify T cell epitopes and determine the CD4+ or CD8+ T cell component response. Additionally, we generate data on the T cell phenotype and measure polyfunctional cytokine secretion by these antigen specific cells. We show candidate peptides able to elicit a T cell response in EBOV survivors and provide inferred human leukocyte antigen (HLA) allele restriction. This data informs on the long-term T cell response to Ebola virus disease and highlights potentially important immunodominant peptides.


2021 ◽  
Vol 6 (5) ◽  
pp. e004762
Author(s):  
Césaire Ahanhanzo ◽  
Ermel Ameswue Kpogbe Johnson ◽  
Ejemai Amaize Eboreime ◽  
Sombié Issiaka ◽  
Ben Idrissa Traoré ◽  
...  

The world continues to battle the ongoing COVID-19 pandemic. Whereas many countries are currently experiencing the second wave of the outbreak; Africa, despite being the last continent to be affected by the virus, has not experienced as much devastation as other continents. For example, West Africa, with a population of 367 million people, had confirmed 412 178 cases of COVID-19 with 5363 deaths as of 14 March 2021; compared with the USA which had recorded almost 30 million cases and 530 000 deaths, despite having a slightly smaller population (328 million). Several postulations have been made in an attempt to explain this phenomenon. One hypothesis is that African countries have leveraged on experiences from past epidemics to build resilience and response strategies which may be contributing to protecting the continent’s health systems from being overwhelmed. This practice paper from the West African Health Organization presents experience and data from the field on how countries in the region mobilised support to address the pandemic in the first year, leveraging on systems, infrastructure, capacities developed and experiences from the 2014 Ebola virus disease outbreak.


2017 ◽  
Vol 13 ◽  
pp. 67-70 ◽  
Author(s):  
Mahmoud Elmahdawy ◽  
Gihan H. Elsisi ◽  
Joao Carapinha ◽  
Mohamed Lamorde ◽  
Abdulrazaq Habib ◽  
...  

2016 ◽  
Vol 339 (11-12) ◽  
pp. 517-528 ◽  
Author(s):  
Alexandre Hassanin ◽  
Nicolas Nesi ◽  
Julie Marin ◽  
Blaise Kadjo ◽  
Xavier Pourrut ◽  
...  

2016 ◽  
Vol 3 (8) ◽  
pp. 160294 ◽  
Author(s):  
Andrew M. Kramer ◽  
J. Tomlin Pulliam ◽  
Laura W. Alexander ◽  
Andrew W. Park ◽  
Pejman Rohani ◽  
...  

Controlling Ebola outbreaks and planning an effective response to future emerging diseases are enhanced by understanding the role of geography in transmission. Here we show how epidemic expansion may be predicted by evaluating the relative probability of alternative epidemic paths. We compared multiple candidate models to characterize the spatial network over which the 2013–2015 West Africa epidemic of Ebola virus spread and estimate the effects of geographical covariates on transmission during peak spread. The best model was a generalized gravity model where the probability of transmission between locations depended on distance, population density and international border closures between Guinea, Liberia and Sierra Leone and neighbouring countries. This model out-performed alternative models based on diffusive spread, the force of infection, mobility estimated from cell phone records and other hypothesized patterns of spread. These findings highlight the importance of integrated geography to epidemic expansion and may contribute to identifying both the most vulnerable unaffected areas and locations of maximum intervention value.


Author(s):  
Nadege Goumkwa Mafopa ◽  
Gianluca Russo ◽  
Raoul Emeric Guetiya Wadoum ◽  
Emmanuel Iwerima ◽  
Vincent Batwala ◽  
...  

A serosurvey of anti-Ebola Zaire virus nucleoprotein IgG prevalence was carried out among Ebola virus disease survivors and their Community Contacts in Bombali District, Sierra Leone. Our data suggest that the specie of Ebola virus (Zaire) responsible of the 2013-2016 epidemic in West Africa may cause mild or asymptomatic infection in a proportion of cases, possibly due to an efficient immune response.


Author(s):  
M. Xu ◽  
C. X. Cao ◽  
H. F. Guo

Ebola hemorrhagic fever (EHF) is an acute hemorrhagic diseases caused by the Ebola virus, which is highly contagious. This paper aimed to explore the possible gathering area of EHF cases in West Africa in 2014, and identify endemic areas and their tendency by means of time-space analysis. We mapped distribution of EHF incidences and explored statistically significant space, time and space-time disease clusters. We utilized hotspot analysis to find the spatial clustering pattern on the basis of the actual outbreak cases. spatial-temporal cluster analysis is used to analyze the spatial or temporal distribution of agglomeration disease, examine whether its distribution is statistically significant. Local clusters were investigated using Kulldorff’s scan statistic approach. The result reveals that the epidemic mainly gathered in the western part of Africa near north Atlantic with obvious regional distribution. For the current epidemic, we have found areas in high incidence of EVD by means of spatial cluster analysis.


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