Sugammadex: An Update

Tiberiu Ezri; Mona Boaz; Alexander Sherman; Marwan Armaly; Yitzhak Berlovitz

doi:10.1515/jccm-2016-0005

Sugammadex: An Update

The Journal of Critical Care Medicine ◽

10.1515/jccm-2016-0005 ◽

2016 ◽

Vol 2 (1) ◽

pp. 16-21

Author(s):

Tiberiu Ezri ◽

Mona Boaz ◽

Alexander Sherman ◽

Marwan Armaly ◽

Yitzhak Berlovitz

Keyword(s):

Critical Care ◽

Clinical Use ◽

Comprehensive Description

Abstract The purpose of this update is to provide recent knowledge and debates regarding the use of sugammadex in the fields of anesthesia and critical care. The review is not intended to provide a comprehensive description of sugammadex and its clinical use.

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Seven-step framework to enhance practitioner explanations and parental understandings of research without prior consent in paediatric emergency and critical care trials

Emergency Medicine Journal ◽

10.1136/emermed-2020-209488 ◽

2020 ◽

pp. emermed-2020-209488

Author(s):

Louise Roper ◽

Mark D Lyttle ◽

Carrol Gamble ◽

Amy Humphreys ◽

Shrouk Messahel ◽

...

Keyword(s):

Critical Care ◽

Emergency Treatment ◽

Comprehensive Description ◽

Telephone Interviews ◽

Paediatric Emergency ◽

Prior Consent ◽

Clear Explanation ◽

Recruitment Practice ◽

Trial Intervention ◽

Parent Trial

BackgroundAlternatives to prospective informed consent enable the conduct of paediatric emergency and critical care trials. Research without prior consent (RWPC) involves practitioners approaching parents after an intervention has been given and seeking consent for their child to continue in the trial. As part of an embedded study in the ‘Emergency treatment with Levetiracetam or Phenytoin in Status Epilepticus in children’ (EcLiPSE) trial, we explored how practitioners described the trial and RWPC during recruitment discussions, and how well this information was understood by parents. We aimed to develop a framework to assist trial conversations in future paediatric emergency and critical care trials using RWPC.MethodsQualitative methods embedded within the EcLiPSE trial processes, including audiorecorded practitioner–parent trial discussions and telephone interviews with parents. We analysed data using thematic analysis, drawing on the Realpe et al (2016) model for recruitment to trials.ResultsWe analysed 76 recorded trial discussions and conducted 30 parent telephone interviews. For 19 parents, we had recorded trial discussion and interview data, which were matched for analysis. Parental understanding of the EcLiPSE trial was enhanced when practitioners: provided a comprehensive description of trial aims; explained the reasons for RWPC; discussed uncertainty about which intervention was best; provided a balanced description of trial intervention; provided a clear explanation about randomisation and provided an opportunity for questions. We present a seven-step framework to assist recruitment practice in trials involving RWPC.ConclusionThis study provides a framework to enhance recruitment practice and parental understanding in paediatric emergency and critical care trials involving RWPC. Further testing of this framework is required.

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Near-Infrared Spectroscopy: Clinical Use in High-Risk Neonates

Neonatal Network The Journal of Neonatal Nursing ◽

10.1891/0730-0832/11-t-678 ◽

2021 ◽

Vol 40 (2) ◽

pp. 73-79

Author(s):

Nhu N. Tran ◽

Michelle Tran ◽

Jeraldine Lopez ◽

Maxine Ogbaa ◽

Jodie K. Votava-Smith ◽

...

Keyword(s):

Critical Care ◽

Infrared Spectroscopy ◽

High Risk ◽

Oxygen Saturation ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Indirect Evidence ◽

Early Interventions ◽

Clinical Use ◽

Venous Oxygen Saturation

In this review, we describe the near-infrared spectroscopy (NIRS) technology and its clinical use in high-risk neonates in critical care settings. We searched databases (e.g., PubMed, Google Scholar, EBSCOhost) to find studies describing the use of NIRS on critically ill and high-risk neonates. Near-infrared spectroscopy provides continuous noninvasive monitoring of venous oxygen saturation. It uses technology similar to pulse oximetry to measure the oxygen saturation of hemoglobin in a tissue bed to describe the relative delivery and extraction of oxygen. Near-infrared spectroscopy can be a valuable bedside tool to provide clinicians indirect evidence of perfusion. It may prompt early interventions that promote oxygen delivery, which can improve high-risk neonatal outcomes.

