scholarly journals An infertile female delivered a baby after removal of primary renal carcinoid tumor

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 146-148
Author(s):  
Syu Jhang ◽  
Allen W. Chiu
Keyword(s):  
Carcinoid Tumor ◽  
English Literature ◽  
Carcinoid Tumors ◽  
Primary Infertility ◽  
First Case

Abstract Primary renal carcinoid tumors are exceedingly rare. We report a 37-year-old woman with primary infertility, who was found to have a primary renal carcinoid tumor. She became pregnant and gave birth to a baby after removal of the tumor. This is the first case in the English literature of primary renal carcinoid tumor related with primary infertility.

scholarly journals A rare benign genitourinary tumor in a Japanese male: urinary retention owing to aggressive angiomyxoma of the prostate

Rare Tumors ◽  
2010 ◽  
Vol 2 (1) ◽  
pp. 43-45 ◽  
Author(s):  
Yugo Sawada ◽  
Fumio Ito ◽  
Hayakazu Nakazawa ◽  
Nobuhiko Tsushima ◽  
Hikaru Tomoe ◽  
...  
Keyword(s):  
Renal Dysfunction ◽  
Urinary Retention ◽  
Bladder Neck ◽  
English Literature ◽  
Pathological Examination ◽  
Aggressive Angiomyxoma ◽  
Urethral Meatus ◽  
First Case ◽  
Japanese Male ◽  
Old Japanese

Close examination of a 67-year-old Japanese man, who complained of persistent nocturia, revealed that a semitransparent polypoid tumor had developed from the bladder neck to the prostatic urethra obstructing the internal urethral meatus, which resulted in excessive urinary retention and post-renal dysfunction. The tumor was resected by a transurethral procedure and a pathological examination of specimens revealed aggressive angiomyxoma (AAM) of the prostate. AAM usually develops in the intrapelvic and perineal organs of females. So far as we know, this is the second case of primary prostatic AAM reported in the English literature, and is the first case where the patient encountered urethral obstruction.

scholarly journals Our Parenchyma-Sparing Surgical Treatment Results in Carcinoid Tumors and Changes in the Surgical Approach

2021 ◽  
Author(s):  
Figen Türk ◽  
Gökhan Yuncu ◽  
Tolga Semerkant ◽  
Yasin Ekinci ◽  
Gökhan Öztürk
Keyword(s):  
Surgical Treatment ◽  
Carcinoid Tumor ◽  
Surgical Approach ◽  
Carcinoid Tumors ◽  
Diagnostic Methods ◽  
Normal Lung ◽  
Sleeve Resection ◽  
Surgical Methods ◽  
Prolonged Air Leak ◽  
Parenchyma Sparing

INTRODUCTION: Hilar/mediastinal lymph node sampling with lobectomy are the most common surgical methods used for the surgical treatment of carcinoid tumors. Bronchoplastic approaches together with lobectomy enable sparing of normal lung tissue and provide an alternative surgical approach to avoid pneumonectomy by enabling sleeve resection for centrally located tumors. The aim of this study was to present our parenchyma-sparing open surgical treatment experiences with the carcinoid tumor cases operated in our clinic in light of the new developments in the literature METHODS: The 11 tumor cases that had been diagnosed with carcinoid tumor and undergone surgical resection at our clinic between 2006 and 2012 were retrospectively revealed for tumor epidemiology, diagnostic methods, tumor localization, surgical treatment method, type and stage and postoperative complications. RESULTS: There were 7 males and 4 females with a mean age of 54.81±13.75 years (31-72 years). Cough was the most common presentation symptom with 8 cases (72.7%). A bronchoscopic biopsy was used for the definite diagnosis in 8 cases (72.7%). There were 11 (84.6%) typical and 2 (15.4%) atypical carcinoid tumors in the 11 cases. The most common surgical methods were lobectomy in 7 cases (53.8%) (3 sleeve, 1 bronchoplastic) and wedge resection in 4 cases. We found bilateral synchronous and 3 years later metachronous carcinoid tumor in a single case. The postoperative pathology diagnosis was T2N0M0 in 6 cases (54.5%) and T1N0M0 in 3 cases (27.2%). There was 1 atelectasis and 1 prolonged air leak in the postoperative stage. DISCUSSION AND CONCLUSION: Although we still use thoracotomy and lobectomy for the surgical treatment of carcinoid tumors in our clinic, we currently prefer minimal invasive surgery with the VATS and robotic surgery techniques that are gradually becoming more popular.

