scholarly journals Association between VEGF-2578 C>A Polymorphism with Gastric Premalignant Lesion in Gastritis with Helicobacter

2021 ◽  
Vol 8 (8) ◽  
pp. 13-18
Author(s):  
Mario Eka Paskah Sinulingga ◽  
Gontar Alamsyah Siregar ◽  
Ilhamd .
Keyword(s):  
Gastric Cancer ◽  
Chronic Atrophic Gastritis ◽  
Epidemiological Studies ◽  
Cross Sectional Study ◽  
Endoscopic Examination ◽  
Premalignant Lesions ◽  
Cross Sectional ◽  
Common Causes ◽  
H Pylori ◽  
Histopathological Studies

Introduction: Gastric cancer is one of the most common causes of cancer-related deaths worldwide. Many epidemiological studies have shown several risk factors associated with the development of gastric cancer, including gastritis. The most common cause of gastritis is H. pylori infection. In the H.pylori-infected mucosa, there was a significant increase in VEGF levels. Several SNPs are thought to be involved in the etiology of malignancy, one of which is the VEGF-2578C>A polymorphism. Methods: A cross sectional study was conducted in Medan with 59 H. Pylori gastritis patients. Endoscopic examination was performed to assess the gastric mucosa. H.pylori status was determined by examination of Urea breath Test (UBT) and Campylobacter Like Organism (CLO) test followed by histopathological studies evaluating the presence of changes to pre-malignant lesions such as chronic atrophic gastritis, intestinal metaplasia, intestinal dysplasia. Genotype analysis was carried out using Polymerase Chain Reaction (RT-PCR). Data analysis was carried out by univariate and bivariate Result: Of the 59 patients with H. pylori gastritis, 35.8% of patients showed premalignant lesions. The majority of premalignant lesions had a CC genotype (37.9%, n = 11), but there was no significant relationship between the VEGF-2578 C>A polymorphism and the incidence of gastric premalignant lesions. Conclusion: Based on this study, the VEGF -2578C>A polymorphism was not associated with gastric premalignant lesions in H. pylori gastritis patients.. Keywords: Polymorphism VEGF, VEGF -2578C>A, Premalignant lesions, H. Pylori.

scholarly journals GENDER, AGE, ENDOSCOPIC FINDINGS, UREASE AND HELICOBACTER PYLORI: ALL UNCORRELATED WITHIN A SAMPLE OF A HIGH GASTRIC CANCER PREVALENCE POPULATION IN AMAZON

2019 ◽  
Vol 56 (3) ◽  
pp. 264-269
Author(s):  
Ariney Costa de MIRANDA ◽  
Cássio CALDATO ◽  
Mira Nabil SAID ◽  
Caio de Souza LEVY ◽  
Claudio Eduardo Corrêa TEIXEIRA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Cross Sectional Study ◽  
Upper Gastrointestinal Endoscopy ◽  
Histopathological Analysis ◽  
Rapid Urease Test ◽  
Cross Sectional ◽  
Cancer Prevalence ◽  
Urease Test ◽  
H Pylori

ABSTRACT BACKGROUND: It is widely assumed that gender, age, gastritis and Helicobacter pylori , all have some degree of correlation and, therefore, can synergistically lead to the development of gastric cancer. OBJECTIVE: In this cross-sectional study, we expected to observe the above mentioned correlation in the analysis of medical records of 67 patients of both sexes (female, n=44), mean age ± standard deviation: 41±12 years old, all from Belém (capital of Pará State, Brazilian Amazon), a city historically known as one with the highest gastric cancer prevalence in this country. METHODS: All patients were submitted to upper gastrointestinal endoscopy for gastric biopsy histopathological analysis and rapid urease test. All diagnoses of gastritis were recorded considering its topography, category and the degree of inflammatory activity, being associated or not associated with H. pylori infection. RESULTS: The results show that no statistically relevant associations were found among the prevalences of the observed variables. CONCLUSION: The authors hypothesize that observed risk factors associated to gastric cancer might be lesser synergistic than is usually expected.

scholarly journals Helicobacter Pylori and its Determinations on Gastric Biopsies

