Olfactory mucosa: a rich source of cell therapy for central nervous system repair

2015 ◽  
Vol 26 (3) ◽  
Author(s):  
Da Duan ◽  
Ming Lu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Therapy ◽  
Functional Disability ◽  
Autologous Transplantation ◽  
Adult Life ◽  
Olfactory Mucosa ◽  
Rich Source ◽  
Basal Cells ◽  
Cns Repair

AbstractDamage to the brain and spinal cord leads to permanent functional disability because of the very limited capacity of the central nervous system (CNS) for repair. Cell therapy is thought to be a promising strategy for CNS repair. The proper cell type of transplantation for CNS repair has not been identified until now, but autologous transplantation would be advantageous. The olfactory mucosa (OM), from the olfactory system, in which the neurosensory cells are replaced throughout adult life, is thought to be a rich source of cell therapy for CNS repair. The OM is a heterogeneous tissue composed of a variety of cells supporting both normal function and regenerative capacity, in which many studies focused on four major types of cells, including horizontal basal cells (HBCs), globose basal cells (GBC), mesenchymal stem cells (MSCs), and olfactory ensheathing cells (OECs). Here, we review the four major types of cells in the OM and shed light on the potential of the OM for CNS repair.

scholarly journals Progenitor Cell Therapy for the Treatment of Central Nervous System Injury: A Review of the State of Current Clinical Trials

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Peter A. Walker ◽  
Matthew T. Harting ◽  
Shinil K. Shah ◽  
Mary-Clare Day ◽  
Ramy El Khoury ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Clinical Trials ◽  
Nervous System ◽  
Ischemic Stroke ◽  
Cell Therapy ◽  
Progenitor Cell ◽  
Neurological Injury ◽  
Cell Therapies ◽  
Potential Efficacy ◽  
Cord Injury

Recent preclinical work investigating the role of progenitor cell therapies for central nervous system (CNS) injuries has shown potential neuroprotection in the setting of traumatic brain injury (TBI), spinal cord injury (SCI), and ischemic stroke. Mechanisms currently under investigation include engraftment and transdifferentiation, modulation of the locoregional inflammatory milieu, and modulation of the systemic immunologic/inflammatory response. While the exact mechanism of action remains controversial, the growing amount of preclinical data demonstrating the potential benefit associated with progenitor cell therapy for neurological injury warrants the development of well-controlled clinical trials to investigate therapeutic safety and efficacy. In this paper, we review the currently active or recently completed clinical trials investigating the safety and potential efficacy of bone marrow-derived progenitor cell therapies for the treatment of TBI, SCI, and ischemic stroke. Our review of the literature shows that while the preliminary clinical trials reviewed in this paper offer novel data supporting the potential efficacy of stem/progenitor cell therapies for CNS injury, a great deal of additional work is needed to ensure the safety, efficacy, and mechanisms of progenitor cell therapy prior to widespread clinical trials.

scholarly journals Cell therapy for central nervous system disorders: Current obstacles to progress

2019 ◽  
Vol 26 (6) ◽  
pp. 595-602 ◽  
Author(s):  
Takao Yasuhara ◽  
Satoshi Kawauchi ◽  
Kyohei Kin ◽  
Jun Morimoto ◽  
Masahiro Kameda ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Therapy ◽  
Central Nervous System Disorders

scholarly journals Secretome of Olfactory Mucosa Mesenchymal Stem Cell, a Multiple Potential Stem Cell

2016 ◽  
Vol 2016 ◽  
pp. 1-16 ◽  
Author(s):  
Lite Ge ◽  
Miao Jiang ◽  
Da Duan ◽  
Zijun Wang ◽  
Linyu Qi ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Stem Cell ◽  
Ethical Issues ◽  
Olfactory Mucosa ◽  
Proteomic Profiling ◽  
Clinical Biomarkers ◽  
Highly Correlated ◽  
Apoptosis And Inflammation

Nasal olfactory mucosa mesenchymal stem cells (OM-MSCs) have the ability to promote regeneration in the nervous systemin vivo. Moreover, with view to the potential for clinical application, OM-MSCs have the advantage of being easily accessible from patients and transplantable in an autologous manner, thus eliminating immune rejection and contentious ethical issues. So far, most studies have been focused on the role of OM-MSCs in central nervous system replacement. However, the secreted proteomics of OM-MSCs have not been reported yet. Here, proteins secreted by OM-MSCs cultured in serum-free conditions were separated on SDS-PAGE and identified by LC-MS/MS. As a result, a total of 274 secreted proteins were identified. These molecules are known to be important in neurotrophy, angiogenesis, cell growth, differentiation, and apoptosis, and inflammation which were highly correlated with the repair of central nervous system. The proteomic profiling of the OM-MSCs secretome might provide new insights into their nature in the neural recovery. However, proteomic analysis for clinical biomarkers of OM-MSCs needs to be further studied.

scholarly journals Neurologic disorders in 4858 survivors of central nervous system tumors in childhood—an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study

2018 ◽  
Vol 21 (1) ◽  
pp. 125-136 ◽  
Author(s):  
Line Kenborg ◽  
Jeanette Falck Winther ◽  
Karen Markussen Linnet ◽  
Anja Krøyer ◽  
Vanna Albieri ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Childhood Cancer ◽  
Adult Life ◽  
Central Nervous System Tumors ◽  
Nervous System Tumors ◽  
Neurologic Disorders

scholarly journals Strategies to Enhance the Efficacy of T-Cell Therapy for Central Nervous System Tumors

2020 ◽  
Vol 11 ◽  
Author(s):  
Deepak Upreti ◽  
David Bakhshinyan ◽  
Darin Bloemberg ◽  
Parvez Vora ◽  
Chitra Venugopal ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
T Cell ◽  
Cell Therapy ◽  
Central Nervous System Tumors ◽  
T Cell Therapy ◽  
Nervous System Tumors

scholarly journals Advanced Materials to Enhance Central Nervous System Tissue Modeling and Cell Therapy

2020 ◽  
Vol 30 (48) ◽  
pp. 2002931
Author(s):  
Riya J. Muckom ◽  
Rocío G. Sampayo ◽  
Hunter J. Johnson ◽  
David V. Schaffer
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Therapy ◽  
Advanced Materials ◽  
Central Nervous System Tissue ◽  
Tissue Modeling

scholarly journals Cellular and molecular mechanisms of the demyelination in the central nervous system and cell therapy approaches

2017 ◽  
Vol 5 (1) ◽  
pp. 74-78
Author(s):  
V. Tsymbaliuk ◽  
V. Semenova ◽  
L. Pichkur ◽  
O. Velychko ◽  
D. Egorova
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Therapy ◽  
Molecular Mechanisms ◽  
Molecular Genetic ◽  
Light And Electron Microscopy ◽  
Cellular Level ◽  
Molecular Features ◽  
The Central Nervous System ◽  
Demyelinating Disorders

The review summarizes the current concepts of cell-tissue and molecular features of development of demyelinating processes in the central nervous system related to multiple sclerosis and its animal model – allergic encephalomyelitis. An analysis of recently published studies of this pathology, carried out with light and electron microscopy and immunohistochemical and molecular genetic methods, is given. New methodological approaches to the study of the pathomorhological aspects of demyelinating disorders allowed receiving in-depth understanding of the etiology and mechanisms of demyelination processes in the brain and spinal cord tissues at the cellular level and identifying the ways to develop effective modern methods of pathogenetic treatment of these diseases using cell therapy.

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