Variability of lipid and lipoprotein concentrations during puberty in Brazilian boys

2015 ◽  
Vol 28 (1-2) ◽  
Author(s):  
Luis Paulo Gomes Mascarenhas ◽  
Neiva Leite ◽  
Ana Cláudia C. Kapp Titski ◽  
Lilian Messias Sampaio Brito ◽  
Margaret C.S. Boguszewski
Keyword(s):  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Physiological Changes ◽  
Maturation Process ◽  
Enzymatic Method ◽  
Low Density Lipoprotein Cholesterol ◽  
Male Adolescents

AbstractEvaluation of lipid profile in children and adolescents is important for early diagnosis of dyslipidemias. Physiological changes might be observed in the concentration of the lipid profile components, according to the stage of sexual maturation.To evaluate the variation in lipid and lipoprotein concentrations in boys during puberty.The sample consisted of 570 male adolescents with ages between 10 and 17 years. Weight, height, and body mass index (BMI) were assessed. Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) were determined by the enzymatic method, and low-density lipoprotein cholesterol (LDL-C) was calculated. Puberty was classified according to Tanner references. The percentile criterion was adopted for the distribution and identification of lipoprotein levels. The analysis of variance and description tests with p<0.05 was applied.Participants had similar BMILipid and lipoprotein concentrations tend to undergo changes during puberty in boys. The use of percentile values can be very useful to track variations in lipid and lipoprotein levels during the maturation process.

scholarly journals Comparative effects of ethanol leaf and stem bark extracts of Irvingia gabonensis (BUSH MANGO) on sodium arsenite-induced lipid profile perturbtions in wistar rats

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Efosa Godwin Ewere ◽  
Ngozi Paulinus Okolie ◽  
Erhunmwunsee Dalton Avan ◽  
Patience Edet Umoh
Keyword(s):  
Lipid Profile ◽  
Wistar Rats ◽  
Sodium Arsenite ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Stem Bark ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Irvingia Gabonensis

Abstract Background Exposure to arsenic orchestrates a myriad of noxious health effects, including cancer. Different parts of Irvingia gabonensis are used as herbal remedies in traditional medicine. In this study, the comparative effects of the ethanol leaf (ELEIG) and stem bark extracts (ESEIG) of Irvingia gabonensis on sodium arsenite (SA)-induced lipid profile disturbances in Wistar rats were investigated. Methods Fifty five Wistar rats weighing between 100 g and 179 g were distributed into eleven groups (n=5). Group 1 (control) received feed and water ad libitum. Group 2 received SA at a dose of 4.1 mg/kg body weight (kgbw) for 14 days. Groups 3–11 were treated with the extracts with or without SA. Treatment was done by oral intubation for 14 days. Serum concentrations of total cholesterol (TC), triacylglycerol (TAG), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), very low density lipoprotein cholesterol (VLDL-c), total lipids (TL) and atherogenic index of plasma (AIP) were used to determine the lipid profile effects of the extracts. Results Exposure to SA caused significant (p ˂ 0.05) increases in all assayed parameters, relative to control. Post-treatment and simultaneous treatment with ELEIG and ESEIG mitigated the effects of SA. In addition, ELEIG alone at various doses produced results comparable with control values. However, ESEIG alone caused significant (p ˂ 0.05) increases in all assayed parameters, relative to control. Conclusion These results show that ELEIG and ESEIG ameliorate SA-induced lipid profile disturbances in Wistar rats. However, long-term administration of ESEIG alone may be discouraged.

scholarly journals Lipid profile in systemic lupus erythematosus: study from a tertiary teaching hospital of Eastern India

2017 ◽  
Vol 5 (11) ◽  
pp. 4749 ◽  
Author(s):  
Simanchala Dakua ◽  
Manoranjan Behera ◽  
Jayant Kumar Panda ◽  
Prabhat Kumar Padhi
Keyword(s):  
Lipid Profile ◽  
Lupus Erythematosus ◽  
Low Density Lipoprotein ◽  
Tertiary Care ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Eastern India ◽  
Low Density Lipoprotein Cholesterol ◽  
Systemic Lupus

