scholarly journals Electrochemical method for point-of-care determination of ciprofloxacin using boron-doped diamond electrode

2016 ◽  
Vol 9 (2) ◽  
pp. 146-151 ◽  
Author(s):  
Kristína Cinková ◽  
Dana Andrejčáková ◽  
Ľubomír Švorc
Keyword(s):  
Point Of Care ◽  
Electrode Reaction ◽  
Modulation Amplitude ◽  
Boron Doped Diamond ◽  
Buffer Solution ◽  
Solution Ph ◽  
Diamond Electrode ◽  
Boron Doped ◽  
Boron Doped Diamond Electrode ◽  
Relative Standard

Abstract This paper presents an electrochemical behavior study and quantification of fluoroquinolone antibiotic ciprofloxacin using boron-doped diamond electrode. Ciprofloxacin provides a diffusion-driven electrode reaction with an irreversible and poorly defined peak at +1.6 V vs. Ag/AgCl electrode in the presence of Britton-Robinson buffer solution pH 4. Applying differential pulse voltammetry (modulation amplitude of 60 mV, modulation time of 50 ms), the calibration curve with high linearity (R2 = 0.997) was obtained within the concentration range of (0.74 – 20.0) × 10−6 mol L−1 with the detection limit of 6.0 × 10−7 mol L−1 and repeatability expressed by relative standard deviation of 2.7 % (for 20 measurements). Interference study was performed to explore the selectivity of the elaborated procedure. By analysis of pharmaceutical dosages and model human urine samples, the ciprofloxacin content with the recovery values ranging from 88.4 to 121.2 % were determined. The developed approach using point-of-care electrochemical sensor based on boron-doped diamond material could represent inexpensive analytical alternative to separation methods and could be beneficial in analysis of biological samples and in the quality control in pharmaceutical industry.

Rapid Electroanalytical Method for Determination of Nebivolol at a Boron-Doped Diamond Electrode

2015 ◽  
Vol 98 (6) ◽  
pp. 1535-1541 ◽  
Author(s):  
Biljana Nigović ◽  
Ana Mornar ◽  
Mario Završki
Keyword(s):  
High Speed ◽  
Comparative Method ◽  
Potential Range ◽  
Boron Doped Diamond ◽  
Buffer Solution ◽  
Diamond Electrode ◽  
Boron Doped ◽  
Boron Doped Diamond Electrode ◽  
Electroanalytical Method

Abstract A boron-doped diamond electrode provided a sensitive and cost-effective sensing platform for detection and quantitative determination of novel beta(1)-adrenergic receptor antagonist nebivolol. The net square-wave voltammetric response at 1.31 V related to the oxidation of nebivolol was obtained in Britton-Robinson buffer solution at pH 8. It increased linearly with the drug concentration in the range of 2.5 × 10–7 to 1.5 × 10–5 M. The LOD attained was 3.2 × 10–8 M. The practical analytical approach was illustrated by high speed quantification of nebivolol in a commercial pharmaceutical formulation. The RP-HPLC was selected as a comparative method for evaluating the proposed electroanalytical method. The newly developed method at the unmodified electrode surface was faster and simpler in comparison with HPLC (the retention time was 17.6 min), and only 6 s was necessary for direct voltammetric measurement in the potential range from 0.5 to 1.7 V with a 2 mV potential step and pulse frequency of 100 Hz.

scholarly journals The Use of Boron-Doped Diamond Electrode for the Determination of Selected Biocides in Water Samples

Water ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1595 ◽  
Author(s):  
Mielech-Łukasiewicz ◽  
Starczewska
Keyword(s):  
Water Samples ◽  
Square Wave Voltammetry ◽  
Boron Doped Diamond ◽  
Diamond Electrode ◽  
Boron Doped ◽  
Wave Voltammetry ◽  
Boron Doped Diamond Electrode ◽  
Relative Standard ◽  
Cyclic Voltammetry Method

In recent years, the remains of chemical substances in water environments, referred to as emerging organic contaminations, have been more and more often studied by analysts. This work shows the possibility of using a boron-doped diamond electrode to determine low concentration levels of remains of pharmaceuticals in environmental samples. The study focused on selected biocides from the group of azole fungicides (itraconazole and posaconazole) and was performed using quick and sensitive electrochemical methods. The cyclic voltammetry method was used in order to determine the properties of these compounds, whereas analytical characterization was performed using square wave voltammetry. The work involved the specification of the optimum electrooxidation conditions of the selected fungicides, their comparative characterization, and the development of a new, sensitive methods of itraconazole and posaconazole assay. The proposed procedures allowed us to determine itraconazole in the range from 7.9 × 10−8 to 1.2 × 10−6 moL·L−1 and posaconazole in the range from 5.7 × 10−8 to 8.44 × 10−7 moL·L−1. The relative standard deviation of the measurements did not exceed 5.85%. The developed procedures were successfully used to determine itraconazole and posaconazole concentration in water samples and the assay recovery was between 93.5% and 102.8%.