2015 ◽  
Vol 61 (4) ◽  
pp. 303-308
Author(s):  
Fülöp Emöke ◽  
Marcu Simona Tünde ◽  
Borda Angela ◽  
Voidăzan Septimiu ◽  
EF Fülöp ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Medical Literature ◽  
Cross Sectional Study ◽  
Premalignant Lesions ◽  
Infection Prevalence ◽  
Gastric Lesions ◽  
Cross Sectional ◽  
Single Region ◽  
Gastric Biopsies

AbstractBackground and Aims. Gastric cancer, because of its aggressive evolution and the high mortality associated with it, remains one of the most debated subjects in medical literature with Helicobacter pylori (HP) as a major risk factor. Chronic inflammation caused by HP infection represents the initial site of the predisposing and afterwards premalignant lesions for gastric carcinoma. The purpose of this study was to evaluate the prevalence of HP infection, of predisposing and premalignant lesions on gastric biopsies, as well as to identify the correlations between them.Material and method. A retrospective cross-sectional study was performed on gastric biopsies collected endoscopically from a single region, antrum or corpus, and from different regions, between January 2012 and July 2014. Incidence of HP infection, of predisposing and premalignant gastric lesions, the correlation of HP infection and these lesions, were evaluated.Results. HP infection was diagnosed in 32.81%. Predisposing and premalignant lesions were present in 53.64% of biopsies with most of them in the antrum. HP infection stands out for the under 50 yo group (p=0.001). No correlation between frequency of HP infection and predisposing and premalignant lesions was observed.Conclusions. Prevalence of HP infection in our study suggests that besides HP infection, other factors are also involved in gastric cancer development. Biopsies from different regions of the gastric mucosa do not offer extra information regarding HP infection prevalence but may be helpful in evaluating incidence and extension of predisposing and premalignant lesions.

scholarly journals Association between VEGF -2578 C> A Polymorphism with VEGF Serum Levels in Gastritis with Helicobacter Pylori

2021 ◽  
Vol 8 (8) ◽  
pp. 171-175
Author(s):  
Tara Rizvira Monica ◽  
Gontar Alamsyah Siregar ◽  
Taufik Sungkar
Keyword(s):  
Serum Levels ◽  
Mucosal Damage ◽  
Cross Sectional Study ◽  
Endoscopic Examination ◽  
Chain Reaction ◽  
Cross Sectional ◽  
Excess Production ◽  
Polymerase Chain ◽  
H Pylori ◽  
The Relationship

Mucosal damage in people with gastritis causes the production of VEGF. VEGF is a neoangiogenesis function to repair damaged tissue. Excess production can cause cancer risk. VEGF genotype polymorphisms are thought to affect the production of serum VEGF levels. The aim of this study was to determine the relationship between VEGF - 2578 C> A polymorphism and serum VEGF levels in H. pylori gastritis. Method: cross-sectional study was conducted at H. Adam Malik General Hospital and Network Hospital with 100 samples. Endoscopic examination was performed to assess the gastric mucosa and a tissue biopsy was performed. The urea breath test (UBT) test and the Campylobacter like organism (CLO) test to determine H. pylori infection. VEGF - 2578 C> A was checked by Polymerase Chain Reaction (PCR). The data will be analyzed by univariate and bivariate. Result: One hundred people with gastritis, of which 59 people were infected with H. pylori. In this study, H. pylori infection did not have a significant relationship with VEGF levels. VEGF - 2578 C> A polymorphisms also had no relationship to serum VEGF levels. Conclusion: There is no correlation between VEGF - 2578 C> A polymorphism with VEGF serum levels (p> 0.05). Keywords: VEGF polymorphisms, VEGF - 2578 CA, H. pylori, Gastritis.

scholarly journals Prevalence of Helicobacter pylori and Its Associated Factors among Healthy Asymptomatic Residents in the United Arab Emirates

Pathogens ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 44 ◽  
Author(s):  
Ghalia Khoder ◽  
Jibran Muhammad ◽  
Ibrahim Mahmoud ◽  
Sameh Soliman ◽  
Christophe Burucoa
Keyword(s):  
Helicobacter Pylori ◽  
United Arab Emirates ◽  
Epidemiological Studies ◽  
Cross Sectional Study ◽  
Sample Collection ◽  
Cross Sectional ◽  
Prevalence Studies ◽  
Stool Antigen Test ◽  
H Pylori ◽  
Associated Risk Factors

