Squamous Cell Carcinoma Arising from Linear Porokeratosis - a case report and review of the literature

Abstract Porokeratosis belongs to a group of disorders of keratinization that are characterized by the histopathological feature of the cornoid lamella, a column of tightly fitted parakeratotic cells. The etiology of porokeratosis is still unclear. Different variants of porokeratosis (PK) have been subsequently recognized, each with its own specific properties in terms of morphology, distribution and clinical course. Linear porokeratosis is one of the variants of porokeratosis, a rare disorder of keratinization that may develop into several epidermal malignancies, squamous cell carcinoma being the most frequent among all of them. Thus, a clinical surveillance for malignancy is an imperative. We present a case of a 54-year-old man with non-healing ulcer of the lower leg caused by squamous cell carcinoma arising on long-standing linear porokeratosis. The treatment included wide excision of tumor with the reconstruction of the area. Acitretin was prescribed for linear porokeratosis treatment. The follow-up of our patient so far has shown that he does not have new malignant lesions after surgical excision.

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Squamous Cell Carcinoma of the External Ear: A Review of 75 Cases

Otolaryngology ◽

10.1177/019459988709700310 ◽

1987 ◽

Vol 97 (3) ◽

pp. 308-312 ◽

Cited By ~ 30

Author(s):

William W. Shockley ◽

Fred J. Stucker

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cancer Control ◽

Surgical Excision ◽

External Ear ◽

Common Cancer ◽

Node Metastases

Squamous cell carcinoma of the external ear can be a potentially lethal lesion. Although it is the most common cancer involving the pinna, the variables that have the greatest impact on prognosis are still in question. We reviewed 75 cases of squamous cell carcinoma of the external ear to determine patterns of occurrence and treatment failure. Forty patients had adequate follow-up for determination of cancer control rates. Local control was successful with initial treatment in 85% of the cases. The incidence of lymph node metastases was 10%, whereas distant metastasis occurred in only one patient (2.5%). This series differs from others in that most patients were unselected and most of the lesions treated were early (less than 1 cm). The significance of positive margins after surgical excision is also analyzed.

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Management of Squamous Cell Carcinoma in a Chronic Sacrococcygeal Pilonidal Cyst: A Case Report

Surgical Case Reports ◽

10.31487/j.scr.2020.06.18 ◽

2020 ◽

pp. 1-4

Author(s):

Ziad El Rassi ◽

Charbel Aoun ◽

Hani Maalouf ◽

Saleem Abdel Backi ◽

Toufic Saber ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Malignant Transformation ◽

Squamous Cell ◽

Pilonidal Disease ◽

Surgical Excision ◽

High Rate ◽

Pilonidal Cyst ◽

Subcutaneous Tissues

Introduction: Pilonidal disease is a chronic inflammatory process resulting from impaction of natal cleft hair into the subcutaneous tissues creating an abscess or a draining sinus over the sacrococcygeal area. Malignant transformation occurs in around 0.1%, mainly into squamous cell carcinoma (SCC) type. Wide excision with tumor-free margins remains the treatment of choice. Multiple closure techniques were settled and the best one ought to be chosen in a context malignancy and future radiological treatment. Case Presentation: We describe the management of a case of a 69-year-old male with chronic pilonidal disease, recurrent after 25 years found on final pathology to undergo malignant transformation into SCC. Wide and aggressive excision were performed with new margins and with periosteal excision of the sacrum and coccyx. rotational myocutaneous gluteal flap was done for closure of the wound in order to ensure better satisfactory esthetic results without a delay in future treatment. Conclusion: The progression of a chronic pilonidal disease into SCC is a rare but serious complication. The diagnosis is confirmed by biopsies. Workup for metastasis should be made before aggressive surgical excision. Oncoplastic surgeries is recommended for satisfactory results. Routine follow-up postoperatively should be considered due to high rate of recurrence by physical examination and imaging.

