scholarly journals Correlations Between Femoral Intima-media Thickness and Cardiovascular Risk Factors in Patients with Ischemic Heart Disease

2016 ◽  
Vol 1 (1) ◽  
pp. 32-36
Author(s):  
Zsuzsanna Jeremiás ◽  
Katalin Makó ◽  
Norbert Szekeres ◽  
Emese Rapolti ◽  
Imre Benedek ◽  
...  
Keyword(s):  
Heart Disease ◽  
Cardiovascular Risk ◽  
Ischemic Heart Disease ◽  
Intima Media Thickness ◽  
Left Ventricular ◽  
Ischemic Heart ◽  
Peripheral Vascular ◽  
Posterior Tibial ◽  
Media Thickness ◽  
The Mean

Abstract Background: Atherosclerosis has a systemic impact, producing gradual stenoses of the main vessels, and many imaging techniques have been developed in order to detect and quantify the atherosclerotic lesions. Peripheral artery disease has been shown to be associated with the presence of coronary heart disease, at the same time with carotid artery involvement. The utility of the carotid artery intima-media thickness (IMT) in predicting cardiovascular events caused by atherosclerosis, led to the idea that assessing the femoral artery IMT could have a similar impact. Study aim: We sought to determine the correlations between the femoral IMT, the degree of left ventricular systolic dysfunction and cardiovascular risk factors in patients with established diagnosis of ischemic heart disease. Material and methods: We prospectively included 27 patients with diagnosed ischemic heart disease. The ankle-brachial index (ABI) was assessed for the anterior and posterior tibial arteries. The left ventricular ejection fraction (LVEF) was determined by echocardiography. The femoral IMT was measured by peripheral vascular ultrasound, at the common femoral artery, 1 cm proximally from the bifurcation. The patients were divided into 2 groups: Group 1 – patients with IMT<0.9mm, and Group 2: patients with IMT >0.9 mm. Results: The mean age of the study population was 65.52 ± 11.44 years, and 77.77% were males. The mean glycemia levels were 99.89 ± 30.34 mg/dl, total cholesterol: 176.81 ± 43.09 mg/dl and the mean triglyceride level 140 ± 65.12mg/dl. The mean LEVF was 49.98% ± 12.73%, and femoral IMT 0.75 mm ± 0.25 mm. IMT significantly correlated with cholesterol levels (R = 0.383, p = 0.048), anterior and posterior tibial artery pressures (R = 0.450, p = 0.018, R = 0.418, p = 0.029 respectively) and ABI (R = 0.623, p = 0.005). There was no significant correlation between the LVEF and the IMT (R = −0.143, p = 0.475). There was a significant difference between the 2 groups regarding the minimum anterior tibial artery pressure (95.57 mmHg vs. 63.5 mmHg, p = 0.0011) and the minimum ABI (0.85 vs. 0.5, p = 0.015), and the femoral IMT (p = 0.0001). For patients with a femoral IMT >0.9 mm, a significant correlation was found between ABI and femoral IMT (R = −0.710, p <0.0001). Conclusion: The femoral intima-media thickness, assessed with peripheral vascular ultrasound, could be a new marker in evaluating the global cardiovascular risk in patients with ischemic heart disease. Femoral IMT could become a new marker for systemic atherosclerosis.

Intima-Media Thickness is Associated With Non-Traditional Risk Factors and Ischemic Heart Disease in Hemodialysis Patients

2011 ◽  
Vol 16 (1) ◽  
pp. 104-106 ◽  
Author(s):  
Cleto Álvarez-Aguilar ◽  
Daniel Lara-Romero ◽  
Javier Piñón-Escobedo ◽  
Anel Gómez-García ◽  
Alfonso R Álvarez-Paredes
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Intima Media Thickness ◽  
Hemodialysis Patients ◽  
Ischemic Heart ◽  
Media Thickness ◽  
Traditional Risk Factors

scholarly journals Correlation of Coronary Angiographic Severity with Carotid intima Media Thickness and Flow mediated dilatation of brachial Artery in Patients with Ischemic Heart Disease

