Investigation of the relation between thrombocyte counts and serum transaminases in patients with Crimean Congo hemorrhagic fever

AbstractObjective:Fever, thrombocytopenia and transaminase elevation are consistent features of Crimean-Congo hemorrhagic fever (CCHF). This study which was done in a hyperendemic region for CCHF, was carried out to find the frequencies of elevated transaminases among CCHF patients with thrombocytopenia.Methods:Thrombocyte counts, aspartate aminotransferase (AST), alanine aminotransferase (ALT) test results on admission and follow-up of hospitalized CCHF patients were collected retrospectively.Results:When we assessed data on admission, all patients with thrombocyte ≤50,000/μL had elevated AST as well as all but one (98.1%) had elevated ALT levels. When the lowest thrombocyte count was taken into account, concordant AST, ALT levels of all patients with thrombocyte ≤50,000/μL were above normal.Conclusion:Conclusively, acute CCHF patients with thrombocyte <50,000/μL should necessarily have elevated ASTs, ALTs.

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Insulin resistance is associated with elevated transaminases and low aspartate aminotransferase/alanine aminotransferase ratio in young adults with normal weight

European Journal of Gastroenterology & Hepatology ◽

10.1097/meg.0000000000000811 ◽

2017 ◽

Vol 29 (4) ◽

pp. 435-440 ◽

Cited By ~ 8

Author(s):

Luis E. Simental-Mendía ◽

Martha Rodríguez-Morán ◽

Rita Gómez-Díaz ◽

Niels H. Wacher ◽

Heriberto Rodríguez-Hernández ◽

...

Keyword(s):

Insulin Resistance ◽

Young Adults ◽

Aspartate Aminotransferase ◽

Alanine Aminotransferase ◽

Normal Weight ◽

Elevated Transaminases

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Follow-up of patients with tick bite in terms of Crimean Congo hemorrhagic fever: Is tick bite enough for diagnosis?

Gaziantep Medical Journal ◽

10.5455/gmj-30-161587 ◽

2014 ◽

Vol 20 (4) ◽

pp. 309

Author(s):

Samil Hizli ◽

Hulya Sertoz ◽

Mesut Kocak ◽

Aydin Celik ◽

Gonca Yilmaz

Keyword(s):

Hemorrhagic Fever ◽

Tick Bite ◽

Crimean Congo Hemorrhagic Fever

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Liver manifestations in a cohort of 39 patients with congenital disorders of glycosylation: pin-pointing the characteristics of liver injury and proposing recommendations for follow-up

Orphanet Journal of Rare Diseases ◽

10.1186/s13023-020-01630-2 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Rodrigo Tzovenos Starosta ◽

Suzanne Boyer ◽

Shawn Tahata ◽

Kimiyo Raymond ◽

Hee Eun Lee ◽

...

Keyword(s):

Liver Injury ◽

Aspartate Aminotransferase ◽

Alanine Aminotransferase ◽

Metabolic Diseases ◽

Liver Tumors ◽

Transient Elastography ◽

Congenital Disorders ◽

Congenital Disorders Of Glycosylation ◽

Liver Ultrasound

Abstract Background The congenital disorders of glycosylation (CDG) are a heterogeneous group of rare metabolic diseases with multi-system involvement. The liver phenotype of CDG varies not only according to the specific disorder, but also from patient to patient. In this study, we sought to identify common patterns of liver injury among patients with a broad spectrum of CDG, and to provide recommendations for follow-up in clinical practice. Methods Patients were enrolled in the Frontiers in Congenital Disorders of Glycosylation natural history study. We analyzed clinical history, molecular genetics, serum markers of liver injury, liver ultrasonography and transient elastography, liver histopathology (when available), and clinical scores of 39 patients with 16 different CDG types (PMM2-CDG, n = 19), with a median age of 7 years (range: 10 months to 65 years). For patients with disorders which are treatable by specific interventions, we have added a description of liver parameters on treatment. Results Our principal findings are (1) there is a clear pattern in the evolution of the hepatocellular injury markers alanine aminotransferase and aspartate aminotransferase according to age, especially in PMM2-CDG patients but also in other CDG-I, and that the cholangiocellular injury marker gamma-glutamyltransferase is not elevated in most patients, pointing to an exclusive hepatocellular origin of injury; (2) there is a dissociation between liver ultrasound and transient elastography regarding signs of liver fibrosis; (3) histopathological findings in liver tissue of PMM2-CDG patients include cytoplasmic glycogen deposits; and (4) most CDG types show more than one type of liver injury. Conclusions Based on these findings, we recommend that all CDG patients have regular systematic, comprehensive screening for liver disease, including physical examination (for hepatomegaly and signs of liver failure), laboratory tests (serum alanine aminotransferase and aspartate aminotransferase), liver ultrasound (for steatosis and liver tumors), and liver elastography (for fibrosis).

