Antioxidants in patients with hyperthyroidism

2004 ◽  
Vol 42 (2) ◽  
Author(s):  
Ljiljana Mayer ◽  
Željko Romic ◽  
Franjo Škreb ◽  
Vesna Bačic-Vrća ◽  
Ivana Čepelak ◽  
...  
Keyword(s):  
Total Antioxidant Status ◽  
Serum Urate ◽  
Control Group ◽  
Oxygen Utilization ◽  
Sod Activity ◽  
Study Results ◽  
Total Antioxidant ◽  
Group A ◽  
Patient Groups ◽  
Group B

AbstractHyperthyroidism is a hypermetabolic state accompanied by increased oxygen utilization, increased production of reactive oxygen species and consequentially measurable changes in antioxidative factors. Therefore, the activities of whole blood glutathione peroxidase (GPx) and erythrocyte superoxide dismutase (SOD), total antioxidant status (TAS) in serum and erythrocytes, and serum urate and transferrrin concentrations were determined in 70 women: 14 with newly diagnosed Graves' disease (group A); 28 with hyperthyroidism on therapy with methimazole (group B, divided into two subgroups, B1 and B2) and 28 healthy women (group C).In comparison with control group C, GPx activity was significantly decreased in all patient groups (p<0.05), whereas SOD activity was significantly decreased in group A (p<0.01) and significantly increased in group B (p<0.01). In comparison with the control group, serum TAS activity was significantly decreased in group A, and erythrocyte TAS activity in all patient groups.Study results suggest that the impaired antioxidative factor balance leads to the development and presence of oxidative stress in women with hyperthyroidism. The severity of these alterations, considered contradictory by some authors, appears to depend on the use of therapy.

PEG-SOD improves postischemic functional recovery and antioxidant status in blood-perfused rabbit hearts

1992 ◽  
Vol 263 (4) ◽  
pp. H1243-H1249
Author(s):  
Y. Qiu ◽  
M. Galinanes ◽  
R. Ferrari ◽  
A. Cargnoni ◽  
A. Ezrin ◽  
...  
Keyword(s):  
Redox State ◽  
Additive Group ◽  
Rabbit Heart ◽  
Left Ventricular ◽  
Control Group ◽  
Sod Activity ◽  
Group A ◽  
Group B ◽  
Developed Pressure ◽  
Postischemic Recovery

The isolated blood-perfused rabbit heart, subjected to 60 min of cardioplegic arrest and 60 min of reperfusion, was used to assess the effects of polyethylene glycol-conjugated superoxide dismutase (PEG-SOD) on postischemic recovery of left ventricular developed pressure (LVDP), the tissue activity of SOD, and tissue redox state. The five groups studied were the following: PEG-SOD-free control (group A), PEG-SOD as a pretreatment and as an additive during cardioplegia and reperfusion (group B), PEG-SOD as a pretreatment and a cardioplegic additive (group C), PEG-SOD in cardioplegia alone (group D), and PEG-SOD in reperfusion alone (group E). The results show that pretreatment with PEG-SOD improves postischemic recovery of LVDP (72 +/- 2% and 66 +/- 7 vs. 47 +/- 4% in groups B, C, and A, respectively). This protection was associated with an improved tissue redox state. Thus the ischemia-induced rise in oxidized glutathione was reduced from 313 +/- 26% (group A) to 162 +/- 15 and 138 +/- 14% (groups B and C, respectively), and the fall in reduced glutathione was attenuated from 51 +/- 5% to 35 +/- 6 and 13 +/- 5%, respectively. Tissue Mn-SOD activity was also conserved from 36 +/- 4% (group A) to 71 +/- 6 and 94 +/- 4% (groups B and C, respectively). No significant effect was seen when PEG-SOD was applied in cardioplegia or during reperfusion alone.

scholarly journals Per-operative Advantages of Transanal Endorectal Pull Through (TERPT) Over Swenson’s Procedure in the Surgical Treatment of Rectosigmoid Hirschsprung’s Disease (HD)

1970 ◽  
pp. 16-20
Author(s):  
Abu Saleh Md Waliullah ◽  
Shoheli Alam ◽  
MA Aziz ◽  
AR Khan
Keyword(s):  
Blood Loss ◽  
Transfusion Requirement ◽  
Control Group ◽  
Operative Duration ◽  
Transfusion Requirements ◽  
Study Results ◽  
Group A ◽  
Pull Through ◽  
Group B ◽  
A Prospective Study

