Development of Carrot Nutraceutical Products as an Alternative Supplement for the Prevention of Nutritional Diseases

Nutraceuticals can serve as an alternative supplement to overcome nutritional deficiency for a healthy lifestyle. They can also play a key role in disease management. To develop carrot nutraceutical products, 64 genotypes from four different continents were evaluated for a range of morpho-nutrition variables. Genetic variability, heritability, strength and direction of association among variables, and direct and indirect relationships among physiochemical and nutritional traits with β-carotene content were evaluated. Core diameter, foliage weight, root weight and shoulder weight showed significant association with β-carotene accumulation. Principal component analysis for physiochemical and nutritional assessment divided these genotypes into two distinctive groups, Eastern carrots and Western carrots. Caloric and moisture content had high positive associations with β-carotene content while carbohydrate content was negatively associated. Five genotypes (T-29, PI 634658, PI 288765, PI 164798, and Ames 25043) with the highest β-carotene contents were selected for making three nutraceutical supplements (carrot-orange juice, carrot jam and carrot candies). These nutraceutical supplements retained high β-carotene content coupled with antioxidant properties. Carrot jam (6.5 mg/100 g) and carrot candies (4.8 mg/100 g) had greater concentrations of β-carotene than carrot-orange juice (1.017 mg/100 g). Carrot jam presented high antioxidant activity with the highest values in T-29 (39% inhibition of oxidation) followed by PI 634658 (37%), PI 164798 (36.5%), Ames 25043 (36%) and PI 288765 (35.5%). These nutraceutical products, with 4–6.5 mg/100 g β-carotene content, had higher values than the USDA recommended dietary intake of 3–6 mg β-carotene/day can be recommended for daily use to lower the risk of chronic disease.

Laser Fiber Displacement Velocity during Tm-Fiber and Ho:YAG Laser Lithotripsy: Introducing the Concept of Optimal Displacement Velocity

Background: Endocorporeal laser lithotripsy (EL) during flexible ureteroscopy (URS-f) often uses “dusting” settings with “painting” technique. The displacement velocity of the laser fiber (LF) at the stone surface remains unknown and could improve EL’s ablation rates. This in vitro study aimed to define the optimal displacement velocity (ODV) for both holmium:yttrium-aluminium-garnet (Ho:YAG) and thulium fiber laser (Tm-Fiber). Methods: A 50W-TFL (IRE Polus®, Russia) and a 30W-MH1-Ho:YAG laser (Rocamed®), were used with 272µm-Core-Diameter LF (Sureflex, Boston Scientific©), comparing three TFL modes, “fine dusting” (FD:0.05–0.15 J/100–600 Hz); “dusting” (D:0.5 J/30–60 Hz); “fragmentation” (Fr:1 J/15–30 Hz) and two Ho:YAG modes (D:0.5 J/20 Hz, Fr:1 J/15 Hz). An experimental setup consisting of immerged cubes of calcium oxalate monohydrate (COM) stone phantoms (Begostone Plus, Begoã) was used with a 2 seconds’ laser operation time. LF were in contact with the stones, static or with a displacement of 5, 10 or 20 mm. Experiments were repeated four times. Stones were dried and µ-scanned. Ablation volumes (mm3) were measured by 3D-segmentation. Results: ODV was higher in dusting compared to fragmentation mode during Ho:YAG lithotripsy (10 mm/sec vs. 5 mm/sec, respectively). With Tm-Fiber, dusting and fragmentation OVDs were similar (5 mm/sec). Tm-Fiber ODV was lower than Ho:YAGs in dusting settings (5 mm/s vs. 10 mm/sec, respectively). Without LF displacement, ablation volumes were at least two-fold higher with Tm-Fiber compared to Ho:YAG. Despite the LF-DV, we report a 1.5 to 5-fold higher ablation volume with Tm-Fiber compared to Ho:YAG. Conclusions: In dusting mode, the ODVTm-Fiber is lower compared to ODVHo:YAG, translating to a potential easier Tm-Fiber utilization for “painting” dusting technique. The ODV determinants remain unknown. Dynamic ablation volumes are higher to static ones, regardless of the laser source, settings or LF displacement velocity.

