Sila-Pharmaka, 31. Mitt. [1] Synthese, Struktur und pharmakologische Eigenschaften von Diphenyl(2-piperidinoethoxymethyl)silanol und seinem Kohlenstoff-Analogon / Sila-Pharmaca, 31 th Communication [1] Synthesis, Structure, and Pharmacological Properties of Diphenyl(2-piperidinoethoxymethyl)silanol and its Carbon Analogue

1983 ◽  
Vol 38 (6) ◽  
pp. 738-746 ◽  
Author(s):  
Reinhold Tacke ◽  
Hartwig Lange ◽  
William S. Sheldrick ◽  
Günter Lambrecht ◽  
Ulrich Moser ◽  
...  
Keyword(s):  
Solid State ◽  
Hydrogen Bonds ◽  
Chemical Properties ◽  
Pharmacological Properties ◽  
Physical And Chemical Properties ◽  
Antimuscarinic Agents ◽  
Physical And Chemical ◽  
And Chemical Properties

Abstract In the course of systematic investigations on sila-substituted parasympatholytics the diphenyl(2-aminoethoxymethyl)silanols 3b and 4b (and its carbon analogue 4a) were synthesized and characterized by their physical and chemical properties. In the solid state 4a and 4b form strong O-H---N hydrogen bonds, which are intramolecular (4a) and intermolecular (4b), respectively. 4a and 4b were found to be weak antimuscarinic agents (4b >4a) and strong papaverine-like spasmolytics (4a ≈4b).

scholarly journals RESEARCH OF THE SYNTHETIC, PHYSICAL AND CHEMICAL PROPERTIES OF 3-ALKYLSULFONYL-5-(CHINOLINE-2-YL, 2-HYDROXYCHINOLINE-4-YL)-4-R -2,4-DIHYDRO3N-1,2,4-TRIAZOLES 1

2016 ◽  
Vol 10 (1) ◽  
pp. 81
Author(s):  
Kaplaushenko Tm ◽  
Panasenko Oi ◽  
Kucheryavy Yu
Keyword(s):  
Biological Effects ◽  
Chemical Properties ◽  
Biological Action ◽  
Pharmacological Properties ◽  
Physical And Chemical Properties ◽  
Element Analysis ◽  
Fundamental Research ◽  
Physical And Chemical ◽  
And Chemical Properties

ABSTRACTObjective: Fundamental research in pharmacy and medicine have shown that drugs, which are based on nucleus of the 1,2,4-triazole, have a widerange of biological effects. Derivatives of this heterocyclic system have well-known Ukrainian clinicians and the world scientists due to its antifungal,antidepressant, anticancer, cardio- and hepatoprotective properties. The pharmacological activity of most organic compounds depends on severaldifferent factors, including bioavailability of the substance. Hence, it is very important to consider the results of the synthetic and biological researchesand established dependence of structure on the biological action when scientists model new molecules or improve pharmacological properties of anexisting structure. One of the important social and economic problems of the pharmaceutical industry is the implementation in practice of new drugsthat could compete with expensive imported drugs. In recent times, 1,2,4-triazole-3-thioderivatives take attention of compatriots and scientists offoreign countries who are working on finding bioactive compounds including heterocyclic systems. The structure, physical and chemical properties,pharmacological activities of 1,2,4-triazoles, and their 3-thioderivatives are understudied. Hence, the study of that will be actually and novelty formodern science. The main purpose of our research is synthesis of 3-alkylsulfonyl-5-(chinoline-2-yl, 2-hydroxychinoline-4-yl)-4-R-2,4-dihydro-3N1,2,4-triazoles,studyingof its physicaland chemical properties.Methods: The initial compounds have been synthesized previously using known in literature techniques. Oxidation of the sulfur atom of thesynthesized compounds to the hexavalent condition was carried out adding solution of hydrogen peroxide.Results: The structure of the obtained compounds was determined with the modern physical and chemical analysis methods: Element analysis,infrared-spectrophotometry, and their individuality with thin layer chromatography.Conclusions: Prospect of the further researches is determination of acute toxicity and next studying of pharmacological properties of the synthesizedcompounds.Keywords: 1,2,4-triazoles, Synthesis, Chemical properties, Chinoline.1 

Impact of solid-state photochemical [2+2] cycloaddition on coordination polymers for diverse applications

2020 ◽  
Vol 49 (28) ◽  
pp. 9556-9563 ◽  
Author(s):  
Samim Khan ◽  
Basudeb Dutta ◽  
Mohammad Hedayetullah Mir
Keyword(s):  
Solid State ◽  
Coordination Polymers ◽  
Chemical Properties ◽  
Physical And Chemical Properties ◽  
Physical And Chemical ◽  
Fine Tune ◽  
And Chemical Properties

This Frontier article highlights the advancement of [2+2] photocycloaddition reactions within coordination polymers to fine tune their diverse physical and chemical properties.

scholarly journals Compounds of Complex Halo and Pseudohalo Acids of the Group II B Metals, Part I Etherate, Pyridine and Aniline Compounds of Zn(II)

1979 ◽  
Vol 34 (8) ◽  
pp. 1101-1106 ◽  
Author(s):  
A. G. Galinos ◽  
J. K . Kouinis ◽  
P. V. Ioannou ◽  
Th. F . Zafiropoulos ◽  
S. P. Perlepes
Keyword(s):  
Solid State ◽  
Ir Spectra ◽  
Chemical Properties ◽  
Physical And Chemical Properties ◽  
Uv And Ir Spectra ◽  
Group Ii ◽  
Physical And Chemical ◽  
And Chemical Properties