2013 ◽  
Vol 5 (2) ◽  
pp. 165-172
Author(s):  
SME Mahabub ◽  
AEMM Islam ◽  
KMN Sabah ◽  
AW Chowdhury ◽  
M Ghiasuddin ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Brachial Artery ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Ischemic Heart ◽  
Media Thickness ◽  
Flow Mediated Dilatation ◽  
Extent Score ◽  
Vessel Score

Background: Ischemic Heart Disease which encompasses Acute Coronary Syndrome and Chronic Stable Angina is the most common cause of worldwide mortality and morbidity. Carotid intima media thickness (CIMT) is a non-invasive ultrasonographic technique to image the carotid arteries which measures the thickness of the intima and media of these vessels. It is a marker of atherosclerotic process. Flow mediated dilatation (FMD) is a marker of endothelial function of arteries. Ischemic heart disease can be predicted long before its actual occurrence by observing these two phenomenons. Methods: This cross sectional study done in the Department of Cardiology, Dhaka Medical College Hospital during the period of Oct 2010- Sept 2011.We enrolled 102 patients admitted with IHD by purposive sampling. We assessed FMD of brachial artery, CIMT by vascular duplex. Coronary artery disease severity was assessed by vessel score, stenosis score and extent score from angiography. Results:The mean (±SD) age of the patients was 50.9(±11.3) years. The male- female ratio was 5:1. CIMT has significant negative correlation with FMD (r=-.407, p=<.001). Flow mediated dilatation of brachial artery has weak but significant negative co-relation with vessel score(r=-.609, p=<.001), stenosis score(r=- .493, p=<.001) and extent score (r=-.477, p=<.001). However, carotid intima media thickness has weak but positive correlation with vessel score (r=.447, p=<.001), stenosis score (r=.417, p=<.001) and extent score(r=.412, p=<.001). Conclusion: The present study concludes CIMT has significant negative correlation with flow mediated dilatation of brachial artery. FMD has weak but significant negative co-relation and CIMT has weak but positive correlation with vessel score, stenosis score and extent score of coronary arteries. DOI: http://dx.doi.org/10.3329/cardio.v5i2.14321 Cardiovasc. j. 2013; 5(2): 165-172

scholarly journals A study of lipid profile and carotid artery and abdominal aorta intima-media thickness in children with parental history of premature ischemic heart disease

2018 ◽  
Vol 5 (3) ◽  
pp. 1013 ◽  
Author(s):  
Puneeth K. Pai ◽  
Nagendra K. ◽  
Savitha Mysore Ramaraj
Keyword(s):  
Heart Disease ◽  
Carotid Artery ◽  
Ischemic Heart Disease ◽  
Abdominal Aorta ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Ischemic Heart ◽  
Parental History ◽  
Media Thickness ◽  
History Of

Background: Children born to parents with ischemic heart disease (IHD) can have dyslipidemia, a marker for IHD, detectable in early childhood and track to adulthood. Dyslipidemia along with factors like BMI, diet, sedentary activity increases risk of child developing IHD in adulthood. Early detection with non-invasive methods such as B mode ultrasound to measure carotid artery and abdominal aorta intima-media thickness can help in modification of these risk factors by suitable interventional strategies. The objectives of this study was to study the lipid profile and carotid artery and abdominal aorta intima-media thickness among children in the age group 5-18 years born to parents with history of premature IHD.Methods: 23 children of parents with premature IHD and aged matched 28 controls without any family history of IHD were analyzed for cardiovascular risk factors: lipid profile and carotid and abdominal aorta intima-media thickness. The carotid intima-media thickness and abdominal aorta intima-media thickness was found by using B mode ultrasound.Results: Mean abdominal aorta intima-media thickness was significantly higher among children with parental history of premature IHD than in those without it. Abdominal aorta intima-media thickness also showed significant positive correlation with total cholesterol. Carotid intima-media thickness showed positive correlation with the waist circumference. Mean total cholesterol levels (TC), low density lipoprotein cholesterol (LDL) and triglycerides (TG) were higher in children with family history as compared to children without family history but it was not statistically significant.Conclusions: Abdominal aortic IMT is significantly more among children with parental history of premature ischemic heart disease compared to children without parental history of premature ischemic heart disease. Abdominal aortic intima-media thickness has significant association with total cholesterol while carotid intima-media thickness is significantly associated with waist circumference.