Introduction: Popular Swenson's pull through (1948) is still the most commonly practiced 'Gold Standard' of operative treatment for rectosigmoid hirschsprung's disease (HD). But minimally invasive transanal endorectal pull through (TERPT) is now being increasingly practiced worldwide for its treatment in many centers. Here we are describing our comparative experience between TERPT and Swenson's pull through, at Dhaka Shishu Hospital to show the per-operative advantages of the former over the latter. Materials and methods: It is a prospective study at Dhaka Shishu Hospital during January 2000 to December 2001 in 32 (age, body weight and resected Rectosigmoid length matched) biopsy confirmed patients of HD divided into two Groups: Gr. A (na = 16) and Gr. B (nb = 16) patients who underwent TERPT and Swenson's pull through respectively. Unpaired 't' and χ2 (with Yate's correction) tests were used for statistical analysis whereas operative duration, volume of blood loss and transfusion requirements were used as parameters of the study. Results: For study Group A (TERPT) - operative time, volume of blood loss and transfusion requirement were significantly lesser (P < 0.01, P < 0.001 and P < 0.001 respectively) than the control Group B (Swenson's procedure). Conclusions: Through this small comparative study, TERPT was found to be more advantageous than the Swenson's pull through procedure in terms of operative duration, blood loss and transfusion requirement. Key words: TERPT; Swenson's; Compare. DOI: 10.3329/bjch.v31i1.6068 Bangladesh Journal of Child Health 2007; Vol.31(1-3): 12-15

The Role of Dialysis Membranes on Intradialytic Selenium Removal and on Selenium Status in Patients Receiving Renal Replacement Therapy

2015 ◽  
Vol 41 (1-3) ◽  
pp. 94-99 ◽  
Author(s):  
Macroui Sonikian ◽  
Artemisia Dona ◽  
Jacob Skarakis ◽  
Sophia Trompouki ◽  
Theodora Miha ◽  
...  
Keyword(s):  
Control Group ◽  
Separate Analysis ◽  
Dialysis Session ◽  
Polysulfone Membrane ◽  
Ethylene Vinyl Alcohol ◽  
Before And After ◽  
Selenium Removal ◽  
Group A ◽  
Patient Groups ◽  
Group B

Background/Aims: Dialysis membrane has been implicated in selenium (Se) deficiency in hemodialysis (HD). Intradialytic Se removal into dialysate through different membranes was investigated. Methods: We studied 19 patients on standard HD with low-flux polysulfone membrane (group A), 10 patients on standard HD with ethylene vinyl alcohol membrane (group B), 12 patients on hemodiafiltration (HDF; group C) and 16 healthy subjects (control group D). Se was measured in blood before and after dialysis session and in effluent dialysate every hour during session. Results: In all patients together, pre-dialysis serum Se levels were lower than those in control group, but, in a separate analysis, only in standard HD. In all patient groups, there was a net Se removal into dialysate but it was greater in HDF patients who, however, had similar pre-dialysis serum Se levels to those in healthy controls. Conclusion: An intradialytic Se loss was found with all 3 membrane types, but it is not the principal factor for Se depletion in HD.

scholarly journals AB0314 SEMAPHORIN 3A LEVELS IN LUPUS WITH AND WITHOUT SECONDARY ANTIPHOSPHOLIPID ANTIBODY SYNDROME AND RENAL INVOLVEMENT

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1182.2-1182
Author(s):  
G. S. Kart-Bayram ◽  
D. Bayram ◽  
A. Erden ◽  
S. C. Güven ◽  
B. Özdemir ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Renal Involvement ◽  
Control Group ◽  
Antiphospholipid Antibody ◽  
Antiphospholipid Antibody Syndrome ◽  
Single Group ◽  
Group A ◽  
Patient Groups ◽  
Group B ◽  
And Control