Background: Dyslipidemia is an independent modifiable risk factor for coronary artery disease. Patients with systemic lupus erythematosus (SLE) have dyslipidemia and accelerated atherosclerosis; however, there is paucity of published data on the lipid profile in patients with SLE in Eastern India. This study was done to assess the prevalence and abnormality of lipid profile in patients with SLE admitted to a tertiary care teaching hospital in Eastern India.Methods: This was a hospital based prospective study evaluating SLE patients admitted to a tertiary care institution in Eastern India. 101 patients with SLE admitted consecutively and 100 age and sex matched controls were enrolled for study. Fasting total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured in plasma whereas very low-density lipoprotein cholesterol (VLDL-C) was calculated. Statistical analysis was done using the standard statistical techniques.Results: Out of 101 patients of SLE, 97 were female and 4 were of male gender. The age of the patients ranged from 15 to 47 years with a mean of 27.17 (±8.4) years. Dyslipidemia was found in 58(57.4%) patients. Hypercholesterolemia was found in 23 (22.7%), hypertriglyceridemia in 55 (54.4%), raised LDL-C in 24 (23.7%) cases. Raised TC, TG, and LDL-C was found in 18 (17.8%), and raised TC, TG, LDL-C and low HDL-C was found in 9 (8.9%) cases. There was significant increase in serum cholesterol, triglyceride and VLDL-C while decrease in HDL-C in SLE patients than controls (p <0.001). Statistically no difference in lipid profile was found in between groups of SLE receiving steroid and without steroid.Conclusions: Abnormal lipid profiles are very common in patients with SLE, though the patients are very young. Control of dyslipidemia can favourably affect cardiovascular related morbidity and mortality.  

scholarly journals The Splenectomy Effects on Lipid Profile and Glucose Metabolism in the Major Thalassemia Patients

2021 ◽  
Author(s):  
Zohreh Sajadi Hezaveh ◽  
Mahsa Hadidi ◽  
Farzad Shidfar
Keyword(s):  
Physical Activity ◽  
Glucose Metabolism ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Beta Thalassemia ◽  
Oral Glucose ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

Background: Splenectomy is a common treatment for beta thalassemia. It not only eliminates many complications by reducing the need for blood transfusion, but also causes new complications that threaten the patients' health. The aim of this study was to determine if splenectomy could alter the lipid profile and glucose metabolism in beta thalassemia major patients. Methods: In this case-control study, 41 splenectomized and 42 non-splenectomized eligible beta thalassemia patients were selected from Zafar Thalassemia Clinic, Tehran, Iran. Anthropometric, demographic, and biochemical data were collected using standard methods. Physical activity and food intake were measured using International Physical Activity Questionnaire (IPAQ) and food frequency questionnaires (FFQ), respectively. Results: Demographic characteristics and dietary intake were not significantly different between the two groups. However, triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), very low density lipoprotein cholesterol (VLDL-C), TC/HDL-C, LDL-C/TG, and LDL-C/HDL-C ratios were significantly higher, but HDL-C was significantly lower in splenectomized patients (P < 0.05). Furthermore, fasting blood glucose (P < 0.39) and oral glucose tolerance test (P < 0.53) did not significantly differ between the two groups. Conclusions: Reduced activity of the reticuloendothelial system and reduced removal of cholesterol might be the reason for higher plasma lipid profile and greater risk of cardiovascular diseases in splenectomized patients. On the other hand, glucose metabolism was not affected by splenectomy in adult patients. To clarify this relationship, prospective studies are suggested.

scholarly journals Effectiveness of Probiotics, Metformin and Their Combination Therapy in Ameliorating Dyslipidemia Associated With PCOS