Optical Fiber-Based Monitoring of X-ray Pulse Series from a Linear Accelerator

We investigated in this work the radioluminescence properties of a Ce-doped multimode silica-based optical fiber (core diameter of 50 µm) manufactured by the sol–gel technique when exposed to the high-energy X-rays (~600 keV) of the ORIATRON facility of CEA. We demonstrated its potential to monitor in real-time the beam characteristics of this facility that can either operate in a pulsed regime (pulse duration of 4.8 µs, maximum repetition rate of 250 Hz) or in a quasi-continuous mode. The radiation-induced emission (radioluminescence and a minor Cerenkov contribution) linearly grew with the dose rate in the 15–130 mGy(SiO2)/s range, and the afterglow measured after each pulse was sufficiently limited to allow a clear measurement of pulse trains. A sensor with ~11 cm of sensitive Ce-doped fiber spliced to rad-hard fluorine-doped optical fiber, for the emitted light transport to the photomultiplier tube, exhibited interesting beam monitoring performance, even if the Cerenkov emission in the transport fiber was also considered (~5% of the signal). The beam monitoring potential of this class of optical fiber was demonstrated for such facilities and the possibilities of extending the dose rate range are discussed based on possible architecture choices such as fiber type, length or size.

MEASUREMENT OF THE GEOMETRY OF MANUFACTURED DRILLS USING OPTICAL SCANNING

This article deals with the control of the geometry of manufactured tools. The geometry of the cutting tool has a great influence on the machining process. One of the processes of manufacturing cutting tools is grinding. Grinding cutting tools is a complex process after which it is necessary to check the geometry of the tools. Five solid drilling tools were manufactured for the experiment. The measured parameters were tool diameter, helix angle, point angle, rake angle, relief angle and core diameter of the cutting tools. The geometry of the cutting tools was measured on a non-contact structured 3D scanner ATOS Triple Scan light. The measurement results were evaluated using GOM software. The scanning results were compared with the geometry measurement on an optical measuring device Zoller Genius 3s. It has been found that the use of a non-contact structured 3D scanner is suitable for checking the geometry of cutting tools. Furthermore, the article deals with the roughness arising when grinding a sintered carbide flute.

Quantifying the quality of optical vortices by evaluating their intensity distributions

Optical vortices are widely used in optics and photonics, ranging from microscopy and communications to astronomy. However, little work has been done to quantify the quality of scalar optical vortices. Since the quality of an optical vortex affects measurements and conclusions derived from their use, development of tools to evaluate the vortex quality is crucial. Moreover, the quality of a vortex strongly depends on the application. Therefore, this work aims to establish metrics for the evaluation of optical vortex quality. We propose to evaluate vortex quality using the following intensity parameters: eccentricity of the intensity distribution, cross-sectional peak-to-valley measurements, cross-sectional peak difference, and the ratio of the ring width to the vortex core diameter (doughnut-ratio). These parameters can be used as a guide for the quality of optical vortices depending on their implementation for specific optical technologies.

Effective reduction of magnetisation losses in copper-plated multifilament coated conductors using spiral geometry

We wound copper-plated multifilament coated conductors spirally on a round core to decouple filaments electromagnetically under ac transverse magnetic fields and measured their magnetisation losses. Although the coated conductors were plated with copper, which connects all filaments electrically and allows current sharing among them, the spiral geometry decoupled filaments similar to the twist geometry, and the magnetisation loss was reduced effectively by the multifilament structure. The measured magnetisation loss of a 4 mm-wide, 10-filament coated conductor with a 20 μm-thick copper wound spirally on a 3 mm-core was only 7% of that of the same 10-filament coated conductor with a straight shape under an ac transverse magnetic field with an amplitude and frequency of 100 mT and 65.44 Hz, respectively. We separated the measured magnetisation losses into hysteresis and coupling losses and discussed the influence of filament width, copper thickness, and core diameter on both losses. We compared the hysteresis losses with the analytical values given by Brandt and Indenbom and compared the coupling losses with the values calculated using a general expression of coupling loss with the coupling time constants and geometry factors.