Background:In this study, we aimed to evaluate sema3A levels in SLE patients with and without renal involvementor secondary antiphospholipid antibody syndrome (APS), to further elucidate the contribution ofsema3A in etiopathogenesis these conditionsObjectives:Aim of this study is to evaluate sema3A levels in systemic lupus erythematosus patients (SLE) with and without renal involvement and secondary antiphospholipid antibody syndrome (APS).Methods:SLE patients were grouped according to presence of secondary APS or renal involvement. The control group consisted of age-matched, non-smoker, healthy volunteers. Sema3A levels were compared among groups. All SLE patients were regrouped according to presence of thrombotic events, miscarriages and proteinuria and sema3A levels were investigated. Finally, sema3A levels of all SLE patients as a single group were compared to controls.Results:The mean sema3A values were 16.16±2.84 ng/dL in the control group, 11.28±5.23 ng/dL in SLE patients without nephritis and APS, 9.05±5.65 ng/dL in SLE with APS group, and 8.53±5.11 ng/dL in lupus nephritis group. When all three patient groups were examined as a single group, mean sema3A value was significantly lower than that of the control group. Sema3A was reduced in SLE patients with thromboembolism and/or miscarriage.Conclusion:Sema3A levels were lower in all patient groups compared to the control group. Moreover, the reduced sema3A levels in patients with a history of thromboembolism and/or miscarriage suggests that sema3A may play an important role in the pathogenesis of vasculopathyTable 1.Comparison of sema3A levels between SLE patient groups and control subjectsPatient groupspGroup A (N=20)Group B (N=20)Group C (N=19)Control (N=19)Sema3A, ng/dL, mean ± SD9.05 ± 5.6511.28 ± 5.238.53 ± 5.1116.16 ± 2.84Group A vscontrol<0.001Group B vscontrol<0.001Group C vscontrol<0.001Group A vs B = 0.203Group A vs C = 0.766Group B vs C = 0.106<0.001All patients (N=59)Control (N=19)9.64 ± 5.3816.16 ± 2.84Patients with thrombotic events and/or miscarriages (N=31)Patients without thrombotic events and/or miscarriages (N=48)0.0329.96 ± 5.1112.33 ± 5.84<0.001Patients with proteinuria and/or thrombotic events and/or miscarriages (N=45)Patients without proteinuria and/or thrombotic events and/or miscarriages (N=34)9.05 ± 5.0914.91± 4.50Disclosure of Interests:None declared

scholarly journals Mesodermal Dysmorphogenesis of Ginsenosides: An Experimental Study

2019 ◽  
Vol 1 (1) ◽  
pp. 25-29
Author(s):  
Uzma Daud ◽  
Qasim Muneer ◽  
Javeria Noor ◽  
Fahad Raza ◽  
Sarah Khalid
Keyword(s):  
Control Group ◽  
High Dose ◽  
Lateral Plate Mesoderm ◽  
Active Components ◽  
Lateral Plate ◽  
Over The Counter ◽  
Study Results ◽  
Group A ◽  
Group B ◽  
Derivatives Of

Background: The versatile and dynamic activities of Panax Ginseng are attributed to its active components. They are readily available over the counter and are known for their effects as an aphrodisiac & health building; in addition, they are given rather generously during pregnancy, as they are considered virtuous for the baby and mother. Despite its easy availability and excess usage, little is known about its effects on the fetus. The current experimental design was focused towards the lack of differentiation and inhibition of cell growth of mesodermal derivatives inflicted by PanaxGingex. Methods:18 pregnant albino dams were randomly divided into three groups; Group A was control, Group B was Low dose and Group C was labeled as High dose groups. Tissues (bone, kidney and blood) were selected as derivatives of paraxial, intermediate and lateral plate mesoderm respectively and were used for light microscopic study. Results and Conclusion: The light microscopic examination demonstrated extensive apoptosis and an escalation of angiogenesis. Both the histological findings were not only statistically significant but was clearly indicative of dysmorphogenesis. The results of present study raise a finger towards the unsupervised practice of over the counter preparations especially during the vital antenatal period of development.

scholarly journals Effects of steroid growth promoter on morphological and biochemical adaptations in liver of broiler

2020 ◽  
Vol 13 (11) ◽  
pp. 2330-2337
Author(s):  
Nasrin Sultana ◽  
Marzia Afrose ◽  
Kazi Rafiq
Keyword(s):  
Biochemical Parameters ◽  
Control Group ◽  
Growth Promoter ◽  
Study Results ◽  
Commercial Broiler ◽  
Group A ◽  
Liver Morphology ◽  
Biochemical Analyses ◽  
Group B ◽  
The Individual

