Values of T/QRS ratio in pregnancies complicated by intrauterine growth restriction

2016 ◽  
Vol 44 (7) ◽  
Author(s):  
Tomasz Fuchs
Keyword(s):  
Intrauterine Growth Restriction ◽  
Well Being ◽  
Study Groups ◽  
Growth Restriction ◽  
Healthy Controls ◽  
Value Differences ◽  
Intrauterine Growth ◽  
Non Invasive ◽  
Invasive Method ◽  
Ratio Variables

AbstractAims:To evaluate values of T/QRS ratio in normal pregnancies and those complicated by intrauterine growth restriction (IUGR) using non-invasive method with transabdominal electrodes. Assessment of fetal well-being in IUGR pregnancies.Methods:Fetal electrocardiograms were recorded and analyzed by KOMPOREL software from ITAM (Zabrze, Poland) and T/QRS ratios were automatically calculated. Doppler velocimetry of the middle cerebral artery and umbilical artery was carried out. The study group consisted of IUGR pregnancies with normal cerebroplacental ratios (CPRs) (n=110), IUGR pregnancies with decreased CPRs (n=29), and healthy controls (n=549). Analyses were performed between the study groups and by gestational age. T/QRS ratio variables and CPRs were calculated. Analysis of variance and linear regression were performed.Results:Maximum values, maximum minimal value differences, and standard deviations of T/QRS ratio were significantly different between the IUGR group with reduced CPRs and normal CPRs (P=0.0009, P=0.0000, P=0.0034, respectively) as well as between the IUGR group with reduced CPRs and healthy controls (P=0.0000, P=0.0001, P=0.0009, respectively). Mean maximum values in the IUGR group with reduced CPRs exceeded normal values.Conclusions:T/QRS ratio may be useful in assessing fetal well-being in IUGR pregnancies; however, future studies are needed to determine typical ranges of T/QRS ratio in pregnancies complicated by IUGR.

scholarly journals AMPK activation in pregnant human myometrial arteries from high-altitude and intrauterine growth-restricted pregnancies

2020 ◽  
Vol 319 (1) ◽  
pp. H203-H212
Author(s):  
Ramón A. Lorca ◽  
Christopher J. Matarazzo ◽  
Elise S. Bales ◽  
Julie A. Houck ◽  
David J. Orlicky ◽  
...  
Keyword(s):  
High Altitude ◽  
Gestational Age ◽  
Intrauterine Growth Restriction ◽  
Well Being ◽  
Growth Restriction ◽  
Ampk Activation ◽  
Intrauterine Growth ◽  
Mother And Child ◽  
Appropriate For Gestational Age

Intrauterine growth restriction (IUGR) impairs infant well being and increases susceptibility to later-in-life diseases for mother and child. Our study reveals a novel role for AMPK in vasodilating the myometrial artery (MA) from women residing at high altitude (>2,500 m) with appropriate for gestational age pregnancies but not in IUGR pregnancies at any altitude.

scholarly journals Alteration in 11 Beta-Hydroxysteroid Dehydrogenase Type-2 (HSD11B2) Gene as A Potential Candidate Parameter for Early Detection of Intrauterine Growth Restriction (IUGR) Events

2021 ◽  
Vol 5 (3) ◽  
pp. 98
Author(s):  
Louis Fabio Jonathan Jusni ◽  
Patricia Patricia ◽  
Brigitte Leonie Rosadi
Keyword(s):  
Early Detection ◽  
Doppler Ultrasound ◽  
Intrauterine Growth Restriction ◽  
Prenatal Testing ◽  
Hydroxysteroid Dehydrogenase ◽  
Growth Restriction ◽  
Diagnostic Parameter ◽  
Intrauterine Growth ◽  
Non Invasive

Intrauterine Growth Restriction (IUGR) incidence in Indonesia ranks in the top 10 of the highest in Asia. It is the main perinatal death cause. IUGR also impairs fetal neurodevelopment, which can affect the development of children until later ages. Lack of 11β-hydroxysteroid dehydrogenase type-2 (11β-HSD2) enzyme is influenced by changes in the coding gene, HSD11B2, one of IUGR's causes. The main diagnostic method of IUGR at this time is by using Doppler ultrasound. However, Doppler ultrasound has several limitations as many cases are not detected. Its clinical predictive value in various women is poor, as Doppler ultrasound is not recommended for use in the first trimester, detection of abnormalities in the second trimester seems to be too late for helpful interventions. The study aim is to present an overview concerning HSD11B2 gene alteration in an non-invasive prenatal testing (NIPT) as a possible diagnostic parameter for early detection in IUGR infants. This literature review is based on selected articles and studies taken from the Pubmed, Proquest, and EBSCO databases. A total of 4 studies reported the tendency for DNA methylation and decreased expression of the HSD11B2 gene in IUGR cases. Changes in the HSD11B2 gene have the potential to become a diagnostic parameter in the early detection of infants with IUGR. Further study and investigation of this possibility are needed.Keywords: intrauterine growth restriction, HSD11B2, early detection, diagnostic, non-invasive prenatal testing