The preparation of sixteen new etherate, pyridine and aniline compounds of complex halo and pseudohalo acids of Zn(II) is reported.The study of some physical and chemical properties as well as the UV and IR spectra of these compounds are discussed. Tetrahedral structures are proposed for all compounds in the solid state

Local Halide Distributions in High-Speed Tabular Ag(Br,I) Emulsion Microcrystals by Cryo-FEG-AEM

2001 ◽  
Vol 7 (S2) ◽  
pp. 520-521
Author(s):  
V. Oleshko ◽  
P. Crozier ◽  
L. Garone ◽  
J. Freedman
Keyword(s):  
Solid State ◽  
High Speed ◽  
Information Technologies ◽  
Chemical Properties ◽  
Imaging Systems ◽  
Physical And Chemical Properties ◽  
Electronic Imaging ◽  
Physical And Chemical ◽  
Made In ◽  
And Chemical Properties

The unique physical and chemical properties of AgX (X=C1, Br, I) emulsion microcrystals (optical, solid state, transport, chemical and spectral sensitizations and development) account for their use as basic light quanta detectors in practical photography for over 150 years. in spite of the advances made in other recording systems, especially in electronic imaging, contemporary AgX-based photographic materials are still superior in sensitivity and resolution. Although the replacement of AgX-based imaging systems by electronic imaging was already predicted 20 years ago, their current world manufacturing level is now larger than ever. However, in order to be successfully incorporated into digital and hybrid information technologies for the new Millennium, AgX-based photographic materials should further improve their quantum efficiency and image quality. in order to achieve these objectives, the key components should be intentionally modified with a focus primarily at the nanostructural level.

Theoretical and Spectroscopic Characterization of API-Related Azoles in Solution and in Solid State

2020 ◽  
Vol 26 (38) ◽  
pp. 4847-4857
Author(s):  
Marta Marín-Luna ◽  
Rosa M. Claramunt ◽  
José Elguero ◽  
Ibon Alkorta
Keyword(s):  
Solid State ◽  
Crystal Packing ◽  
Chemical Properties ◽  
Spectroscopic Characterization ◽  
Complete Characterization ◽  
Theoretical Studies ◽  
Physical And Chemical Properties ◽  
Physical And Chemical ◽  
And Chemical Properties

Azoles are a family of five-membered azacyclic compounds with relevant biological and pharmacological activity. Different subclasses of azoles are defined depending on the atomic arrangement and the number of nitrogen atoms present in the ring: pyrazoles, indazoles, imidazoles, benzimidazoles, triazoles, benzotriazoles, tetrazoles and pentazoles. The complete characterization of their structure and the knowledge about their crystal packing and physical and chemical properties are of vital importance for the advancement in the design of new azole-containing drugs. In this review, we report the latest recent contributions to azole chemistry, in particular, those in which theoretical studies have been performed.

scholarly journals Modification of polyolefins by reactive extrusion methods: a comparison of melt and solid-state modifications carried out on the same equipment

2020 ◽  
Vol 1 (11-12) ◽  
pp. 21-26
Author(s):  
A. N. Zelenetsky ◽  
M. D. Sizova ◽  
V. P. Volkov ◽  
S. N. Zelenetsky ◽  
V. S. Bolduev
Keyword(s):  
Solid State ◽  
Liquid Phase ◽  
Solid Phase ◽  
Chemical Properties ◽  
Reactive Extrusion ◽  
Physical And Chemical Properties ◽  
Adhesion Properties ◽  
High Adhesion ◽  
Physical And Chemical ◽  
And Chemical Properties

The modification of polyolefi ns by polar monomers in the melt and solid state on one extruder was investigated. The features of changes in the physical and chemical properties of polyolefi ns with melt and solid modifi cations are studied.The reactivity of comonomers in liquid-phase and solid-phase modifi cation processes has been compared. The method of grafting solid modifi cation, in which pre-ozonated polyethylene is used as a copolymerization initiator, has been investigated. High adhesion properties of the copolymers were found.

scholarly journals Relationship of thermodynamic data with Periodic Law

2019 ◽  
Vol 91 (6) ◽  
pp. 879-893
Author(s):  
Valery P. Vassiliev ◽  
Valery A. Lysenko ◽  
Marcelle Gaune-Escard
Keyword(s):  
Solid State ◽  
Periodic Table ◽  
Chemical Properties ◽  
Standard Entropy ◽  
Physical And Chemical Properties ◽  
Tetrad Effect ◽  
Binary Compounds ◽  
Relationship Of ◽  
Physical And Chemical ◽  
And Chemical Properties

Abstract Relationships between the various physical and chemical properties of isostructural compounds take place according to the Periodic Table that is a fundamental basis of Chemistry. The systematization of this approach, data vs. the Periodic Table, will contribute to further development of the solid state chemistry theory. The lanthanides and the actinides make up the f block of the Periodic Table. The lanthanides are the elements produced as the 4f sublevel is filled with electrons and the actinides are formed while filling the 5f sublevel. In this paper, we analyze some classes of compounds formed by the lanthanides with other elements of the Periodic Table, which can count into the thousands of binary compounds. The special place of lanthanides in the Periodic System of Elements made it possible to establish strict nonlinear relationships between the standard entropy and the lanthanide atomic number of the compounds Ln2X3 (X = O, S, Se, Te), LnN, LnB4, and LnF3 in the solid state. This relationship, based on tetrad-effect, can be applied to other physical and chemical properties of the isostructural compounds. The thermodynamic properties of actinides have been studied much less than lanthanides, but the similarity of physicochemical properties makes it possible for us to estimate, with sufficient accuracy, unexplored properties using fundamental laws. One of these laws is the tetrad-effect concept that is an effective tool to predict missing thermodynamic values for lanthanide and actinide compounds and to rationally plan experiments.

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