Aim: The study was conducted to observe the effects of dexamethasone (DEX) on the gross study and histomorphometry of liver and on the alterations of biochemical parameters of broilers. Materials and Methods: Ninety day-old chicks were collected and assigned to one of three groups: The control, Group A, and Group B. The control, Group A, and Group B were fed for 28 days with a homemade ration, a commercial broiler type ration, and a homemade ration with DEX (7 mg/kg feed), respectively. Liver samples were collected from the individual birds after sacrificing on days 7, 14, 21, and 28 of the experiment. Morphometric characteristics (length, weight, color, and texture) of the liver were examined. Histomorphological alterations of the liver were assessed with routine hematoxylin and eosin staining. To measure the biochemical parameters, blood samples were collected on days 7, 14, 21, and 28 of the experiment. Liver function test was performed spectrophotometrically by analyzing serum biochemical markers, that is, alanine aminotransferase (ALT), aspartate aminotransferase, and alkaline phosphatase (ALP). Thin-layer chromatography (TLC) was performed for the detection of hepatic steroids. Results: Hemorrhagic and congested livers were found in broilers of Group B. There were no significant changes found in weight and length of the livers; only numerical decrease in weight and length was observed in birds of Group B. Liver width was increased in Group B on day 21. Histological observation of livers showed accumulation of lipid droplets, congestion of the sinusoids, and central veins in broilers of Group B. Biochemical analyses showed increased levels of ALT in Group B as compared to Group A on day 14 of the experiment. TLC evaluation revealed a positive result in Group B on 28 days of the experiment. Conclusion: The present study results show that DEX may alter the liver morphology and the concentration of ALT in the circulation of broilers.

scholarly journals Effects of Sub-Lethal Doses of Selenium Nanoparticles on the Health Status of Rats

Toxics ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 28
Author(s):  
Lenka Urbankova ◽  
Sylvie Skalickova ◽  
Magdalena Pribilova ◽  
Andrea Ridoskova ◽  
Pavlina Pelcova ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Specific Treatment ◽  
Total Antioxidant Status ◽  
Liver Parenchyma ◽  
Selenium Nanoparticles ◽  
Male Rats ◽  
Control Group ◽  
Dependent Manner ◽  
Sod Activity ◽  
Total Antioxidant

Selenium nanoparticles (SeNPs) are fast becoming a key instrument in several applications such as medicine or nutrition. Questions have been raised about the safety of their use. Male rats were fed for 28 days on a monodiet containing 0.5, 1.5, 3.0 and 5.0 mg Se/kg. Se content in blood and liver, liver panel tests, blood glucose, total antioxidant capacity (TAC), the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were analysed. Liver and duodenum were subjected to histopathology examination. The weight gain of rats showed no differences between tested groups. Se content in blood was higher in all treated groups compared to the control group. The liver concentration of Se in the treated groups varied in the range from 222 to 238 ng/g. No differences were observed in the activity of AST (aspartate aminotransferase), ALP (alkaline phosphatase) and TAS (total antioxidant status). A significant decrease in ALT activity compared to the control group was observed in the treated groups. GPx activity varied from 80 to 88 U/mL through tested groups. SOD activity in liver was decreased in the SeNP-treated group with 5 mg Se/kg (929 ± 103 U/mL). Histopathological examination showed damage to the liver parenchyma and intestinal epithelium in a dose-dependent manner. This study suggests that short-term SeNP supplementation can be safe and beneficial in Se deficiency or specific treatment.

Cytostatic therapy and blood antioxidants/prooxidants balance in acute myeloblastic leukemia patients

Open Medicine ◽  
2006 ◽  
Vol 1 (1) ◽  
pp. 35-45
Author(s):  
Daniela Gerova ◽  
Vladimir Gerov ◽  
Tatyana Yankova ◽  
Liana Gercheva ◽  
Diana Ivanova
Keyword(s):  
Lipid Peroxidation ◽  
Total Antioxidant Status ◽  
Acute Myeloblastic Leukemia ◽  
Total Serum ◽  
Strong Negative Correlation ◽  
Total Antioxidant ◽  
Group A ◽  
Mda Content ◽  
Group B ◽  
Plasma Antioxidant

AbstractTo analyze the effects of conventional polychemotherapy of acute myeloblastic leukemia (AML) patients on the prooxidants/antioxidants balance in plasma total antioxidant status (TAS) and a single plasma antioxidant — uric acid (UA) were measured. Lipid peroxidation was assessed by malonedialdehyde (MDA) content. Total serum iron was monitored as a potential source of nontransferrin-bound iron with a role in initiation of oxidative burst. A group of patients in the acute phase of AML (group A) and a group of patients in complete remission of AML (group B) were studied. A strong correlation between UA values and TAS (r = 0.8 for group A, r = 0.9 for group B) was revealed in the course of the treatment. Strong negative correlation (r = −0.9) between TAS and MDA was shown for both groups. Total iron significantly increased in the course of chemotherapy. We have established that polychemotherapy leads to the consumption of antioxidants and increased lipid peroxidation in AML patients. An appropriate supplementation with antioxidants at the end of the polychemotherapy treatment could be considered.