The United Arab Emirates (UAE) has been under continuous populational influences from Asia, Europe, and Africa, making it an ideal site for epidemiological studies on Helicobacter pylori. However, there has been a paucity of well-designed prevalence studies on H. pylori from UAE. The aim of this study was to determine the prevalence of H. pylori and its associated risk factors in the UAE. A prospective cross-sectional study was conducted on healthy asymptomatic residents of UAE. Socio-demographic, lifestyle, and gastrointestinal characteristics of participants were obtained through a questionnaire in parallel within the stool sample collection. A total of 350 participants were included in this study and were tested for H. pylori using the stool antigen test (Premier Platinum HpSAT). Out of the total tested study participants, 41% were found to be H. pylori-infected. Logistic regression analysis has shown a significant association between H. pylori infection and gender, age, ethnicity, profession, domestic overcrowding, source of drinking water, and gastrointestinal characteristics of participants. Based on the results from this study, we suggest that preventive measures against H. pylori infection should be considered worthy by public health authorities.

scholarly journals Prevalence and determinants of serological evidence of atrophic gastritis among Arab and Jewish residents of Jerusalem: a cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. e024689 ◽  
Author(s):  
Khitam Muhsen ◽  
Ronit Sinnreich ◽  
Dafna Merom ◽  
Gany Beer-Davidson ◽  
Hisham Nassar ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Atrophic Gastritis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Serological Evidence ◽  
Cross Sectional ◽  
Serum Pepsinogens ◽  
Gastric Cancer Prevention ◽  
Cytotoxin Associated Gene A ◽  
H Pylori

ObjectiveUnderstanding the correlates of premalignant gastric lesions is essential for gastric cancer prevention. We examined the prevalence and correlates of serological evidence of atrophic gastritis, a premalignant gastric condition, using serum pepsinogens (PGs) in two populations with differing trends in gastric cancer incidence.MethodsIn a cross-sectional study, using ELISA we measured serum PGI and PGII concentrations (Biohit, Finland),Helicobacter pyloriserum IgG and cytotoxin-associated gene A (CagA) antigen IgG antibodies in archived sera of 692 Jews and 952 Arabs aged 25–78 years, randomly selected from Israel’s population registry in age–sex and population strata. Multivariable logistic regression analyses were performed.ResultsUsing cut-offs of PGI <30µg/L  or PGI:PGII <3.0, the prevalence of atrophic gastritis was higher among Arab than Jewish participants: 8.8% (95% CIs 7.2% to 10.8%) vs 5.9% (95% CI 4.4% to 7.9%), increasing with age in both groups (p<0.001 for trend). Among Jewish participants, infection withH. pyloriCagA phenotype was positively related to atrophic gastritis: adjusted OR (aOR) 2.16 (95% CI 0.94 to 4.97), but not to non-CagA infections aOR 1.17 (95% CI 0.53 to 2.55). The opposite was found among Arabs: aOR 0.09 (95% CI 0.03 to 0.24) for CagA positive and aOR 0.15 (95% CI 0.06 to 0.41) for Cag A negative phenotypes (p<0.001 for interaction). Women had a higher atrophic gastritis prevalence than men. Obesity and smoking were not significantly related to atrophic gastritis; physical activity tended to be inversely associated in Arabs (p=0.08 for interaction).ConclusionsThe prevalence of atrophic gastritis was higher among Arabs than Jews and was differently associated with the CagA phenotype.

scholarly journals What Predicts Peptic Ulcer in Patients Referred for Endoscopy?

