Weight-adjusted versus fixed dose of linezolid for Chinese healthy volunteers of higher and lower body weight: a Phase I pharmacokinetic and pharmacodynamic study

2013 ◽  
Vol 22 (3) ◽  
pp. 309-315 ◽  
Author(s):  
Yun Cai ◽  
Dong Chai ◽  
Matthew E Falagas ◽  
Drosos E Karageorgopoulos ◽  
Rui Wang ◽  
...  
2014 ◽  
Vol 8 (6) ◽  
pp. 388-393 ◽  
Author(s):  
Atif Afzal ◽  
Daniel Fung ◽  
Sean Galligan ◽  
Ellen M. Godwin ◽  
John G. Kral ◽  
...  

2018 ◽  
Vol 243 (5) ◽  
pp. 408-417 ◽  
Author(s):  
Yong-Sub Byun ◽  
Eun-Kyoung Kim ◽  
Kimi Araki ◽  
Ken-ichi Yamamura ◽  
Kihoon Lee ◽  
...  

FRY like transcription coactivator ( Fryl) gene located on chromosome 5 is a paralog of FRY microtubule binding protein ( Fry) in vertebrates. It encodes a protein with unknown functions. Fryl gene is conserved in various species ranging from eukaryotes to human. Although there are several reports on functions of Fry gene, functions of Fryl gene remain unclear. A mouse line containing null mutation in Fryl gene by gene trapping was produced in this study for the first time. The survival and growth of Fryl−/− mice were observed. Fryl gene expression levels in mouse tissues were determined and histopathologic analyses were conducted. Most Fryl−/− mice died soon after birth. Rare Fryl−/− survivors showed growth retardation with significantly lower body weight compared to their littermate controls. Although they could breed, more than half of Fryl−/− survivors died of hydronephrosis before age 1. No abnormal histopathologic lesion was apparent in full-term embryo or adult tissues except the kidney. Abnormal lining cell layer detachments from walls of collecting and convoluted tubules in kidneys were apparent in Fryl−/− neonates and full-term embryos. Fryl gene was expressed in renal tubular tissues including the glomeruli and convoluted and collecting tubules. This indicates that defects in tubular systems are associated with Fryl functions and death of Fryl−/− neonates. Fryl protein is required for normal development and functional maintenance of kidney in mice. This is the first report of in vivo Fryl gene functions. Impact statement FRY like transcription coactivator ( Fryl) gene is conserved in various species ranging from eukaryotes to human. It expresses a protein with unknown function. We generated a Fryl gene mutant mouse line and found that most homozygous mice died soon after their birth. Rare Fryl−/− survivors showed growth retardation with significantly lower body weight compared to their littermate controls. Although they could breed, more than half of Fryl−/− survivors died of hydronephrosis before age 1. Full-term mutant embryos showed abnormal collecting and convoluted tubules in kidneys where Fryl gene was expressed. Collectively, these results indicate that Fryl protein is required for normal development and functional maintenance of kidney in mice. To the best of our knowledge, this is the first report on in vivo Fryl gene functions.


2020 ◽  
Vol 28 (8) ◽  
pp. 476-481
Author(s):  
Michael Caesario ◽  
Dicky Fakhri ◽  
Pribadi Wiranda Busro ◽  
Salomo Purba ◽  
Liza Fitria ◽  
...  

Background Data regarding predictors of the eventual need for postoperative peritoneal dialysis in infants undergoing open heart surgery is still limited. We aimed to determine whether prolonged cardiopulmonary bypass time, surgical complexity classified according to Risk Adjustment for Congenital Heart Surgery category, younger age, and lower body weight increase the probability of requiring postoperative peritoneal dialysis. Methods We retrospectively analyzed data of 181 infants who underwent open heart surgery at our institution from January 1 to December 31, 2018. Cardiopulmonary bypass time, Risk Adjustment for Congenital Heart Surgery category, age, body weight, and the need for postoperative peritoneal dialysis were recorded and analyzed. Results Thirteen (7.2%) of the 181 patients required postoperative peritoneal dialysis. This group was found to have a longer cardiopulmonary bypass time, younger age, and lower body weight. Longer cardiopulmonary bypass time ( p = 0.001), higher Risk Adjustment for Congenital Heart Surgery category ( p = 0.018), younger age ( p < 0.001), and lower body weight ( p < 0.001) significantly increased the risk of postoperative peritoneal dialysis. Conclusion Longer cardiopulmonary bypass time, more complex surgery, younger age, and lower body weight increase the probability of requiring postoperative peritoneal dialysis in infants undergoing open heart surgery.


Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 4082-4082
Author(s):  
Heinz Lubenau ◽  
Rolf Pokorny ◽  
Luis Lopez-Lazaro ◽  
Peter Bias ◽  
Bruce Wallin ◽  
...  

Abstract XM22 is a glycoPEGylated recombinant human G-CSF that interacts with the G-CSF receptor by binding and activation. In pilot studies in non-neutropenic animals, XM22 demonstrated a similar PK/PD profile compared to pegfilgrastim. By its longer duration of action compared to filgrastim a once per cycle dosing as fixed dose in chemotherapy treated cancer patients for the reduction of duration of severe neutropenia and incidence of febrile neutropenia is intended. METHODS: A single center, randomized, single-blind study of XM22, administered as single fixed dose given by the s.c. route, was conducted to assess safety, pharmacokinetic profile and pharmacodynamic properties based on absolute neutrophil count (ANC) and CD34+ cell count. Male or female healthy volunteers were assigned to either XM22 6 mg or pegfilgrastim 6 mg fixed dose treatment. RESULTS: 36 healthy volunteers were enrolled in two treatment groups and completed 21 day follow-up. Injections were generally well-tolerated with no discontinuations due to adverse events or serious adverse events. Pharmacodynamic data were compared between the fixed doses of 6 mg XM22 and pegfilgrastim and in body weight strata within the treatment groups. Pharmacokinetic and antibody data will be presented. CONCLUSIONS: Single doses of 6 mg fixed dose of XM22 administered to healthy volunteers were generally well-tolerated with regard to the expected side effect profile and demonstrated increases in absolute neutrophil count and CD34+ cell count. These results supplement data from another study in healthy volunteers in which XM22 was administered in ascending single doses adjusted according to body-weight.


2015 ◽  
Vol 10 (2) ◽  
pp. 101-104
Author(s):  
Сибагатуллин ◽  
Fatikh Sibagatullin ◽  
Шайдуллин ◽  
Radik Shaydullin ◽  
Ганиев ◽  
...  

The aim of this work was to study the reproductive capacity of fresh cows with various genotypes of kappa-casein gene and diatsetilglitserin O-acetyl transferase. It was revealed that at an early age of insemination and calving, animals have a lower body weight at first calving. Cows on the gene locus of kappa-casein AB and BB, gene of butterfat AK and KK were observed elongated expectancy service- and between calving periods (106 and 394 days, 105 and 400 days) and a lower coefficient of reproductive ability and Doha’s index (0.93 and 46.2, 0.91 and 45.8), which suggests a slight decrease in their reproductive capacity.


2017 ◽  
Vol 31 (4) ◽  
pp. e69 ◽  
Author(s):  
Louis F. Salciccioli ◽  
Haroon Kamran ◽  
Yang Liu ◽  
John G. Kral ◽  
Jason M. Lazar

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