scholarly journals Helicobacter Pylori and its Determinations on Gastric Biopsies

2015 ◽  
Vol 61 (4) ◽  
pp. 303-308
Author(s):  
Fülöp Emöke ◽  
Marcu Simona Tünde ◽  
Borda Angela ◽  
Voidăzan Septimiu ◽  
EF Fülöp ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Medical Literature ◽  
Cross Sectional Study ◽  
Premalignant Lesions ◽  
Infection Prevalence ◽  
Gastric Lesions ◽  
Cross Sectional ◽  
Single Region ◽  
Gastric Biopsies

AbstractBackground and Aims. Gastric cancer, because of its aggressive evolution and the high mortality associated with it, remains one of the most debated subjects in medical literature with Helicobacter pylori (HP) as a major risk factor. Chronic inflammation caused by HP infection represents the initial site of the predisposing and afterwards premalignant lesions for gastric carcinoma. The purpose of this study was to evaluate the prevalence of HP infection, of predisposing and premalignant lesions on gastric biopsies, as well as to identify the correlations between them.Material and method. A retrospective cross-sectional study was performed on gastric biopsies collected endoscopically from a single region, antrum or corpus, and from different regions, between January 2012 and July 2014. Incidence of HP infection, of predisposing and premalignant gastric lesions, the correlation of HP infection and these lesions, were evaluated.Results. HP infection was diagnosed in 32.81%. Predisposing and premalignant lesions were present in 53.64% of biopsies with most of them in the antrum. HP infection stands out for the under 50 yo group (p=0.001). No correlation between frequency of HP infection and predisposing and premalignant lesions was observed.Conclusions. Prevalence of HP infection in our study suggests that besides HP infection, other factors are also involved in gastric cancer development. Biopsies from different regions of the gastric mucosa do not offer extra information regarding HP infection prevalence but may be helpful in evaluating incidence and extension of predisposing and premalignant lesions.

scholarly journals Perbedaan Prevalensi Infeksi Helicobacter pylori antara Etnis Tionghoa dan Dayak dengan Sindrom Dispepsia

2017 ◽  
Vol 3 (1) ◽  
pp. 29
Author(s):  
Willy Brodus Uwan ◽  
Ari Fahrial Syam ◽  
C Rinaldi A. Lesmana ◽  
Cleopas Martin Rumende
Keyword(s):  
Helicobacter Pylori ◽  
Cross Sectional Study ◽  
Native People ◽  
Bivariate Analysis ◽  
Infection Prevalence ◽  
Chi Square ◽  
Cross Sectional ◽  
Endoscopic Findings ◽  
H Pylori ◽  
Epidemiological Characteristics