scholarly journals Frequency of Fibromyalgia in a Sample of Iraqi Patients in Mosul with Ischemic Heart Disease

2021 ◽  
Vol 9 (B) ◽  
pp. 1672-1676
Author(s):  
Ali Younis ◽  
Mohammad Harith Alsaaty
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Multivariate Logistic Regression Analysis ◽  
Left Ventricular ◽  
Ischemic Heart ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
Ibn Sina ◽  
American College Of Rheumatology ◽  
The Mean

BACKGROUND: Fibromyalgia is a common chronic condition characterized by widespread musculoskeletal pain together with mood and cognitive dysfunction. Data on the frequency of fibromyalgia in ischemic heart disease (IHD) are scarce. AIM: This study aimed to assess the frequency of fibromyalgia in IHD patients and to evaluate the characteristics of IHD patients with comorbid fibromyalgia. METHODS: The study was conducted in the coronary care unit, Department of Medicine in Ibn Sina Teaching Hospital in Mosul city, between March and November 2020. One hundred patients with IHD and 100 healthy controls were studied. The diagnosis of fibromyalgia was according to the 2011 modification of the 2010 American College of Rheumatology preliminary diagnostic criteria for fibromyalgia. Socio-demographic features and IHD characteristics of patients were recorded. RESULTS: The frequency of fibromyalgia was significantly higher among patients with IHD (29%) as compared to controls (7%). The mean age and proportion of women were significantly higher in IHD patients with fibromyalgia than those without fibromyalgia. It was also more common in patients with the present MI (p = 0.032) and in patients who had previous coronary angiography (p = 0.008). Patients with comorbid fibromyalgia had lower left ventricular ejection fraction (LVEF) (p = 0.0003) and higher scores on beck depression inventory (p = 0.0025). However, on multivariate logistic regression analysis, only two variables remained significant, (1) among IHD patients, fibromyalgia was more frequent in women (odds ratio [OR] = 3.839, p = 0.022) and (2) in patients having lower LVEF (OR = 0.917, p = 0.008). CONCLUSION: There is a high frequency of fibromyalgia in patients with IHD. Those IHD patients with comorbid fibromyalgia are more likely to be older, women, and with poor LVEF.

scholarly journals A Study on Carotid Intima-Media Thickness and Ankle Brachial Index In Patients with Various Stages of Chronic Kidney Disease

2020 ◽  
Vol 11 (SPL2) ◽  
pp. 290-296
Author(s):  
Dhileepan T ◽  
Mohamed Azeem S ◽  
Mariraj I ◽  
Jagadeesan M ◽  
Mahendrakumar K ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Heart Disease ◽  
Kidney Disease ◽  
Ischemic Heart Disease ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Ankle Brachial Index ◽  
Intima Media Thickness ◽  
Ischemic Heart ◽  
Peripheral Vascular

The presence of peripheral vascular disease in chronic kidney disease portends a dismal prognosis due to the increased morbidity and mortality from cardiovascular events. Peripheral vascular disease is asymptomatic in about 40%. The study was designed to identify the prevalence of the peripheral vascular disease in chronic kidney disease, which is a state of accelerated atherosclerosis. A sample of 90 patients of chronic kidney disease attending the outpatient department in medicine and nephrology were assessed for the prevalence of peripheral vascular disease by measuring the Ankle-brachial index and Carotid intima-media thickness. Gender, smoking, hypertension, diabetes and ischemic heart disease profiles of the sample were analyzed for association with peripheral vascular disease. Majority of the patients belonged to the age group 40-50 years. 82 were males, of these 47 were smokers. 6 patients in the sample had symptoms suggestive of peripheral vascular disease. While 21%(n=19) of patients in the sample were diabetics and 21%(n=19) had evidence of ischemic heart disease, hypertension was present in 41%(n=37) of the patients. 50% of the patients belonged to CRF stage 4. The prevalence of the peripheral vascular disease, as determined by ABI<0.9, was 31.1%. CIMT thickness > 0.9mm has a positive correlation with CKD stages and has a statistically significant P value of <0.05. In conclusion, this study revealed that there is an increased prevalence of PVD in smokers, diabetics and in ischemic heart disease compared to those with hypertension.

