Lethality among Patients with HIV/AIDS Monitored in the Clinic of Infectious Diseases in St George University Hospital, Plovdiv, 2010–2014

AbstractBackground: The introduction of complex antiretroviral therapy has resulted in signifi cant decrease in the mortality rate of HIV positive patients, but it still remains unacceptably high, especially in some groups of patients. Aim: To investigate the death rate in patients with HIV/AIDS, lethality and mortality in co-infection, and the most common causes and predictors of fatal outcome, focused on early diagnosis and appropriate therapy. Materials and methods: The study included 53 deceased patients with HIV/AIDS, monitored at the Clinic of Infectious Diseases in St George University Hospital, Plovdiv between 01.01.2010 and 31.12.2014. The methods of research included clinical analysis, laboratory tests, microbiological and serological tests (HCV, HBV, toxoplasmosis), ELISA, PCR. Statistical analysis was performed by descriptive statistics, the Student’s t-test, the method of Van der Ward, and regression analysis (logistic regression). Results: During the study period 316 patients with HIV/AIDS were monitored, 53 of them with lethal outcome. Lethality was 16.7% for the whole group; in intravenous drug users - 13.8%; in co-infected patients: HIV/M. tuberculosis - 46%, in HIV/HCV - 17.8%. Lethality and mortality in HIV(+) patients with co-infections in populations of diff erent age, gender, duration since starting сАRТ and degree of immunodefi ciency (according to CD4, VL) was compared with the lethality and mortality in patients with these conditions from the general population. Conclusions: Fatal outcome in patients with HIV/AIDS was most commonly associated with co-infections HIV/M. tuberculosis and HIV/HCV. Predictors of a fatal outcome are pulmonary tuberculosis, advanced immunodefi ciency with VL> 500 000 c/μL and CD4 <100/mm3, absence or non-systemic antiretroviral therapy.

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Definition of a novel vaccination pathway in PLWHA: experience of a Southern University Hospital

European Journal of Public Health ◽

10.1093/eurpub/ckaa166.837 ◽

2020 ◽

Vol 30 (Supplement_5) ◽

Author(s):

S D'Amato ◽

G F Pellicanò ◽

C Genovese ◽

F Mazzitelli ◽

G Nunnari ◽

...

Keyword(s):

Infectious Diseases ◽

Vaccination Coverage ◽

Clinical Pathway ◽

Drop Out ◽

University Hospital ◽

Treatment Center ◽

People Living With Hiv ◽

Vaccination Rates ◽

Operating Unit ◽

Hiv Aids

Abstract Background At the end of 2018 across the globe there are ∼37.9 million people with HIV/AIDS also thanks to the use of HAART which led to an increase in life expectancy. The Italy Immunization Plan 2017-19 recommend vaccines to these patients but a protocol still isn't present. Moreover, despite the availability of effective vaccines, coverage remained very low for many reasons including problems with privacy. The objectives of this study were a) the appliance of a shared clinical pathway between the “Immunization Center of Hospital Hygiene Operating Unit” and the “HIV/AIDS Disease Prevention, Diagnosis and Treatment Center of Infectious Diseases Operating Unit” b) the increase in vaccination coverage and the evaluation of side effects. Methods A prospective study was conducted from Oct 2019 to Feb 2020 at the G. Martino University Hospital of Messina. In particular, of the 138 patients followed by the Infectious Diseases OU, after evaluation of their immune status, 62% were enrolled in this study. Following the acquisition of informed consent, we collected socio-anagraphical data and we started the free administration of vaccines by providing an hoc calendar in the Immunization Center. Statistical analysis was performed with R software. Results The sample was represented by 86 patients (74% males and 26% females, 21% foreigners and 79% Italian, mean age=40±13.6 SD). We didn't observe drop out and no differences were observed for local/systemic AEs generally reported. We obtained an increase of vaccination coverage with a total of 74 doses administered for flu (+164%) and 240 for other vaccines (+172%). In particular, we immunized a total of 74% of patients for HPV (2% in 2018), 42% for HAV (28% in 2018), 37% for HBV (28% in 2018), 58% for pneumococcal (21% in 2018), 54% for meningococcal ACWY and B (0% in 2018). Conclusions The undertook clinical pathway showed the relevance of specific management of these patients and the need to increase the vaccination offer. Key messages The immunization in people living with HIV is priority to reduce the risk of infectious disease. It’s important to implement a shared clinical pathway to increase vaccination rates of these patients. The application of the protocol had an high impact in patients' adhesion to vaccination also thanks to the chance of accessing to the service in a comfortable setting and suitable to protect privacy.

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RATES OF HIV/AIDS CARE AND ANTIRETROVIRAL THERAPY RESPONSE AMONG ACTIVE INJECTION DRUG USERS

Addiction ◽

10.1111/j.1360-0443.2007.01975.x ◽

2007 ◽

Vol 102 (9) ◽

pp. 1503-1505 ◽

Cited By ~ 5

Keyword(s):

Antiretroviral Therapy ◽

Injection Drug Users ◽

Drug Users ◽

Therapy Response ◽

Injection Drug ◽

Hiv Aids

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The Dimensions of the Quality Perceived by Users in a Clinical Analysis Laboratory of A University Hospital

International Journal of Business Economics and Management ◽

10.18488/journal.62.2020.76.343.359 ◽

2020 ◽

Vol 7 (6) ◽

pp. 343-359

Author(s):

Raquel Lara Furlan ◽

Luiz Rodrigo Cunha Moura ◽

Cristiana Trindade Ituassu ◽

Nina Rosa da Silveira Cunha

Keyword(s):

Clinical Analysis ◽

University Hospital ◽

Analysis Laboratory

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Infectious Diseases Physicians’ Approach to Antiretroviral Therapy in HIV/AIDS Patients Admitted to an Intensive Care Unit