2019 ◽  
Vol 1 (1) ◽  
pp. 1-8
Author(s):  
Omran Habib ◽  
Rifka Abdul-Wahab
Keyword(s):  
Peptic Ulcer ◽  
Clinical Manifestations ◽  
Diagnostic Techniques ◽  
Cross Sectional Study ◽  
Endoscopic Examination ◽  
Peptic Ulcers ◽  
Gastric Lesions ◽  
Information Sheet ◽  
Cross Sectional ◽  
H Pylori

Background: Peptic ulcers and other gastric lesions are significant medical conditions. Endoscopy is one useful diagnostic tool, the use of which is dependent on patient selection. Objectives: This study attempts to explore how predictive selected symptoms may be, along with their characteristics in diagnosing peptic ulcers and other gastric lesions in patients undergoing endoscopy. Methods: A cross-sectional study was conducted with 152 patients referred to the endoscopic unit at Al-Sadr teaching hospital in Basrah. The patients were carefully interviewed to determine clinical and sociodemographic characteristics. They were subjected to endoscopic examination by a specialist physician, and their results were recorded on the same information sheet. Data were analyzed using the Statistical Package for Social Science, version 20. Results: Given the complexity of the risk factors, clinical manifestations and diagnostic techniques, it seems difficult to predict which patients are likely to have peptic ulcers and which are not. In this study, only self-reported stress and H pylori infection were found to significantly predict the likelihood of peptic ulcers among patients subjected to endoscopic examination. Conclusions: Patients subjected to endoscopy are expected to have a variety of gastric lesions, including peptic ulcer. A substantial proportion of these patients were entirely lesion free. Key words: Prediction, peptic ulcer, Basrah, endoscopy

scholarly journals Correlation Between Endoscopic and Histological Findings of Dyspeptic Patients and their Association with Helicobacter Pylori Infection

2019 ◽  
Vol 13 (2) ◽  
pp. 11-17
Author(s):  
Saifa Kismat ◽  
Nusrat Noor Tanni ◽  
Rokshana Akhtar ◽  
Chandan Kumar Roy ◽  
Mohammad Mosiur Rahman ◽  
...  
Keyword(s):  
Duodenal Ulcer ◽  
Cross Sectional Study ◽  
Endoscopic Examination ◽  
Case Definition ◽  
Histological Findings ◽  
Cross Sectional ◽  
Total Study Population ◽  
Study Population ◽  
Bangladeshi Population ◽  
H Pylori

There is a high prevalence of H. pylori infection in Bangladeshi population that causes site specific diseases which includes gastritis, gastric ulcer, duodenal ulcer and gastric carcinoma. The Cross sectional study was carried out in the Department of Microbiology and immunology, Bangabandhu Medical University (BSMMU), during the period of September, 2018 to July, 2019. Dyspeptic patients, who underwent endoscopic examination at the Department of Gastroenterology of Dhaka medical College and Hospital, who fulfilled the inclusion criteria were enrolled as study population. Collected gastric and duodenal biopsy specimens from 142 patients were categorized as H. pylori positive cases (34.5%) and H. pylori negative cases (35.2%) based on the case definition used in the study by RUT, Histology and ureC gene PCR. All of the laboratory works were performed at Department of Microbiology and Immunology except Histology which was performed at the Department of Pathology of BSMMU. Endoscopic findings significantly co-related with histological findings (p = 0.001). Highest rate of H. pylori infection was found in 76% of duodenal ulcer cases and lowest in Adenocarcinoma group being only 9% of total study population. H. pylori infection was positively associated with duodenal ulcer cases (p=0.014) and negatively with adeno carcinoma cases (p=0.002) in a statistically significant manner. Bangladesh J Med Microbiol 2019; 13 (2): 11-17

scholarly journals Helicobacter pylori Prevalence and Risk Factors in Three Rural Indigenous Communities of Northern Arizona

2022 ◽  
Vol 19 (2) ◽  
pp. 797
Author(s):  
Robin B. Harris ◽  
Heidi E. Brown ◽  
Rachelle L. Begay ◽  
Priscilla R. Sanderson ◽  
Carmenlita Chief ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Indigenous Communities ◽  
The United States ◽  
Cross Sectional Study ◽  
Navajo Nation ◽  
Cross Sectional ◽  
Northern Arizona ◽  
Barriers To Screening ◽  
H Pylori

