scholarly journals Treatment of SEC62 over-expressing tumors by Thapsigargin and Trifluoperazine

2018 ◽  
Vol 9 (1) ◽  
pp. 53-63 ◽  
Author(s):  
Christina Körbel ◽  
Maximilian Linxweiler ◽  
Florian Bochen ◽  
Silke Wemmert ◽  
Bernhard Schick ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Therapeutic Strategy ◽  
The Novel ◽  
Calmodulin Antagonist ◽  
New Approach ◽  
Over Expression ◽  
Fadu Cells ◽  
Novel Concept ◽  
The Impact ◽  
Combinatorial Treatment

AbstractTreatment with analogues of the SERCA-inhibitor Thapsigargin is a promising new approach for a wide variety of cancer entities. However, our previous studies on various tumor cells suggested resistance of SEC62 over-expressing tumors to this treatment. Therefore, we proposed the novel concept that e.g. lung-, prostate-, and thyroid-cancer patients should be tested for SEC62 over-expression, and developed a novel therapeutic strategy for a combinatorial treatment of SEC62 over-expressing tumors. The latter was based on the observations that treatment of SEC62 over-expressing tumor cells with SEC62-targeting siRNAs showed less resistance to Thapsigargin as well as a reduction in migratory potential and that the siRNA effects can be mimicked by the Calmodulin antagonist Trifluoperazine. Therefore, the combinatorial treatment of SEC62 over-expressing tumors was proposed to involve Thapsigargin and Trifluoperazine. Here, we addressed the impact of Thapsigargin and Trifluoperazine in separate and combined treatments of heterotopic tumors, induced by inoculation of human hypopharyngeal squamous cell carcinoma (FaDu)-cells into the mouse flank. Seeding of the tumor cells and/or their growth rate were significantly reduced by all three treatments, suggesting Trifluoperazine is a small molecule to be considered for future therapeutic strategies for patients, suffering from Sec62-overproducing tumors.

scholarly journals Measuring and Tracking Externalized Work to Support Industrialized Construction

2016 ◽  
Author(s):  
Perry Daneshgari ◽  
Heather Moore ◽  
Hisham Said
Keyword(s):  
Tacit Knowledge ◽  
Performance Outcomes ◽  
The Novel ◽  
Construction Operations ◽  
Planning And Control ◽  
Expected Performance ◽  
Control Framework ◽  
Novel Concept ◽  
And Control ◽  
The Impact

The same principles that have made other skilled-trade-based industries more efficient are being deployed in construction through Industrialization, which requires understanding skilled trade work and segregating/externalizing the work from the jobsite. The construction industry still relies heavily on skilled trades and their tacit knowledge, while most of the information available at the points of installation is not passed on. A significant increase of work externalization requires a measuring and tracking method that can: 1) tap into this tacit knowledge as the basis for work planning and control; and 2) understand, quantify, and minimize the manipulation effort done onsite for the prefabricated assemblies. As such, this paper presents a planning and control framework for industrialized construction operations that integrates information entropy and the novel concept of work manipulations to monitor and measure the expected performance outcomes, in a more sophisticated approach beyond measuring äóìhoursäó� and äóìquantitiesäó� of the work. The development of the proposed framework is based on the analysis of a set of case studies that illustrate the impact of information predictability manipulation strategies on construction prefabrication decisions.

scholarly journals Design of an Innovative Test Rig for Industrial Bearing Monitoring with Self-Balancing Layout

Machines ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 54
Author(s):  
Eugenio Brusa ◽  
Cristiana Delprete ◽  
Lorenzo Giorio ◽  
Luigi Gianpio Di Maggio ◽  
Vittorio Zanella
Keyword(s):  
Industrial Applications ◽  
The Novel ◽  
Axial Loads ◽  
Test Rig ◽  
System Failures ◽  
Novel Concept ◽  
Time Required ◽  
The Impact ◽  
Bearing Monitoring

The remote prognosis and diagnosis of bearings can prevent industrial system failures, but the availability of realistic experimental data, being as close as possible to those detected in industrial applications, is essential to validate the monitoring algorithms. In this paper, an innovative bearing test rig architecture is presented, based on the novel concept of “self-contained box”. The monitoring activity is applicable to a set of four middle-sized bearings simultaneously, while undergoing the independent application of radial and axial loads in order to simulate the behavior of the real industrial machinery. The impact of actions on the platform and supports is mitigated by the so-called “self-contained box” layout, leading to self-balancing of actions within the rotor system. Moreover, the high modularity of this innovative layout allows installing various sized bearings, just changing mechanical adapters. This leads to a reduction of cost as well as of system down-time required to change bearings. The test rig is equipped with suitable instrumentation to develop effective procedures and tools for in- and out-monitoring of the system. An initial characterization of the healthy system is presented.