Infectious Diseases in Clinical Practice ◽

10.1097/ipc.0b013e318291c9de ◽

2014 ◽

Vol 22 (2) ◽

pp. 78-84 ◽

Cited By ~ 1

Author(s):

Jomy M. George ◽

Quinn A. Czosnowski ◽

Henry Fraimow ◽

Susan E. Beekmann ◽

Philip M. Polgreen

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Antiretroviral Therapy ◽

Infectious Diseases ◽

Aids Patients ◽

Hiv Aids

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Factors Affecting Adherence to Co-Trimoxazole Preventive Therapy in HIV/AIDS Patients Attending an Antiretroviral Therapy Clinic in Ethiopia University Hospital: A Cross-Sectional Study

Patient Preference and Adherence ◽

10.2147/ppa.s252805 ◽

2020 ◽

Vol Volume 14 ◽

pp. 881-890

Author(s):

Gashaw Binega Mekonnen ◽

Surafel Ashenafi Addis

Keyword(s):

Antiretroviral Therapy ◽

Cross Sectional Study ◽

Preventive Therapy ◽

University Hospital ◽

Sectional Study ◽

Aids Patients ◽

Cross Sectional ◽

Factors Affecting ◽

Therapy Clinic ◽

Hiv Aids

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Pattern of Traditional Medicine Utilization among HIV/AIDS Patients on Antiretroviral Therapy at a University Hospital in Northwestern Ethiopia: A Cross-Sectional Study

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2017/1724581 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6 ◽

Cited By ~ 6

Author(s):

Abyot Endale Gurmu ◽

Fitsum Sebsibe Teni ◽

Wondmagegn Tamiru Tadesse

Keyword(s):

Antiretroviral Therapy ◽

Nigella Sativa ◽

Cross Sectional Study ◽

Traditional Healers ◽

University Hospital ◽

Aids Patients ◽

Cross Sectional ◽

Herbal Products ◽

Specialized Hospital ◽

Hiv Aids

The objective of this study was to assess traditional, complementary, and alternative medicine (TCAM) utilization pattern among HIV/AIDS patients on antiretroviral therapy at University of Gondar Comprehensive Specialized Hospital. Materials and Methods. Data on sociodemographic profile and clinical and TCAM utilization were collected using a structured, pretested questionnaire from April 01 to May 28, 2014, through interviews with patients. Data on CD4 count, HIV stage, and ART regimen were collected from patient records. Analysis was conducted descriptively using SPSS version 20. Results. Of the 300 participants, 43.7% reported using TCAM, with the largest proportion of them from religious institutions (churches/mosques) (41.22%), followed by home prepared (32.82%) and traditional healers (16.03%). The leading forms of TCAM used were spiritual and herbal therapies constituting 56.49% and 36.64% of the patients, respectively. The most frequently used herbal products included Nigella sativa (22.92%) and Moringa oleifera (20.83%). Most of the patients (73.30%) using TCAM reported improvement in their conditions. Conclusions. TCAM utilization among HIV/AIDS patients on ART was common and different sources and types were used alongside ART, with improvement reported by most. Further research is needed to identify CAM therapies which may be used as adjunct treatments among these patients.

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The influence of social isolation on the incidence of positivity in covid-19 tests in a metropolitan region of São Paulo, Brazil

Journal of Human Growth and Development ◽

10.36311/jhgd.v31.12656 ◽

2021 ◽

Vol 31 (3) ◽

pp. 476-483

Author(s):

Alexandre José Natário ◽

Glaucia Luciano da Veiga ◽

Vagner Loduca Lima ◽

Thaís Gascón ◽

José Claudio dos Santos Pinheiro ◽

...

Keyword(s):

Social Isolation ◽

Laboratory Data ◽

Clinical Analysis ◽

Sao Paulo ◽

Metropolitan Region ◽

São Paulo ◽

Rt Pcr ◽

Serological Tests ◽

The Social ◽

Analysis Laboratory

Introduction: With the arrival of the SARS-CoV-2 (Coronavirus 2 of severe acute respiratory syndrome) pandemic in Brazil, especially in the city of São Paulo, there was a need to apply social isolation policies associated with testing, covering all municipalities. The Clinical Analysis Laboratory of Centro Universitário FMABC was one of the first laboratories to receive certification and qualification to perform RT-PCR (reverse transcriptase reaction followed by polymerase chain reaction) tests in the metropolitan region of São Paulo. Objective: Aim to analyze the influence of adopting social isolation on the incidence of positivity in COVID-19 tests in the metropolitan region of São Paulo, Brazil. Methods: a descriptive study carried out from March to May 2020, epidemiological data were collected from each unit served and organized by the data controllership team of the Clinical Analysis Laboratory of FMABC. Epidemiological, demographic, and laboratory data were extracted from the Matrix® outpatient data management system. Clinically suspected cases and confirmed by laboratory tests (RT-PCR and serological tests) were entered. The tests were divided into serological tests using the RT-PCR molecular test, on samples of nasopharyngeal mucosal scrapings collected with sterile Swab. Results: It were evaluated PCR test and antibody presence (IgA, IgM and IgG) in blood samples of 16.297 patients. 22.718 tests were performed for the diagnosis of COVID-19, both RT-PCR (10.410 tests) and serological tests to detect anti-SARS-CoV-2 antibodies, IgA, IgM and IgG, a total of 16.297 patients were assessed, 63% women and 37% men. It was observed that the social isolation policies adopted during this period contained the massive expansion of contamination, at least while the social isolation rates were above 55%. Conclusion: The data of this study demonstrated the effectiveness of social isolation in containing the positive contamination of SARS-CoV-2 in the metropolitan region of São Paulo, at least for the first three months.

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