scholarly journals Tai Chi Exercise Increases SOD Activity and Total Antioxidant Status in Saliva and Is Linked to an Improvement of Periodontal Disease in the Elderly

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Víctor Manuel Mendoza-Núñez ◽  
Beatriz Hernández-Monjaraz ◽  
Edelmiro Santiago-Osorio ◽  
José Miguel Betancourt-Rule ◽  
Mirna Ruiz-Ramos
Keyword(s):  
Older Adults ◽  
Periodontal Disease ◽  
Antioxidant Status ◽  
Tai Chi ◽  
Total Antioxidant Status ◽  
The Elderly ◽  
Control Group ◽  
Sod Activity ◽  
Spectrophotometric Methods ◽  
Total Antioxidant

The aim of this study was to determine the effect of Tai Chi on biological markers of oxidative stress in saliva and its relationship with periodontal disease (PD) in older adults. We carried out a quasi-experimental study with a sample of 71 sedentary volunteers with PD who were divided into a control group of 34 subjects and an experimental group of 37 subjects who performed Tai Chi 5 days a week for a period of 6 months. PD status was characterized using the Periodontal Disease Index (PDI). Superoxide dismutase (SOD), total antioxidant status (TAS), and TBARS levels of both groups were measured by spectrophotometric methods. In addition, inflammation markers (TNF-α, IL-1β, IL-6, IL-8, and IL-10) were measured by flow cytometry. We found a statistically significant increase in SOD activity (P<0.001) and TAS concentration (P<0.05), whereas levels of IL-1βwere significantly lower (P<0.01). Likewise, a statistically significant decrease in the PDI (P<0.05) was observed in subjects who performed Tai Chi during a period of 6 months. Our findings suggest that the practice of Tai Chi has both antioxidant and anti-inflammatory effects that are linked to the improvement of PD in older adults.

scholarly journals Effectiveness of transdermal NSAID administration in analgesia for rib fracture patients: a comparative study with intravenous NSAID administration

2018 ◽  
Vol 5 (5) ◽  
pp. 1856
Author(s):  
Vikas Sankar Kottareddygari ◽  
Shashirekha C. A. ◽  
Asadulla Baig ◽  
Suryateja N. ◽  
Sreeramulu P. N.
Keyword(s):  
Rib Fracture ◽  
Research Centre ◽  
Control Group ◽  
Long Run ◽  
Study Results ◽  
Group A ◽  
Blunt Trauma Chest ◽  
Group B ◽  
A Prospective Study ◽  
Male Subjects

Background: Simple rib fractures are the most common injuries sustained following blunt trauma chest, accounting for more than half of thoracic injuries from nonpenetrating trauma. Looking into new modalities of administration like transdermal patches helps reduce morbidity in such patients with minimal side effects. The objectives of this study were to assess the effectiveness of transdermal NSAID administration in analgesia for rib fracture patients and to compare the effectiveness with intravenous NSAID administration.Methods: A prospective study comprising of 50 rib fracture patients who presented to the Emergency Medicine Department at RL Jalappa Hospital and Research Centre, Tamaka, Kolar. Study group were administered transdermal NSAID and the control group were administered intravenous NSAID.Results: Of the 50 subjects studied, 9 were female and 41 were male. Group A in which transdermal NSAIDs were administered consisted of 2 females and 23 male subjects while Group B in which intravenous NSAIDs were administered consisted of 7 females and 18 male subjects. The comparison was made between the two groups. The study results showed that the analgesia effect with transdermal NSAID administration is slow in onset as evidenced by higher VAS readings on day 1 whereas it is comparable with analgesia effect of intravenous NSAID administration in the long run as evidenced by VAS readings on day 3.Conclusions: Transdermal NSAID administration is effective in analgesia for rib fracture cases. The analgesia effect with transdermal NSAID administration is slow in onset as evidenced by high VAS readings on day 1 whereas it is comparable with analgesia effect of intravenous NSAID administration in the long run as evidenced by VAS readings on day 3.

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