scholarly journals Plithogenic Cognitive Maps in Decision Making

2020 ◽  
pp. 09-21
Author(s):  
Nivetha .. ◽  
◽  
◽  
Florentin Smarandache
Keyword(s):  
Decision Making ◽  
Research Work ◽  
Cognitive Maps ◽  
Connection Matrix ◽  
The Novel ◽  
New Approach ◽  
Fuzzy Matrix ◽  
Resultant Vector ◽  
Novel Concept ◽  
New Research

Plithogenic sets introduced by Smarandache (2018) have disclosed new research vistas and this paper introduces the novel concept of plithogenic cognitive maps (PCM) and its applications in decision making. The new approach of defining instantaneous state neutrosophic vector with the confinement of indeterminacy to (0,1] is proposed to quantify the degree of indeterminacy. The resultant vector is obtained by applying instantaneous state vector through the connection matrix together with plithogenic operators comprising the contradiction degrees. The connection matrix is represented as fuzzy matrix and neutrosophic matrix and the resultant vector is determined by applying plithogenic fuzzy operators and plithogenic neutrosophic operators respectively. The obtained results are highly feasible in making the decision as it incorporates the contradiction degree of the conceptual nodes with respect to the dominant node. This research work will certainly pave the way for developing new approaches in decision making using PCM.

scholarly journals A novel approach to assess radial distribution system for optimal sizing of microgrid

2020 ◽  
Vol 17 (3) ◽  
pp. 1618
Author(s):  
Shalaka Chaphekar ◽  
Anjali A. Dharme
Keyword(s):  
Distributed Generation ◽  
Radial Distribution ◽  
Distribution System ◽  
The Novel ◽  
Radial Distribution System ◽  
Novel Approach ◽  
Penetration Ratio ◽  
Daily Energy ◽  
Novel Concept ◽  
The Impact

<p>The performance of Radial Distribution System (RDS) is enhanced by maintaining the appropriate Penetration Ratio (PR) of Distributed generation.  However, it has been observed that Penetration Ratio cannot be useful to analyze the impact of a Microgrid on performance of RDS. Hence a new index ‘Relief Factor’ (RF) is defined in this paper and the impact of Microgrid at different RF is studied. This paper presents an approach to compute daily energy losses variation when Microgrids of varying RF are connected to RDS having different maximum demands.  A methodology has been proposed for finding optimal RF and location of Microgrid.  In addition, the impact of maximum demand of RDS on optimum RF is analyzed. This paper gives the novel concept of assessing the RDS for integration of Microgrid based on maximum demand of RDS as well as Microgrid and sizing of Microgrid based on optimum Relief Factor.</p>

scholarly journals The Switch between Protective and Nonprotective Autophagy; Implications for Autophagy Inhibition as a Therapeutic Strategy in Cancer

Biology ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 12
Author(s):  
David A. Gewirtz
Keyword(s):  
Tumor Cells ◽  
Therapeutic Strategy ◽  
Response To Therapy ◽  
Treatment Modalities ◽  
System Response ◽  
Metabolic Intermediates ◽  
Response To Chemotherapy ◽  
Radiation Induced ◽  
The Impact ◽  
Autophagy Inhibition

Autophagy, a process of cellular self-degradation and cell survival whereby the cell generates energy and metabolic intermediates under conditions of stress (i.e., nutrient deprivation), is also commonly induced in tumor cells in response to chemotherapy and radiation. While chemotherapy-induced autophagy and radiation-induced autophagy are generally considered to have cytoprotective functions, thereby reducing tumor cell sensitivity (and potentially conferring resistance) to various treatment modalities, autophagy can also be nonprotective; furthermore, the nature of the autophagy can be altered via the “autophagic switch” depending on such factors as the p53 status of the tumor cells. Defective or compromised autophagy has also been associated with neurodegenerative diseases, raising concerns as to the impact of autophagy inhibition on normal tissue function. Furthermore, the impact of autophagy inhibition on the immune system response to therapy as well as the influence of autophagy inhibition in combination with chemotherapy or radiation on critical tissue sites such as the bone marrow remain uncertain. These are factors requiring serious consideration within the context of current clinical efforts to exploit autophagy inhibition as a therapeutic strategy in cancer.