Role of Shatavaryadi Ksheerapaka Basti in Garbha Kshaya - Case Series

2017 ◽  
Vol 2 (05) ◽  
Author(s):  
Suprabha K. ◽  
Laxmipriya Dei
Keyword(s):  
Fetal Growth ◽  
Intrauterine Growth Restriction ◽  
Case Series ◽  
Well Being ◽  
Fetal Movement ◽  
Growth Restriction ◽  
Maternal Weight ◽  
Related Disorder ◽  
Intrauterine Growth ◽  
Reduced Fetal Movement

Garbha Kshaya comprising of (Anunnata Kukshi) fundal height less than the period of gestation and (Garbha Aspandana) reduced fetal movement due to reduced amniotic fluid can be taken as fetal growth related disorder mainly IUGR (Intrauterine growth restriction). Ayurveda mentions Ksheera Basti (medicated milk enema) as a classical treatment in the management of Garbha Kshaya. In this case series, total 3 pregnant patients completing their 7th months of pregnancy, with the complaint of intrauterine growth restriction, reduced fetal movement and oligohydraminos were administered with Shatavaryadi Ksheerapaka Basti. Shatavaryadi Ksheerapaka Basti consists of fine powder of Shatavari, Bala and Arjuna 10 g each made into Ksheerapaka form and administered once daily in the morning, for consecutive 10 days. It was observed that after the Basti treatment, there was increase in the fetal movements, liquor and also fetal weight. In addition, there was also increase in maternal weight and improvement in fatigue, body ache, etc. From the study it has been observed that, in conditions of Garbha Kshaya (IUGR), administration of Shatavaryadi Ksheerapaka Basti is beneficial in terms of fetal growth and maternal well being.

scholarly journals The Role of Cellular Stress in Intrauterine Growth Restriction and Postnatal Dysmetabolism

2021 ◽  
Author(s):  
Shelby L Oke ◽  
Daniel Barry Hardy
Keyword(s):  
Birth Weight ◽  
Intrauterine Growth Restriction ◽  
Molecular Mechanisms ◽  
Pathological Condition ◽  
Cellular Stress ◽  
Well Being ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
The Metabolic Syndrome

Disruption of the in utero environment can have dire consequences on fetal growth and development. Intrauterine growth restriction (IUGR) is a pathological condition by which the fetus deviates from its expected growth trajectory, resulting in low birth weight and impaired organ function. The developmental origins of health and disease (DOHaD) postulates that IUGR has lifelong consequences on offspring well-being, as human studies have established an inverse relationship between birth weight and long-term metabolic health. While these trends are apparent in epidemiological data, animal studies have been essential in defining the molecular mechanisms that contribute to this relationship. One such mechanism is cellular stress, a prominent underlying cause of the metabolic syndrome. As such, this review considers the role of oxidative stress, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and inflammation in the pathogenesis of metabolic disease in IUGR offspring. In addition, we summarize how uncontrolled cellular stress can lead to programmed cell death within the metabolic organs of IUGR offspring.

Maternal endothelial damage as a disorder shared by early preeclampsia, late preeclampsia and intrauterine growth restriction

2017 ◽  
Vol 45 (7) ◽  
Author(s):  
Sebastian Kwiatkowski ◽  
Barbara Dołegowska ◽  
Ewa Kwiatkowska ◽  
Rafał Rzepka ◽  
Natalia Marczuk ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Study Groups ◽  
Endothelial Damage ◽  
Growth Restriction ◽  
Control Group ◽  
C Reactive Protein ◽  
Intrauterine Growth ◽  
Reactive Protein ◽  
Disease Entities ◽  
Placental Ischemia

AbstractIntroduction:Preeclampsia (PE) and intrauterine growth restriction (IUGR) are separate disease entities that have frequently been reported as sharing the same pathogenesis. In both of them, angiogenesis disorders and generalized endothelial damage with an accompanying inflammation are the dominant symptoms. In this study, we attempted to prove that both these processes demonstrate the same profile in early PE, late PE and IUGR patients, while the only difference is in the degree of exacerbation of the lesions.Patients, materials and methods:In 167 patients divided into four groups, three of those with early PE, late PE and IUGR and one control group, fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), high sensitive c-reactive protein (hsCRP) and fibronectin were determined. The behavior of these parameters in each of the groups was studied, and correlations between them were sought for.Results:Higher concentrations of sFlt-1, hsCRP and fibronectin and a lower concentration of PlGF were found in the study groups compared to the control group. Significant correlations were observed between the factors concerned.Conclusions:The higher values of disordered angiogenesis markers, endothelial damage markers and inflammatory markers both in the PE and the intrauterine growth restriction (IUGR) groups suggest the existence of shared disorders in the development of these pathologies. The correlations between disordered angiogenesis markers and endothelial damage markers argue in favor of a mutual relationship between these two processes in the development of pathologies evolving as secondary to placental ischemia. The results obtained confirm that the lesion profiles are the same in both PE and IUGR patients, which can be utilized in developing common diagnostic criteria.

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