Pendahuluan. Risiko infeksi Helicobacter pylori (H. pylori) dikaitkan dengan banyak faktor yang terkait dengan pejamuagen-lingkungan. Etnis adalah salah satu faktor dari pejamu yang banyak diteliti di luar negeri. Prevalensi infeksi H. pylori didapatkan lebih tinggi pada etnis tertentu seperti misalnya di Cina. Berdasarkan teori migrasi dan teori transmisi, diduga infeksi H. pylori akan dibawa oleh penduduk yang bermigrasi dari daerah dengan prevalensi tinggi ke tempat tujuan migrasi. Etnis Tionghoa di Kalimantan Barat berasal dari daerah Cina Selatan dengan prevalensi infeksi H.pylori tinggi. Diperkirakan ada perbedaan angka prevalensi infeksi H. pylori pada etnis Tionghoa dibandingkan pada etnis asli Kalimantan Barat, yaitu etnis Dayak. Penelitian ini dilakukan untuk mengetahui perbedaan angka prevalensi, karakteristik epidemiologis dan gambaran hasil pemeriksaan endoskopi pada subjek etnis Tionghoa dan Dayak dengan sindrom dispepsia.Metode. Penelitian ini menggunakan studi potong lintang untuk mengetahui perbedaan angka prevalensi infeksi H.pylori. Penelitian dilakukan di RSU Santo Antonius Pontianak dari bulan Desember 2014 sampai Juni 2015 dengan metode pengambilan sampel secara consecutive sampling. Angka prevalensi infeksi H. pylori disajikan dalam angka persentase, sedangkan perbedaan karakteristik epidemiologis dan perbedaan gambaran hasil pemeriksaan endoskopi pada etnis Tionghoa dan Dayak dianalisis dengan analisis bivariat menggunakan chi-square dengan tingkat kemaknaan (p)=0,05.Hasil. Dari 203 subjek yang diteliti, terdiri dari 102 subjek etnis Tionghoa dan 101 subjek etnis Dayak, didapatkan angkaprevalensi H. pylori sebesar 40,8%. Prevalensi pada etnis Tionghoa didapatkan lebih tinggi dibanding etnis Dayak,berturut-turut sebesar 48,0% dan 33,7%. Tidak ditemukan adanya perbedaan karakteristik epidemiologis dan temuan hasil pemeriksaan endoskopi yang bermakna pada kedua kelompok etnis.Simpulan. Terdapat perbedaan angka prevalensi infeksi H. pylori pada etnis Tionghoa (48,0%) dibanding etnis Dayak (33,7%). Namun, tidak ada perbedaan karakteristik epidemiologis dan gambaran hasil pemeriksaan endoskopi pada kedua kelompok etnis tersebut.Kata kunci: Dayak, etnis, Helicobacter pylori, sindrom dispepsia, Tionghoa The Difference in Prevalence of Helicobacter pylori Infection between Chinese and Dayak Ethnics with Dyspepsia SyndromeIntroduction. Helicobacter pylori (H. pylori) infection risk is associated with many factors related to host-agent-environment. Ethnicity is one of the host factors which was the most studied factor overseas. The prevalence of H. pylori infection was found higher in certain ethnic such among Chinese. Based on migration and transmission theory, it was suspected that H. pylori infection was transmitted by people migrating from areas with a high prevalence of infection to the destination area. Chinese in West Borneo are originated from South China region where the prevalence of H. pylori infection is high. It is estimated that there are differences in the prevalence of H. pylori infection among Chinese compared to the native people of West Borneo, the Dayaknese. Methods. This was a cross-sectional study to determine the differences in the prevalence of H. pylori infection. The study was conducted at St. Antonius General Hospital Pontianak from December 2014 to June 2015 with consecutive samplingmethod. H. pylori infection prevalence is presented in percentage numbers, while the epidemiological characteristics and endoscopic finding differences among Chinese and Dayaknese were analyzed by bivariate analysis using the chi-square with significance value (p) = 0.05.Results. From a total of 203 subjects in this study, consisted of 102 Chinese subjects and 101 Dayaknese subjects, the prevalence of H. pylori infection was 40.8%. The prevalence among Chinese is higher than Dayaknese, which is 48.0% and 33.7%, respectively. There is no difference in the epidemiological characteristics and endoscopic findings in both ethnic groups.Conclusions. The prevalence of H. pylori infection among the Chinese (48.0%) is higher than among Dayaknese (33.7%). There is no difference in the epidemiological characteristics and endoscopic findings among both ethnic groups.Keywords: Chinese, Dayak, Dyspeptic syndrome, Ethnic, Helicobacter pylori

scholarly journals GENDER, AGE, ENDOSCOPIC FINDINGS, UREASE AND HELICOBACTER PYLORI: ALL UNCORRELATED WITHIN A SAMPLE OF A HIGH GASTRIC CANCER PREVALENCE POPULATION IN AMAZON

2019 ◽  
Vol 56 (3) ◽  
pp. 264-269
Author(s):  
Ariney Costa de MIRANDA ◽  
Cássio CALDATO ◽  
Mira Nabil SAID ◽  
Caio de Souza LEVY ◽  
Claudio Eduardo Corrêa TEIXEIRA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Cross Sectional Study ◽  
Upper Gastrointestinal Endoscopy ◽  
Histopathological Analysis ◽  
Rapid Urease Test ◽  
Cross Sectional ◽  
Cancer Prevalence ◽  
Urease Test ◽  
H Pylori