Glutamine Is Cardioprotective in Patients with Ischemic Heart Disease following Cardiopulmonary Bypass

2011 ◽  
Vol 14 (6) ◽  
pp. 384 ◽  
Author(s):  
Vladimir V. Lomivorotov ◽  
Sergey M. Efremov ◽  
Vladimir A. Shmirev ◽  
Dmitry N. Ponomarev ◽  
Vladimir N. Lomivorotov ◽  
...  
Keyword(s):  
Heart Disease ◽  
Placebo Group ◽  
Cardiopulmonary Bypass ◽  
Ischemic Heart Disease ◽  
Troponin I ◽  
Left Ventricular ◽  
Ischemic Heart ◽  
Left Ventricular Ejection ◽  
Study Group ◽  
Cardioprotective Effects

<p><b>Background:</b> The aim of the present study was to investigate the cardioprotective effects of the perioperative use of N(2)-L-alanyl-L-glutamine (GLN) in patients with ischemic heart disease (IHD) who undergo their operations under cardiopulmonary bypass (CPB).</p><p><b>Methods:</b> This double-blind, placebo-controlled, randomized study included 50 patients who underwent cardiac surgery with CPB. Exclusion criteria were a left ventricular ejection fraction <50%, diabetes mellitus, <3 months since the onset of myocardial infarction, and emergency surgery. Patients in the study group (n = 25) received 0.4 g/kg GLN (Dipeptiven, 20% solution) per day. Patients in the control group (n = 25) were administered a placebo (0.9% NaCl). The primary end point was the dynamics of troponin I at the following stages: (1) prior to anesthesia, (2) 30 minutes after CPB, (3) 6 hours after CPB, (4) 24 hours after surgery, and (5) 48 hours after surgery. Secondary end points included measurements of hemodynamics with a Swan-Ganz catheter.</p><p><b>Results:</b> On the first postoperative day after the surgery, the median troponin I level was significantly lower in the study group than in the placebo group: 1.280 ng/mL (interquartile range [IQR], 0.840-2.230 ng/mL) versus 2.410 ng/mL (IQR, 1.060-6.600 ng/mL) (<i>P</i> = .035). At 4 hours after cardiopulmonary bypass (CPB), the median cardiac index was higher in the patients in the study group: 2.58 L/min per m<sup>2</sup> (IQR, 2.34-2.91 L/min per m<sup>2</sup>) versus 2.03 L/min per m<sup>2</sup> (IQR, 1.76-2.32 L/min per m<sup>2</sup>) (<i>P</i> = .002). The median stroke index also was higher in the patients who received GLN: 32.8 mL/m<sup>2</sup> (IQR, 27.8-36.0 mL/m<sup>2</sup>) versus 26.1 mL/m<sup>2</sup> (IQR, 22.6-31.8 mL/m<sup>2</sup>) (<i>P</i> = .023). The median systemic vascular resistance index was significantly lower in the study group than in the placebo group: 1942 dyn�s/cm<sup>5</sup> per m<sup>2</sup> (IQR, 1828-2209 dyn�s/cm<sup>5</sup> per m<sup>2</sup>) versus 2456 dyn�s/cm<sup>5</sup> per m<sup>2</sup> (IQR, 2400-3265 dyn�s/cm<sup>5</sup> per m<sup>2</sup>) (<i>P</i> = .001).</p><p><b>Conclusion:</b> Perioperative administration of GLN during the first 24 hours has cardioprotective effects in IHD patients following CPB. This technique enhances the troponin concentration at 24 hours after surgery and is associated with improved myocardial function.</p>

Sign in / Sign up

Export Citation Format

Share Document