Helicobacter pylori (H. pylori) is one of the most common bacterial stomach infections and is implicated in a majority of non-cardia gastric cancer. While gastric cancer has decreased in the United States (US), the incidence in the Navajo Nation is nearly four times higher than surrounding Non-Hispanic White populations. Little is known about H. pylori prevalence in this population or other Indigenous communities in the lower 48 states. In this cross-sectional study, 101 adults representing 73 households from three Navajo Nation chapter communities completed surveys and a urea breath test for active H. pylori. Accounting for intrahousehold correlation, H. pylori prevalence was 56.4% (95% CI, 45.4–66.8) and 72% of households had at least one infected person. The odds of having an active infection in households using unregulated water were 8.85 (95% CI, 1.50–53.38) that of the use of regulated water, and males had 3.26 (95% CI, 1.05–10.07) higher odds than female. The prevalence of H. pylori in Navajo is similar to that seen in Alaska Natives. Further investigation into factors associated with prevention of infection is needed as well as understanding barriers to screening and treatment.

scholarly journals Trend of Mortality Rate Due To Traffic Accidents In Iran From 2006 to 2018

2021 ◽  
Author(s):  
Saeed Erfanpoor ◽  
Jalil Hasani ◽  
Seyed Davood Mirtorabi ◽  
Reza Haj Manouchehri ◽  
Seyed Saeed Hashemi Nazari
Keyword(s):  
Mortality Rate ◽  
Traffic Accidents ◽  
Negative Binomial ◽  
Negative Binomial Regression ◽  
Epidemiological Studies ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Factors Affecting ◽  
Common Causes ◽  
Causes Of Mortality

Abstract Background: Traffic accidents are one of the most common causes of mortality and physical disabilities, endangering the lives of many people all over the world annually and are among the top public health problems worldwide. In the present study, we aimed to investigate the trend of mortality rate due to traffic accidents in the provinces of Iran.Methods: In this cross-sectional study, all the deaths caused by traffic accidents in Iran during 2006-2018 were investigated. Using the population of the country by age, sex, and provinces of the country, the mortality rate was calculated and the trend of 13-year changes was studied. The negative binomial regression was used to analyze the linear or nonlinear trend of reduction in mortality rate during the study years. Microsoft Excel 2016 and Stata version 14 software were used to analyze the data.Results: During the study period, 259995 traffic accidents deaths occurred in Iran, of which 78.6% were men and 21.4% were women. The mean age of the deceased was 37.6 ± 20.7 years (37.4 ± 20 years in men and 38.6 ± 23 years in women). The number of the deaths in these years has decreased from 27,567 in 2006 to 17,183 in 2018 and the mortality rate has dropped from 39 per 100,000 in 2006 to 21 per 100,000 in 2018.Conclusion: Despite the decreasing trend in the mortality rate of traffic accidents in Iran during the study years, this trend was different across the provinces. Therefore, it seems necessary to design epidemiological studies to be conducted in different area and provinces of a country, to better and more accurately determine the factors affecting the occurrence of these deaths.

scholarly journals Association of Helicobacter pylori infection with gastric carcinoma

2009 ◽  
Vol 35 (1) ◽  
pp. 7-10 ◽  
Author(s):  
M.A. Majid ◽  
T.I.M.A. Faruq ◽  
A.B.M. Bayezid Hossain
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Cross Sectional Study ◽  
Body Region ◽  
Upper Gastrointestinal Endoscopy ◽  
Rapid Urease Test ◽  
Cross Sectional ◽  
Urease Test ◽  
H Pylori ◽  
Upper Gastrointestinal

This is a cross-sectional study on 140 gastric neoplasm subjects diagnosed by upper gastrointestinal endoscopy. The commonest site of cancer was the antrum of stomach (52.86%), followed by the antrum and body (32.86%) and only body region (12.14%). Histology revealed adenocarcinoma in all patients. The associations of Helicobacter pylori with gastric cancer were studied by rapid urease test, serology and histology by Giemsa stain. The positivity of H. pylori determined by serology in 70 patients (50%) was significantly higher than those determined by histology 22 patients (15.71%). No significant association between H. pylori infection and gastric cancer was observed.Keywords: Gastric cancer; Helicobacter pylori; InfectionOnline: 20 May 2009DOI: 10.3329/bmrcb.v35i1.2315Bangladesh Med Res Counc Bull 2009; 35: 7-10

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