Imaging modalities using magnetic nanoparticles – overview of the developments in recent years

2013 ◽  
Vol 2 (4) ◽  
pp. 381-394 ◽  
Author(s):  
Marc Schwarz ◽  
Arnd Dörfler ◽  
Tobias Engelhorn ◽  
Tobias Struffert ◽  
Rainer Tietze ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Tumor Imaging ◽  
Imaging Modality ◽  
Superparamagnetic Iron Oxide ◽  
Imaging Modalities ◽  
Resonance Imaging ◽  
New Techniques ◽  
Different Types

AbstractThe use of nanoparticles in tumor imaging, molecular imaging, and drug delivery has significantly expanded in the last few years. The relatively new field of “theranostics” combines their capacity for drug delivery with their potential as contrast agents. Depending on the imaging modality used, several types of nanoparticles are available, such as gold for optical imaging or superparamagnetic iron oxide for magnetic resonance imaging. This review will give a short overview of the different types of nanoparticles as well as their development and potential application in recent years. Furthermore, it describes the research on classic imaging modalities as well as on new techniques to image nanoparticles in vivo and focuses on magnetic-based imaging modalities.

scholarly journals Tracking Transplanted Stem Cells Using Magnetic Resonance Imaging and the Nanoparticle Labeling Method in Urology

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Jae Heon Kim ◽  
Hong J. Lee ◽  
Yun Seob Song
Keyword(s):  
Magnetic Resonance Imaging ◽  
Stem Cells ◽  
Molecular Imaging ◽  
Magnetic Resonance ◽  
Imaging Modality ◽  
Imaging Techniques ◽  
Image Resolution ◽  
Imaging Method ◽  
Resonance Imaging

A reliablein vivoimaging method to localize transplanted cells and monitor their viability would enable a systematic investigation of cell therapy. Most stem cell transplantation studies have used immunohistological staining, which does not provide information about the migration of transplanted cellsin vivoin the same host. Molecular imaging visualizes targeted cells in a living host, which enables determining the biological processes occurring in transplanted stem cells. Molecular imaging with labeled nanoparticles provides the opportunity to monitor transplanted cells noninvasively without sacrifice and to repeatedly evaluate them. Among several molecular imaging techniques, magnetic resonance imaging (MRI) provides high resolution and sensitivity of transplanted cells. MRI is a powerful noninvasive imaging modality with excellent image resolution for studying cellular dynamics. Several types of nanoparticles including superparamagnetic iron oxide nanoparticles and magnetic nanoparticles have been used to magnetically label stem cells and monitor viability by MRI in the urologic field. This review focuses on the current role and limitations of MRI with labeled nanoparticles for tracking transplanted stem cells in urology.

scholarly journals Implication of Magnetic Nanoparticles in Cancer Detection, Screening and Treatment

2019 ◽  
Vol 5 (4) ◽  
pp. 55 ◽  
Author(s):  
Hosu ◽  
Tertis ◽  
Cristea
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Cancer Detection ◽  
Imaging Technique ◽  
Antineoplastic Drugs ◽  
Resonance Imaging ◽  
Sensing Systems

During the last few decades, magnetic nanoparticles have been evaluated as promising materials in the field of cancer detection, screening, and treatment. Early diagnosis and screening of cancer may be achieved using magnetic nanoparticles either within the magnetic resonance imaging technique and/or sensing systems. These sensors are designed to selectively detect specific biomarkers, compounds that can be related to the onset or evolution of cancer, during and after the treatment of this widespread disease. Some of the particular properties of magnetic nanoparticles are extensively exploited in cancer therapy as drug delivery agents to selectively target the envisaged location by tailored in vivo manipulation using an external magnetic field. Furthermore, individualized treatment with antineoplastic drugs may be combined with magnetic resonance imaging to achieve an efficient therapy. This review summarizes the studies about the implications of magnetic nanoparticles in cancer diagnosis, treatment and drug delivery as well as prospects for future development and challenges of magnetic nanoparticles in the field of oncology.

Iron-oxide-based twin nanoplates with strong T2 relaxation shortening for contrast-enhanced magnetic resonance imaging

Nanoscale ◽  
2018 ◽  
Vol 10 (38) ◽  
pp. 18398-18406 ◽  
Author(s):  
Ruixue Wei ◽  
Tiantian Zhou ◽  
Chengjie Sun ◽  
Hongyu Lin ◽  
Lijiao Yang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Tumor Imaging ◽  
Resonance Imaging ◽  
T2 Relaxation ◽  
Contrast Enhanced

Iron oxide twin nanoplates with high T2 relaxivity for in vivo contrast-enhanced magnetic resonance imaging and tumor imaging were reported.

Fe3O4–ZIF-8 assemblies as pH and glutathione responsive T2–T1 switching magnetic resonance imaging contrast agent for sensitive tumor imaging in vivo

2019 ◽  
Vol 55 (4) ◽  
pp. 478-481 ◽  
Author(s):  
Jiaomin Lin ◽  
Pengyan Xin ◽  
Lu An ◽  
Yanjun Xu ◽  
Cheng Tao ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Tumor Imaging ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Contrast ◽  
Imaging Contrast Agent

Fe3O4 nanoparticles were assembled into a zeolitic-imidazole framework to form a pH- and glutathione-responsive T2–T1 switching contrast agent for sensitive tumor imaging.

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