Investigation on cavitation bubble dynamics induced by clinically available Ho:YAG lasers

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Karl Stock ◽  
Daniel Steigenhöfer ◽  
Thomas Pongratz ◽  
Rainer Graser ◽  
Ronald Sroka
Keyword(s):  
Cavitation Bubble ◽  
Bubble Dynamics ◽  
Laser Energy ◽  
Bubble Collapse ◽  
High Contrast ◽  
Core Diameter ◽  
Ho:Yag Laser ◽  
Fiber Core ◽  
Set Up ◽  
Short Time

AbstractEndoscopic laser lithotripsy is the preferred technique for minimally invasive destruction of ureteral and kidney stones, and is mostly performed by pulsed holmium:yttrium-aluminum-garnet (Ho:YAG) laser irradiation. The absorbed laser energy heats the water creating a vapor bubble which collapses after the laser pulse, thus producing a shock wave. Part of the laser energy strikes the stone through the vapor bubble and induces thermomechanical material removal. Aim of the present study was to visualize the behavior and the dynamics of the cavitation bubble using a specially developed ultra-short-time illumination system and then to determine important characteristics related to clinically used laser and application parameters for a more detailed investigation in the future.In accordance with Toepler’s Schlieren technique, in the ultra-short-time-illumination set-up the cavitation bubble which had been induced by Ho:YAG laser irradiation at the fiber end, was illuminated by two Q-switched lasers and the process was imaged in high contrast on a video camera. Cavitation bubbles were induced using different pulse energies (500 mJ/pulse and 2000 mJ/pulse) and fiber core diameters (230 μm and 600 μm) and the bubble dynamics were recorded at different times relative to the Ho:YAG laser pulse. The time-dependent development of the bubble formation was determined from the recordings by measuring the bubble diameter in horizontal and vertical directions, together with the volume and localization of the center of the bubble collapse.The results show that the bubble dynamics can be visualized and studied with both high contrast and high temporal resolution. The bubble volume increases with pulse energy and with fiber diameter. The bubble shape is almost round when a larger fiber core diameter is used, and elliptical when using a fiber of smaller core diameter. Moreover, the center of the resulting bubble is slightly further away from the fiber end and the center of the bubble collapse for a smaller fiber core diameter.The experimental set-up developed gives a better understanding of the bubble dynamics. The experiments indicate that the distance between fiber tip and target surface, as well as the laser parameters used have considerable impact on the cavitation bubble dynamics. Both the bubble dynamics and their influence on the stone fragmentation process require further investigation.

Modelling of material pitting from cavitation bubble collapse

2014 ◽  
Vol 755 ◽  
pp. 142-175 ◽  
Author(s):  
Chao-Tsung Hsiao ◽  
A. Jayaprakash ◽  
A. Kapahi ◽  
J.-K. Choi ◽  
Georges L. Chahine
Keyword(s):  
Cavitation Bubble ◽  
Bubble Dynamics ◽  
Numerical Approach ◽  
Bubble Collapse ◽  
Material Surface ◽  
Collapse Pressure ◽  
Flow Solver ◽  
Incompressible Boundary ◽  
The Impact ◽  
Impulsive Pressure

AbstractMaterial pitting from cavitation bubble collapse is investigated numerically including two-way fluid–structure interaction (FSI). A hybrid numerical approach which links an incompressible boundary element method (BEM) solver and a compressible finite difference flow solver is applied to capture non-spherical bubble dynamics efficiently and accurately. The flow codes solve the fluid dynamics while intimately coupling the solution with a finite element structure code to enable simulation of the full FSI. During bubble collapse high impulsive pressures result from the impact of the bubble re-entrant jet on the material surface and from the collapse of the remaining bubble ring. A pit forms on the material surface when the impulsive pressure is large enough to result in high equivalent stresses exceeding the material yield stress. The results depend on bubble dynamics parameters such as the size of the bubble at its maximum volume, the bubble standoff distance from the material wall, and the pressure driving the bubble collapse. The effects of these parameters on the re-entrant jet, the following bubble ring collapse pressure, and the generated material pit characteristics are investigated.

scholarly journals Cavitation and bubble dynamics: the Kelvin impulse and its applications

