Radical Quenching by Rosmarinic Acid from Lavandula vera MM Cell Culture

This study was conducted to evaluate the radical scavenging capacities of extracts and preparations from a Lavandula vera MM plant cell culture with different rosmarinic acid content and to compare them with pure rosmarinic and caffeic acids as well. The methods, which were used are superoxide anion and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radicals scavenging assays. Results showed that extracts and preparations from Lavandula vera MM possess strong radical scavengers, as the best both radical scavengers appeared to be the fractions with enriched rosmarinic acid content, obtained after ethylacetate fractioning (47.7% inhibition of superoxide radicals and 14.2 μᴍ 6-hydroxy- 2,5,7,8-tetramethylchroman-2-carboxylic acid equivalents, respectively). These data reveal the possibilities for application of these preparations as antioxidants.

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Peripherally substituted soluble nickel phthalocyanines: Synthesis, characterization, aggregation behavior and antioxidant properties

Journal of Porphyrins and Phthalocyanines ◽

10.1142/s1088424619501645 ◽

2019 ◽

Vol 23 (11n12) ◽

pp. 1478-1485

Author(s):

Senem Çolak Yazıcı ◽

Sibel Kahraman ◽

Salih Z. Yıldız ◽

Mahmut D. Yılmaz

Keyword(s):

Sulfonic Acid ◽

Antioxidant Activities ◽

Radical Scavenging Activity ◽

Antioxidant Properties ◽

Radical Scavenging ◽

Scavenging Activity ◽

The Novel ◽

Diammonium Salt ◽

Ft Ir ◽

Radical Scavenging Ability

Tetra-zwitterionic-substituted nickel(II) phthalocyanine derivatives were newly synthesized starting from nonionic 2(3),9(10),16(17),23(24)-tetrakis-[2-([Formula: see text]-((3-dimethylamino)propyl)carbamate)oxyethyl)phthalocyaninato nickel (II). The novel compounds have been characterized by a combination of UV-vis, FT-IR and mass spectroscopies and elemental analysis. The critical micelle concentrations of the prepared compounds were measured, and the antioxidant activities were analyzed with radical scavenging ability of 1,1-diphenyl-2-picrylhydrazyl (DPPH) and with 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS). The zwitterionic molecules showed aggregated spectra in the UV-vis region, and they might be good surfactant candidates for the detergent industry with their appropriate critical micelle concentration (CMC) properties in water. The compounds exhibited ABTS radical scavenging activity and thus they have antioxidant activity.

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Fistuloates A–C: New antioxidative aromatic compounds isolated from Cassia fistula

Journal of Chemical Research ◽

10.1177/1747519819875052 ◽

2019 ◽

Vol 43 (11-12) ◽

pp. 516-521

Author(s):

Zahida Aftab ◽

Masood Afzal ◽

Bushra ◽

Hidayatullah Khan ◽

Syed Badshah ◽

...

Keyword(s):

Aromatic Compounds ◽

Superoxide Anion ◽

Sulfonic Acid ◽

Anion Radical ◽

Soluble Fraction ◽

Antioxidant Properties ◽

Radical Scavenging ◽

Cassia Fistula ◽

Anti Oxidant ◽

Structural Formulae

Three new aromatic compounds named fistuloates: A (3-butyl-6-ethylnonyl-3-(1-phenylethyl) benzoate), B (3-(6- tert-butyl-1-ethoxy-5-ethyl-4-methylnonyl)-5-ethylbenzoic acid isobutyl ester) and C (4,5-diethoxy-2-propylbenzoic acid 7-(6-pentyltetrahydropyran-2-yl)-heptyl ester) were isolated from the ethyl acetate soluble fraction of Cassia fistula Linn. The structural formulae of the isolated compounds A–C were established through interpretation of their spectral data. Compounds A–C exhibited significant antioxidant properties in 2,2-diphenyl-1-picrylhydrazyl, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and superoxide anion radical scavenging assays that signifies that C. fistula carries potential anti-oxidant constituents and may assist to cure diseases associated with oxidative stress and others.