ABSTRACT BACKGROUND: It is widely assumed that gender, age, gastritis and Helicobacter pylori , all have some degree of correlation and, therefore, can synergistically lead to the development of gastric cancer. OBJECTIVE: In this cross-sectional study, we expected to observe the above mentioned correlation in the analysis of medical records of 67 patients of both sexes (female, n=44), mean age ± standard deviation: 41±12 years old, all from Belém (capital of Pará State, Brazilian Amazon), a city historically known as one with the highest gastric cancer prevalence in this country. METHODS: All patients were submitted to upper gastrointestinal endoscopy for gastric biopsy histopathological analysis and rapid urease test. All diagnoses of gastritis were recorded considering its topography, category and the degree of inflammatory activity, being associated or not associated with H. pylori infection. RESULTS: The results show that no statistically relevant associations were found among the prevalences of the observed variables. CONCLUSION: The authors hypothesize that observed risk factors associated to gastric cancer might be lesser synergistic than is usually expected.

scholarly journals RELATIONSHIP BETWEEN ESOPHAGITIS GRADES AND HELICOBACTER PYLORI

2016 ◽  
Vol 29 (3) ◽  
pp. 135-137 ◽  
Author(s):  
Patrícia Fernanda Saboya RIBEIRO ◽  
Luiz Fernandao KUBRUSLY ◽  
Paulo Afonso Nunes NASSIF ◽  
Irma Cláudia Saboya RIBEIRO ◽  
Andressa de Souza BERTOLDI ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Type A ◽  
Cross Sectional Study ◽  
Endoscopic Examination ◽  
Type B ◽  
Gastric Lesions ◽  
Sectional Study ◽  
Cross Sectional ◽  
Urease Test ◽  
Significant Difference

ABSTRACT Background: The Helicobacter pylori infection (HP) is related to the development of gastric lesions and lymphoma; however, it is not known if there is a relation with gastroesophageal reflux disease and reflux esophagitis. Aim: To evaluate HP's relationship with esophagitis in patients undergoing upper endoscopy. Methods: Observational, retrospective and cross-sectional study, being evaluated 9576 patients undergoing outpatient endoscopic examination during the period between January and December 2015. Were included patients with any esophageal alteration at the examination; greater than 18; of both genders; independent of the complaint or the reason for the examination, illness or drug use. Were excluded those with active bleeding during the examination and in use of anticoagulants. The variables gender, age, esophagitis and result of the urease test, were studied. For statistical analysis was used the Epi Info software 7.1.5.2. Results: Most of the samples consisted of women and the overall average age was 46.54±16.32 years. The presence of infection was balanced for gender: 1204 (12.56%) women and 952 (13.92%) men. Relating degree of esophagitis HP- and HP+ was observed that the type A was the most common (58.79%, n=1460); 604 (24.32%) had grade B; 334 (13.45%) grade C, and 85 (3.42%) grade D. In the relation between the grade of esophagitis with gender, esophagitis A was predominant in women and present in 929 (63.33%), followed by type B, 282 (46.68%), 136 C (40.71%) and D 30 (35.29%). In men 531 (36.36%) showed type A, 322 (53.31%) B, 198 (59.28%) C, and 55 (64.70%) D. Among the groups 40-50 and over 60 years there was a significant difference in whether have or not have HP+. Conclusion: There is no significant difference between HP infection and the different grades of esophagitis.

scholarly journals A Decrease of Histone Deacetylase 6 Expression Caused by Helicobacter Pylori Infection is Associated with Oncogenic Transformation in Gastric Cancer

2017 ◽  
Vol 42 (4) ◽  
pp. 1326-1335 ◽  
Author(s):  
Qing He ◽  
Guoqiang Li ◽  
Xin Wang ◽  
Shubin Wang ◽  
Jiang Hu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Histone Deacetylase ◽  
Cell Lines ◽  
Western Blotting ◽  
Cox Regression ◽  
Premalignant Lesions ◽  
Gastric Lesions ◽  
Histone Deacetylase 6 ◽  
Oncogenic Transformation