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Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up

Disease Markers ◽

10.1155/2016/4857917 ◽

2016 ◽

Vol 2016 ◽

pp. 1-9 ◽

Cited By ~ 13

Author(s):

Miyuki Yokoyama ◽

Tetsu Watanabe ◽

Yoichiro Otaki ◽

Hiroki Takahashi ◽

Takanori Arimoto ◽

...

Keyword(s):

Cardiovascular Disease ◽

General Population ◽

Cardiovascular Mortality ◽

Aspartate Aminotransferase ◽

Alanine Aminotransferase ◽

Cost Effective ◽

Health Check ◽

Logistic Analysis ◽

Cox Proportional Hazard Regression

Background. Early identification of high risk subjects for cardiovascular disease in health check-up is still unmet medical need. Cardiovascular disease is characterized by the superior increase in aspartate aminotransferase (AST) to alanine aminotransferase (ALT). However, the association of AST/ALT ratio with brain natriuretic peptide (BNP) levels and cardiovascular mortality remains unclear in the general population. Methods and Results. This longitudinal cohort study included 3,494 Japanese subjects who participated in a community-based health check-up, with a 10-year follow-up. The AST/ALT ratio increased with increasing BNP levels. And multivariate logistic analysis showed that the AST/ALT ratio was significantly associated with a high BNP (≥100 pg/mL). There were 250 all-cause deaths including 79 cardiovascular deaths. Multivariate Cox proportional hazard regression analysis revealed that a high AST/ALT ratio (>90 percentile) was an independent predictor of all-cause and cardiovascular mortality after adjustment for confounding factors. Kaplan-Meier analysis demonstrated that cardiovascular mortality was higher in subjects with a high AST/ALT ratio than in those without. Conclusions. The AST/ALT ratio was associated with an increase in BNP and was predictive of cardiovascular mortality in a general population. Measuring the AST/ALT ratio during routine health check-ups may be a simple and cost-effective marker for cardiovascular mortality.

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Two dry-reagent systems evaluated for determinations of enzyme activities.

Clinical Chemistry ◽

10.1093/clinchem/34.1.155 ◽

1988 ◽

Vol 34 (1) ◽

pp. 155-157 ◽

Cited By ~ 6

Author(s):

J C Hafkenscheid ◽

J van der Ven-Jongekrijg

Keyword(s):

Enzyme Activities ◽

Aspartate Aminotransferase ◽

Alanine Aminotransferase ◽

Test Results ◽

Routine Procedure ◽

Commercial Test ◽

Wet Chemistry ◽

Activity Concentrations ◽

Low Concentrations ◽

Routine Procedures

Abstract We evaluated the Kodak Ektachem DT60/DTSC and the Boehringer Mannheim Reflotron for measuring activity concentrations of six enzymes. The Ektachem CVs for low concentrations of aspartate aminotransferase and alanine aminotransferase were high. As compared with the Ektachem and a routine "wet-chemistry" system, values for aspartate aminotransferase and alanine aminotransferase were lower as measured by the Reflotron, because no pyridoxal 5'-phosphate is included in the Reflotron slides. Activity concentrations of gamma-glutamyltransferase and creatine kinase measured with the Ektachem and with the routine procedure did not agree well, possibly because the Ektachem gave too-high results for the enzyme activities. Assays of several commercial test sera indicated that test results by the dry-chemistry and routine procedures are not interconvertible. This contrasts with our previous experience, in which between-test agreement for several analytes was acceptable.