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Oxford Textbook of Advanced Critical Care Echocardiography

10.1093/med/9780198749288.001.0001 ◽

2020 ◽

Keyword(s):

Critical Care ◽

Critically Ill Patients ◽

Transthoracic Echocardiography ◽

Clinical Problem ◽

Evidence Based ◽

Clinical Use ◽

Multiple Choice Questions ◽

Critical Care Echocardiography ◽

Reference Guide ◽

Specific Assessment

This book is a physiological and evidence-based reference guide to the principles and techniques of advanced echocardiography. Both transoesophageal and transthoracic echocardiography are addressed, where appropriate. The foundations of advanced echocardiography are outlined in Part 1, preceding specific assessment methods of critical care echo which are demonstrated and discussed in Part 2. In reality, most critically ill patients do not suffer only one clinical problem, so Part 3 integrates techniques learned in Part 2 to answer both common and unexpected critical care questions. The future use of echocardiography in critical care is explored in Part 4. Important reference values for clinical use can be accessed easily in the appendices. An appendix includes videos, cases, and multiple-choice questions that can be used to reinforce understanding.

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Clinical use of [TIMP-2]•[IGFBP7] biomarker testing to assess risk of acute kidney injury in critical care: guidance from an expert panel

Critical Care ◽

10.1186/s13054-019-2504-8 ◽

2019 ◽

Vol 23 (1) ◽

Cited By ~ 14

Author(s):

Louis M. Guzzi ◽

Tobias Bergler ◽

Brian Binnall ◽

Daniel T. Engelman ◽

Lui Forni ◽

...

Keyword(s):

Acute Kidney Injury ◽

Critical Care ◽

Expert Panel ◽

Kidney Injury ◽

Clinical Use ◽

Biomarker Testing

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Assessing Functional Language in School-Aged Children Using Language Sample Analysis

Perspectives of the ASHA Special Interest Groups ◽

10.1044/2020_persp-19-00079 ◽

2020 ◽

Vol 5 (3) ◽

pp. 622-636

Author(s):

John Heilmann ◽

Alexander Tucci ◽

Elena Plante ◽

Jon F. Miller

Keyword(s):

Computer Hardware ◽

School Age Children ◽

Functional Language ◽

School Age ◽

Clinical Use ◽

Sample Analysis ◽

Validity And Reliability ◽

Language Sample Analysis ◽

Accuracy And Repeatability ◽

Language Sample

Purpose The goal of this clinical focus article is to illustrate how speech-language pathologists can document the functional language of school-age children using language sample analysis (LSA). Advances in computer hardware and software are detailed making LSA more accessible for clinical use. Method This clinical focus article illustrates how documenting school-age student's communicative functioning is central to comprehensive assessment and how using LSA can meet multiple needs within this assessment. LSA can document students' meaningful participation in their daily life through assessment of their language used during everyday tasks. The many advances in computerized LSA are detailed with a primary focus on the Systematic Analysis of Language Transcripts (Miller & Iglesias, 2019). The LSA process is reviewed detailing the steps necessary for computers to calculate word, morpheme, utterance, and discourse features of functional language. Conclusion These advances in computer technology and software development have made LSA clinically feasible through standardized elicitation and transcription methods that improve accuracy and repeatability. In addition to improved accuracy, validity, and reliability of LSA, databases of typical speakers to document status and automated report writing more than justify the time required. Software now provides many innovations that make LSA simpler and more accessible for clinical use. Supplemental Material https://doi.org/10.23641/asha.12456719

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Translation Research for the Rehabilitation of Left Spatial Neglect and Associated Disorders of Attention in Stroke Patients

Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders ◽

10.1044/nnsld18.2.55 ◽

2008 ◽

Vol 18 (2) ◽

pp. 55-65 ◽

Cited By ~ 2

Author(s):

Nkiruka Arene ◽

Argye E. Hillis

Keyword(s):

Theoretical Basis ◽

Attention Bias ◽

Spatial Neglect ◽

Clinical Use ◽

Stroke Patients ◽

Translation Research ◽

Unilateral Neglect ◽

Assessment And Treatment ◽

Sound Theoretical Basis ◽

Review Current

Abstract The syndrome of unilateral neglect, typified by a lateralized attention bias and neglect of contralateral space, is an important cause of morbidity and disability after a stroke. In this review, we discuss the challenges that face researchers attempting to elucidate the mechanisms and effectiveness of rehabilitation treatments. The neglect syndrome is a heterogeneous disorder, and it is not clear which of its symptoms cause ongoing disability. We review current methods of neglect assessment and propose logical approaches to selecting treatments, while acknowledging that further study is still needed before some of these approaches can be translated into routine clinical use. We conclude with systems-level suggestions for hypothesis development that would hopefully form a sound theoretical basis for future approaches to the assessment and treatment of neglect.

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