Background: Histone deacetylase 6 (HDAC6) plays a role in the progression of many tumors. However, the relationship between the level of HDAC6 expression and gastric tumorigenesis is still unclear. Here, we illustrate the potential correlation between Helicobacter pylori (HP) infection and the variation of HDAC6 expression in different gastric lesions, as well as the clinical significance of HDAC6 expression in gastric cancer (GC) patients. Materials and Methods: Between 2011 and 2016, 364 patients with different types of gastric lesions were enrolled in Baotou City Central Hospital. Immunostaining of HDAC6 expression and HP infection were performed in the following cohort including 21 normal tissues (Normal); 40 samples with chronic superficial gastritis (CSG); 106 with chronic atrophic gastritis (CAG); 94 with intestinal metaplasia (IM); 64 with dysplasia (DYS) and 39 with gastric cancer (GC). Survival analysis was performed in another 80 GC patients using the Kaplan-Meier method and multivariate Cox regression analyses. The level of HDAC6 expression was determined by Real-time PCR, Western blotting and IHC staining in gastric cell lines and tissues. Furthermore, the correlation between HDAC6 expression and clinicopathological features and prognosis was analyzed in the GC cohort. HP strains were lavaged into Kunming mice to investigate the effects of HP infection on the expression of different HDAC members in this mouse model. Results: Higher levels of HDAC6 expression were detected in normal and premalignant lesions than in the GC tissues (p<0.01), and decreased HDAC6 expression was associated with HP infection and TNM stage (p<0.01 and p=0.048, respectively). Multivariate analysis revealed that HDAC6 expression was an independent predictor of the outcome of GC patients (p=0.04). HP mediated HDAC6 expression in the cell lines and KM mice. HP infection could promote HDAC1 and HDAC4 expression as determined by Western blotting. Conclusions: HDAC6 is a promising biomarker for early diagnosis and prognosis during the oncogenic transformation of gastric cancer.

4725 Preneoplastic gastric lesions in a population with high incidence of gastric cancer: a cross-sectional study.

2000 ◽  
Vol 51 (4) ◽  
pp. AB214 ◽  
Author(s):  
Gianluca Bersani ◽  
Giorgio Ricci ◽  
Angelo Rossi ◽  
Gianfranco DeFabritiis ◽  
Francesco Santilli ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cross Sectional Study ◽  
Gastric Lesions ◽  
Sectional Study ◽  
Cross Sectional ◽  
High Incidence

scholarly journals Association between VEGF-2578 C>A Polymorphism with Gastric Premalignant Lesion in Gastritis with Helicobacter

2021 ◽  
Vol 8 (8) ◽  
pp. 13-18
Author(s):  
Mario Eka Paskah Sinulingga ◽  
Gontar Alamsyah Siregar ◽  
Ilhamd .
Keyword(s):  
Gastric Cancer ◽  
Chronic Atrophic Gastritis ◽  
Epidemiological Studies ◽  
Cross Sectional Study ◽  
Endoscopic Examination ◽  
Premalignant Lesions ◽  
Cross Sectional ◽  
Common Causes ◽  
H Pylori ◽  
Histopathological Studies

Introduction: Gastric cancer is one of the most common causes of cancer-related deaths worldwide. Many epidemiological studies have shown several risk factors associated with the development of gastric cancer, including gastritis. The most common cause of gastritis is H. pylori infection. In the H.pylori-infected mucosa, there was a significant increase in VEGF levels. Several SNPs are thought to be involved in the etiology of malignancy, one of which is the VEGF-2578C>A polymorphism. Methods: A cross sectional study was conducted in Medan with 59 H. Pylori gastritis patients. Endoscopic examination was performed to assess the gastric mucosa. H.pylori status was determined by examination of Urea breath Test (UBT) and Campylobacter Like Organism (CLO) test followed by histopathological studies evaluating the presence of changes to pre-malignant lesions such as chronic atrophic gastritis, intestinal metaplasia, intestinal dysplasia. Genotype analysis was carried out using Polymerase Chain Reaction (RT-PCR). Data analysis was carried out by univariate and bivariate Result: Of the 59 patients with H. pylori gastritis, 35.8% of patients showed premalignant lesions. The majority of premalignant lesions had a CC genotype (37.9%, n = 11), but there was no significant relationship between the VEGF-2578 C>A polymorphism and the incidence of gastric premalignant lesions. Conclusion: Based on this study, the VEGF -2578C>A polymorphism was not associated with gastric premalignant lesions in H. pylori gastritis patients.. Keywords: Polymorphism VEGF, VEGF -2578C>A, Premalignant lesions, H. Pylori.

Sign in / Sign up

Export Citation Format

Share Document