scholarly journals Highly sensitive determination of α-lipoic acid in pharmaceuticals on a boron-doped diamond electrode

2021 ◽  
Vol 19 (1) ◽  
pp. 843-854
Author(s):  
Agata Skorupa ◽  
Slawomir Michalkiewicz ◽  
Magdalena Jakubczyk
Keyword(s):  
Lipoic Acid ◽  
Pharmaceutical Preparations ◽  
Reference Method ◽  
Boron Doped Diamond ◽  
Buffer Solution ◽  
Diamond Electrode ◽  
Boron Doped ◽  
Boron Doped Diamond Electrode ◽  
Highly Sensitive

Abstract A simple, highly sensitive, and selective differential pulse voltammetry method for the determination of α-lipoic acid (LA) in pharmaceutical preparations was developed and validated. The method is based on a quasi-reversible, diffusion-controlled, one-electron anodic oxidation of LA on a boron-doped diamond electrode (BDDE) in a McIlvaine (citrate-phosphate, C-PB) buffer solution at pH 3.0. For the first time, this environment was used for LA determination. A linear calibration curve was obtained within the concentration range 5.82 × 10−8 to 4.00 × 10−4 mol L−1 with a correlation coefficient of 0.9999. The limits of detection was estimated to be 1.94 × 10−8 mol L−1, which is one of the lowest values characteristic of voltammetric and chromatographic methods of LA determination. The proposed procedure is sensitive, accurate, and precise. Its utility was demonstrated in the determination of LA in pharmaceuticals without the need for its separation from the matrices. The results were comparable to those obtained by high performance liquid chromatography reference method and were in good accordance with the once declared by manufacturers. Thus, our method can be considered as an alternative to the dominant chromatographic determinations of α-LA in real samples.

Simultaneous Square-Wave Voltammetric Determination of Paracetamol, Caffeine and Orphenadrine in Pharmaceutical Formulations Using a Cathodically Pretreated Boron-Doped Diamond Electrode

2013 ◽  
Vol 25 (7) ◽  
pp. 1734-1741 ◽  
Author(s):  
Ana Paula Pires Eisele ◽  
Débora Nóbile Clausen ◽  
César Ricardo Teixeira Tarley ◽  
Luiz Henrique Dall'Antonia ◽  
Elen Romão Sartori
Keyword(s):  
Pharmaceutical Formulations ◽  
Voltammetric Determination ◽  
Boron Doped Diamond ◽  
Square Wave ◽  
Diamond Electrode ◽  
Boron Doped ◽  
Boron Doped Diamond Electrode

Fast and simultaneous determination of nimesulide and paracetamol by batch injection analysis with amperometric detection on bare boron-doped diamond electrode

2013 ◽  
Vol 39 ◽  
pp. 41-46 ◽  
Author(s):  
Polyana Fernandes Pereira ◽  
Mariana Cardoso Marra ◽  
Amanda Barbosa Lima ◽  
Wallans Torres Pio dos Santos ◽  
Rodrigo Alejandro Abarza Munoz ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Amperometric Detection ◽  
Boron Doped Diamond ◽  
Diamond Electrode ◽  
Boron Doped ◽  
Boron Doped Diamond Electrode

scholarly journals A Comparative Analysis of 2-(Thiocyanomethylthio)-Benzothiazole Degradation Using Electro-Fenton and Anodic Oxidation on a Boron-Doped Diamond Electrode

2018 ◽  
Vol 2018 ◽  
pp. 1-9
Author(s):  
Armando Vázquez ◽  
Lucía Alvarado ◽  
Isabel Lázaro ◽  
Roel Cruz ◽  
José Luis Nava ◽  
...  
Keyword(s):  
Anodic Oxidation ◽  
Oxidation Process ◽  
Volumetric Flow Rate ◽  
Boron Doped Diamond ◽  
Aquatic Life ◽  
Diamond Electrode ◽  
Boron Doped ◽  
Boron Doped Diamond Electrode ◽  
Acidic Chloride ◽  
Anodic Oxidation Process

2-(Thiocyanomethylthio)-benzothiazole (TCMTB) is used as fungicide in the paper, tannery, paint, and coatings industries, and its study is important as it is considered toxic to aquatic life. In this study, a comparison of direct anodic oxidation (AO) using a boron-doped diamond electrode (BDD) and electro-Fenton (EF) processes for TCMTB degradation in acidic chloride and sulfate media using a FM01-LC reactor was performed. The results of the electrolysis processes studied in the FM01-LC reactor showed a higher degradation of TCMTB with the anodic oxidation process than with the electro-Fenton process, reaching 81% degradation for the former process versus 47% degradation for the latter process. This difference was attributed to the decrease in H2O2 during the EF process, due to parallel oxidation of chlorides. The degradation rate and current efficiency increased as a function of volumetric flow rate, indicating that convection promotes anodic oxidation and electro-Fenton processes. The results showed that both AO and EF processes could be useful strategies for TCMTB toxicity reduction in wastewaters.

Sign in / Sign up

Export Citation Format

Share Document