2015 ◽  
Vol 5 (5) ◽  
pp. 20150017 ◽  
Author(s):  
John R. Blake ◽  
David M. Leppinen ◽  
Qianxi Wang
Keyword(s):  
Cavitation Bubble ◽  
High Speed ◽  
Bubble Dynamics ◽  
Clinical Medicine ◽  
Bubble Collapse ◽  
Rigid Boundary ◽  
Design Problems ◽  
Practical Applications ◽  
Wide Range ◽  
Naval Engineering

Cavitation and bubble dynamics have a wide range of practical applications in a range of disciplines, including hydraulic, mechanical and naval engineering, oil exploration, clinical medicine and sonochemistry. However, this paper focuses on how a fundamental concept, the Kelvin impulse, can provide practical insights into engineering and industrial design problems. The pathway is provided through physical insight, idealized experiments and enhancing the accuracy and interpretation of the computation. In 1966, Benjamin and Ellis made a number of important statements relating to the use of the Kelvin impulse in cavitation and bubble dynamics, one of these being ‘One should always reason in terms of the Kelvin impulse, not in terms of the fluid momentum…’. We revisit part of this paper, developing the Kelvin impulse from first principles, using it, not only as a check on advanced computations (for which it was first used!), but also to provide greater physical insights into cavitation bubble dynamics near boundaries (rigid, potential free surface, two-fluid interface, flexible surface and axisymmetric stagnation point flow) and to provide predictions on different types of bubble collapse behaviour, later compared against experiments. The paper concludes with two recent studies involving (i) the direction of the jet formation in a cavitation bubble close to a rigid boundary in the presence of high-intensity ultrasound propagated parallel to the surface and (ii) the study of a ‘paradigm bubble model’ for the collapse of a translating spherical bubble, sometimes leading to a constant velocity high-speed jet, known as the Longuet-Higgins jet.

Numerical Investigation of Liquid Parameters Effect on the Oscillation of Cavitation Bubble

2014 ◽  
Vol 568-570 ◽  
pp. 1794-1800
Author(s):  
Xiu Mei Liu ◽  
Bei Bei Li ◽  
Wen Hua Li ◽  
Jie He ◽  
Jian Lu ◽  
...  
Keyword(s):  
Surface Tension ◽  
Cavitation Bubble ◽  
Bubble Dynamics ◽  
Dynamic Performance ◽  
Bubble Radius ◽  
Gas Content ◽  
Viscous Force ◽  
Bubble Collapse ◽  
Hydraulic Systems ◽  
Increasing Temperature

Cavitation is a common harmful phenomenon in hydraulic transmission systems. It not only damages flow continuity and reduces medium physical performance, but also induces vibration and noise. At the same time, the efficiency of a system is reduced due to cavitation, especially dynamic performance are deteriorated. Applying commercial CFD software FLUENT, the cavitation issuing from the orifice was numerically investigated, reducing the harm. The effect of liquid parameters (such as surface tension, gas content, and the temperature) on the oscillation of bubble is studied numerically. The modified Rayleigh-Plesset equations are presented to describe the oscillation of bubble in different liquids. Employing the finite difference calculus, the behavior of a cavitation bubble in liquids with different physics parameters are obtained. Meanwhile, the numerical results are compared with experiment results. It is observed that the viscous force decreases the growth and collapse of a bubble, making it expand or collapse less violently. And the surface-tension forces stave bubble growth progress and speed up bubble collapse process. On the other hand, both the maximum bubble radius and bubble lifetime increase with increasing temperature. These results can provide theory basis for understanding cavitation bubble dynamics in the hydraulic systems.

Cavitation bubble dynamics in a liquid gap of variable height

2011 ◽  
Vol 682 ◽  
pp. 241-260 ◽  
Author(s):  
SILVESTRE ROBERTO GONZALEZ-AVILA ◽  
EVERT KLASEBOER ◽  
BOO CHEONG KHOO ◽  
CLAUS-DIETER OHL
Keyword(s):  
Cavitation Bubble ◽  
High Speed ◽  
Strong Influence ◽  
Bubble Dynamics ◽  
Bubble Collapse ◽  
High Speed Photography ◽  
Expansion Time ◽  
Gap Height ◽  
Bubble Splitting ◽  
Narrow Gaps

