Recent developments and future perspectives on neuroelectronic devices

Abstract Neuroscientific discoveries and the development of recording and stimulation tools are deeply connected. Over the past decades, the progress in seamlessly integrating such tools in the form of neuroelectronic devices has been tremendous. Here, we review recent advances and key aspects of this goal. Firstly, we illustrate improvements with respect to the coupling between cells/tissue and recording/stimulation electrodes. Thereafter, we cover attempts to mitigate the foreign body response by reducing the devices’ invasiveness. We follow up with a description of specialized electronic hardware aimed at the needs of bioelectronic applications. Lastly, we outline how additional modalities such as optical techniques or ultrasound could in the future be integrated into neuroelectronic implants.

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Mesenchymal stem cell-based bioengineered constructs: foreign body response, cross-talk with macrophages and impact of biomaterial design strategies for pelvic floor disorders

Interface Focus ◽

10.1098/rsfs.2018.0089 ◽

2019 ◽

Vol 9 (4) ◽

pp. 20180089 ◽

Cited By ~ 18

Author(s):

Shayanti Mukherjee ◽

Saeedeh Darzi ◽

Kallyanashis Paul ◽

Jerome A. Werkmeister ◽

Caroline E. Gargett

Keyword(s):

Foreign Body ◽

Pelvic Floor ◽

Critical Role ◽

Pelvic Organ ◽

Foreign Body Response ◽

Design Strategies ◽

Macrophage Response ◽

Improved Outcomes ◽

Key Aspects ◽

Body Response

An excessive foreign body response (FBR) has contributed to the adverse events associated with polypropylene mesh usage for augmenting pelvic organ prolapse surgery. Consequently, current biomaterial research considers the critical role of the FBR and now focuses on developing better biocompatible biomaterials rather than using inert implants to improve the clinical outcomes of their use. Tissue engineering approaches using mesenchymal stem cells (MSCs) have improved outcomes over traditional implants in other biological systems through their interaction with macrophages, the main cellular player in the FBR. The unique angiogenic, immunomodulatory and regenerative properties of MSCs have a direct impact on the FBR following biomaterial implantation. In this review, we focus on key aspects of the FBR to tissue-engineered MSC-based implants for supporting pelvic organs and beyond. We also discuss the immunomodulatory effects of the recently discovered endometrial MSCs on the macrophage response to new biomaterials designed for use in pelvic floor reconstructive surgery. We conclude with a focus on considerations in biomaterial design that take into account the FBR and will likely influence the development of the next generation of biomaterials for gynaecological applications.

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Prospective study to assess the tissue response to HPC-coated p48 flow diverter stents compared to uncoated devices in the rabbit carotid artery model

European Radiology Experimental ◽

10.1186/s41747-019-0128-z ◽

2019 ◽

Vol 3 (1) ◽

Cited By ~ 8

Author(s):

Tim Lenz-Habijan ◽

Pervinder Bhogal ◽

Catrin Bannewitz ◽

Ralf Hannes ◽

Hermann Monstadt ◽

...

Keyword(s):

Foreign Body ◽

Flow Diverter ◽

Foreign Body Response ◽

Tissue Response ◽

Acute Setting ◽

Significant Difference ◽

And Performance ◽

Surface Modified ◽

Common Carotid Arteries

Abstract Background Flow diverters (FDs) are widely used in the treatment of intracranial aneurysms, but the required medication increases the risk of haemorrhagic complications and limits their use in the acute setting. Surface modified FDs may limit the need for dual antiplatelet therapy (DAPT). Hydrophilic polymer coating (HPC) may reduce the need of medication. Methods This explorative study, approved by the local authorities and the local welfare committee, compared stent behaviour and overall tissue response between HPC-coated FDs and uncoated FDs, both implanted into the common carotid arteries of eight New Zealand white rabbits. Endothelialisation, inflammatory response, and performance during implantation were assessed. Angiographic follow-up was performed to observe the patency of the devices after implantation and after 30 days. Histological examinations were performed at 30 days to assess foreign body reaction and endothelialisation. Kruskal-Wallis and Wilcoxon tests were used to compare non-parametric variables. Results Angiography showed that both coated and uncoated FDs performed well during implantation. All devices remained patent during immediate follow-up and after 30 days. Histopathology showed no significant difference in inflammation within the vessel wall between the two cohorts (2.12 ± 0.75 vs. 1.96 ± 0.79, p = 0.7072). Complete endothelialisation of the stent struts was seen with very similar (0.04 ± 0.02 mm vs. 0.04 ± 0.03 mm, p = 0.892) neoendothelial thickness between the two cohorts after 30 days. Conclusion Taking into account the limitation in sample size, non-significant differences between the HPC-coated and uncoated FDs regarding implantation, foreign body response, and endothelialisation were found.