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Kırım-Kongo Kanamalı Ateşi: 16 Olgunun Klinik Özelliklerinin ve Laboratuvar Bulgularının Retrospektif Değerlendirilmesi

Flora the Journal of Infectious Diseases and Clinical Microbiology ◽

10.5578/flora.69200 ◽

2020 ◽

Vol 25 (4) ◽

pp. 544-548

Author(s):

Deniz Akyol ◽

Esra Erdem Kıvrak ◽

Hüseyin Aytaç Erdem ◽

Hüsnü Pullukçu ◽

Oğuz Reşat Sipahi ◽

...

Keyword(s):

Blood Count ◽

Blood Product ◽

Clinical Symptoms ◽

Hemorrhagic Fever ◽

Test Results ◽

Blood Products ◽

Important Public Health ◽

Crimean Congo Hemorrhagic Fever ◽

Contact Isolation ◽

History Of

Introduction: Crimean-Congo Hemorrhagic Fever (CCHF) is a zoonotic disease frequently transmitted by tick bite and accompanied by fever and bleeding. It may cause important public health problems. Besides clinical symptoms and epidemiological history, blood count and biochemical test results are the first clues for CCHF. In this study, we aimed to retrospectively evaluate 16 patients who were followed and treated due to CCHF in our hospital. Materials and Methods: The patients who were followed up and treated with CCHF between 2009-2019 in our clinic were evaluated retrospectively in terms of demographic characteristics, presenting complaints, presence of tick history, laboratory parameters, necessity of blood products replacement, hospitalization periods, ribavirin treatment and one-month survival. Results: Sixteen patients [ten females, six males, mean age 50.37 ± 18.01 (min: 18-max: 79)] with the diagnosis of CCHF were included into the study. Presenting complaints were fever (16/16, 100%), fatigue (16/16, 100%), bleeding (9/16, 56.2%), petechial rash (7/16, 43.7%). nausea and vomiting (6/16, 37.5%). There was a history of tick contact in 14 cases (87.5%) but not in two cases. Supportive treatment was applied to all cases, and droplet and contact isolation were applied. Blood product replacement was performed in five patients (31.2%), and ribavirin was administered in nine patients (56.2%). Mortality rate was 6.3% (1/16). Conclusion: Crimean-Congo Hemorrhagic Fever is an endemic disease in our country. Especially in spring and summer months, patients with fever and cytopenia on hemogram should be questioned, and tick contact should be sought.

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An overview of procalcitonin in Crimean-Congo hemorrhagic fever: clinical diagnosis, follow-up, prognosis and survival rates

Turkish Journal of Biochemistry ◽

10.1515/tjb-2020-0001 ◽

2020 ◽

Vol 45 (5) ◽

pp. 593-600

Author(s):

Nahide Ekici-Günay ◽

Serhat Koyuncu

Keyword(s):

Roc Curve ◽

Survival Rates ◽

Hemorrhagic Fever ◽

Curve Analysis ◽

Control Group ◽

Operating Characteristics ◽

Roc Curve Analysis ◽

Crimean Congo Hemorrhagic Fever ◽

Diagnostic Threshold

AbstractObjectivesThis study investigates whether a diagnostic threshold value of procalcitonin exists in Crimean-Congo hemorrhagic fever (CCHF), while also determining the correlation between serum procalcitonin and routine diagnostic laboratory markers, monitoring changes in procalcitonin levels over time during hospitalization, and exploring the effect of procalcitonin levels on survival rates.MethodsA total of 161 patients, including 100 with laboratory-confirmed diagnosis of CCHF and 61 as a control group, were retrospectively investigated. Receiver operating characteristics (ROC) curve analysis was performed to evaluate the contribution of procalcitonin when diagnosing the onset in CCHF patients. Procalcitonin levels were measured with Diazyme latex-enhanced immunoturbidimetric method in Roche Cobas C501 analyzer. A Mann–Whitney U-test was applied to compare the groups, a Mantel–Haenszel (log-rank) test was used to calculate for graphic of original individual patient time-to-event data, and a Kaplan–Meier survival curve was plotted.ResultsA ROC curve analysis identified a best predictive procalcitonin level cut-off point of 0.560 μg/L, with a specificity of 97% and sensitivity of 27% for CCHF. The highest levels of procalcitonin were measured on day 2 during the follow-up throughout and on the 5th day peaked for a second time, lower than the first.ConclusionsProcalcitonin may serve as prognostic indicator and an auxiliary biomarker to rule out of CCHF.

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