Protective effect of Moringa oleifera oil against HgCl2-induced hepato- and nephro-toxicity in rats

2017 ◽  
Vol 28 (4) ◽  
Author(s):  
Sunny O. Abarikwu ◽  
Sussan Benjamin ◽  
Sunday Godspower Ebah ◽  
Godbless Obilor ◽  
Goodluck Agbam
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Protective Effect ◽  
Wistar Rats ◽  
Moringa Oleifera ◽  
Negative Effects ◽  
Male Wistar Rats ◽  
Moringa Oleifera Oil

Abstract:Background:Various parts of theMethods:Male Wistar rats were administered MO (1.798 mg/kg p.o.) or HgClResults:In the liver, malondialdehyde (MDA) level, glutathione (GSH), and superoxide dismutase (SOD) activities were higher whereas catalase (CAT) activity was lower in the HgClConclusions:MO decreased the negative effects of Hg-induced oxidative stress in rats.

Attenuation of Lead-Induced Oxidative Stress in Rat Brain, Liver, Kidney and Blood of Male Wistar Rats by Moringa Oleifera Seed Powder

2014 ◽  
Vol 33 (4) ◽  
pp. 323-337 ◽  
Author(s):  
Manoj Kumar Velaga ◽  
Lucius K. Daughtry ◽  
Angelica C. Jones ◽  
Prabhakara Rao Yallapragada ◽  
Sharada Rajanna ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Wistar Rats ◽  
Moringa Oleifera ◽  
Male Wistar Rats ◽  
Moringa Oleifera Seed

scholarly journals THE EFFECTS OF EXPOSURE DURATION TO ELECTRONIC CIGARETTE SMOKE ON DIFFERENCES IN SUPEROXIDE DISMUTASE AND MALONDIALDEHYDE IN BLOOD OF WISTAR RATS

2019 ◽  
pp. 13-16
Author(s):  
RIVAN VIRLANDO SURYADINATA ◽  
BAMBANG WIRJATMADI ◽  
MERRYANA ADRIANI ◽  
SRI SUMARMI
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Free Radicals ◽  
Cigarette Smoke ◽  
Wistar Rats ◽  
Cell Damage ◽  
The Body ◽  
Electronic Cigarette ◽  
Male Wistar Rats ◽  
The Relationship

Objective: Exposure to electronic cigarette smoke causes an increase of free radicals. Physiologically, the body produces antioxidant superoxide dismutase to neutralize the free radicals. However, an excessive increase of the free radicals will result in an imbalance between the amount of free radicals and antioxidants. The free radicals in the body can trigger lipid peroxidation so that it will result in oxidative stress causing cell damage. Malondialdehyde increase is a marker of oxidative stress in the body. The aim of this research is to understand the changes and the relationship between levels of superoxide dismutase and malondialdehyde in the blood due to exposure to electronic cigarette smoke. Methods: This research is an experimental study using male Wistar rats as experimental animal models. In the study, the exposure to electronic cigarette smoke with different duration of administration was carried out. Next, blood samples were taken to check the levels of superoxide dismutase and malondialdehyde. Results: The results showed a difference in antioxidant levels between antioxidant Superoxide Dismutase and malondialdehyde (p<0.05). Meanwhile the relationship between the two groups showed a strong (r = 0.893) and significant (p = 0.000) relationship. Conclusion: The exposure to electronic cigarette smoke can reduce the level of antioxidant superoxide dismutase and increase the level of malondialdehyde in blood. In addition, changes in the levels of antioxidant superoxide dismutase and malondialdehyde had a strong and significant relationship.

scholarly journals Ameliorative Effect of Aqueous Leaf Extract of Moringa oleifera on Reproductive Function Following Cadmium Chloride Induced Oxidative Stress in Male Wistar Rats

2019 ◽  
Vol 11 (4) ◽  
pp. 352-357 ◽  
Author(s):  
Avwerosuoghene ODODO ◽  
Sunday O. OJEKA ◽  
Victor D. DAPPER
Keyword(s):  
Oxidative Stress ◽  
Cadmium Chloride ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Moringa Oleifera ◽  
Reproductive Function ◽  
Testicular Tissue ◽  
Cellular Damage ◽  
Male Wistar Rats ◽  
Aqueous Leaf Extract