scholarly journals Improving Energy Efficiency by Utilizing Wetted Cellulose Pads in Passive Cooling Systems

Energies ◽  
2022 ◽  
Vol 15 (1) ◽  
pp. 369
Author(s):  
Ebrahim Morady ◽  
Madjid Soltani ◽  
Farshad Moradi Kashkooli ◽  
Masoud Ziabasharhagh ◽  
Armughan Al-Haq ◽  
...  
Keyword(s):  
Passive Cooling ◽  
The Novel ◽  
Airflow Velocity ◽  
Cross Sectional ◽  
Cooling Systems ◽  
Good Potential ◽  
Novel Concept ◽  
Passive Cooling Systems ◽  
The Impact ◽  
Psychrometric Chart

The effectiveness of using wetted cellulose pads on improving the performance of two conventional passive cooling systems has been evaluated. First, an experimental design was developed to determine the impact of using a wetted cellulose pad on the temperature and velocity of the airflow. A cellulose pad (7090 model) with a cross-sectional area of 0.5 × 0.5 m2 and three different thicknesses of 10, 15, and 30 cm were selected and tested. The results indicated that using wetted cellulose pads with thicknesses ranging from 10–30 cm decreased the outlet airflow temperature from 11.3 to 13.7 °C on average. For free airflow at velocity 3.5 m/s, the outlet airflow velocity from the wetted cellulose pad decreased to 0.9, 0.7 and 0.6 m/s, respectively, for cellulose pads with thicknesses of 10, 15, and 30 cm. By applying experimental results on a psychrometric chart, the humidity ratio of outlet airflow was obtained between 40–70%. The study established airflow velocity as the critical parameter in passive cooling systems. With the novel concept of combining wetted cellulose pads for passive cooling systems (i.e., wind catchers and induced ventilation), there is good potential to reduce the energy requirements for thermal comfort in buildings in regions with a hot and arid climate.

scholarly journals Irinotecan/scFv co-loaded liposomes coaction on tumor cells and CAFs for enhanced colorectal cancer therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Zhaohuan Li ◽  
Chunxi Liu ◽  
Chenglei Li ◽  
Fangqing Wang ◽  
Jianhao Liu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Cells ◽  
Tumor Invasion ◽  
Antitumor Effect ◽  
The Novel ◽  
Cell Models ◽  
New Approach ◽  
Metastasis Model

Abstract Background Cancer-associated fibroblasts (CAFs), as an important component of stroma, not only supply the “soils” to promote tumor invasion and metastasis, but also form a physical barrier to hinder the penetration of therapeutic agents. Based on this, the combinational strategy that action on both tumor cells and CAFs simultaneously would be a promising approach for improving the antitumor effect. Results In this study, the novel multifunctional liposomes (IRI-RGD/R9-sLip) were designed, which integrated the advantages including IRI and scFv co-loading, different targets, RGD mediated active targeting, R9 promoting cell efficient permeation and lysosomal escape. As expected, IRI-RGD/R9-sLip showed enhanced cytotoxicity in different cell models, effectively increased the accumulation in tumor sites, as well as exhibited deep permeation ability both in vitro and in vivo. Notably, IRI-RGD/R9-sLip not only exhibited superior in vivo anti-tumor effect in both CAFs-free and CAFs-abundant bearing mice models, but also presented excellent anti-metastasis efficiency in lung metastasis model. Conclusion In a word, the novel combinational strategy by coaction on both “seeds” and “soils” of the tumor provides a new approach for cancer therapy, and the prepared liposomes could efficiently improve the antitumor effect with promising clinical application prospects. Graphical Abstract

Experimental study of thermohydraulic characteristics and irreversibility analysis of novel axial corrugated tube with spring tape inserts

2020 ◽  
Vol 92 (3) ◽  
pp. 30901
Author(s):  
Suvanjan Bhattacharyya ◽  
Debraj Sarkar ◽  
Ulavathi Shettar Mahabaleshwar ◽  
Manoj K. Soni ◽  
M. Mohanraj
Keyword(s):  
Heat Transfer ◽  
Experimental Study ◽  
Thermal Performance ◽  
Working Fluid ◽  
The Novel ◽  
Heat Exchanger Tube ◽  
Heat Transfer Augmentation ◽  
Corrugated Tube ◽  
The Impact ◽  
Exchanger Tube

