scholarly journals Endermologie New Aproach in the Medicine Treatment

2017 ◽  
Vol 14 (1) ◽  
pp. 27-30 ◽  
Author(s):  
Viktória Mezencevová ◽  
Jozef Torok ◽  
Tatiana Czánová ◽  
Ján Zajac
Keyword(s):  
Connective Tissue ◽  
Tissue Regeneration ◽  
Mechanism Of Action ◽  
Cellular Response ◽  
Health Improvement ◽  
Mechanical Forces ◽  
Target Tissue ◽  
Physiological Effects ◽  
Positive Target ◽  
Post Traumatic

Abstract Using the effect of mechanical forces affecting cellular response in the treatment of post-traumatic, postoperative, post-imlantation conditions through the application of Endermologie®- mechanotransduction represents a revolutionary solution in tissue-rehabilitation and positive target tissue influencing, with faster regeneration (1). Endermologie® is a noninvasive, painless, natural method of treatments of all connective tissue transformations, muscle and circulation pathologies. The aim of our study is investigation and explanation the mechanism of action by observing the physiological effects of Endermologie® based on human studies. The paper is focused on monitoring of possitive effect tissue regeneration using endermologie as a tools mechanostimulation improvements of systems integridy and health improvement.

scholarly journals The Radiation-Induced Regenerative Response of Adult Tissue-Specific Stem Cells: Models and Signaling Pathways

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 855
Author(s):  
Paola Serrano Martinez ◽  
Lorena Giuranno ◽  
Marc Vooijs ◽  
Robert P. Coppes
Keyword(s):  
Signaling Pathways ◽  
Progenitor Cells ◽  
Tissue Regeneration ◽  
Normal Tissue ◽  
Cellular Response ◽  
Adult Tissue ◽  
Tissue Specific ◽  
Radiation Induced

Radiotherapy is involved in the treatment of many cancers, but damage induced to the surrounding normal tissue is often inevitable. Evidence suggests that the maintenance of homeostasis and regeneration of the normal tissue is driven by specific adult tissue stem/progenitor cells. These tasks involve the input from several signaling pathways. Irradiation also targets these stem/progenitor cells, triggering a cellular response aimed at achieving tissue regeneration. Here we discuss the currently used in vitro and in vivo models and the involved specific tissue stem/progenitor cell signaling pathways to study the response to irradiation. The combination of the use of complex in vitro models that offer high in vivo resemblance and lineage tracing models, which address organ complexity constitute potential tools for the study of the stem/progenitor cellular response post-irradiation. The Notch, Wnt, Hippo, Hedgehog, and autophagy signaling pathways have been found as crucial for driving stem/progenitor radiation-induced tissue regeneration. We review how these signaling pathways drive the response of solid tissue-specific stem/progenitor cells to radiotherapy and the used models to address this.

scholarly journals THE EARLY CELLULAR REACTION OF EYE TISSUES TO THE IMPLANTATION OF BIORESORBABLE DRAINAGES SATURATED BY IMMUNOSUPPRESSANTS WITH A SELECTIVE MECHANISM OF ACTION

2020 ◽  
Vol 28 (3) ◽  
pp. 15-20
Author(s):  
Viktoria N. Germanova ◽  
Natal'ya N. Sarbaeva ◽  
Elena V. Karlova ◽  
Larisa T. Volova ◽  
Irina F. Nefyodova ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Mechanism Of Action ◽  
Cellular Response ◽  
Collagen Synthesis ◽  
Mononuclear Cells ◽  
Early Postoperative Period ◽  
Lower Amount ◽  
Control Group ◽  
Eye Tissues ◽  
Selective Mechanism