We report on an experimental study of cavitation bubble dynamics within sub-millimetre-sized narrow gaps. The gap height is varied, while the position of the cavitation event is fixed with respect to the lower gap wall. Four different sizes of laser-induced cavitation bubbles are studied using high-speed photography of up to 430,000 frames per second. We find a strong influence of the gap height, H, on the bubble dynamics, in particular on the collapse scenario. Also, similar bubble dynamics was found for the same non-dimensional gap height η = H/Rx, where Rx is the maximum radius in the horizontal direction. Three scenarios are observed: neutral collapse at the gap centre, collapse onto the lower wall and collapse onto the upper wall. For intermediate gap height the bubble obtains a conical shape 1.4 < η < 7.0. For large distances, η > 7.0, the bubble no longer feels the presence of the upper wall and collapses hemispherically. The collapse time increases with respect to the expansion time for decreasing values of η. Due to the small scales involved, the final stage of the bubble collapse could not be resolved temporally and numerical simulations were performed to elucidate the details of the flow. The simulations demonstrate high-speed jetting towards the upper and lower walls and complex bubble splitting for neutral collapses.

scholarly journals Fast transient microjets induced by hemispherical cavitation bubbles

2015 ◽  
Vol 767 ◽  
pp. 31-51 ◽  
Author(s):  
Silvestre Roberto Gonzalez Avila ◽  
Chaolong Song ◽  
Claus-Dieter Ohl
Keyword(s):  
Cavitation Bubble ◽  
High Speed ◽  
Bubble Dynamics ◽  
Silicone Oil ◽  
Bubble Collapse ◽  
High Speed Photography ◽  
Drug Delivery Device ◽  
Spray Formation ◽  
Novel Method ◽  
Fast Transient

AbstractWe report on a novel method to generate fast transient microjets and study their characteristics. The simple device consists of two electrodes on a substrate with a hole in between. The side of the substrate with the electrodes is submerged in a liquid. Two separate microjets exit through the tapered hole after an electrical discharge is induced between the electrodes. They are formed during the expansion and collapse of a single cavitation bubble. The cavitation bubble dynamics as well as the jets were studied with high-speed photography at up to 500 000 f.p.s. With increasing jet velocity they become unstable and spray formation is observed. The jet created during expansion (first jet) is in most cases slower than the jet created during bubble collapse, which can reach up to $400~\text{m}~\text{s}^{-1}$. The spray exiting the orifice is at least in part due to the presence of cavitation in the microchannel as observed by high-speed recording. The effect of viscosity was tested using silicone oil of 10, 50 and 100 cSt. Interestingly, for all liquids the transition from a stable to an unstable jet occurs at $We\sim 4600$. We demonstrate that these microjets can penetrate into soft material; thus they can be potentially used as a needleless drug delivery device.

Numerical Prediction of Impact Force in Cavitating Flows

2010 ◽  
Vol 132 (10) ◽  
Author(s):  
Hong Wang ◽  
Baoshan Zhu
Keyword(s):  
Numerical Method ◽  
Cavitation Bubble ◽  
Bubble Dynamics ◽  
Impact Force ◽  
Quantitative Agreement ◽  
Bubble Collapse ◽  
Cavitating Flows ◽  
Cavitation Model ◽  
Model Based ◽  
The Impact

A numerical method including a macroscopic cavitation model based on the homogeneous flow theory and a microscopic cavitation model based on the bubble dynamics is proposed for the prediction of the impact force caused by cavitation bubble collapse in cavitating flows. A large eddy simulation solver, which is incorporated with a macroscopic cavitation model, is applied to simulate the unsteady cavitating flows. Based on the simulated flow field, the evolution of the cavitation bubbles is determined by a microscopic cavitation model from the resolution of a Rayleigh–Plesset equation including the effects of the surface tension, the viscosity and compressibility of fluid, the thermal conduction and radiation, the phase transition of water vapor at the interface, and the chemical reactions. The cavitation flow around a hydrofoil is simulated to validate the macroscopic cavitation model. A good quantitative agreement is obtained between the prediction and the experiment. The proposed numerical method is applied to predict the impact force at cavitation bubble collapse on a KT section in cavitating flows. It is found that the shock pressure caused by cavitation bubble collapse is very high. The impact force is predicted qualitatively compared with the experimental data.