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Examinations of a new long-term degradable electrospun polycaprolactone scaffold in three rat abdominal wall models

Journal of Biomaterials Applications ◽

10.1177/0885328216687664 ◽

2017 ◽

Vol 31 (7) ◽

pp. 1077-1086 ◽

Cited By ~ 3

Author(s):

Hanna Jangö ◽

Søren Gräs ◽

Lise Christensen ◽

Gunnar Lose

Keyword(s):

Pelvic Organ Prolapse ◽

Foreign Body ◽

Abdominal Wall ◽

Muscle Fiber ◽

Pelvic Organ ◽

Foreign Body Response ◽

Heavy Load ◽

Tissue Construct ◽

Body Response

Alternative approaches to reinforce native tissue in reconstructive surgery for pelvic organ prolapse are warranted. Tissue engineering combines the use of a scaffold with the regenerative potential of stem cells and is a promising new concept in urogynecology. Our objective was to evaluate whether a newly developed long-term degradable polycaprolactone scaffold could provide biomechanical reinforcement and function as a scaffold for autologous muscle fiber fragments. We performed a study with three different rat abdominal wall models where the scaffold with or without muscle fiber fragments was placed (1) subcutaneously (minimal load), (2) in a partial defect (partial load), and (3) in a full-thickness defect (heavy load). After 8 weeks, no animals had developed hernia, and the scaffold provided biomechanical reinforcement, even in the models where it was subjected to heavy load. The scaffold was not yet degraded but showed increased thickness in all groups. Histologically, we found a massive foreign body response with numerous large giant cells intermingled with the fibers of the scaffold. Cells from added muscle fiber fragments could not be traced by PKH26 fluorescence or desmin staining. Taken together, the long-term degradable polycaprolactone scaffold provided biomechanical reinforcement by inducing a marked foreign-body response and attracting numerous inflammatory cells to form a strong neo-tissue construct. However, cells from the muscle fiber fragments did not survive in this milieu. Properties of the new neo-tissue construct must be evaluated at the time of full degradation of the scaffold before its possible clinical value in pelvic organ prolapse surgery can be evaluated.

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Beneficial effects of hydrocortisone or spironolactone coating on foreign body response to mesh biomaterial in a mouse model

Journal of Biomedical Materials Research Part A ◽

10.1002/jbm.a.33136 ◽

2011 ◽

Vol 99A (3) ◽

pp. 335-343 ◽

Cited By ~ 16

Author(s):

Christopher J. Brandt ◽

Daniel Kammer ◽

Anette Fiebeler ◽

Uwe Klinge

Keyword(s):

Foreign Body ◽

Mouse Model ◽

Foreign Body Response ◽

Beneficial Effects ◽

Body Response

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Mitigating the foreign body response through ‘immune-instructive’ biomaterials

Journal of Immunology and Regenerative Medicine ◽

10.1016/j.regen.2021.100040 ◽

2021 ◽

Vol 12 ◽

pp. 100040

Author(s):

Lisa Kämmerling ◽

Leanne E. Fisher ◽

Ezgi Antmen ◽

Gorkem M. Simsek ◽

Hassan M. Rostam ◽

...

Keyword(s):

Foreign Body ◽

Foreign Body Response ◽

Body Response

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A Polymer-Biologic Hybrid Hernia Construct: Review of Data and Early Experiences

Polymers ◽

10.3390/polym13121928 ◽

2021 ◽

Vol 13 (12) ◽

pp. 1928

Author(s):

Michael Sawyer ◽

Stephen Ferzoco ◽

George DeNoto

Keyword(s):

Foreign Body ◽

Hernia Repair ◽

Surgical Mesh ◽

Foreign Body Response ◽

Host Cells ◽

Mesh Reinforcement ◽

Decellularized Extracellular Matrix ◽

Early Experiences ◽

Tissue Matrix ◽

Body Response

Surgical mesh reinforcement of the human abdominal wall has been found to reduce the chance of recurrence in hernia repairs. While traditionally polymer meshes have been used in hernia repair, alternative mesh options have been engineered to prevent the inflammatory foreign body response invoked by polymers. A reinforced tissue matrix (RTM) mesh has been developed by embedding a polymer within a decellularized extracellular matrix. This combination has been attributed to the recruitment of host cells, a pro-healing response, and attenuation of the foreign body response. This has been observed to lead to the regeneration of functional tissue within the repair site that is reinforced by the polymer to offload abdominal pressures over time. This manuscript presents the review of OviTex, an RTM, in several types of hernia repair. The authors have found that the use of RTM in hernia repair is effective in preventing foreign body response, promoting wound healing, and providing reinforcement to lower the risk of hernia recurrence.

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Immunobiology and Application of Aloe vera-Based Scaffolds in Tissue Engineering

International Journal of Molecular Sciences ◽

10.3390/ijms22041708 ◽

2021 ◽

Vol 22 (4) ◽

pp. 1708

Author(s):

Saeedeh Darzi ◽

Kallyanashis Paul ◽

Shanilka Leitan ◽

Jerome A. Werkmeister ◽

Shayanti Mukherjee

Keyword(s):

Tissue Engineering ◽

Foreign Body ◽

Scientific Evidence ◽

Aloe Vera ◽

Material Design ◽

Foreign Body Response ◽

The Body ◽

Design Strategies ◽

Immunomodulatory Effects ◽

Body Response

Aloe vera (AV), a succulent plant belonging to the Liliaceae family, has been widely used for biomedical and pharmaceutical application. Its popularity stems from several of its bioactive components that have anti-oxidant, anti-microbial, anti-inflammatory and even immunomodulatory effects. Given such unique multi-modal biological impact, AV has been considered as a biomaterial for regenerative medicine and tissue engineering applications, where tissue repair and neo-angiogenesis are vital. This review outlines the growing scientific evidence that demonstrates the advantage of AV as tissue engineering scaffolds. We particularly highlight the recent advances in the application of AV-based scaffolds. From a tissue engineering perspective, it is pivotal that the implanted scaffolds strike an appropriate foreign body response to be well-accepted in the body without complications. Herein, we highlight the key cellular processes that regulate the foreign body response to implanted scaffolds and underline the immunomodulatory effects incurred by AV on the innate and adaptive system. Given that AV has several beneficial components, we discuss the importance of delving deeper into uncovering its action mechanism and thereby improving material design strategies for better tissue engineering constructs for biomedical applications.

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