scholarly journals The single-cell transcriptional landscape of lung carcinoid tumors

2021 ◽  
Author(s):  
Philip Bischoff ◽  
Alexandra Trinks ◽  
Jennifer Wiederspahn ◽  
Benedikt Obermayer ◽  
Jan Patrick Pett ◽  
...  
Keyword(s):  
Gene Expression ◽  
Single Cell ◽  
Carcinoid Tumor ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Carcinoid Tumors ◽  
Cellular Composition ◽  
Cell Gene Expression ◽  
Cell Gene ◽  
Lung Carcinoid

AbstractLung carcinoid tumors, also referred to as pulmonary neuroendocrine tumors or lung carcinoids, are rare neoplasms of the lung with a more favorable prognosis than other subtypes of lung cancer. Still, some patients suffer from relapsed disease and metastatic spread while no consensus treatment exists for metastasized carcinoids. Several recent single-cell studies have provided detailed insights into the cellular heterogeneity of more common lung cancers, such as adeno- and squamous cell carcinoma. However, the characteristics of lung carcinoids on the single-cell level are yet completely unknown.To study the cellular composition and single-cell gene expression profiles in lung carcinoids, we applied single-cell RNA sequencing to three lung carcinoid tumor samples and normal lung tissue. The single-cell transcriptomes of carcinoid tumor cells reflected intertumoral heterogeneity associated with clinicopathological features, such as tumor necrosis and proliferation index. The immune microenvironment was specifically enriched in noninflammatory monocyte-derived myeloid cells. Tumor-associated endothelial cells were characterized by distinct gene expression profiles. A spectrum of vascular smooth muscle cells and pericytes predominated the stromal microenvironment. We found a small proportion of myofibroblasts exhibiting features reminiscent of cancer-associated fibroblasts. Stromal and immune cells exhibited potential paracrine interactions which may shape the microenvironment via NOTCH, VEGF, TGFβ and JAK/STAT signaling. Moreover, single-cell gene signatures of pericytes and myofibroblasts demonstrated prognostic value in bulk gene expression data.Here, we provide first comprehensive insights into the cellular composition and single-cell gene expression profiles in lung carcinoids, demonstrating the non-inflammatory and vessel-rich nature of their tumor microenvironment, and outlining relevant intercellular interactions which could serve as future therapeutic targets.

Monophasic Synovial Sarcoma Arising in the Vulva: A Case Report and Review of the Literature

2008 ◽  
Vol 132 (4) ◽  
pp. 698-702
Author(s):  
Beverly E. White ◽  
Alan Kaplan ◽  
Dolores H. Lopez-Terrada ◽  
Jae Y. Ro ◽  
Robert S. Benjamin ◽  
...  
Keyword(s):  
Synovial Sarcoma ◽  
Soft Tissues ◽  
English Literature ◽  
Review Of The Literature ◽  
First Case ◽  
Additional Surgery ◽  
Synovial Sarcomas ◽  
The Right ◽  
Disease Free ◽  
Vulvar Mass

Abstract Synovial sarcomas most commonly arise in the soft tissue of the extremities. Less commonly, these tumors present in the head and neck, abdominal wall, and other sites. However, synovial sarcoma occurring in the vulvar area is extremely rare. Only 2 previous cases of biphasic synovial sarcoma of the vulva have been reported, but no case of vulvar monophasic synovial sarcoma has been described in the English literature. We report the third case of synovial sarcoma and apparently the first case of monophasic synovial sarcoma arising in soft tissues of the vulva. The patient was a 33-year-old woman who presented for evaluation of a painless vulvar mass. The tumor was located in the deep fibroadipose tissue of the right vulva (6.5 × 4.2 × 3.5 cm). The histology of the lesion was that of a monophasic synovial sarcoma with a hemangiopericytic vascular pattern. A subsequent molecular analysis revealed SYT-SSX2 gene fusion, which confirmed the diagnosis of synovial sarcoma. After an initial wide local excision, the patient developed a recurrence in the right groin and received chemotherapy and additional surgery. The patient is currently disease free, on adjuvant chemotherapy, and being followed up closely.