The current study experimentally investigates the heat transfer augmentation on the novel axial corrugated heat exchanger tube in which the spring tape is introduced. Air (Pr = 0.707) is used as a working fluid. In order to augment the thermohydraulic performance, a corrugated tube with inserts is offered. The experimental study is further extended by varying the important parameters like spring ratio (y = 1.5, 2.0, 2.5) and Reynolds number (Re = 10 000–52 000). The angular pitch between the two neighboring corrugations and the angle of the corrugation is kept constant through the experiments at β = 1200 and α = 600 respectively, while two different corrugations heights (h) are analyzed. While increasing the corrugation height and decreasing the spring ratio, the impact of the swirling effect improves the thermal performance of the system. The maximum thermal performance is obtained when the corrugation height is h = 0.2 and spring ratio y = 1.5. Eventually, correlations for predicting friction factor (f) and Nusselt number (Nu) are developed.

The impact of HER2 phenotype of circulating tumor cells in metastatic breast cancer: a study in 107 patients

2014 ◽  
Vol 74 (S 01) ◽  
Author(s):  
M Wallwiener ◽  
AD Hartkopf ◽  
S Riethdorf ◽  
J Nees ◽  
FA Taran ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Metastatic Breast ◽  
The Impact

Wacana Kolonial dalam Novel Max Havelaar: Sebuah Kajian Poskolonial

Metahumaniora ◽  
2017 ◽  
Vol 7 (3) ◽  
pp. 411
Author(s):  
Abu Bakar Ramadhan Muhamad
Keyword(s):  
Point Of View ◽  
The Other ◽  
The Novel ◽  
Colonial Discourse ◽  
The Impact ◽  
The Voice

AbstrakHegemoni kolonialisme dalam budaya poskolonial merupakan alasan penelitian inikemudian mengkaji wacana kolonial dalam novel Max Havellar (MH) khususnya dampakditimbulkannya. Dampak dimaksud adalah posisi keberpihakan pemikiran tersirat darikarya tersebut. Hasil pembahasan menunjukkan, secara temporal maupun permanen MHmenyuarakan ketidakadilan dalam kondisi-kondisi kolonial menyangkut penindasan sangpenjajah terhadap terjajah. Hanya saja, upaya mengatasnamakan atau mewakili suarakaum terjajah terbukti mengimplikasikan ciri ideologis statis kerangka kolonialisme(orientalisme); yakni cara pandang Eropasentris, di mana “Barat” sebagai self adalah superior,dan “Timur” sebagai other adalah inferior. Dalam konteks poskolonialisme, MH dengan sifatkritisnya yang berupaya “menyuarakan” nasib pribumi terjajah, justru menampilkan stigmapenguatan kolonialitas itu sendiri secara hegemonik. Artinya, “menyuarakan” nasib pribumidimaknai sebagai keberpihankan kolonial yang kontradiktif, di mana stigma penguatankolonialitas justru lebih terasa, ujung-ujungnya melanggengkan hegemoni kolonial. Tidakmembela yang terjajah, tetapi memperhalus cara kerja mesin kolonial.AbstractThe hegemony of colonialism in the culture of postcolonial society is the reason this studythen examines the colonial discourse in the novel Max Havellar (MH) in particular the impactit brings. The impact in question is the implied position of thought in the work. The resultsof the discussion show that, temporarily or permanently, MH voiced injustice in the colonialconditions regarding the oppression of the colonist against the colonized. However, the effort toname or represent the voice of the colonized has proven to imply a static ideological characterin the framework of colonialism (orientalism); ie Eropacentric point of view, in which “West” asself is superior, and “East” as the other is the inferior. In the context of postcolonialism, MH withits critical nature that seeks to “voice” the fate of the colonized natives, actually presents thestigma of strengthening coloniality itself hegemonicly. That is, “voicing” the fate of the pribumiis interpreted as a contradictory colonial flare, where the stigma of strengthening colonialityis more pronounced, which ultimately perpetuates the hegemony of colonialism. No longerdefending the colonized, but refining the workings of the colonial machinery.

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