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Rosmarinic acid from Lavandula vera MM cell culture

Phytochemistry ◽

10.1016/s0031-9422(96)00426-8 ◽

1996 ◽

Vol 43 (6) ◽

pp. 1243-1244 ◽

Cited By ~ 14

Author(s):

E. Kovatcheva ◽

A. Pavlov ◽

I. Koleva ◽

M. Ilieva ◽

M. Mihneva

Keyword(s):

Cell Culture ◽

Rosmarinic Acid ◽

Lavandula Vera Mm

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Flavone C-Glycosides from Lychnis senno and their Antioxidative Activity

Natural Product Communications ◽

10.1177/1934578x1300801018 ◽

2013 ◽

Vol 8 (10) ◽

pp. 1934578X1300801

Author(s):

Hari Prasad Devkota ◽

Kumiko Fukusako ◽

Koji Ishiguro ◽

Shoji Yahara

Keyword(s):

Sulfonic Acid ◽

Antioxidative Activity ◽

Radical Scavenging ◽

Aerial Parts ◽

Diammonium Salt ◽

First Time

A new flavone C-glycoside, 5- O-acetyl-2″-α-rhamnopyranosylisovitexin (1), was isolated from the aerial parts of Lychnis senno Siebold et Zucc. (Family Caryophyllaceae), along with 2″-α-rhamnopyranosylisovitexin (2), 2″-α-rhamnopyranosylisoorientin (3) and isoorientin 3′-mehyl ether (4). All these compounds were isolated for the first time from L. senno and their antioxidative activity was analyzed by the 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radical-scavenging method. Compound 3 showed moderate antioxidative activity.

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Free Radical Scavengers and Antioxidants from Tagetes mendocina

Zeitschrift für Naturforschung C ◽

10.1515/znc-2004-5-610 ◽

2004 ◽

Vol 59 (5-6) ◽

pp. 345-353 ◽

Cited By ~ 23

Author(s):

Guillermo Schmeda-Hirschmann ◽

Alejandro Tapia ◽

Cristina Theoduloz ◽

Jaime Rodríguez ◽

Susana López ◽

...

Keyword(s):

Free Radical ◽

Superoxide Anion ◽

Radical Scavenging ◽

Lung Fibroblasts ◽

Free Radical Scavengers ◽

Total Phenolic ◽

Antioxidant Compounds ◽

Radical Scavenger ◽

Radical Scavengers ◽

Crude Drug

Tagetes mendocina (Asteraceae) is a medicinal plant widely used in the Andean provinces of Argentina. Preliminary assays showed free radical scavenging activity in the methanol extract of the aerial parts, measured by the decoloration of a methanolic solution of the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and scavenging of the superoxide anion. Assayguided isolation led to 4′-hydroxyacetophenone (1), protocatechuic acid (2), syringic acid (3), patuletin (4), quercetagetin 7-O-β-d-glucoside (5), patuletin 7-O-β-d-glucoside (6) and axillarin 7-O-β-d-glucoside (7) as the free radical scavengers and antioxidant compounds from Tagetes mendocina. On the basis of dry starting material, the total phenolic content of the crude drug was 3.00% with 0.372% of flavonoids. The content of compounds 1-7 in the crude drug was 0.008, 0.015, 0.010, 0.029, 0.238, 0.058 and 0.017%, respectively. Quercetagetin 7-O-β-d-glucoside proved to be the main free radical scavenger of the extracts measured by the DPPH decoloration test as well as for quenching the superoxide anion and inhibition of lipoperoxidation in erythrocytes. In the lipid peroxidation assay the percentual inhibition was related with the number of methoxy groups in the molecule, ranging from 86% for the quercetagetin glucoside to 67% for the monomethoxylated and 31% for the dimethoxylated derivative. The compounds showed low cytotoxicity towards human lung fibroblasts with IC50 > 1mᴍ for compounds 1-3 and 0.24 to 0.52 mm for the flavonoids 4-7.

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