scholarly journals Acquired smooth muscle hamartoma: A case report on the lower extremity with hidrosis

2019 ◽  
Vol 7 ◽  
pp. 2050313X1989383
Author(s):  
Malika A Ladha ◽  
Todd Remington
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Lower Extremity ◽  
Smooth Muscle Cells ◽  
English Literature ◽  
Surgical Excision ◽  
Muscle Cells ◽  
Clinical Spectrum ◽  
Rare Entity ◽  
First Case

Smooth muscle hamartomas are benign dermal proliferations of smooth muscle cells. Smooth muscle hamartomas are sub-divided into congenital or acquired; the latter is a rare entity with less than 20 cases being reported in the English literature. Most often asymptomatic, acquired smooth muscle hamartomas follow an indolent course. Treatment in the form of surgical excision can be utilized for symptomatic or cosmetic purposes. Here, we report the first case of an acquired smooth muscle hamartomas of the shin which also uniquely presented with hidrosis. This case highlights the varied clinical spectrum of acquired smooth muscle hamartomas.

Dramatic neurological recovery with delayed correction of traumatic lumbar spondyloptosis

2007 ◽  
Vol 6 (6) ◽  
pp. 606-610 ◽  
Author(s):  
Michael P. Bellew ◽  
Bradley J. Bartholomew
Keyword(s):  
Patient Outcome ◽  
English Literature ◽  
Cauda Equina ◽  
Neurological Function ◽  
Neurological Recovery ◽  
Delayed Treatment ◽  
First Case ◽  
Remarkable Recovery ◽  
Operative Decompression

✓The authors describe a 36-year-old woman with traumatic lateral spondyloptosis at L-2 and complete cauda equina injury who experienced a remarkable recovery after delayed treatment. To the authors' knowledge, this is the first case of traumatic spondyloptosis at L2–3 described in the English literature. A review of previous cases of lumbar spondyloptosis suggests that the degree of anatomical injury found at surgery is a better predictor of patient outcome than fracture severity assessed radiologically. Concomitant multisystem injury is common with spine disruptions of this magnitude and may mask clinical neurological function. Even when delayed, operative decompression of these severe lesions should be considered because dramatic neurological recovery is possible.

scholarly journals Endoscopic Repair of a Colonic Perforation following Polypectomy Using an Endoclip

2004 ◽  
Vol 18 (2) ◽  
pp. 105-106 ◽  
Author(s):  
Sonny S Dhalla
Keyword(s):  
Case Report ◽  
English Literature ◽  
Colonic Perforation ◽  
Endoscopic Repair ◽  
First Case

Endoscopic repair using an endoclip device for colonic perforation following polypectomy is described. This is the first case report of a repair following a regular polypectomy-induced perforation described in the English literature.

Value of Peptide Receptor Scintigraphy Using 123I-Vasoactive Intestinal Peptide and 111In-DTPA-D-Phe1-Octreotide in 194 Carcinoid Patients: Vienna University Experience, 1993 to 1998

2000 ◽  
Vol 18 (6) ◽  
pp. 1331-1336 ◽  
Author(s):  
Markus Raderer ◽  
Amir Kurtaran ◽  
Maria Leimer ◽  
Peter Angelberger ◽  
Bruno Niederle ◽  
...  
Keyword(s):  
Vasoactive Intestinal Peptide ◽  
Carcinoid Tumor ◽  
Diagnostic Yield ◽  
Random Order ◽  
Tracer Uptake ◽  
Carcinoid Tumors ◽  
Conventional Imaging ◽  
Peptide Receptor ◽  
Imaging Results ◽  
Metastatic Sites

