To date the greenest method for the preparation of α-hydroxyphosphonates from substituted benzaldehydes and dialkyl phosphites

2017 ◽  
Vol 6 (2) ◽  
Author(s):  
György Keglevich ◽  
Zita Rádai ◽  
Nóra Zsuzsa Kiss
Keyword(s):  
General Procedure ◽  
Solvent Free ◽  
Pure Form ◽  
Synthetic Methods ◽  
Green Solvent ◽  
Minimum Quantity ◽  
Pudovik Reaction ◽  
Dialkyl Phosphites ◽  
The Pudovik Reaction ◽  
Substituted Benzaldehydes

AbstractRecent synthetic methods for α-hydroxyphosphonates comprise a green, solvent-free accomplishment of the Pudovik reaction that was typically followed by extractions and recrystallization, or even by chromatography, or other operations. We now developed a general procedure applying 10% of triethylamine as the catalyst and a minimum quantity of acetone as the solvent, giving the products in a pure form after a reflux of 5–120 min following the addition of some

scholarly journals The synthesis of α-aryl-α-aminophosphonates and α-aryl-α-aminophosphine oxides by the microwave-assisted Pudovik reaction

2017 ◽  
Vol 13 ◽  
pp. 76-86 ◽  
Author(s):  
Erika Bálint ◽  
Ádám Tajti ◽  
Anna Ádám ◽  
István Csontos ◽  
Konstantin Karaghiosoff ◽  
...  
Keyword(s):  
Dft Calculations ◽  
Solvent Free ◽  
Primary Amines ◽  
Diphenylphosphine Oxide ◽  
Dimer Formation ◽  
X Ray ◽  
Microwave Assisted ◽  
Pudovik Reaction ◽  
Dialkyl Phosphites ◽  
Benzaldehyde Derivatives

A family of α-aryl-α-aminophosphonates and α-aryl-α-aminophosphine oxides was synthesized by the microwave-assisted solvent-free addition of dialkyl phosphites and diphenylphosphine oxide, respectively, to imines formed from benzaldehyde derivatives and primary amines. After optimization, the reactivity was mapped, and the fine mechanism was evaluated by DFT calculations. Two α-aminophosphonates were subjected to an X-ray study revealing a racemic dimer formation made through a N–H···O=P intermolecular hydrogen bridges pair.

The Pudovik Reaction

2004 ◽  
pp. 1
Author(s):  
T. Ooi ◽  
K. Maruoka
Keyword(s):  
Pudovik Reaction ◽  
The Pudovik Reaction

scholarly journals DBU Catalyzed Phospho-Aldol-Brook Rearrangement for Rapid Preparation of α-Phosphates Amide in Solvent-Free Conditions

Catalysts ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1445
Author(s):  
Shunhong Chen ◽  
Shengxin Guo ◽  
Feng He ◽  
Yingxia Zhang ◽  
Zengxue Wu ◽  
...  
Keyword(s):  
Room Temperature ◽  
Solvent Free ◽  
The Novel ◽  
Rapid Preparation ◽  
Good Tolerance ◽  
Amide Derivatives ◽  
Solvent Free Conditions ◽  
Brook Rearrangement ◽  
Rearrangement Reaction ◽  
Dialkyl Phosphites

The 1,8-diazabicyclo [5.4.0] undec-7-ene DBU-catalyzed Phospho-Aldol-Brook Rearrangement reaction of α-ketoamide and dialkyl phosphites was developed under solvent-free at room temperature. The novel α-Phosphate Amide derivatives could be obtained with good yield (86–96%), which also exhibited good tolerance of various dialkyl phosphites and α-ketoamide, including isatins. In addition, the reaction was conducted in both gram-scale and mol-scale, and the title compounds could also be obtained in excellent yield (more than 91%) within 5 min.

Heteropoly acid catalysts for the synthesis of fragrance compounds from bio-renewables: acetylation of nopol and terpenic alcohols

RSC Advances ◽  
2016 ◽  
Vol 6 (49) ◽  
pp. 43217-43222 ◽  
Author(s):  
Vinicius V. Costa ◽  
Kelly A. da Silva Rocha ◽  
Luiz C. A. Oliveira ◽  
Elena F. Kozhevnikova ◽  
Ivan V. Kozhevnikov ◽  
...  
Keyword(s):  
Heterogeneous Catalyst ◽  
Heteropoly Acid ◽  
Solvent Free ◽  
Acid Catalysts ◽  
Green Solvent ◽  
Ambient Conditions ◽  
Terpenic Alcohols ◽  
Commercially Important ◽  
Catalytic Processes ◽  
Fragrance Compounds

Commercially important esters are obtained from biomass-based alcoholsviagreen solvent-free catalytic processes under ambient conditions using a simple heterogeneous catalyst.

A One-Pot, Three-Component, Solvent-Free Synthesis of Novel 6H-Chromeno[3’,4’:5,6]Pyrido[2,3-d]Pyrimidine-Triones under Microwave Irradiation

2018 ◽  
Vol 42 (12) ◽  
pp. 604-607
Author(s):  
Loghman Firoozpour ◽  
Hoda Yahyavi ◽  
Ramona Ejtemaei ◽  
Setareh Moghimi ◽  
Alireza Foroumadi
Keyword(s):  
Microwave Irradiation ◽  
Efficient Method ◽  
Barbituric Acid ◽  
Reaction Times ◽  
Solvent Free ◽  
One Pot ◽  
Solvent Free Conditions ◽  
Substituted Benzaldehydes ◽  
High Yields ◽  
Solvent Free Synthesis

A green and efficient method for preparing novel heterocyclic systems is established through the reaction of differently substituted benzaldehydes, barbituric acid and 4-amino-2H-chromene-2-one under solvent-free conditions. This method affords 6H-chromeno[3’,4’:5,6] pyrido[2,3-d]pyrimidine-trione derivatives in high yields and short reaction times.

Fabrication of extended-dissolution divalproex tablets: a green solvent-free granulation technique

2020 ◽  
Vol 46 (6) ◽  
pp. 975-987 ◽  
Author(s):  
Amr Khaled ◽  
Sameh Abdel-Hamid ◽  
Maha Nasr ◽  
Omaima A. Sammour
Keyword(s):  
Solvent Free ◽  
Green Solvent

N-Acyl-N-(4-chlorophenyl)-4-nitrobenzenesulfonamides: highly selective and efficient reagents for acylation of amines in water

2016 ◽  
Vol 71 (2) ◽  
pp. 95-104 ◽  
Author(s):  
Sara Ebrahimi ◽  
Safoura Saiadi ◽  
Simin Dakhilpour ◽  
Seyed Nezamoddin Mirsattari ◽  
Ahmad Reza Massah
Keyword(s):  
High Stability ◽  
Solvent Free ◽  
Secondary Amines ◽  
Primary Amines ◽  
Green Solvent ◽  
One Pot ◽  
Selective Protection ◽  
Solvent Free Conditions ◽  
Aryl Amines ◽  
Acylation Reactions

AbstractA variety ofN-acyl-N-(4-chlorophenyl)-4-nitrobenzenesulfonamides (1a–e) were synthesized in one pot from 4-chloroaniline under solvent-free conditions and have been developed as chemoselective N-acylation reagents. Selective protection of primary amines in the presence of secondary amines, acylation of aliphatic amines in the presence of aryl amines, and monofunctionalization of primary-secondary diamines as well as selective N-acylation of amino alcohols using these reagents are described. All of the acylation reactions were carried out in water as a green solvent. High stability and easy preparation of these acylating reagents are other advantages of this method.

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