Axial Shuffling on Pebble Bed Reactor using PRAKTIK 3D-HTR

With moving fuel, the pebble bed reactor (PBR) provides flexibility in the fuel management process due to the capability of online fuel refueling. This capability allows the reactor to operate at any given time without the need to shut down for refueling. The complexity of the depletion and burnup analysis requires the problem to be solved with sophisticated and robust computer codes that can handle the fuel shuffling. Since the fuel refueling is conducted from top to bottom, the shuffling and fuel movement in the axial direction should be modeled with acceptable accuracy. The purpose of the simulation is to obtain the equilibrium or even a critical condition of the reactor. The model used is based on the simplified pebble bed reactor with 200 MWt of thermal reactor power, 3 meters of core diameter, and 10 meters of core height. To model the axial shuffling on the reactor, a neutronic computer code called PRAKTIK 3D-HTR is used. The code utilizes the diffusion method in a three-dimensional cylindrical geometry to model the neutronic phenomena in the reactor. Moreover, PRAKTIK 3D-HTR is equipped with the burnup calculation and depletion analysis to be able to handle fuel movement. Finally, the axial shuffling mechanism is implemented using the once-through-then-out (OTTO) method. Implementing this method to the reactor, an equilibrium condition can be obtained. In this condition, the reactor condition in terms of criticality and flux shape is relatively constant. The critical condition can also be searched using PRAKTIK 3D-HTR to obtain the condition when the multiplication factor is equal to unity. The criticality search is conducted by changing the fuel movement speed. If the multiplication factor is less than 1, then the shuffling speed needs to be increased. Otherwise, if it is more than 1, the shuffling speed will be decreased.

Er-Doped Tapered Fiber Amplifier for High Peak Power Sub-ns Pulse Amplification

A tapered Er-doped fiber amplifier for high peak power pulses amplification has been developed and tested. The core diameter changed from 15.8 µm (mode field diameter (MFD) 14.5 µm) to 93 µm (MFD 40 µm) along 3.7 m maintaining single-mode performance at 1555 nm (according to the S2-method, the part of the power of high-order modes does not exceed 1.5%). The amplification of 0.9 ns pulses with spectral width below 0.04 nm up to a peak power above 200 kW (limited by self-phase modulation) with a slope pump-to-signal conversion efficiency of 15.6% was demonstrated.

Effect of optical fiber core diameter on Brillouin scattering loss

This paper reports the effect of core diameter of optical fiber cables on stimulated Brillouin scattering loss, which is one of the major loss characteristics of an optical fiber communication system. Analysis of this loss characteristic at three windows of the operating wavelength of a laser has been carried out through a numerical approach. Among different types of optical fiber cables, multi-mode step index silica fiber, multi-mode graded index silica fiber and plastic fibers have been considered for the numerical analysis. The numerical analysis has been performed using MATLAB in this research work. Through the comparative analysis, it has been ascertained that the Brillouin scattering loss is not only affected by the operating wavelength, but also by the core diameter of the different type of the cable. From the investigation of the comparative analysis, it is revealed that Brillouin scattering loss declines with the application of multi-mode graded index silica fiber. However, in the plastic fiber category, plastic step index fiber offers better performance.

The influence of IONPs core size on their biocompatibility and activity in in vitro cellular models

Although the key factor affecting the biocompatibility of IONPs is the core size, there is a lack of regular investigation concerning the impact of the parameter on the toxicity of these nanomaterials. Therefore, such studies were carried out in this paper. Their purpose was to compare the influence of PEG-coated-magnetite NPs with the core of 5, 10 and 30 nm on six carefully selected cell lines. The proliferation rate, viability, metabolic activity, migration activity, ROS levels and cytoskeleton architecture of cells have been evaluated for specified incubation periods. These were 24 and 72-h long incubations with IONPs administered in two doses: 5 and 25 µg Fe/ml. A decrease in viability was observed after exposure to the tested NPs for all the analyzed cell lines. This effect was not connected with core diameter but depended on the exposure time to the nanomaterials. IONPs increased not only the proliferation rate of macrophages—being phagocytic cells—but also, under certain conditions stimulated tumor cell divisions. Most likely, the increase in proliferation rate of macrophages contributed to the changes in the architecture of their cytoskeleton. The growth in the level of ROS in cells had been induced mainly by the smallest NPs. This effect was observed for HEK293T cells and two cancerous lines: U87MG (at both doses tested) and T98G (only for the higher dose). This requires further study concerning both potential toxicity of such IONPs to the kidneys and assessing their therapeutic potential in the treatment of glioblastoma multiforme.