The Boundary Integral Method Applied to Non-Spherical Cavitation Bubble Growth and Collapse Close to a Rigid Boundary

2015 ◽  
Author(s):  
Ali Alhelfi ◽  
Bengt Sunden
Keyword(s):  
Cavitation Bubble ◽  
Integral Method ◽  
Bubble Dynamics ◽  
Boundary Integral ◽  
Solid Surfaces ◽  
Boundary Integral Method ◽  
Bubble Collapse ◽  
Surface Erosion ◽  
Rigid Boundary ◽  
Cavitation Phenomenon

Recently much attention has been paid to studies concerning bubble dynamics in the cavitation phenomena and this topic has been the subject of many research works. In fact, the simulation of non-spherical bubble dynamics and its interaction with solid boundaries have received much less attention due to the complexity of the problem. One of the main reasons of the structural damages in the cavitation phenomenon is due to the formation of micro jets generated due to the bubble collapse and impinging on the solid surfaces or boundaries. The boundary integral method (BIM) based on Green’s function is used to model the oscillation and collapse of a cavitation bubble close to a rigid boundary. The liquid is considered to be incompressible, inviscid, and irrational around the bubble. These assumptions satisfy the conditions for the Laplacian equation. The theory permits one to predict correctly the interaction between the bubble and the rigid boundary, which is of great importance in the study of cavitation damage due to a bubble collapsing close to the boundaries. The results reveal that the amplitude of bubble oscillation depends on the bubble location away from a rigid surface. Also, the theory for the cavitation bubble dynamics presented in this study has many advantages in various situations and might be helpful to understand effects of the cavitation phenomenon such as generation of excessive vibration, surface erosion and undesirable acoustic emission.

Numerical Study on Mass Transfer Effects on Spherical Cavitation Bubble Collapse in an Acoustic Field

2010 ◽  
Author(s):  
Ehsan Samiei ◽  
Mehrzad Shams ◽  
Reza Ebrahimi
Keyword(s):  
Mass Transfer ◽  
Cavitation Bubble ◽  
Bubble Dynamics ◽  
Numerical Study ◽  
Bubble Radius ◽  
Numerical Code ◽  
Bubble Collapse ◽  
Growth Time ◽  
Transfer Effects ◽  
Low Amplitude

A numerical code to simulate mass transfer effects on spherical cavitation bubble collapse in an acoustic pressure domain in quiescent water has been developed. Gilmore equation is used to simulate bubble dynamics, with considering mass diffusion and heat transfer. Bubbles with different initial radii were considered in quiescent infinite water in interaction with sinusoidal shock waves with different magnitudes of amplitude and frequency. Simulations were done in two cases; with and without considering mass transfer. Good agreement with reference data was achieved. For bubbles with small radii in high frequency pressure field with low amplitude, mass transfer causes larger maximum radii and growth time, and more violent resultant collapse. Decreasing pressure frequency or increasing its amplitude causes larger maximum radii, longer collapse time, and more violent collapse. But, in cases with mass transfer because at the last moments of collapse stage a large amount of water vapor is trapped inside the bubble, the collapse will become less violent. For larger bubbles collapse becomes more violent for the cases without mass transfer in all pressure amplitudes and higher frequencies. But decreasing pressure frequency makes the collapse of the bubbles with mass transfer more violent. However, mass transfer effects decreases with increasing initial bubble radius.

Rapid, Refined, and Robust Method for Expression, Purification, and Characterization of Recombinant Human Amyloid-beta M1-42

2019 ◽  
Author(s):  
Priya Prakash ◽  
Travis Lantz ◽  
Krupal P. Jethava ◽  
Gaurav Chopra
Keyword(s):  
Amyloid Beta ◽  
Western Blots ◽  
Force Microscopy ◽  
E Coli ◽  
Atomic Force ◽  
Set Up ◽  
Short Time

Amyloid plaques found in the brains of Alzheimer’s disease (AD) patients primarily consists of amyloid beta 1-42 (Ab42). Commercially, Ab42 is synthetized using peptide synthesizers. We describe a robust methodology for expression of recombinant human Ab(M1-42) in Rosetta(DE3)pLysS and BL21(DE3)pLysS competent E. coli with refined and rapid analytical purification techniques. The peptide is isolated and purified from the transformed cells using an optimized set-up for reverse-phase HPLC protocol, using commonly available C18 columns, yielding high amounts of peptide (~15-20 mg per 1 L culture) in a short time. The recombinant Ab(M1-42) forms characteristic aggregates similar to synthetic Ab42 aggregates as verified by western blots and atomic force microscopy to warrant future biological use. Our rapid, refined, and robust technique to purify human Ab(M1-42) can be used to synthesize chemical probes for several downstream in vitro and in vivo assays to facilitate AD research.

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