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Conjunctival keratoacanthoma

Revista do Hospital das Clínicas ◽

10.1590/s0041-87812004000300008 ◽

2004 ◽

Vol 59 (3) ◽

pp. 135-137 ◽

Cited By ~ 6

Author(s):

Fernanda Braga Perdigão ◽

Paulo de Tarso P. Pierre-Filho ◽

Renato José Mendonça Natalino ◽

Roberto Caldato ◽

Marcelo Torigoe ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Differential Diagnosis ◽

Cell Carcinoma ◽

Squamous Cell ◽

Safety Margin ◽

Surgical Excision ◽

Complete Surgical Excision ◽

Rare Differential Diagnosis

Keratoacanthoma generally occurs on the skin; it is rarely found in the conjunctiva. A case of a 34-year-old woman with a rapidly growing conjunctival mass is reported. The tumor was excised with a safety margin to exclude squamous cell carcinoma. Histopathologically it was crateriform and consistent with atypical keratoacanthoma. There has been no recurrence in 2 years of follow-up. Conjunctival keratoacanthoma is rare; differential diagnosis of conventional squamous cell carcinoma and keratoacanthoma can be difficult. We recommend complete surgical excision and careful follow-up of crateriform squamous proliferations.

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Skin Tumours of the Hand

Journal of Hand Surgery (European Volume) ◽

10.1016/0266-7681(93)90153-7 ◽

1993 ◽

Vol 18 (4) ◽

pp. 484-486 ◽

Cited By ~ 23

Author(s):

I. CHAKRABARTI ◽

J.D. WATSON ◽

H. DORRANCE

Keyword(s):

Squamous Cell Carcinoma ◽

Retrospective Study ◽

Cell Carcinoma ◽

Plastic Surgery ◽

Squamous Cell ◽

Surgical Excision ◽

Squamous Cell Carcinomas ◽

Histological Type ◽

Skin Tumours ◽

Malignant Lesions

A 10-year retrospective study was performed in order to determine the incidence, distribution, histological type and behaviour of skin tumours of the hand that were referred to a regional Plastic Surgery unit. 85 patients were studied and 98 malignant or pre-malignant lesions identified. The majority were squamous cell carcinomas in male manual workers. Recurrence after excision was seen only in lesions greater than 1.5 cm in diameter. The overall incidence of squamous cell carcinoma of the hand (requiring surgical excision) was seen to be five cases per million per year. Other skin tumours were rare.

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Papillary squamous cell carcinoma of the larynx

The Journal of Laryngology & Otology ◽

10.1258/0022215011907631 ◽

2001 ◽

Vol 115 (2) ◽

pp. 164-166 ◽

Cited By ~ 16

Author(s):

Cosme Ereño ◽

José I López ◽

José M. Sánchez ◽

Francisco J. Bilbao

Keyword(s):

Squamous Cell Carcinoma ◽

Differential Diagnosis ◽

Cell Carcinoma ◽

Squamous Cell ◽

Clinical Course ◽

Squamous Cell Carcinomas ◽

Papillary Squamous Cell Carcinoma ◽

Carcinoma Of The Larynx ◽

Microscopic Features

A case of papillary squamous cell carcinoma of the larynx in a 50-year-old man is reported. The lesion was located in the supraglottic region and grossly presented a characteristic finger-like pattern of growth. The tumour pursued an indolent clinical course, and the patient is well and free of disease after 47 months of follow-up. The present paper recapitulates the macro- and microscopic features of this rare neoplasm and stresses its differential diagnosis with other exophytic squamous cell carcinomas of the region.

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Recurrent Squamous Cell Carcinoma of the Submandibular Region after Surgery in a Dog: A Case Report

World s Veterinary Journal ◽

10.54203/scil.2021.wvj93 ◽

2021 ◽

Vol 11 (4) ◽

pp. 731-734

Author(s):

Athip Lorsirigool ◽

Yuttana Sudjaroen ◽

Narong Kulnides

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Cell Carcinoma ◽

Squamous Cell ◽

Malignant Tumor ◽

Surgical Excision ◽

Intact Male ◽

Submandibular Region ◽

Recurrent Squamous Cell Carcinoma

Squamous cell carcinoma (SCC) is a malignant tumor that has been reported in several organs of different dog breeds. An 8-year-old Shih Tzu, an intact male dog, came to an animal clinic in the Thonburi area, Bangkok Province, Thailand, and a mass of 4.5 × 4.5 cm (width × length) by size was found at the submandibular area. Surgical excision to remove the mass and subsequent histological examination identified the mass as SCC. After conducting the surgery and follow-up, the mass was recurrent at the same location after 33 days and a dog died. Therefore, one of the possible reasons for the death of the dog could be SCC metastasis.

