Promising approaches in using magnetic nanoparticles in oncology

Abstract The development of new and effective drug delivery systems for cancer treatment represents one of the significant challenges facing biomedical technology in the last decade. Among the different methods of drug delivery, magnetic drug targeting, by enabling specific delivery of chemotherapeutic agents through the use of magnetic nanoparticles and magnetic field gradient, could be a promising approach. Recently, magnetic nanoparticles have attracted additional attention because of their potential as contrast agents for magnetic resonance imaging and heat mediators for cancer therapy. This review summarizes these approaches in the use of magnetic nanoparticles in biomedical applications and novel methods for their optimization.

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Recent Advances in Synthesis and Biomedical Applications of Magnetic Nanoparticles

Biomedical Engineering ◽

10.4018/978-1-5225-3158-6.ch060 ◽

2018 ◽

pp. 1424-1447

Author(s):

Irshad Ahmad Wani

Keyword(s):

Magnetic Resonance Imaging ◽

Drug Delivery ◽

Magnetic Nanoparticles ◽

Magnetic Resonance ◽

Biomedical Applications ◽

Resonance Imaging ◽

Recent Advances ◽

Biomedical Field ◽

Magnetic Resonance Imaging Mri

Magnetic nanoparticles due to their unique magnetic phenomenon, are gaining immense interest due to the utilization of these properties for a wide variety of applications in various arena especially in biomedical field. This book chapter, therefore, summarizes the synthesis of various types of magnetic nanoparticles using different approaches depending of their ability to generate either single core of multcore magnetic nanoparticles. The various biomedical applications of magnetic nanoparticles like Magnetic Resonance Imaging (MRI), drug delivery etc. along with possible limitations and challenges for their extended applications in medicine are also discussed.

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Magnetogels: Prospects and Main Challenges in Biomedical Applications

Pharmaceutics ◽

10.3390/pharmaceutics10030145 ◽

2018 ◽

Vol 10 (3) ◽

pp. 145 ◽

Cited By ~ 8

Author(s):

Sérgio Veloso ◽

Paula Ferreira ◽

J. Martins ◽

Paulo Coutinho ◽

Elisabete Castanheira

Keyword(s):

Magnetic Field ◽

Drug Delivery ◽

Magnetic Nanoparticles ◽

Biomedical Applications ◽

Magnetic Field Gradient ◽

Resonance Imaging ◽

Conventional Chemotherapy ◽

Future Goals ◽

Promising Application ◽

New Generation

Drug delivery nanosystems have been thriving in recent years as a promising application in therapeutics, seeking to solve the lack of specificity of conventional chemotherapy targeting and add further features such as enhanced magnetic resonance imaging, biosensing and hyperthermia. The combination of magnetic nanoparticles and hydrogels introduces a new generation of nanosystems, the magnetogels, which combine the advantages of both nanomaterials, apart from showing interesting properties unobtainable when both systems are separated. The presence of magnetic nanoparticles allows the control and targeting of the nanosystem to a specific location by an externally applied magnetic field gradient. Moreover, the application of an alternating magnetic field (AMF) not only allows therapy through hyperthermia, but also enhances drug delivery and chemotherapeutic desired effects, which combined with the hydrogel specificity, confer a high therapeutic efficiency. Therefore, the present review summarizes the magnetogels properties and critically discusses their current and recent biomedical applications, apart from an outlook on future goals and perspectives.

