1H -NMRInvestigations on the Hydrogen Bond Formation between the Tranquilizers Diazepam and Nitrazepam and Some Nucleobases
1978 ◽
Vol 33
(11-12)
◽
pp. 870-875
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Keyword(s):
The formation of hydrogen bonds between the minor tranquilizers diazepam and nitrazepam and a few nucleobases was studied in deuterochloroform solution by means of proton magnetic resonance spectroscopy. The thermodynamic and spectroscopic data of the associations were evaluated on the basis of a dimer model, using the concentration dependent shifts of the protons involved in hydrogen bonds. The interactions of nitrazepam (ΔH0= -10 to -21 k J/mol; ΔG250 - 0.2 to -7.4 kJ/mol) were found to be stronger than those of diazepam (ΔH0 = - 10 to - 13 kJ/mol; ΔG250 = 6.0 to 6.4 k j/mol). The various binding sites of the benzodiazepines for hydrogen bonds are discussed.
1973 ◽
Vol 28
(5-6)
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pp. 323-330
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Keyword(s):
1973 ◽
Vol 95
(2)
◽
pp. 631-633
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1982 ◽
pp. 374-375
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Keyword(s):
2020 ◽
2014 ◽
Vol 111
(10)
◽
pp. E888-E895
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1969 ◽
Vol 47
(19)
◽
pp. 3655-3660
◽
1997 ◽
Vol 53
(4)
◽
pp. 680-695
◽
2012 ◽
Vol 68
(4)
◽
pp. o174-o178
◽
2020 ◽