2019 ◽  
pp. 1-9
Author(s):  
Urooj Zafar ◽  
Jahan Ara Hassan ◽  
Kauser Ismail ◽  
Shanza Agha ◽  
Zahida Memon ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Tertiary Care ◽  
Density Lipoprotein ◽  
The Body ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Care Hospital ◽  
Low Density Lipoprotein Cholesterol

Background: Polycystic ovary syndrome (PCOS) is a heterogeneous metabolic disorder affecting women of the child-bearing age. Alteration in lipid profile is one of the troublesome features faced by PCOS patients that need to be treated. Aim: The purpose of this study was to compare the effects of Probiotics, Metformin and their Combination therapy on lipid profile in women suffering from PCOS. Study Design: Single-Centered Randomized Controlled Trial. Setting: Gynecological clinic of Karachi at Tertiary care Hospital from December 2018 to May 2019. Patients and Methods: Total 78 PCOS patients of age between 18 to 40 years were involved in this trial rendering to Rotterdam criteria. After taking written and informed consent they were randomly allocated to three groups and were received: Metformin 500 mg B.D (n = 26), Probiotic Capsule 180 mg B.D (n = 26) and Combination of Metformin 500 mg B.D / Probiotic Capsule 180 mg B.D for 12-weeks. Lipid profile was measured at baseline and after 12-weeks of intervention along with the body weight. In the end, pre versus post therapy and comparison of different group’s results were analyzed. Results: Metformin and Met/Pro Combination groups resulted in a significant reduction in Total Cholesterol (TC) as compared to Probiotic group. Fall in Low-Density Lipoprotein Cholesterol (LDL-C) levels were noteworthy after Probiotics and Met/Pro treatment. Serum TG concentrations were significantly reduced in all the groups. High-Density Lipoprotein Cholesterol (HDL-C) levels were slightly elevated after Probiotics treatment, which was not statistically significant but Metformin and Met/Pro group increases it to the significant value. No substantial change was found in the Very Low-Density Lipoprotein Cholesterol VLDL-C levels in any of the three groups. Conclusion: Overall, Probiotics treatment in PCOS women for 12 weeks exhibited noteworthy changes in TG, and LDL-C levels. Metformin markedly improve Cholesterol, TG and HDL-C. However, Met/Pro improved all the lipid changes to the significant value except for VLDL-C.

Lipid profile and prevalence of dyslipidemia in urban women of Jaipur district, Rajasthan, India

2015 ◽  
Vol 45 (3) ◽  
pp. 412-422
Author(s):  
Aachu Agrawal ◽  
Kanika Varma ◽  
Rajeev Gupta
Keyword(s):  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Urban Women ◽  
Overweight And Obesity ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Age Group ◽  
Low Density Lipoprotein Cholesterol ◽  
Content Type

Purpose – The purpose of this study is to investigate the lipid profile and prevalence of dyslipidemia, as serum lipid levels have a major contribution in the development of cardiovascular diseases, in adult urban women of Jaipur district, Rajasthan, India. Design/methodology/approach – A house-to-house survey was done in four urban locations, and 501 women in the age group of 35-70 years were enrolled in the study. A general questionnaire was used to gather background information and general health status. Fasting blood samples were collected to determine the level of serum triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol. Dyslipidemia was assessed based on the criteria given in the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (NCEP ATP-III). Findings – Mean age of the women was 45.63 ± 9.91 years. Population mean levels of TC, LDL-C, HDL-C and TGs were 183.9 ± 15.3, 111.8 ± 18.0, 44.0 ± 6.2 and 140.6 ± 30.9 mg/dl, respectively. Prevalence of overweight and obesity was 33.9 and 18.7 per cent, respectively. Of a total of 500 subjects, 13.8 per cent had TC = 200 mg/dl, 12.6 per cent had LDL = 130 mg/dl, 85.4 per cent had HDL-C < 50 mg/dl and 23.0 per cent had TG = 150 mg/dl. An increase in serum lipids was most prominent in the 40-59 year age group. Originality/value – High prevalence of overweight and obesity was observed in the community. Prevalence of low HDL-C was very high among the subjects.