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Recent Advances in Synthesis and Biomedical Applications of Magnetic Nanoparticles

Advancing Medicine through Nanotechnology and Nanomechanics Applications - Advances in Medical Technologies and Clinical Practice ◽

10.4018/978-1-5225-1043-7.ch010 ◽

2017 ◽

pp. 219-249

Author(s):

Irshad Ahmad Wani

Keyword(s):

Magnetic Resonance Imaging ◽

Drug Delivery ◽

Magnetic Nanoparticles ◽

Magnetic Resonance ◽

Biomedical Applications ◽

Resonance Imaging ◽

Recent Advances ◽

Biomedical Field ◽

Magnetic Resonance Imaging Mri

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Magnetic Resonance Imaging of Polymeric Drug Delivery Systems in Breast Cancer Solid Tumors

10.21236/ada439254 ◽

2005 ◽

Author(s):

Bahar Zarabi ◽

Hamid Ghandehari

Keyword(s):

Breast Cancer ◽

Magnetic Resonance Imaging ◽

Drug Delivery ◽

Magnetic Resonance ◽

Solid Tumors ◽

Drug Delivery Systems ◽

Resonance Imaging ◽

Polymeric Drug Delivery ◽

Polymeric Drug ◽

Polymeric Drug Delivery Systems

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New advances on Au–magnetic organic hybrid core–shells in MRI, CT imaging, and drug delivery

RSC Advances ◽

10.1039/d1ra00415h ◽

2021 ◽

Vol 11 (12) ◽

pp. 6517-6525

Author(s):

Fatemeh Mohajer ◽

Ghodsi Mohammadi Ziarani ◽

Alireza Badiei

Keyword(s):

Magnetic Resonance Imaging ◽

Drug Delivery ◽

Magnetic Nanoparticles ◽

Targeted Drug Delivery ◽

Magnetic Storage ◽

Resonance Imaging ◽

Organic Hybrid ◽

Storage Media ◽

Targeted Drug ◽

Magnetic Storage Media

Magnetic nanoparticles have been studied for scientific and technological applications such as magnetic storage media, contrast agents for magnetic resonance imaging, biolabelling, separation of biomolecules, and magnetic-targeted drug delivery.

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Doxorubicin-modified magnetic nanoparticles as a drug delivery system for magnetic resonance imaging-monitoring magnet-enhancing tumor chemotherapy

International Journal of Nanomedicine ◽

10.2147/ijn.s94139 ◽

2016 ◽

pp. 2021 ◽

Cited By ~ 7

Author(s):

Win-Li Lin ◽

Po-Chin Liang ◽

Yung-Chu Chen ◽

Chi-Feng Chiang ◽

Lein-Ray Mo ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Drug Delivery ◽

Magnetic Nanoparticles ◽

Magnetic Resonance ◽

Drug Delivery System ◽

Delivery System ◽

Resonance Imaging ◽

Modified Magnetic Nanoparticles

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Implication of Magnetic Nanoparticles in Cancer Detection, Screening and Treatment

Magnetochemistry ◽

10.3390/magnetochemistry5040055 ◽

2019 ◽

Vol 5 (4) ◽

pp. 55 ◽

Cited By ~ 13

Author(s):

Hosu ◽

Tertis ◽

Cristea

Keyword(s):

Magnetic Resonance Imaging ◽

Drug Delivery ◽

Magnetic Nanoparticles ◽

Magnetic Resonance ◽

Cancer Detection ◽

Imaging Technique ◽

Antineoplastic Drugs ◽

Resonance Imaging ◽

Sensing Systems

During the last few decades, magnetic nanoparticles have been evaluated as promising materials in the field of cancer detection, screening, and treatment. Early diagnosis and screening of cancer may be achieved using magnetic nanoparticles either within the magnetic resonance imaging technique and/or sensing systems. These sensors are designed to selectively detect specific biomarkers, compounds that can be related to the onset or evolution of cancer, during and after the treatment of this widespread disease. Some of the particular properties of magnetic nanoparticles are extensively exploited in cancer therapy as drug delivery agents to selectively target the envisaged location by tailored in vivo manipulation using an external magnetic field. Furthermore, individualized treatment with antineoplastic drugs may be combined with magnetic resonance imaging to achieve an efficient therapy. This review summarizes the studies about the implications of magnetic nanoparticles in cancer diagnosis, treatment and drug delivery as well as prospects for future development and challenges of magnetic nanoparticles in the field of oncology.

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