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Preoperative combined cisplatin-based chemotherapy and radiotherapy for squamous cell carcinoma of the oral cavity—evaluation of more than 5-year follow up cases

International Journal of Oral and Maxillofacial Surgery ◽

10.1016/s0901-5027(97)81222-2 ◽

1997 ◽

Vol 26 ◽

pp. 126

Author(s):

H. Shimooka ◽

T. Kirita ◽

N. Kamikaidou ◽

K. Yamamoto ◽

K. Ohgi ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell

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Oral findings during follow-up of nasopharyngeal squamous cell carcinoma treatment: A case report

SAGE Open Medical Case Reports ◽

10.1177/2050313x211033037 ◽

2021 ◽

Vol 9 ◽

pp. 2050313X2110330

Author(s):

Atsushi Musha ◽

Nobuteru Kubo ◽

Naoko Okano ◽

Hidemasa Kawamura ◽

Yuhei Miyasaka ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Concurrent Chemoradiotherapy ◽

Nasopharyngeal Cancer ◽

Inflammatory Conditions ◽

Positron Emission ◽

History Of ◽

Oral Area

A 50-year-old woman with a long history of nasopharyngeal cancer (T2N2M0, squamous cell carcinoma) underwent chemoradiotherapy and surgery. In the past, to prevent tumor recurrence or metastasis, she underwent concurrent chemoradiotherapy or neck dissection. However, during a follow-up 10 years after the surgery, intense F-18 fluorodeoxyglucose uptake was detected in the oral area (SUVmax 6.0). A biopsy of the area with F-18 fluorodeoxyglucose uptake revealed pathological inflammation. Radiography showed the presence of a wisdom tooth, located at the F-18 fluorodeoxyglucose accumulation site, and pericoronitis of this tooth was detected. Our findings indicate the importance of considering the effect of inflammatory conditions, such as periodontal disease, in using F-18 fluorodeoxyglucose positron emission tomography/computed tomography during follow-up after head and neck cancer treatment.

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Squamous cell carcinoma of the scrotum in HIV: two case reports

African Journal of Urology ◽

10.1186/s12301-021-00177-3 ◽

2021 ◽

Vol 27 (1) ◽

Author(s):

Jeff John ◽

Ken Kesner ◽

John Lazarus

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Case Reports ◽

Treatment Options ◽

Punch Biopsy ◽

Delayed Treatment ◽

Clinical Presentations ◽

T1 N0 M0

Abstract Background Squamous cell carcinoma (SCC) of the scrotum was the first malignancy known to be associated with exposure to an occupational carcinogen—in this case, soot trapped in the breeches of chimney sweeps. Better civil rules and regulations and the replacement of hearths with other forms of heating have rendered SCC of the scrotum a rarity. We report two cases of scrotal SCC with vastly differing clinical presentations and management. Case presentation Case 1 had T1 N0 M0 disease and presented with a small (< 2 cm), innocuous-looking, non-healing ulcer of eight years duration. A punch biopsy revealed a superficially invasive SCC confirmed on immunohistochemical profiling. A wide local excision of the lesion was subsequently performed. Follow-up at three years showed no signs of recurrence. Case 2 presented with T4 N1 M1 disease and rapidly progressing locally destructive mass. A punch biopsy of the scrotal lesion confirmed invasive moderately differentiated focally keratinising SCC. The metastatic evaluation confirmed the presence of metastatic, extensive para-aortic lymphadenopathy. He was managed with cisplatin-based chemoradiotherapy. Conclusion Early detection and management of patients with SCC of the scrotum are essential. If the diagnosis is delayed, treatment options become limited, and the prognosis is poor. Notwithstanding the rarity of this disease, multicentre trials are needed to provide more precise guidelines as to the optimal management of these patients.

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