Prolonged use of immunosuppressants with a selective mechanism of action is a promising strategy in the prevention of postoperative scarring in glaucoma surgery. In order to assess the cellular response of eye tissues to the implantation of bioresorbable drains saturated with cyclosporin A or everolimus, a filter-type hypotensive operation with implantation of polylactide-based drains was simulated in 12 rabbits. Drainages implanted in rabbits of the two experimental groups under study were pre-saturated with either cyclosporin A or everolimus. The control group consisted of animals that were implanted with drains not saturated with any drugs. On the 7th day after the operation, the animals were taken out of the experiment, the eyeballs were enucleated, and histological preparations stained with hematoxylin and eosin, as well as hematoxylin and Picrosirius-red were prepared. Using a score on a scale from 0 to 5, the cellular composition within the drainage material, the intensity of collagen synthesis in the drainage, the thickness of the capsule around the drainage, and the number of blood vessels were analyzed. In comparison with the control group, the study groups showed a significantly lower amount of mononuclear cells, fibroblasts and giant cells of foreign bodies, as well as a lower thickness of the capsules surrounding the drainage, up to their complete absence. In addition, the intensity of collagen synthesis inside the drainage material of the studied groups was significantly lower. The drains of the everolimus group were characterized by an extremely low density of viable cellular elements inside the implanted material and a complete absence of collagen. At the same time, no toxic effect of the substance on the surrounding tissues was found. Thus, the saturation of bioresorbable drainages based on polylactide with cyclosporin A and everolimus contributed to a decrease in the intensity of the formation of connective tissue elements both inside and around the drainage in the early postoperative period.

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

2018 ◽  
Vol 10 (422) ◽  
pp. eaao0475 ◽  
Author(s):  
Marsha C. Lampi ◽  
Cynthia A. Reinhart-King
Keyword(s):  
Extracellular Matrix ◽  
Clinical Trials ◽  
Cellular Response ◽  
Molecular Mechanisms ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Therapeutic Interventions ◽  
Target Tissue ◽  
Matrix Stiffness ◽  
Extracellular Matrix Stiffness

Tissues stiffen during aging and during the pathological progression of cancer, fibrosis, and cardiovascular disease. Extracellular matrix stiffness is emerging as a prominent mechanical cue that precedes disease and drives its progression by altering cellular behaviors. Targeting extracellular matrix mechanics, by preventing or reversing tissue stiffening or interrupting the cellular response, is a therapeutic approach with clinical potential. Major drivers of changes to the mechanical properties of the extracellular matrix include phenotypically converted myofibroblasts, transforming growth factor β (TGFβ), and matrix cross-linking. Potential pharmacological interventions to overcome extracellular matrix stiffening are emerging clinically. Aside from targeting stiffening directly, alternative approaches to mitigate the effects of increased matrix stiffness aim to identify and inhibit the downstream cellular response to matrix stiffness. Therapeutic interventions that target tissue stiffening are discussed in the context of their limitations, preclinical drug development efforts, and clinical trials.

Biomimetic silk fibroin and xanthan gum blended hydrogels for connective tissue regeneration

2020 ◽  
Vol 165 ◽  
pp. 874-882
Author(s):  
Prasanna Kumar Byram ◽  
Krishna Chaitanya Sunka ◽  
Anwesha Barik ◽  
Manish Kaushal ◽  
Santanu Dhara ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Silk Fibroin ◽  
Tissue Regeneration ◽  
Xanthan Gum ◽  
Connective Tissue Regeneration

scholarly journals A review of protein adsorption on bioceramics

2012 ◽  
Vol 2 (3) ◽  
pp. 259-277 ◽  
Author(s):  
Kefeng Wang ◽  
Changchun Zhou ◽  
Youliang Hong ◽  
Xingdong Zhang
Keyword(s):  
Tissue Regeneration ◽  
Protein Interactions ◽  
Tissue Repair ◽  
Cellular Response ◽  
Biological Activities ◽  
Biological Mechanisms ◽  
Hard Tissue ◽  
Coated Layer ◽  
Sense And Respond

Bioceramics, because of its excellent biocompatible and mechanical properties, has always been considered as the most promising materials for hard tissue repair. It is well know that an appropriate cellular response to bioceramics surfaces is essential for tissue regeneration and integration. As the in vivo implants, the implanted bioceramics are immediately coated with proteins from blood and body fluids, and it is through this coated layer that cells sense and respond to foreign implants. Hence, the adsorption of proteins is critical within the sequence of biological activities. However, the biological mechanisms of the interactions of bioceramics and proteins are still not well understood. In this review, we will recapitulate the recent studies on the bioceramic–protein interactions.