scholarly journals Evaluation of Serum Magnesium Level along with Lipid Profile in a Gujarati Population diagnosed with Diabetes Mellitus

2017 ◽  
Vol 21 (2) ◽  
pp. 112-116
Author(s):  
Sandip S Sendhav ◽  
Amit Kakaiya ◽  
Bijoya Chatterjee
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Profile ◽  
Serum Magnesium ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Magnesium Level ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Serum Magnesium Level ◽  
Low Density Lipoprotein Cholesterol

ABSTRACT Aims and objectives Diabetes is a common endocrinal disorder. Abnormal lipid and magnesium levels are observed in diabetes in many studies. The current study was done with an aim to find the relationship between lipid with magnesium and diabetes mellitus in Gujarati population. Materials and methods The cross-sectional study included 60 diabetics and 50 healthy subjects. Each subject was interviewed, examined, and investigated for serum lipid profile and magnesium. A 12-hour overnight fasting was recommended. The statistical analysis of data obtained was done by Student's t-test and calculation of Pearson correlation coefficient. Result Routine biochemical investigations showed a significant rise (p < 0.01) of fasting plasma glucose, triglycerides (TGs), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and very low-density lipoprotein-cholesterol (VLDL-C) in diabetics, in comparison with controls (p < 0.01). Among diabetics, males have significantly higher (p < 0.01) TC, TG, and LDL-C while significantly lower high-density lipoprotein-cholesterol (HDL-C). Significant inverse correlation of magnesium with TC (r = −0.18), TGs (r = −0.14), LDL-C (r = −0.27), fasting blood sugar (FBS; r = −0.12) and direct correlation with HDL-C (r = 026) were observed in cases. Conclusion The major highlights of the current study are lower magnesium levels in cases compared with controls. In the current study, serum magnesium level has been found to be inversely related to cholesterol, TG, and LDL-C levels, while it is directly associated with HDL-C level. Hence, it could play a role in controlling the risk of coronary artery disease (CAD)-associated morbidities in future. How to cite this article Sendhav SS, Kakaiya A, Chatterjee B. Evaluation of Serum Magnesium Level along with Lipid Profile in a Gujarati Population diagnosed with Diabetes Mellitus. Indian J Med Biochem 2017;21(2):112-116.

scholarly journals Association of Lipid Profile with Non-Alcoholic Fatty Liver Disease diagnosed on Ultrasound

2020 ◽  
Vol 24 (4) ◽  
pp. 334-338
Author(s):  
Ambreen Zahoor ◽  
Iram ` Iqbal ◽  
Sajid Naseem ◽  
Zaidan Idrees Choudhary
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Fatty Liver Disease ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Objectives: To evaluate lipid profile parameters in patients with various grades of non-alcoholic fatty liver disease (NAFLD) diagnosed on sonography.  Material and Method: This descriptive cross-sectional study was conducted at HBS General Hospital, Islamabad over a period of six months from January 2018 to June 2018. Seventy-nine adults of either gender diagnosed with NAFLD on ultrasonography were consecutively included. Fasting blood sample of all the subjects was analyzed for total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) Comparison of lipid abnormalities between different grades of NAFLD was done by statistical analysis with p-value <0.05 considered statistically significant. Results: Out of the total 79 patients, grade I, II, and III NAFLD was diagnosed in 56.6%, 45.5%, and 3.9% respectively. Total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) were raised in 28 (35.4%), 43 (54.4%) and 43 (54.4%) patients respectively. Low serum high-density lipoprotein cholesterol (HDL-C) levels were seen in 74 (93.6%) of patients. Statistical analysis showed a significant increase in frequency as well as mean values in all serum lipid profile parameters with the severity of NAFLD grades except total cholesterol (TC). Conclusion: Increasing grades of NAFLD showed a significant correlation with higher levels of cholesterol, LDL, and decreasing levels of HDL, which are all associated with cardiovascular problems.

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