Phenylboronic acid-decorated polymeric nanomaterials for advanced bio-application

Abstract The paradigm of using phenylboronic acid-decorated polymeric nanomaterials for advanced bio-application has been well established over the past decade. Phenylboronic acid and its derivatives are known to form reversible complexes with polyols, including sugar, diol and diphenol. This unique chemistry of phenylboronic acid has given many chances to be exploited for diagnostic and therapeutic applications. This review highlights the recent advances in fabrication of phenylboronic acid-decorated polymeric nanomaterials, especially focus on the interactions with glucose and sialic acid. Applications of these phenylboronic acid-decorated nanomaterials in drug delivery systems and biosensors are discussed.

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Recent advances in metallopolymer-based drug delivery systems

RSC Advances ◽

10.1039/c9ra06678k ◽

2019 ◽

Vol 9 (63) ◽

pp. 37009-37051 ◽

Cited By ~ 4

Author(s):

Gulzhian I. Dzhardimalieva ◽

Lev N. Rabinskiy ◽

Kamila A. Kydralieva ◽

Igor E. Uflyand

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

The Past ◽

Recent Advances

The recent (over the past five years) advances and problems associated with the use of metallopolymers as drug delivery systems (DDSs) are presented and assessed.

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What Drives Innovation: The Canadian Touch on Liposomal Therapeutics

Pharmaceutics ◽

10.3390/pharmaceutics11030124 ◽

2019 ◽

Vol 11 (3) ◽

pp. 124 ◽

Cited By ~ 6

Author(s):

Ada Leung ◽

Carolyn Amador ◽

Lin Chuan Wang ◽

Urmi Mody ◽

Marcel Bally

Keyword(s):

Drug Delivery ◽

Coordination Chemistry ◽

Drug Delivery Systems ◽

Pharmaceutical Products ◽

Delivery Systems ◽

The Past ◽

Entrepreneurial Spirit ◽

Recent Advances ◽

The Future ◽

The Individual

Liposomes are considered one of the most successful drug delivery systems (DDS) given their established utility and success in the clinic. In the past 40–50 years, Canadian scientists have made ground-breaking discoveries, many of which were successfully translated to the clinic, leading to the formation of biotech companies, the creation of research tools, such as the Lipex Extruder and the NanoAssemblr™, as well as contributing significantly to the development of pharmaceutical products, such as Abelcet®, MyoCet®, Marqibo®, Vyxeos®, and Onpattro™, which are making positive impacts on patients’ health. This review highlights the Canadian contribution to the development of these and other important liposomal technologies that have touched patients. In this review, we try to address the question of what drives innovation: Is it the individual, the teams, the funding, and/or an entrepreneurial spirit that leads to success? From this perspective, it is possible to define how innovation will translate to meaningful commercial ventures and products with impact in the future. We begin with a brief history followed by descriptions of drug delivery technologies influenced by Canadian researchers. We will discuss recent advances in liposomal technologies, including the Metaplex technology from the author’s lab. The latter exemplifies how a nanotechnology platform can be designed based on multidisciplinary groups with expertise in coordination chemistry, nanomedicines, disease, and business to create new therapeutics that can effect better outcomes in patient populations. We conclude that the team is central to the effort; arguing if the team is entrepreneurial and well positioned, the funds needed will be found, but likely not solely in Canada.

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Recent Advances of Mesoporous Silica Based Multifunctional Nano Drug Delivery Systems

ACTA AGRONOMICA SINICA ◽

10.3724/sp.j.1206.2013.00303 ◽

2013 ◽

Vol 40 (10) ◽

pp. 1014

Author(s):

Xiao-Hong HAO ◽

Cui-Miao ZHANG ◽

Xiao-Long LIU ◽

Xing-Jie LIANG ◽

Guang JIA ◽

...

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Recent Advances ◽

Nano Drug Delivery

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Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557519666190904145355 ◽

2020 ◽

Vol 20 (11) ◽

pp. 1001-1016

Author(s):

Sandra Ramírez-Rave ◽

María Josefa Bernad-Bernad ◽

Jesús Gracia-Mora ◽

Anatoly K. Yatsimirsky

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Drug Delivery Systems ◽

Mesoporous Silica Nanoparticles ◽

High Surface ◽

Delivery Systems ◽

Surface Reactivity ◽

External Stimulus ◽

Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

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