Different Effects of Foam Rolling on Passive Tissue Stiffness in Experienced and Nonexperienced Athletes

2020 ◽  
Vol 29 (7) ◽  
pp. 926-933 ◽  
Author(s):  
Isabel Mayer ◽  
Matthias W. Hoppe ◽  
Jürgen Freiwald ◽  
Rafael Heiss ◽  
Martin Engelhardt ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Sagittal Plane ◽  
Case Series ◽  
Muscle Stiffness ◽  
Acoustic Radiation Force Impulse ◽  
Iliotibial Band ◽  
Vastus Lateralis Muscle ◽  
Target Tissue ◽  
Tissue Stiffness ◽  
Foam Rolling

Context: Foam rolling (FR) has been developed into a popular intervention and has been established in various sports disciplines. However, its effects on target tissue, including changes in stiffness properties, are still poorly understood. Objective: To investigate muscle-specific and connective tissue-specific responses after FR in recreational athletes with different FR experience. Design: Case series. Setting: Laboratory environment. Participants: The study was conducted with 40 participants, consisting of 20 experienced (EA) and 20 nonexperienced athletes (NEA). Intervention: The FR intervention included 5 trials per 45 seconds of FR of the lateral thigh in the sagittal plane with 20 seconds of rest between each trial. Main Outcome Measures: Acoustic radiation force impulse elastosonography values, represented as shear wave velocity, were obtained under resting conditions (t0) and several times after FR exercise (0 min [t1], 30 min [t2], 6 h [t3], and 24 h [t4]). Data were assessed in superficial and deep muscle (vastus lateralis muscle; vastus intermedius muscle) and in connective tissue (iliotibial band). Results: In EA, tissue stiffness of the iliotibial band revealed a significant decrease of 13.2% at t1 (P ≤ .01) and 12.1% at t3 (P = .02). In NEA, a 6.2% increase of stiffness was found at t1, which was not significantly different to baseline (P = .16). For both groups, no significant iliotibial band stiffness changes were found at further time points. Also, regarding muscle stiffness, no significant changes were detected at any time for EA and NEA (P > .05). Conclusions: This study demonstrates a significant short-term decrease of connective tissue stiffness in EA, which may have an impact on the biomechanical output of the connective tissue. Thus, FR effects on tissue stiffness depend on the athletes’ experience in FR, and existing studies have to be interpreted cautiously in the context of the enrolled participants.

scholarly journals VII. EnteropathogenicEscherichia coli: physiological alterations from an extracellular position

2001 ◽  
Vol 281 (1) ◽  
pp. G1-G7 ◽  
Author(s):  
Gail Hecht
Keyword(s):  
Host Cells ◽  
Signaling Cascades ◽  
Target Tissue ◽  
Physiological Effects ◽  
Intestinal Epithelial ◽  
Infantile Diarrhea ◽  
Physiological Alterations ◽  
Host Target ◽  
Extracellular Location ◽  
Secretory Apparatus

Enteropathogenic Escherichia coli (EPEC) is primarily associated with infantile diarrhea in developing countries. This intriguing pathogen exerts numerous physiological effects on its host target tissue, the intestinal epithelium, all from an extracellular location. Expression of a type III secretory apparatus allows this organism to transfer bacterial effector molecules directly into host cells. As a result of EPEC attachment to and/or translocation of proteins into intestinal epithelial cells, many signaling cascades are activated. Ultimately, host functions are perturbed, including alteration of ion transport, disruption of the tight junction barrier, and activation of the inflammatory response.

Connective tissue regeneration to periodontally diseased teeth.

1980 ◽  
Vol 15 (1) ◽  
pp. 1-9 ◽  
Author(s):  
R. T. Cole ◽  
M. Crigger ◽  
G. Bogle ◽  
J. Egelberg ◽  
K. A. Selvig
Keyword(s):  
Connective Tissue ◽  
Tissue Regeneration ◽  
Connective Tissue Regeneration
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