PURPOSE: To report our experience with both 123I-vasoactive intestinal peptide (VIP) and 111In-DTPA-D-Phe1-octreotide for imaging to identify primary and metastatic tumor sites in carcinoid patients. PATIENTS AND METHODS: One hundred ninety-four patients with a verified or clinically suspected diagnosis of a carcinoid tumor were injected with 111In-DTPA-D-Phe1-OCT for imaging purposes, while 133 patients underwent scanning with both 123I-VIP and 111In-DTPA-D-Phe1-OCT in random order. Imaging results were compared with computed tomography scans, results of conventional ultrasound, endosonography, and endoscopy, and results of surgical exploration in case of inconclusive conventional imaging. RESULTS: Primary or recurrent carcinoid tumors could be visualized with 111In-DTPA-D-Phe1-OCT in 95 (91%) of 104 patients; metastatic sites were identified in 110 (95%) of 116 patients. In 11 (51%) of 21 patients with suggestive symptoms but without identified lesions by conventional imaging, focal tracer uptake located the carcinoid tumor. In addition, metastatic disease was demonstrated in three patients after resection. In a direct comparison in the 133 patients who underwent both imaging modalities, 111In-DTPA-D-Phe1-OCT was found to be superior to 123I-VIP, with 35 (93%) of 38 versus 32 (82%) of 38 scans being positive in primary or recurrent tumors, 58 (90%) of 65 versus 53 (82%) of 65 being positive in patients with metastatic sites, and seven (44%) of 16 versus four (25%) of 16 being positive in patients with symptoms but otherwise negative work-ups. Overall, additional lesions not seen on conventional imaging were imaged in 43 (41%) of 158 versus 25 (25%) of 103 scans with 111In-DTPA-D-Phe1-OCT and 123I-VIP, respectively. CONCLUSION: Both peptide tracers have a high sensitivity for localizing tumor sites in patients with ascertained or suspected carcinoid tumors, with 111In-DTPA-D-Phe1-OCT scintigraphy being more sensitive than 123I-VIP receptor scanning. Both, however, had a higher diagnostic yield than conventional imaging, as verified by surgical intervention or long-term follow-up. The combination of both peptide receptor scans does not seem to further enhance diagnostic information.

scholarly journals First Description of Alveolar Rhabdomyosarcoma of the Larynx in a Young Child

2020 ◽  
pp. 014556132097377
Author(s):  
Julien Quéré ◽  
Jean-Christophe Leclere ◽  
Julien Prévot ◽  
Virginie Conan ◽  
Rémi Marianowski
Keyword(s):  
Lymph Node ◽  
Young Child ◽  
Poor Prognosis ◽  
Pediatric Population ◽  
English Literature ◽  
Endoscopic Biopsy ◽  
Alveolar Rhabdomyosarcoma ◽  
Histological Subtypes ◽  
First Case ◽  
Node Metastases

Rhabdomyosarcoma of the larynx has been very rarely described in pediatric population. There are 3 histological subtypes: embryonal, pleomorphic, and alveolar. With regard to the English literature, we present the first case of alveolar rhabdomyosarcoma of the larynx ever described in a child. This tumor has been diagnosed on an endoscopic biopsy. Thus, a unilateral arytenoidectomy has been performed. This tumor has a poor prognosis. Lymph node metastases were successfully treated by chemotherapy and radiotherapy. Surgery has shifted from radical to conservative combined with adjuvant treatments.

scholarly journals Resolution of Right-Sided Heart Failure Symptoms after Resection of a Primary Ovarian Carcinoid Tumor

2014 ◽  
Vol 41 (5) ◽  
pp. 533-536 ◽  
Author(s):  
Todd Goldman ◽  
Kathi Adamson ◽  
Eugene Yang
Keyword(s):  
Heart Failure ◽  
Heart Disease ◽  
Gastrointestinal Tract ◽  
Surgical Resection ◽  
Carcinoid Tumor ◽  
Fallopian Tube ◽  
Complete Resolution ◽  
Rare Condition ◽  
Carcinoid Tumors ◽  
Carcinoid Heart Disease

Carcinoid tumors are rare neuroendocrine malignancies that typically originate from the gastrointestinal tract. Patients who are diagnosed with carcinoid heart disease generally have poor prognoses because of advanced metastases during staging and few therapeutic options. We present the case of a 61-year-old woman with right-sided heart failure, secondary to carcinoid heart disease caused by a primary ovarian carcinoid tumor. After undergoing surgical resection of the left ovary and fallopian tube, the patient experienced complete resolution of her heart failure symptoms. In addition to the patient's case, we discuss the diagnosis, nature, and treatment of this rare condition.

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