Cadmium disrupts the blood-testes barrier, interferes with various antioxidant levels thus enhancing lipid peroxidation and ultimately leading to apoptosis and necrosis of testicular tissue. Moringa oleifera is a medicinal plant and a rich source of essential phytochemicals possessing antioxidant properties. The effect of aqueous leaf extract of M. oleifera on reproductive function following cadmium chloride induced oxidative stress in male Wistar rats was investigated. Forty adult male Wistar rats were assigned into five groups of eight rats each. Treatment was administered orally daily as follows: Group 1 (control): animal feed and tap water ad libitum; Group 2: 5 mg kg-1 cadmium chloride for 21 days; Group 3: 500 mg kg-1 of M. oleifera and 5 mg kg-1 of cadmium chloride for 21 days; Group 4: 5 mg kg-1 cadmium chloride for 21 days followed by 500 mg kg-1 M. oleifera for the next 35 days; Group 5: 5 mg kg-1 cadmium chloride for 21 days followed by 750 mg kg-1 M. oleifera for the next 35 days. At the end of treatment, blood was obtained by direct cardiac puncture for fertility hormone assay and testicular tissue specimens were harvested for semen analysis and determination of antioxidant levels. Results obtained indicated that rats treated with the various extracts had significantly increased superoxide dismutase, malondialdehyde and catalase levels, increased serum concentrations of testosterone, follicle stimulating hormone and luteinizing hormone and increased percentage of viable and normal spermatozoa compared to control and only cadmium chloride treated rats (p < 0.05). The results obtained suggest that treatments with M. oleifera extract could ameliorate possible cellular damage caused by administration of cadmium chloride.

Protective effect of naringin against BPA-induced cardiotoxicity through prevention of oxidative stress in male Wistar rats

2018 ◽  
Vol 43 (1) ◽  
pp. 85-95 ◽  
Author(s):  
Mohammad Javad Khodayar ◽  
Heibatollah Kalantari ◽  
Masoud Mahdavinia ◽  
Layasadat Khorsandi ◽  
Soheila Alboghobeish ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Wistar Rats ◽  
Male Wistar Rats

scholarly journals Effects of Exercise on Oxidative Stress in Rats Induced by Ozone

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Catalina Martinez-Campos ◽  
Eleazar Lara-Padilla ◽  
Rosa Amalia Bobadilla-Lugo ◽  
Robert David Kross ◽  
Cleva Villanueva
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Aerobic Exercise ◽  
Wistar Rats ◽  
Acute Exercise ◽  
Chronic Exercise ◽  
Sod Activity ◽  
Pilot Experiment ◽  
Male Wistar Rats ◽  
Adaptation To Exercise

Oxidative stress (OS) induced by acute exercise is reduced by chronic exercise. Ozone (O3) exposure produces OS. The aim of this study was to determine if aerobic exercise (AE) reduced OS produced by O3. A pilot experiment was performed with male Wistar rats submitted to AE (trained to swim 90 min/day). Adaptation to exercise was demonstrated three weeks after training by means of changes in reduced nitrates (NOx) in plasma. Therefore, two-week training was chosen for the following experiments. Six of twelve trained rats were exposed to O3(0.5 ppm, 4 h/day, one hour before exercise). Two groups of sedentary animals (n=6each) were used as controls, one of which was exposed to O3. At the end of the experiments NOx, 8-isoprostane (8-IP), malondialdehyde (MDA), superoxide dismutase (SOD) activity, and carbonyls (CBs) were measured in plasma. CBs did not change in any group. O3-induced OS was manifested by reduced NOxand SOD activity, as well as increased 8-IP and MDA. Exercise significantly blocked O3effects although SOD was also decreased by exercise (a greater drop occurring in the O3group). It is concluded that AE protects against OS produced by O3and the effect is independent of SOD.

Melatonin prevents and ameliorates lead-induced gonadotoxicity through antioxidative and hormonal mechanisms

2018 ◽  
Vol 34 (9) ◽  
pp. 596-608 ◽  
Author(s):  
Luqman Aribidesi Olayaki ◽  
Isiaka Abdullateef Alagbonsi ◽  
Amin Halimat Abdulrahim ◽  
Wale Johnson Adeyemi ◽  
Muftiat Bakare ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Biochemical Markers ◽  
Wistar Rats ◽  
Reduced Glutathione ◽  
Gonadotropin Releasing Hormone ◽  
Semen Parameters ◽  
Total Antioxidant ◽  
Male Wistar Rats

We investigated the effects of melatonin on sperm parameters and some biochemical markers in lead-exposed male Wistar rats. Lead (50 mg/kg bw/day) and/or melatonin (4 mg/kg or 10 mg/kg bw/day) was administered for 4 weeks, while 2-week lead exposure was preceded by or followed by 2-week treatment with both doses of melatonin in other groups. Lead reduced glutathione, catalase, adjusted testes weight, semen parameters but did not change malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase, and total antioxidant capacity. Though independent of prolactin, lead-induced gonadotoxicity was both centrally and peripherally mediated, as it reduced gonadotropin-releasing hormone and testosterone levels, while gonadotropin levels did not change significantly probably due to negative feedback by elevated estradiol. However, pre-, simultaneous, or posttreatment of lead-exposed rats with melatonin reduced MDA, SOD, and estradiol but dose-dependently increased other parameters. Conclusively, lead causes male gonadotoxicity through oxidative stress and endocrine mechanisms, and these could be dose-dependently prevented and ameliorated by melatonin.

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